UTP23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UTP23_HUMAN
• UniProt AC: Q9BRU9
• Protein Name: rRNA-processing protein UTP23 homolog
• Gene Name: UTP23
• Organism: Homo sapiens (Human).
• Sequence Length: 249
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Involved in rRNA-processing and ribosome biogenesis..
• Protein Sequence: MKITRQKHAKKHLGFFRNNFGVREPYQILLDGTFCQAALRGRIQLREQLPRYLMGETQLCTTRCVLKELETLGKDLYGAKLIAQKCQVRNCPHFKNAVSGSECLLSMVEEGNPHHYFVATQDQNLSVKVKKKPGVPLMFIIQNTMVLDKPSPKTIAFVKAVESGQLVSVHEKESIKHLKEEQGLVKNTEQSRRKKRKKISGPNPLSCLKKKKKAPDTQSSASEKKRKRKRIRNRSNPKVLSEKQNAEGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Acetylation	CTTRCVLKELETLGK HHHHHHHHHHHHHCC	39.60	26051181
74	Ubiquitination	KELETLGKDLYGAKL HHHHHHCCHHHHHHH	47.90	29967540
74	Acetylation	KELETLGKDLYGAKL HHHHHHCCHHHHHHH	47.90	23236377
80	Acetylation	GKDLYGAKLIAQKCQ CCHHHHHHHHHHHCC	35.74	26822725
85	Acetylation	GAKLIAQKCQVRNCP HHHHHHHHCCCCCCC	20.01	25953088
85	Ubiquitination	GAKLIAQKCQVRNCP HHHHHHHHCCCCCCC	20.01	32015554
168	Phosphorylation	VESGQLVSVHEKESI EHHCCEEEEECHHHH	26.75	28122231
174	Phosphorylation	VSVHEKESIKHLKEE EEEECHHHHHHHHHH	48.26	25159151
179	Sumoylation	KESIKHLKEEQGLVK HHHHHHHHHHCCCCC	59.95	28112733
179	Sumoylation	KESIKHLKEEQGLVK HHHHHHHHHHCCCCC	59.95	-
186	Ubiquitination	KEEQGLVKNTEQSRR HHHCCCCCCHHHHHH	64.29	33845483
200	Phosphorylation	RKKRKKISGPNPLSC HHHHHCCCCCCHHHH	58.01	25159151
206	Phosphorylation	ISGPNPLSCLKKKKK CCCCCHHHHHHHCCC	20.75	25159151
217	Phosphorylation	KKKKAPDTQSSASEK HCCCCCCCCCCHHHH	29.32	29396449
219	Phosphorylation	KKAPDTQSSASEKKR CCCCCCCCCHHHHHH	29.93	29396449
220	Phosphorylation	KAPDTQSSASEKKRK CCCCCCCCHHHHHHH	26.46	29396449
222	Phosphorylation	PDTQSSASEKKRKRK CCCCCCHHHHHHHHH	52.47	28985074
235	Phosphorylation	RKRIRNRSNPKVLSE HHHHHHCCCHHHHCH	62.12	21712546
238	Ubiquitination	IRNRSNPKVLSEKQN HHHCCCHHHHCHHCC	61.12	22817900
241	Phosphorylation	RSNPKVLSEKQNAEG CCCHHHHCHHCCCCC	45.82	26055452
243 (in isoform 1)	Ubiquitination	-	45.54	21906983
243	Acetylation	NPKVLSEKQNAEGE- CHHHHCHHCCCCCC-	45.54	26051181
243	Ubiquitination	NPKVLSEKQNAEGE- CHHHHCHHCCCCCC-	45.54	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UTP23_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UTP23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UTP23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
K1C40_HUMAN	KRT40	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
RRS1_HUMAN	RRS1	physical	26344197
FCF1_HUMAN	FCF1	physical	28082392
RRP7A_HUMAN	RRP7A	physical	28082392
NHP2_HUMAN	NHP2	physical	28082392
DDX52_HUMAN	DDX52	physical	28082392

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.