STX16_HUMAN - dbPTM
STX16_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STX16_HUMAN
UniProt AC O14662
Protein Name Syntaxin-16
Gene Name STX16
Organism Homo sapiens (Human).
Sequence Length 325
Subcellular Localization Golgi apparatus membrane
Single-pass type IV membrane protein.
Isoform C: Cytoplasm.
Protein Description SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network..
Protein Sequence MATRRLTDAFLLLRNNSIQNRQLLAEQVSSHITSSPLHSRSIAAELDELADDRMALVSGISLDPEAAIGVTKRPPPKWVDGVDEIQYDVGRIKQKMKELASLHDKHLNRPTLDDSSEEEHAIEITTQEITQLFHRCQRAVQALPSRARACSEQEGRLLGNVVASLAQALQELSTSFRHAQSGYLKRMKNREERSQHFFDTSVPLMDDGDDNTLYHRGFTEDQLVLVEQNTLMVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCIKTEDGLKQLHKAEQYQKKNRKMLVILILFVIIIVLIVVLVGVKSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MATRRLTDAFLLLR
-CCCHHHHHHHHHHH		24.3824247654
17PhosphorylationFLLLRNNSIQNRQLL
HHHHHCCCHHHHHHH		29.15-
29PhosphorylationQLLAEQVSSHITSSP
HHHHHHHHHHHCCCC		18.8530108239
30PhosphorylationLLAEQVSSHITSSPL
HHHHHHHHHHCCCCC		21.7630108239
33PhosphorylationEQVSSHITSSPLHSR
HHHHHHHCCCCCCHH		20.0923401153
34PhosphorylationQVSSHITSSPLHSRS
HHHHHHCCCCCCHHH		29.3821712546
35PhosphorylationVSSHITSSPLHSRSI
HHHHHCCCCCCHHHH		23.8822617229
39PhosphorylationITSSPLHSRSIAAEL
HCCCCCCHHHHHHHH		35.0928122231
41PhosphorylationSSPLHSRSIAAELDE
CCCCCHHHHHHHHHH		21.4230266825
41 (in isoform 5)Phosphorylation-21.42-
50 (in isoform 2)Phosphorylation-18.0124719451
58PhosphorylationDDRMALVSGISLDPE
HHHHHHHHCCCCCHH		31.1225072903
61PhosphorylationMALVSGISLDPEAAI
HHHHHCCCCCHHHHC		30.1927251275
71PhosphorylationPEAAIGVTKRPPPKW
HHHHCCCCCCCCCCC		19.0025072903
77UbiquitinationVTKRPPPKWVDGVDE
CCCCCCCCCCCCCCH		66.67-
87PhosphorylationDGVDEIQYDVGRIKQ
CCCCHHCCCHHHHHH		20.46-
97MethylationGRIKQKMKELASLHD
HHHHHHHHHHHHHHH		57.5223644510
98 (in isoform 3)Phosphorylation-46.1825921289
99 (in isoform 3)Phosphorylation-3.0725921289
111PhosphorylationDKHLNRPTLDDSSEE
HHHCCCCCCCCCCCH		39.3124719451
115PhosphorylationNRPTLDDSSEEEHAI
CCCCCCCCCCHHHHH		39.0428348404
116PhosphorylationRPTLDDSSEEEHAIE
CCCCCCCCCHHHHHH		56.9024247654
185 (in isoform 1)Ubiquitination-41.8022053931
185UbiquitinationHAQSGYLKRMKNREE
HHHHHHHHHHCCHHH		41.8022053931
194PhosphorylationMKNREERSQHFFDTS
HCCHHHHHHHHCCCC		31.1430108239
200PhosphorylationRSQHFFDTSVPLMDD
HHHHHCCCCCCCCCC		26.8530576142
201PhosphorylationSQHFFDTSVPLMDDG
HHHHCCCCCCCCCCC		24.4730108239
212PhosphorylationMDDGDDNTLYHRGFT
CCCCCCCCEECCCCC		35.3728796482
214PhosphorylationDGDDNTLYHRGFTED
CCCCCCEECCCCCHH		6.3428796482
246PhosphorylationEIRQIVQSISDLNEI
HHHHHHHHHHHHHHH		17.1127732954
248PhosphorylationRQIVQSISDLNEIFR
HHHHHHHHHHHHHHH		41.0927732954
277 (in isoform 2)Ubiquitination-39.04-
278PhosphorylationIDYNVEQSCIKTEDG
ECCCCHHHHEECHHH		12.3328555341
280 (in isoform 2)Ubiquitination-8.1821906983
281UbiquitinationNVEQSCIKTEDGLKQ
CCHHHHEECHHHHHH		50.63-
284 (in isoform 4)Ubiquitination-73.3221906983
287UbiquitinationIKTEDGLKQLHKAEQ
EECHHHHHHHHHHHH		57.24-
301UbiquitinationQYQKKNRKMLVILIL
HHHHHHHHHHHHHHH		46.082190698
301 (in isoform 1)Ubiquitination-46.0822053931
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STX16_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STX16_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STX16_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VAMP3_HUMANVAMP3physical
11839770
VAMP4_HUMANVAMP4physical
11839770
VAMP5_HUMANVAMP5physical
25416956
SNAB_HUMANNAPBphysical
25416956
VATB2_HUMANATP6V1B2physical
26344197
Drug and Disease Associations
Kegg Disease
H00244 Pseudohypoparathyroidism
OMIM Disease
603233Pseudohypoparathyroidism 1B (PHP1B)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STX16_HUMAN

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Related Literatures of Post-Translational Modification

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