dbPTM

STX7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STX7_HUMAN
UniProt AC	O15400
Protein Name	Syntaxin-7
Gene Name	STX7
Organism	Homo sapiens (Human).
Sequence Length	261
Subcellular Localization	Early endosome membrane Single-pass type IV membrane protein.
Protein Description	May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes..
Protein Sequence	MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYTPGVGG ------CCCCCCCCC	37.40	27155012
2	Acetylation	------MSYTPGVGG ------CCCCCCCCC	37.40	22223895
3	Phosphorylation	-----MSYTPGVGGD -----CCCCCCCCCC	18.69	25159151
4	Phosphorylation	----MSYTPGVGGDP ----CCCCCCCCCCH	13.27	25159151
24	Ubiquitination	RISSNIQKITQCSVE HHHHHHHHHHHCHHH	43.88	23000965
24	Malonylation	RISSNIQKITQCSVE HHHHHHHHHHHCHHH	43.88	26320211
28	S-nitrosocysteine	NIQKITQCSVEIQRT HHHHHHHCHHHHHHH	3.54	-
28	S-nitrosylation	NIQKITQCSVEIQRT HHHHHHHCHHHHHHH	3.54	19483679
35	Phosphorylation	CSVEIQRTLNQLGTP CHHHHHHHHHHCCCC	17.43	23403867
41	Phosphorylation	RTLNQLGTPQDSPEL HHHHHCCCCCCCHHH	26.77	25159151
45	Phosphorylation	QLGTPQDSPELRQQL HCCCCCCCHHHHHHH	18.28	25159151
55	Ubiquitination	LRQQLQQKQQYTNQL HHHHHHHHHHHHHHH	26.80	32015554
66	Phosphorylation	TNQLAKETDKYIKEF HHHHHHHHHHHHHHH	36.76	30624053
68	Ubiquitination	QLAKETDKYIKEFGS HHHHHHHHHHHHHCC	57.19	23000965
69	Phosphorylation	LAKETDKYIKEFGSL HHHHHHHHHHHHCCC	21.75	23312004
71	Ubiquitination	KETDKYIKEFGSLPT HHHHHHHHHHCCCCC	43.85	23000965
71 (in isoform 1)	Ubiquitination	-	43.85	21890473
71 (in isoform 2)	Ubiquitination	-	43.85	21890473
75	Phosphorylation	KYIKEFGSLPTTPSE HHHHHHCCCCCCHHH	36.17	23401153
78	Phosphorylation	KEFGSLPTTPSEQRQ HHHCCCCCCHHHHHH	57.54	30266825
79	Phosphorylation	EFGSLPTTPSEQRQR HHCCCCCCHHHHHHH	23.91	19664994
81	Phosphorylation	GSLPTTPSEQRQRKI CCCCCCHHHHHHHHH	44.24	30266825
87	Acetylation	PSEQRQRKIQKDRLV HHHHHHHHHHHHHHH	40.94	7977159
90	Acetylation	QRQRKIQKDRLVAEF HHHHHHHHHHHHHHH	48.57	7977171
98	Phosphorylation	DRLVAEFTTSLTNFQ HHHHHHHHHHCHHHH	13.64	26270265
99	Phosphorylation	RLVAEFTTSLTNFQK HHHHHHHHHCHHHHH	27.36	26270265
100	Phosphorylation	LVAEFTTSLTNFQKV HHHHHHHHCHHHHHH	30.09	26270265
102	Phosphorylation	AEFTTSLTNFQKVQR HHHHHHCHHHHHHHH	33.48	26270265
106	Ubiquitination	TSLTNFQKVQRQAAE HHCHHHHHHHHHHHH	35.88	33845483
125	Phosphorylation	FVARVRASSRVSGSF HHHHHHHHHCCCCCC	14.23	30266825
126	Phosphorylation	VARVRASSRVSGSFP HHHHHHHHCCCCCCC	35.40	29255136
129	Phosphorylation	VRASSRVSGSFPEDS HHHHHCCCCCCCCCC	27.84	29255136
131	Phosphorylation	ASSRVSGSFPEDSSK HHHCCCCCCCCCCCC	30.07	29255136
136	Phosphorylation	SGSFPEDSSKERNLV CCCCCCCCCCCCCCC	41.47	23927012
137	Phosphorylation	GSFPEDSSKERNLVS CCCCCCCCCCCCCCC	51.35	23927012
138	Ubiquitination	SFPEDSSKERNLVSW CCCCCCCCCCCCCCH	65.72	33845483
144	Phosphorylation	SKERNLVSWESQTQP CCCCCCCCHHCCCCC	28.43	27251789
147	Phosphorylation	RNLVSWESQTQPQVQ CCCCCHHCCCCCCEE	32.06	28857561
149	Phosphorylation	LVSWESQTQPQVQVQ CCCHHCCCCCCEEEC	52.04	22817900
161	Phosphorylation	QVQDEEITEDDLRLI EECCCCCCHHHHHHH	36.32	-
173	Phosphorylation	RLIHERESSIRQLEA HHHHHHHHHHHHHHH	36.97	28450419
174	Phosphorylation	LIHERESSIRQLEAD HHHHHHHHHHHHHHH	19.62	28450419
205	Phosphorylation	EQGDVIDSIEANVEN CCCCHHHHHHHHHHH	15.94	25850435
225	Phosphorylation	QQANQQLSRAADYQR HHHHHHHHHHHHHHH	18.61	27080861
239	S-palmitoylation	RKSRKTLCIIILILV HHHHHHHHHHHHHHH	2.25	18980942

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STX7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STX7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STX7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAMP8_HUMAN	VAMP8	physical	11101518
VTI1A_HUMAN	VTI1A	physical	11101518
STX8_HUMAN	STX8	physical	11101518
VTI1B_HUMAN	VTI1B	physical	12114520
VPS11_HUMAN	VPS11	physical	11382755
VPS18_HUMAN	VPS18	physical	11382755
SNP29_HUMAN	SNAP29	physical	9852078
GTF2I_HUMAN	GTF2I	physical	11278762
STX6_HUMAN	STX6	physical	11278762
VAMP8_HUMAN	VAMP8	physical	11278762
T10B_HUMAN	TIMM10B	physical	22939629
YKT6_HUMAN	YKT6	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	26186194
ZN101_HUMAN	ZNF101	physical	26186194
ZKSC1_HUMAN	ZKSCAN1	physical	26186194
VPS45_HUMAN	VPS45	physical	26186194
SNAA_HUMAN	NAPA	physical	26186194
STX4_HUMAN	STX4	physical	26186194
USE1_HUMAN	USE1	physical	26186194
STX18_HUMAN	STX18	physical	26186194
GOSR1_HUMAN	GOSR1	physical	26186194
NOP14_HUMAN	NOP14	physical	26186194
GORS1_HUMAN	GORASP1	physical	26186194
SNAG_HUMAN	NAPG	physical	26186194
STX5_HUMAN	STX5	physical	26186194
STXB5_HUMAN	STXBP5	physical	26186194
STX10_HUMAN	STX10	physical	26186194
SNP23_HUMAN	SNAP23	physical	26186194
SNP47_HUMAN	SNAP47	physical	26186194
PTTG_HUMAN	PTTG1IP	physical	26186194
STX12_HUMAN	STX12	physical	26186194
VTI1A_HUMAN	VTI1A	physical	26186194
ADPGK_HUMAN	ADPGK	physical	26186194
TYW5_HUMAN	TYW5	physical	26186194
STX3_HUMAN	STX3	physical	26186194
VAMP4_HUMAN	VAMP4	physical	26186194
SNP29_HUMAN	SNAP29	physical	26186194
STX8_HUMAN	STX8	physical	26186194
GOSR2_HUMAN	GOSR2	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
VAMP2_HUMAN	VAMP2	physical	26186194
NOC4L_HUMAN	NOC4L	physical	26186194
CLDN1_HUMAN	CLDND1	physical	26186194
VAMP8_HUMAN	VAMP8	physical	26186194
VAMP7_HUMAN	VAMP7	physical	26186194
ADCY9_HUMAN	ADCY9	physical	26186194
COPT1_HUMAN	SLC31A1	physical	26186194
BET1_HUMAN	BET1	physical	26344197
EHD1_HUMAN	EHD1	physical	26344197
EHD3_HUMAN	EHD3	physical	26344197
EHD4_HUMAN	EHD4	physical	26344197
SNAG_HUMAN	NAPG	physical	28514442
STXB5_HUMAN	STXBP5	physical	28514442
GOSR1_HUMAN	GOSR1	physical	28514442
ZKSC1_HUMAN	ZKSCAN1	physical	28514442
VTI1A_HUMAN	VTI1A	physical	28514442
GOSR2_HUMAN	GOSR2	physical	28514442
STX8_HUMAN	STX8	physical	28514442
STX3_HUMAN	STX3	physical	28514442
VAMP8_HUMAN	VAMP8	physical	28514442
SNP47_HUMAN	SNAP47	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
ZN101_HUMAN	ZNF101	physical	28514442
CLDN1_HUMAN	CLDND1	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
STX10_HUMAN	STX10	physical	28514442
ADCY9_HUMAN	ADCY9	physical	28514442
TYW5_HUMAN	TYW5	physical	28514442
STX5_HUMAN	STX5	physical	28514442
STX4_HUMAN	STX4	physical	28514442
YKT6_HUMAN	YKT6	physical	28514442
STX16_HUMAN	STX16	physical	28514442
VAMP2_HUMAN	VAMP2	physical	28514442
USE1_HUMAN	USE1	physical	28514442
SNP23_HUMAN	SNAP23	physical	28514442
NOP14_HUMAN	NOP14	physical	28514442
STX12_HUMAN	STX12	physical	28514442
COPT1_HUMAN	SLC31A1	physical	28514442
ADPGK_HUMAN	ADPGK	physical	28514442
SNAA_HUMAN	NAPA	physical	28514442
PTTG_HUMAN	PTTG1IP	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
STX18_HUMAN	STX18	physical	28514442
GORS1_HUMAN	GORASP1	physical	28514442
VAMP7_HUMAN	VAMP7	physical	28514442
SNP29_HUMAN	SNAP29	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STX7_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides."; Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.; Nat. Biotechnol. 21:566-569(2003). Cited for: PROTEIN SEQUENCE OF 2-17, AND ACETYLATION AT SER-2.	12665801 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-3, AND MASSSPECTROMETRY.	19413330 [Abstract]