NOL6_HUMAN - dbPTM
NOL6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOL6_HUMAN
UniProt AC Q9H6R4
Protein Name Nucleolar protein 6
Gene Name NOL6
Organism Homo sapiens (Human).
Sequence Length 1146
Subcellular Localization Nucleus, nucleolus . Chromosome. Localizes to condensed chromosomes in mitosis..
Protein Description
Protein Sequence MGPAPAGEQLRGATGEPEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRIDAFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPMIRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLRLERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPAASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILEDFAVLGEGLVQTVEARSERWTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20SulfoxidationATGEPEVMEPALEGT
CCCCCCHHCHHHCCC		4.9421406390
27PhosphorylationMEPALEGTGKEGKKA
HCHHHCCCCCCCCCC		35.3925159151
29AcetylationPALEGTGKEGKKASS
HHHCCCCCCCCCCCC		64.2325953088
33UbiquitinationGTGKEGKKASSRKRT
CCCCCCCCCCCCCCC		65.4424816145
40PhosphorylationKASSRKRTLAEPPAK
CCCCCCCCCCCCCCC		33.1028555341
47UbiquitinationTLAEPPAKGLLQPVK
CCCCCCCCCCCCCEE		56.7333845483
54UbiquitinationKGLLQPVKLSRAELY
CCCCCCEECCHHHHH		47.6427667366
56PhosphorylationLLQPVKLSRAELYKE
CCCCEECCHHHHHCC		24.5920860994
62 (in isoform 3)Ubiquitination-70.6021906983
62UbiquitinationLSRAELYKEPTNEEL
CCHHHHHCCCCHHHH		70.6021906983
62AcetylationLSRAELYKEPTNEEL
CCHHHHHCCCCHHHH		70.6026051181
62 (in isoform 4)Ubiquitination-70.6021906983
62 (in isoform 1)Ubiquitination-70.6021906983
62 (in isoform 2)Ubiquitination-70.6021906983
82PhosphorylationTEILFHSSLLRLQVE
HHHHHCHHHHHHHHH		23.8924719451
93UbiquitinationLQVEELLKEVRLSEK
HHHHHHHHHHCCCHH		67.7821963094
121PhosphorylationQRVVRVPSVPETELT
HHEEECCCCCCCCCC		47.6627067055
149AcetylationHQVPYAVKGCFRFLP
HHCCHHCCCHHHCCC		41.6126051181
149UbiquitinationHQVPYAVKGCFRFLP
HHCCHHCCCHHHCCC		41.6121963094
181UbiquitinationPDINVDVALTMPREI
CCCCEEEEECCCHHH		7.8921963094
192MalonylationPREILQDKDGLNQRY
CHHHHCCCCCCCHHH		40.5126320211
192AcetylationPREILQDKDGLNQRY
CHHHHCCCCCCCHHH		40.5126051181
1922-HydroxyisobutyrylationPREILQDKDGLNQRY
CHHHHCCCCCCCHHH		40.51-
192UbiquitinationPREILQDKDGLNQRY
CHHHHCCCCCCCHHH		40.5129967540
200UbiquitinationDGLNQRYFRKRALYL
CCCCHHHHHHHHHHH		8.9321963094
271UbiquitinationPCRLLPTKNNVRSAW
CCCCCCCCCCCCCCH		44.5827667366
276PhosphorylationPTKNNVRSAWYRGQS
CCCCCCCCCHHCCCC		20.9024719451
279PhosphorylationNNVRSAWYRGQSPAG
CCCCCCHHCCCCCCC		12.4624719451
283 (in isoform 3)Phosphorylation-21.38-
283 (in isoform 2)Phosphorylation-21.38-
283PhosphorylationSAWYRGQSPAGDGSP
CCHHCCCCCCCCCCC		21.3830266825
289PhosphorylationQSPAGDGSPEPPTPR
CCCCCCCCCCCCCCC		30.7230266825
289 (in isoform 3)Phosphorylation-30.72-
289 (in isoform 2)Phosphorylation-30.72-
294 (in isoform 3)Phosphorylation-30.98-
294PhosphorylationDGSPEPPTPRYNTWV
CCCCCCCCCCCCCHH		30.9830266825
294 (in isoform 2)Phosphorylation-30.98-
367PhosphorylationVSTRKIHTTMSGYQV
HHCCCCCCCCCHHHH		27.8921406692
368PhosphorylationSTRKIHTTMSGYQVL
HCCCCCCCCCHHHHH		8.6520860994
370PhosphorylationRKIHTTMSGYQVLRS
CCCCCCCCHHHHHHH		32.0520068231
372PhosphorylationIHTTMSGYQVLRSVL
CCCCCCHHHHHHHHH		6.5320068231
377PhosphorylationSGYQVLRSVLQFLAT
CHHHHHHHHHHHHHC		24.0224719451
490SumoylationQAACHRLKLWPELQD
HHHHHHHHCCHHHHH		48.76-
543AcetylationDISQDPPKHKDSGTL
CCCCCCCCCCCCCEE		69.5426051181
549PhosphorylationPKHKDSGTLTLGLLL
CCCCCCCEEEEEEEE		22.1130631047
551PhosphorylationHKDSGTLTLGLLLRP
CCCCCEEEEEEEECC		20.7230631047
611AcetylationEAASMSQKRLIPHQV
HHHCCCCCCCCCHHH		41.6926051181
611UbiquitinationEAASMSQKRLIPHQV
HHHCCCCCCCCCHHH		41.6921963094
651PhosphorylationLIQGLKETSSTGEEA
HHHHHHHCCCCHHHH		26.7925690035
652PhosphorylationIQGLKETSSTGEEAL
HHHHHHCCCCHHHHH		27.3025278378
653PhosphorylationQGLKETSSTGEEALV
HHHHHCCCCHHHHHH		48.1025278378
654PhosphorylationGLKETSSTGEEALVA
HHHHCCCCHHHHHHH		48.6725278378
726AcetylationSLLPRLDKPCPAYVE
CCCCCCCCCCCCCCC		53.7826051181
726UbiquitinationSLLPRLDKPCPAYVE
CCCCCCCCCCCCCCC		53.78-
788AcetylationATHTDVLKDGFVFRI
EEECCHHCCCEEEEE		56.5026051181
788UbiquitinationATHTDVLKDGFVFRI
EEECCHHCCCEEEEE		56.5021963094
804 (in isoform 4)Ubiquitination-49.2221906983
807UbiquitinationQREPQILKEVQSPEG
CCCCHHHHHCCCCCC		58.4221963094
807 (in isoform 2)Ubiquitination-58.4221906983
807 (in isoform 1)Ubiquitination-58.4221906983
811PhosphorylationQILKEVQSPEGMISL
HHHHHCCCCCCCEEH		30.0530266825
811 (in isoform 2)Phosphorylation-30.05-
815SulfoxidationEVQSPEGMISLRDTA
HCCCCCCCEEHHHHH		1.4721406390
817PhosphorylationQSPEGMISLRDTAAS
CCCCCCEEHHHHHHH		14.4130266825
821PhosphorylationGMISLRDTAASLRLE
CCEEHHHHHHHHHHC		20.0721406692
824PhosphorylationSLRDTAASLRLERDT
EHHHHHHHHHHCCHH		16.1421406692
838PhosphorylationTRQLPLLTSALHGLQ
HCHHHHHHHHHHHHH		21.4524043423
839PhosphorylationRQLPLLTSALHGLQQ
CHHHHHHHHHHHHHH		28.8924043423
852PhosphorylationQQQHPAFSGVARLAK
HHHCCCHHHHHHHHH		34.1724043423
908PhosphorylationLRFLFLVSTFDWKNN
HHHHHHHHCCCCCCC		26.0425159151
1028PhosphorylationRHRQAVDSPAASFCR
CHHCCCCCHHHHHHH		15.1619691289
1032PhosphorylationAVDSPAASFCRGLLS
CCCCHHHHHHHHHHC		27.3022817900
1044PhosphorylationLLSQPGPSSLMPVLG
HHCCCCCCCCCCCCC		41.8625332170
1045PhosphorylationLSQPGPSSLMPVLGY
HCCCCCCCCCCCCCC		31.6425332170
1052PhosphorylationSLMPVLGYDPPQLYL
CCCCCCCCCCCHHHH		22.5525332170
1087AcetylationEVIGVLWKPTSFQPQ
EEEEEEECCCCCCCC		33.9726051181
1097MethylationSFQPQPFKASSTKGR
CCCCCCCCCCCCCCC		54.78115974115
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOL6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOL6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOL6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RS4X_HUMANRPS4Xphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOL6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, AND MASSSPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-289 ANDSER-811, AND MASS SPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, AND MASSSPECTROMETRY.

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