RRP7A_HUMAN - dbPTM
RRP7A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RRP7A_HUMAN
UniProt AC Q9Y3A4
Protein Name Ribosomal RNA-processing protein 7 homolog A
Gene Name RRP7A
Organism Homo sapiens (Human).
Sequence Length 280
Subcellular Localization
Protein Description
Protein Sequence MVARRRKCAARDPEDRIPSPLGYAAIPIKFSEKQQASHYLYVRAHGVRQGTKSTWPQKRTLFVLNVPPYCTEESLSRLLSTCGLVQSVELQEKPDLAESPKESRSKFFHPKPVPGFQVAYVVFQKPSGVSAALALKGPLLVSTESHPVKSGIHKWISDYADSVPDPEALRVEVDTFMEAYDQKIAEEEAKAKEEEGVPDEEGWVKVTRRGRRPVLPRTEAASLRVLERERRKRSRKELLNFYAWQHRESKMEHLAQLRKKFEEDKQRIELLRAQRKFRPY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Methylation-MVARRRKCAARDPE
-CCCCCCCHHCCCHH		26.81116254053
19PhosphorylationDPEDRIPSPLGYAAI
CHHHCCCCCCCEEEE		30.3130266825
23PhosphorylationRIPSPLGYAAIPIKF
CCCCCCCEEEEEEEC		10.6720068231
29UbiquitinationGYAAIPIKFSEKQQA
CEEEEEEECCHHHCC		37.1722817900
31PhosphorylationAAIPIKFSEKQQASH
EEEEEECCHHHCCCE		38.5924719451
33UbiquitinationIPIKFSEKQQASHYL
EEEECCHHHCCCEEE		46.6521963094
58UbiquitinationTKSTWPQKRTLFVLN
CCCCCCCCEEEEEEC		43.18-
80PhosphorylationESLSRLLSTCGLVQS
HHHHHHHHHHCCCCE		26.6624732914
81PhosphorylationSLSRLLSTCGLVQSV
HHHHHHHHHCCCCEE		15.5724732914
87PhosphorylationSTCGLVQSVELQEKP
HHHCCCCEEECHHCC		15.3024732914
93AcetylationQSVELQEKPDLAESP
CEEECHHCCCHHCCC		30.7626051181
93UbiquitinationQSVELQEKPDLAESP
CEEECHHCCCHHCCC		30.7621963094
99PhosphorylationEKPDLAESPKESRSK
HCCCHHCCCHHHHHH		35.3529255136
101UbiquitinationPDLAESPKESRSKFF
CCHHCCCHHHHHHCC		77.0629967540
103PhosphorylationLAESPKESRSKFFHP
HHCCCHHHHHHCCCC		48.2428387310
149UbiquitinationSTESHPVKSGIHKWI
ECCCCCCCCHHHHHH		47.6321906983
154UbiquitinationPVKSGIHKWISDYAD
CCCCHHHHHHHHHHH		44.2822817900
183SumoylationFMEAYDQKIAEEEAK
HHHHHHHHHHHHHHH		40.77-
183UbiquitinationFMEAYDQKIAEEEAK
HHHHHHHHHHHHHHH		40.7721963094
192SumoylationAEEEAKAKEEEGVPD
HHHHHHHHHHHCCCC		66.02-
192UbiquitinationAEEEAKAKEEEGVPD
HHHHHHHHHHHCCCC		66.0229967540
192SumoylationAEEEAKAKEEEGVPD
HHHHHHHHHHHCCCC		66.02-
205UbiquitinationPDEEGWVKVTRRGRR
CCCCCCEEEEECCCC		31.2329967540
250UbiquitinationAWQHRESKMEHLAQL
HHHHHHHHHHHHHHH		43.4821890473
260UbiquitinationHLAQLRKKFEEDKQR
HHHHHHHHHHHHHHH		52.1224816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RRP7A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RRP7A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RRP7A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
U2AF2_HUMANU2AF2physical
22939629
U2AF1_HUMANU2AF1physical
22939629
TPR_HUMANTPRphysical
22939629
ATP4A_HUMANATP4Aphysical
26186194
STXB1_HUMANSTXBP1physical
26186194
DPYL1_HUMANCRMP1physical
26186194
DPYL3_HUMANDPYSL3physical
26186194
DPYL2_HUMANDPYSL2physical
26186194
NOL6_HUMANNOL6physical
26186194
GBG2_HUMANGNG2physical
26186194
KCC2A_HUMANCAMK2Aphysical
26186194
RL24_HUMANRPL24physical
26344197
RS7_HUMANRPS7physical
26344197
NOL6_HUMANNOL6physical
28514442
ATP4A_HUMANATP4Aphysical
28514442
DPYL1_HUMANCRMP1physical
28514442
KCC2A_HUMANCAMK2Aphysical
28514442
DPYL3_HUMANDPYSL3physical
28514442
GBG2_HUMANGNG2physical
28514442
STXB1_HUMANSTXBP1physical
28514442
SYT1_HUMANSYT1physical
28514442
TAU_HUMANMAPTphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RRP7A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.

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