ATP4A_HUMAN - dbPTM
ATP4A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATP4A_HUMAN
UniProt AC P20648
Protein Name Potassium-transporting ATPase alpha chain 1
Gene Name ATP4A
Organism Homo sapiens (Human).
Sequence Length 1035
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach..
Protein Sequence MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MGKAENYELYSVEL
-CCCCCCEEEEEEEE		9.9812480547
10PhosphorylationKAENYELYSVELGPG
CCCCEEEEEEEECCC		9.9512480547
27PhosphorylationGDMAAKMSKKKKAGG
CHHHHHHCCCCCCCC		40.398886014
30MethylationAAKMSKKKKAGGGGG
HHHHCCCCCCCCCCH		52.1412692561
31MethylationAKMSKKKKAGGGGGK
HHHCCCCCCCCCCHH		62.23-
31AcetylationAKMSKKKKAGGGGGK
HHHCCCCCCCCCCHH		62.234199055
38UbiquitinationKAGGGGGKRKEKLEN
CCCCCCHHHHHHHHH		64.67-
40AcetylationGGGGGKRKEKLENMK
CCCCHHHHHHHHHHH		63.797493299
58PhosphorylationEINDHQLSVAELEQK
CCCHHHCCHHHHHHH		16.83-
77PhosphorylationATKGLSASLAAELLL
CCCCCCHHHHHHHHH		18.37-
171PhosphorylationKSTNIIASFKNLVPQ
HCCCEEHHHCCCCCC		26.7524719451
227PhosphorylationQGCKVDNSSLTGESE
CCCEECCCCCCCCCC		23.4323401153
228PhosphorylationGCKVDNSSLTGESEP
CCEECCCCCCCCCCC		35.8823927012
230PhosphorylationKVDNSSLTGESEPQT
EECCCCCCCCCCCCC		40.6323927012
233PhosphorylationNSSLTGESEPQTRSP
CCCCCCCCCCCCCCC		56.7923927012
237PhosphorylationTGESEPQTRSPECTH
CCCCCCCCCCCCCCC		43.7818510355
239PhosphorylationESEPQTRSPECTHES
CCCCCCCCCCCCCCC		28.5622210691
286PhosphorylationGRIASLASGVENEKT
HHHHHHHCCCCCCCC		48.98-
389PhosphorylationSVICSDKTGTLTQNR
EEEEECCCCCCCCCE		40.1526437602
391PhosphorylationICSDKTGTLTQNRMT
EEECCCCCCCCCEEE		31.6826437602
393PhosphorylationSDKTGTLTQNRMTVS
ECCCCCCCCCEEEEE		24.5226437602
398PhosphorylationTLTQNRMTVSHLWFD
CCCCCEEEEEEEEEC		18.6722798277
413PhosphorylationNHIHTADTTEDQSGQ
CCEEECCCCCCCCCC		29.6222798277
428PhosphorylationTFDQSSETWRALCRV
CCCCCHHHHHHHHHH		23.3822798277
463PhosphorylationRIVIGDASETALLKF
EEEECCCCHHHHHHH		39.97-
471PhosphorylationETALLKFSELTLGNA
HHHHHHHHHCCCCCC		30.06-
551PhosphorylationQWREAFQTAYLSLGG
HHHHHHHHHHHHHCC		15.7124961811
555PhosphorylationAFQTAYLSLGGLGER
HHHHHHHHHCCHHHH		16.58-
601PhosphorylationLCFAGLVSMIDPPRA
CCEEHHHHHCCCCCC		18.31-
628PhosphorylationGIRVIMVTGDHPITA
CCEEEEEECCCCCHH		21.3623186163
634PhosphorylationVTGDHPITAKAIAAS
EECCCCCHHHHHHHH		26.93-
733PhosphorylationTGDGVNDSPALKKAD
ECCCCCCCHHHHHCC		13.5828985074
750PhosphorylationVAMGIAGSDAAKNAA
EEEECCCHHHHHHHH		18.30-
784UbiquitinationRLIFDNLKKSIAYTL
CCCHHCHHHHHHHHH		51.2121890473
840PhosphorylationLAYEKAESDIMHLRP
HHHHHHHHCCCCCCC		36.98-
954PhosphorylationIRKTRRLSAFQQGFF
HHHHHHHHHHHHCCH		25.8121082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
954SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATP4A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATP4A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLH1_HUMANCLTCphysical
17255364
MAL2_HUMANMAL2physical
17255364
PRAF3_HUMANARL6IP5physical
17255364
SYPL1_HUMANSYPL1physical
17255364
RAB1A_HUMANRAB1Aphysical
17255364
RAB5C_HUMANRAB5Cphysical
17255364
RAB10_HUMANRAB10physical
17255364
RB11A_HUMANRAB11Aphysical
17255364
RB11B_HUMANRAB11Bphysical
17255364
RAB25_HUMANRAB25physical
17255364
SC22B_HUMANSEC22Bphysical
17255364
SCAM2_HUMANSCAMP2physical
17255364
SCAM3_HUMANSCAMP3physical
17255364
SNAA_HUMANNAPAphysical
17255364
SNG2_HUMANSYNGR2physical
17255364
STX3_HUMANSTX3physical
17255364
STX7_HUMANSTX7physical
17255364
STX12_HUMANSTX12physical
17255364
VATA_HUMANATP6V1Aphysical
17255364
VAT1_HUMANVAT1physical
17255364
VAMP1_HUMANVAMP1physical
17255364
VAMP2_HUMANVAMP2physical
17255364
VAMP3_HUMANVAMP3physical
17255364
VAMP5_HUMANVAMP5physical
17255364
VAMP8_HUMANVAMP8physical
17255364
LMAN2_HUMANLMAN2physical
17255364
AHNK_HUMANAHNAKphysical
17255364
TPRA1_HUMANTPRA1physical
17255364
ANXA1_HUMANANXA1physical
17255364
ANXA2_HUMANANXA2physical
17255364
ANXA6_HUMANANXA6physical
17255364
ANXA7_HUMANANXA7physical
17255364
ANX11_HUMANANXA11physical
17255364
AGR2_HUMANAGR2physical
17255364
APOA1_HUMANAPOA1physical
17255364
APOH_HUMANAPOHphysical
17255364
BAP31_HUMANBCAP31physical
17255364
BASI_HUMANBSGphysical
17255364
CAH9_HUMANCA9physical
17255364
CBPD_HUMANCPDphysical
17255364
CTND1_HUMANCTNND1physical
17255364
CAV1_HUMANCAV1physical
17255364
AOC3_HUMANAOC3physical
17255364
HYEP_HUMANEPHX1physical
17255364
FAM3B_HUMANFAM3Bphysical
17255364
FAM3C_HUMANFAM3Cphysical
17255364
LG3BP_HUMANLGALS3BPphysical
17255364
IF_HUMANGIFphysical
17255364
LIPG_HUMANLIPFphysical
17255364
GNAQ_HUMANGNAQphysical
17255364
GNAI1_HUMANGNAI1physical
17255364
GNAI2_HUMANGNAI2physical
17255364
GBG2_HUMANGNG2physical
17255364
ATP4A_HUMANATP4Aphysical
17255364
ATP4B_HUMANATP4Bphysical
17255364
ERG7_HUMANLSSphysical
17255364
ACSL1_HUMANACSL1physical
17255364
C163A_HUMANCD163physical
17255364
MRC1_HUMANMRC1physical
17255364
MPRD_HUMANM6PRphysical
17255364
GANAB_HUMANGANABphysical
17255364
AIRE_HUMANAIREphysical
17255364
PEPC_HUMANPGCphysical
17255364
KCNQ1_HUMANKCNQ1physical
17255364
PTN1_HUMANPTPN1physical
17255364
SCRB2_HUMANSCARB2physical
17255364
AT1A1_HUMANATP1A1physical
17255364
AT1B1_HUMANATP1B1physical
17255364
S12A2_HUMANSLC12A2physical
17255364
S26A9_HUMANSLC26A9physical
17255364
3BHS2_HUMANHSD3B2physical
17255364
TFR2_HUMANTFR2physical
17255364
KCNE2_HUMANKCNE2physical
17255364
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00355 Lansoprazole (JAN/USP/INN); Prevacid (TN)
D00455 Omeprazole (JP16/USP/INN); Prilosec (TN)
D00724 Sodium rabeprazole (JP16); Rabeprazole sodium (USAN); Aciphex (TN); Pariet (TN)
D01207 Omeprazole sodium (USAN); Losec sodium (TN)
D01920 Tenatoprazole (JAN/INN); TU 199
D01984 Esomeprazole magnesium hydrate (JAN); Esomeprazole magnesium (USAN); Nexium (TN)
D02593 Pantoprazole Sodium Hydrate (JAN); Pantoprazole sodium (USAN); Protonix (TN)
D04056 Esomeprazole sodium (USAN); Nexium IV (TN)
D05259 Omeprazole magnesium (USAN); Prilosec OTC (TN)
D05261 Omeprazole sodium injection (JAN); Omeprazole sodium hydrate; Omepral (TN)
D05353 Pantoprazole (USAN/INN)
D05900 Timoprazole (INN)
D05901 Picoprazole (INN)
D05906 Leminoprazole (INN)
D07917 Esomeprazole (INN); Inexium paranova (TN)
D08463 Rabeprazole (INN); Eraloc (TN)
D08903 Dexlansoprazole (INN/USAN)
D09339 Esomeprazole potassium (USAN)
D10120 Esomeprazole strontium (USAN); Esomeprazole strontium tetrahydrate
DrugBank
DB00736Esomeprazole
DB00448Lansoprazole
DB00338Omeprazole
DB00213Pantoprazole
DB01129Rabeprazole
Regulatory Network of ATP4A_HUMAN

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Related Literatures of Post-Translational Modification

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