FREM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FREM2_HUMAN
• UniProt AC: Q5SZK8
• Protein Name: FRAS1-related extracellular matrix protein 2
• Gene Name: FREM2
• Organism: Homo sapiens (Human).
• Sequence Length: 3169
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein ; Extracellular side .
• Protein Description: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion..
• Protein Sequence: MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAEPFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNDGIGSPPEAELQGSLYPTSMRIGDEGRLAVHFKTEAQFHGLFVLSHPASFTSSVIMSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTAPSHQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNAEYGCLADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYTVRSKDNANRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPSLAWEIGAENSRGTNIQHIALDRTKRQIPHGRAPPDGILPWELNSPSSAVSLVTVVGGTTVGLLTICLTVIAVLMCRGKESFRGKDAPKGSSSSEPMVPPQSHHNDSSEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	AFGRALLSPGLAGAA HHHHHHCCCCCCCCC	20.12	-
108	Phosphorylation	PGDRCAVSVLDNDAL CCCCEEEEEECCHHH	9.84	-
123	Phosphorylation	AQRPGRLSPKRFPCD HCCCCCCCCCCCCCC	27.32	26091039
125	Acetylation	RPGRLSPKRFPCDFG CCCCCCCCCCCCCCC	64.39	30588857
295	Phosphorylation	SRGAPVGSPALKREH HCCCCCCCHHHCHHC	13.77	-
358	N-linked_Glycosylation	PSDLLIFNLTSPFQP CCCEEEEECCCCCCC	35.10	UniProtKB CARBOHYD
498	Phosphorylation	HLVILGASSGSSAPK EEEEEECCCCCCCCC	33.17	28857561
499	Phosphorylation	LVILGASSGSSAPKS EEEEECCCCCCCCCC	42.00	28857561
501	Phosphorylation	ILGASSGSSAPKSFT EEECCCCCCCCCCEE	25.85	28857561
502	Phosphorylation	LGASSGSSAPKSFTV EECCCCCCCCCCEEH	52.71	28857561
786	Phosphorylation	INHHKIAYRPPGQEL CCCCCEEECCCCCCC	27.42	-
797	Phosphorylation	GQELGVATRVAQFQF CCCCCEEEEEEEEEE	24.22	-
880	Phosphorylation	KHGHMRVSGQILHVG CCCCEEECCEEEEEC	18.02	-
982	Phosphorylation	ETDDLMLTFLLEDPP CCCCEEEEEECCCCC	9.77	24275569
1134	Phosphorylation	SRAGIAISAFNLKDL HCCCEEEEECCHHHH	20.13	21964256
1244	N-linked_Glycosylation	HIMNQLINGTVLVES HHHHHHHCCEEEEEE	48.99	UniProtKB CARBOHYD
1291	Phosphorylation	GKHSVEKTVLIIVIP CCCCEEEEEEEEEEE	13.67	-
1303	Phosphorylation	VIPVDDETPRMTINN EEECCCCCCCEEECC	24.16	-
1319	Phosphorylation	LEIEIGDTKIINNKI EEEEECCEEEECCEE	20.94	-
1369	N-linked_Glycosylation	ENITLGMNFTQDEVD CCEEECCCCCHHHHH	34.71	UniProtKB CARBOHYD
1440	Phosphorylation	EGGKVTLTTDLLSTS CCCEEEEEECCCCCC	14.65	24719451
1445	Phosphorylation	TLTTDLLSTSDLNSP EEEECCCCCCCCCCC	32.91	24719451
1459	Phosphorylation	PDENLVFTITRAPMR CCCCEEEEEECCCCC	17.60	24719451
1525	Phosphorylation	VFRTFRISISDVDNK EEEEEEEEHHHCCCC	16.28	-
1527	Phosphorylation	RTFRISISDVDNKKP EEEEEEHHHCCCCCC	25.45	-
1537	Phosphorylation	DNKKPVVTIHKLVVS CCCCCEEEEEEEEEE	20.00	-
1584	N-linked_Glycosylation	IHGHLLFNNTRPVMV ECCEEECCCCCCEEE	49.27	UniProtKB CARBOHYD
1695	Phosphorylation	DRDSLHISLRFIVTE CCCCCEEEEEEEEEE	11.62	24719451
1741	N-linked_Glycosylation	YVLREGANATSDMFY EEECCCCCCCCCEEE	55.39	16335952
1796	Phosphorylation	VVLKRRGYLGETSFI HHHHHCCCCCCCEEE	15.10	-
1800	Phosphorylation	RRGYLGETSFISIGT HCCCCCCCEEEEEEC	27.43	-
1804	Phosphorylation	LGETSFISIGTRDRT CCCCEEEEEECCCCC	16.98	-
1947	Phosphorylation	ISRPEDHTSVVRFDK CCCCCCCCCEEECCH	35.22	22210691
2035	Phosphorylation	VQVWRTGTDLSKSSS EEEEECCCCCCCCCC	32.90	21712546
2044	Phosphorylation	LSKSSSVTVRSRKTD CCCCCCEEEEECCCC	16.49	21712546
2047	Phosphorylation	SSSVTVRSRKTDPPS CCCEEEEECCCCCCC	33.52	21712546
2050	Phosphorylation	VTVRSRKTDPPSADA EEEEECCCCCCCCCC	53.26	-
2059	Phosphorylation	PPSADAGTDYVGISR CCCCCCCCCCEEECC	26.36	-
2061	Phosphorylation	SADAGTDYVGISRNL CCCCCCCCEEECCCC	10.62	-
2065	Phosphorylation	GTDYVGISRNLDFAP CCCCEEECCCCCCCC	14.80	22210691
2119	Phosphorylation	EPSKATVSINDSVSD CCCCCEEECCCCHHH	16.00	28787133
2125	Phosphorylation	VSINDSVSDLPKMQF EECCCCHHHCCCCCE	37.06	25954137
2137	Phosphorylation	MQFKERIYTGSESDG CCEEEEEECCCCCCC	15.98	-
2138	Phosphorylation	QFKERIYTGSESDGQ CEEEEEECCCCCCCC	31.68	-
2140	Phosphorylation	KERIYTGSESDGQIV EEEEECCCCCCCCEE	26.57	-
2158	Phosphorylation	HRTGDVQYRSSVRCY EECCCCEEEEEEEEE	16.59	22817900
2160	Phosphorylation	TGDVQYRSSVRCYTR CCCCEEEEEEEEEEC	28.40	22985185
2256	Phosphorylation	TVIKFGETKFSVTEP EEEEECCCEEEECCC	37.46	22210691
2299	Phosphorylation	TKDGSATSGEDYHPV ECCCCCCCCCCCCCC	39.64	24505115
2338	Phosphorylation	REMREAFTVHLKPDE HHHHHEEEEEECCCC	17.67	29978859
2370	Phosphorylation	MSSMADVTFPSVPQI HHCCCCCCCCCHHHH	30.31	19413330
2433	Phosphorylation	INDTLTRYRWLISAP CCCHHHEEEEHHCCC	10.82	-
2581	Phosphorylation	RVGNHKCSNLLDYTE EECCCCCCCCCCCCE	35.00	30206219
2586	Phosphorylation	KCSNLLDYTEVKTHY CCCCCCCCCEEEEEE	12.55	30206219
2587	Phosphorylation	CSNLLDYTEVKTHYG CCCCCCCCEEEEEEC	33.69	30206219
2591	Phosphorylation	LDYTEVKTHYGFLTD CCCCEEEEEECCCCC	26.04	30206219
2593	Phosphorylation	YTEVKTHYGFLTDAT CCEEEEEECCCCCCC	18.14	30206219
2597	Phosphorylation	KTHYGFLTDATKNPE EEEECCCCCCCCCHH	22.71	30206219
2600	Phosphorylation	YGFLTDATKNPEIIG ECCCCCCCCCHHHCC	33.88	30206219
2614	Phosphorylation	GETYPYQYSLSIRGS CCCCCEEEEEEECCC	13.02	25884760
2615	Phosphorylation	ETYPYQYSLSIRGST CCCCEEEEEEECCCC	10.50	24719451
2617	Phosphorylation	YPYQYSLSIRGSTTL CCEEEEEEECCCCEE	12.33	24719451
2850	Phosphorylation	DIRFQQVSDPVAAEF EEEEEECCCCCEEEE	31.68	26074081
2858	Phosphorylation	DPVAAEFSLNTQMYL CCCEEEEECHHHHHH	16.53	26074081
2861	Phosphorylation	AAEFSLNTQMYLLSK EEEEECHHHHHHEEC	21.72	26074081
2864	Phosphorylation	FSLNTQMYLLSKKSL EECHHHHHHEECCEE	8.48	26074081
2867	Phosphorylation	NTQMYLLSKKSLWLS HHHHHHEECCEEEEC	35.13	26074081
3058	Phosphorylation	KKREIRSTPSLAWEI HHHHCCCCCCHHHHH	13.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FREM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FREM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FREM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FREM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00687: Fraser syndrome
• OMIM Disease
• 219000: Fraser syndrome (FRASS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1741, AND MASSSPECTROMETRY.
PubMed: 16335952