VPS45_HUMAN - dbPTM
VPS45_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS45_HUMAN
UniProt AC Q9NRW7
Protein Name Vacuolar protein sorting-associated protein 45
Gene Name VPS45
Organism Homo sapiens (Human).
Sequence Length 570
Subcellular Localization Golgi apparatus membrane
Peripheral membrane protein. Endosome membrane
Peripheral membrane protein. Associated with Golgi/endosomal vesicles and the trans-Golgi network..
Protein Description May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network..
Protein Sequence MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQVITKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationVVFAVKQYISKMIED
HHHHHHHHHHHHHHH		11.0522817900
18PhosphorylationISKMIEDSGPGMKVL
HHHHHHHCCCCCEEE		33.8129978859
64UbiquitinationSQNREIMKHLKAICF
HCCHHHHHHHHHHHH		51.99-
75PhosphorylationAICFLRPTKENVDYI
HHHHHCCCHHHHHHH		44.5530576142
76UbiquitinationICFLRPTKENVDYII
HHHHCCCHHHHHHHH		50.39-
81PhosphorylationPTKENVDYIIQELRR
CCHHHHHHHHHHHHC		8.81-
158PhosphorylationDPAQLSRTTQGLTAL
CHHHHHHHHHHHHHH		21.7920068231
159PhosphorylationPAQLSRTTQGLTALL
HHHHHHHHHHHHHHH		21.3820068231
163PhosphorylationSRTTQGLTALLLSLK
HHHHHHHHHHHHHHC		23.2920068231
168PhosphorylationGLTALLLSLKKCPMI
HHHHHHHHHCCCCCH		37.8024719451
170UbiquitinationTALLLSLKKCPMIRY
HHHHHHHCCCCCHHH		49.2921890473
170UbiquitinationTALLLSLKKCPMIRY
HHHHHHHCCCCCHHH		49.2921890473
171UbiquitinationALLLSLKKCPMIRYQ
HHHHHHCCCCCHHHH		49.19-
185UbiquitinationQLSSEAAKRLAECVK
HCCHHHHHHHHHHHH		55.8021906983
192AcetylationKRLAECVKQVITKEY
HHHHHHHHHHHHHCH		50.9725953088
192UbiquitinationKRLAECVKQVITKEY
HHHHHHHHHHHHHCH		50.97-
192MalonylationKRLAECVKQVITKEY
HHHHHHHHHHHHHCH		50.9726320211
197UbiquitinationCVKQVITKEYELFEF
HHHHHHHHCHHHHCC		47.37-
250PhosphorylationNNNRIDLSRVPGISK
CCCCCCHHHCCCCCH		27.7330387612
257UbiquitinationSRVPGISKDLREVVL
HHCCCCCHHHHHHHH		59.8821890473
257UbiquitinationSRVPGISKDLREVVL
HHCCCCCHHHHHHHH		59.8821890473
272PhosphorylationSAENDEFYANNMYLN
HCCCCCHHHCCCEEE		13.33-
296UbiquitinationNLMEDFQKKKPKEQQ
HHHHHHHHCCHHHHH		63.86-
297UbiquitinationLMEDFQKKKPKEQQK
HHHHHHHCCHHHHHH		64.62-
304UbiquitinationKKPKEQQKLESIADM
CCHHHHHHHHHHHHH		54.65-
307PhosphorylationKEQQKLESIADMKAF
HHHHHHHHHHHHHHH		33.2526657352
312UbiquitinationLESIADMKAFVENYP
HHHHHHHHHHHHHCH		38.9421906983
318PhosphorylationMKAFVENYPQFKKMS
HHHHHHHCHHHHHCC		5.7225884760
3222-HydroxyisobutyrylationVENYPQFKKMSGTVS
HHHCHHHHHCCCCCC		42.17-
322UbiquitinationVENYPQFKKMSGTVS
HHHCHHHHHCCCCCC		42.17-
322MethylationVENYPQFKKMSGTVS
HHHCHHHHHCCCCCC		42.17115978745
323MethylationENYPQFKKMSGTVSK
HHCHHHHHCCCCCCC		39.32115978753
323UbiquitinationENYPQFKKMSGTVSK
HHCHHHHHCCCCCCC		39.32-
327PhosphorylationQFKKMSGTVSKHVTV
HHHHCCCCCCCCEEH		17.82-
330UbiquitinationKMSGTVSKHVTVVGE
HCCCCCCCCEEHHHH		37.45-
339PhosphorylationVTVVGELSRLVSERN
EEHHHHHHHHHHHCC		21.18-
371UbiquitinationSSALQNIKRLLQNPK
HHHHHHHHHHHHCCC		44.54-
378UbiquitinationKRLLQNPKVTEFDAA
HHHHHCCCCCHHHHH		70.1421906983
418UbiquitinationRNKGVSEKYRKLVSA
HHCCCCHHHHHHHHH		42.73-
419 (in isoform 2)Phosphorylation-14.6627174698
420 (in isoform 2)Phosphorylation-36.5827174698
424PhosphorylationEKYRKLVSAVVEYGG
HHHHHHHHHHHHCCC		26.2828857561
430 (in isoform 2)Phosphorylation-22.9527174698
431 (in isoform 2)Phosphorylation-17.4427174698
432MalonylationAVVEYGGKRVRGSDL
HHHHCCCEECCCCCC		43.2726320211
432UbiquitinationAVVEYGGKRVRGSDL
HHHHCCCEECCCCCC		43.27-
435 (in isoform 2)Phosphorylation-42.8227174698
437PhosphorylationGGKRVRGSDLFSPKD
CCEECCCCCCCCHHH		22.1526471730
441PhosphorylationVRGSDLFSPKDAVAI
CCCCCCCCHHHHHHH		38.0321815630
443UbiquitinationGSDLFSPKDAVAITK
CCCCCCHHHHHHHHH		58.0621906983
450UbiquitinationKDAVAITKQFLKGLK
HHHHHHHHHHHHHCC		32.7021890473
450UbiquitinationKDAVAITKQFLKGLK
HHHHHHHHHHHHHCC		32.7021890473
454UbiquitinationAITKQFLKGLKGVEN
HHHHHHHHHCCCCCC		64.58-
457UbiquitinationKQFLKGLKGVENVYT
HHHHHHCCCCCCCCC		70.36-
479UbiquitinationETLDHLIKGRLKENL
HHHHHHHHCHHHHCC		44.32-
483MalonylationHLIKGRLKENLYPYL
HHHHCHHHHCCCCCC		43.1026320211
483UbiquitinationHLIKGRLKENLYPYL
HHHHCHHHHCCCCCC		43.1021890473
483UbiquitinationHLIKGRLKENLYPYL
HHHHCHHHHCCCCCC		43.1021890473
487PhosphorylationGRLKENLYPYLGPST
CHHHHCCCCCCCHHH		11.0428634120
489PhosphorylationLKENLYPYLGPSTLR
HHHCCCCCCCHHHCC		15.6722210691
494PhosphorylationYPYLGPSTLRDRPQD
CCCCCHHHCCCCCCC		29.0122210691
511PhosphorylationVFVIGGATYEEALTV
EEEECCCCHHHHHHH		34.4422210691
557UbiquitinationSGLHSRSKESSQVTS
CCCCCCCCCHHCCCC		61.58-
559PhosphorylationLHSRSKESSQVTSRS
CCCCCCCHHCCCCCC		29.7925262027
560PhosphorylationHSRSKESSQVTSRSA
CCCCCCHHCCCCCCC		29.7525262027
563PhosphorylationSKESSQVTSRSASRR
CCCHHCCCCCCCCCC		15.7018077418
564PhosphorylationKESSQVTSRSASRR-
CCHHCCCCCCCCCC-		25.94-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS45_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS45_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS45_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN827_HUMANZNF827physical
22939629
RBNS5_HUMANRBSNphysical
25416956
DAG1_HUMANDAG1physical
26344197
RBNS5_HUMANRBSNphysical
26344197
SCFD1_HUMANSCFD1physical
26344197
VP33A_HUMANVPS33Aphysical
26344197
STX16_HUMANSTX16physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615285Neutropenia, severe congenital 5, autosomal recessive (SCN5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS45_HUMAN

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Related Literatures of Post-Translational Modification

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