ZN827_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN827_HUMAN
• UniProt AC: Q17R98
• Protein Name: Zinc finger protein 827
• Gene Name: ZNF827
• Organism: Homo sapiens (Human).
• Sequence Length: 1081
• Subcellular Localization: Nucleus.
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MPRRKQEQPKRLPSHVSRQEEAEGELSEGEHWYGNSSETPSEASYGEVQENYKLSLEDRIQEQSTSPDTSLGSTTPSSHTLELVALDSEVLRDSLQCQDHLSPGVSSLCDDDPGSNKPLSSNLRRLLEAGSLKLDAAATANGRVESPVNVGSNLSFSPPSHHAQQLSVLARKLAEKQEQNDQYTPSNRFIWNQGKWLPNSTTTCSLSPDSAILKLKAAANAVLQDKSLTRTEETMRFESFSSPFSSQSASSTLAALSKKVSERSLTPGQEHPPPASSFLSLASMTSSAALLKEVAARAAGSLLAEKSSLLPEDPLPPPPSEKKPEKVTPPPPPPPPPPPPPPPQSLELLLLPVPKGRVSKPSNSASEEESGKPFQCPICGLVIKRKSYWKRHMVIHTGLKSHQCPLCPFRCARKDNLKSHMKVHQHQDRGETFQCQLCPFTSSRHFSLKLHMRCHQHFLRTEAKVKEEIPDPDVKGSPHLSDSACLGQQREGGGTELVGTMMTSNTPERTSQGGAGVSPLLVKEEPKEDNGLPTSFTLNAADRPANHTKLKDPSEYVANSASALFSQDISVKMASDFLMKLSAANQKEPMNLNFKVKEEPKEGESLSTTLPRSSYVFSPESEVSAPGVSEDALKPQEGKGSVLRRDVSVKAASELLMKLSAESYKETQMVKIKEEPMEVDIQDSHVSISPSRNVGYSTLIGREKTEPLQKMPEGRVPPERNLFSQDISVKMASELLFQLSEKVSKEHNHTKENTIRTTTSPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLHTEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSICCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGFECVFCNFVCKTKNMFERHLQIHLITRMFECDVCHKFMKTPEQLLEHKKCHTVPTGGLNSGQW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	EEAEGELSEGEHWYG HHHCCCCCCCCCCCC	38.97	28348404
33	Phosphorylation	LSEGEHWYGNSSETP CCCCCCCCCCCCCCC	14.34	28985074
36	Phosphorylation	GEHWYGNSSETPSEA CCCCCCCCCCCCCCC	25.78	28348404
37	Phosphorylation	EHWYGNSSETPSEAS CCCCCCCCCCCCCCC	49.87	28348404
39	Phosphorylation	WYGNSSETPSEASYG CCCCCCCCCCCCCHH	33.78	28348404
64	Phosphorylation	EDRIQEQSTSPDTSL HHHHHHCCCCCCCCC	30.05	30624053
65	Phosphorylation	DRIQEQSTSPDTSLG HHHHHCCCCCCCCCC	43.93	30278072
66	Phosphorylation	RIQEQSTSPDTSLGS HHHHCCCCCCCCCCC	26.48	30278072
69	Phosphorylation	EQSTSPDTSLGSTTP HCCCCCCCCCCCCCC	29.27	27732954
70	Phosphorylation	QSTSPDTSLGSTTPS CCCCCCCCCCCCCCC	37.81	27732954
73	Phosphorylation	SPDTSLGSTTPSSHT CCCCCCCCCCCCCCE	34.11	27732954
74	Phosphorylation	PDTSLGSTTPSSHTL CCCCCCCCCCCCCEE	40.71	27732954
75	Phosphorylation	DTSLGSTTPSSHTLE CCCCCCCCCCCCEEE	23.91	27732954
77	Phosphorylation	SLGSTTPSSHTLELV CCCCCCCCCCEEEEE	32.43	27732954
78	Phosphorylation	LGSTTPSSHTLELVA CCCCCCCCCEEEEEE	22.99	27732954
80	Phosphorylation	STTPSSHTLELVALD CCCCCCCEEEEEEEC	24.71	27732954
94	Phosphorylation	DSEVLRDSLQCQDHL CHHHHHHHHCCCCCC	17.57	29507054
102	Phosphorylation	LQCQDHLSPGVSSLC HCCCCCCCCCHHHHC	19.05	28985074
146	Phosphorylation	TANGRVESPVNVGSN CCCCEECCCCCCCCC	31.15	29255136
152	Phosphorylation	ESPVNVGSNLSFSPP CCCCCCCCCCCCCCC	30.25	29255136
155	Phosphorylation	VNVGSNLSFSPPSHH CCCCCCCCCCCCCHH	28.12	29255136
157	Phosphorylation	VGSNLSFSPPSHHAQ CCCCCCCCCCCHHHH	32.31	29255136
160	Phosphorylation	NLSFSPPSHHAQQLS CCCCCCCCHHHHHHH	31.15	29255136
167	Phosphorylation	SHHAQQLSVLARKLA CHHHHHHHHHHHHHH	15.67	25850435
176	Ubiquitination	LARKLAEKQEQNDQY HHHHHHHHHHHCCCC	54.23	-
176	Sumoylation	LARKLAEKQEQNDQY HHHHHHHHHHHCCCC	54.23	28112733
183	Phosphorylation	KQEQNDQYTPSNRFI HHHHCCCCCCCCCEE	24.39	-
184	Phosphorylation	QEQNDQYTPSNRFIW HHHCCCCCCCCCEEE	18.01	28674419
202	Phosphorylation	KWLPNSTTTCSLSPD CCCCCCCCCEECCCC	26.14	27251275
203	Phosphorylation	WLPNSTTTCSLSPDS CCCCCCCCEECCCCH	10.53	22199227
205	Phosphorylation	PNSTTTCSLSPDSAI CCCCCCEECCCCHHH	29.77	24719451
207	Phosphorylation	STTTCSLSPDSAILK CCCCEECCCCHHHHH	15.46	22199227
210	Phosphorylation	TCSLSPDSAILKLKA CEECCCCHHHHHHHH	22.16	-
216	Ubiquitination	DSAILKLKAAANAVL CHHHHHHHHHHHHHH	34.10	-
216	Sumoylation	DSAILKLKAAANAVL CHHHHHHHHHHHHHH	34.10	28112733
226	Ubiquitination	ANAVLQDKSLTRTEE HHHHHCCCCCCCCCH	34.11	-
226	Sumoylation	ANAVLQDKSLTRTEE HHHHHCCCCCCCCCH	34.11	28112733
242	Phosphorylation	MRFESFSSPFSSQSA HCCCCCCCCCCCCCH	28.14	27050516
264	Phosphorylation	SKKVSERSLTPGQEH HHHHHHCCCCCCCCC	32.32	28348404
266	Phosphorylation	KVSERSLTPGQEHPP HHHHCCCCCCCCCCC	26.98	28348404
276	Phosphorylation	QEHPPPASSFLSLAS CCCCCCCHHHHHHHH	27.65	27251275
277	Phosphorylation	EHPPPASSFLSLASM CCCCCCHHHHHHHHC	32.11	21712546
283	Phosphorylation	SSFLSLASMTSSAAL HHHHHHHHCCCHHHH	28.08	19413330
285	Phosphorylation	FLSLASMTSSAALLK HHHHHHCCCHHHHHH	19.62	19413330
286	Phosphorylation	LSLASMTSSAALLKE HHHHHCCCHHHHHHH	14.88	19413330
328	Phosphorylation	EKKPEKVTPPPPPPP CCCCCCCCCCCCCCC	40.94	-
328	O-linked_Glycosylation	EKKPEKVTPPPPPPP CCCCCCCCCCCCCCC	40.94	30379171
345	O-linked_Glycosylation	PPPPPPQSLELLLLP CCCCCCCCEEEEEEE	29.59	30379171
360	Sumoylation	VPKGRVSKPSNSASE CCCCCCCCCCCCCCH	50.00	28112733
372	Sumoylation	ASEEESGKPFQCPIC CCHHHCCCCCCCCCC	52.52	28112733
397	Phosphorylation	KRHMVIHTGLKSHQC HEEEEEECCCCCCCC	32.84	28555341
466	Sumoylation	LRTEAKVKEEIPDPD HHHHHHHCCCCCCCC	49.26	-
466	Sumoylation	LRTEAKVKEEIPDPD HHHHHHHCCCCCCCC	49.26	28112733
475	Sumoylation	EIPDPDVKGSPHLSD CCCCCCCCCCCCCCC	62.14	28112733
477	Phosphorylation	PDPDVKGSPHLSDSA CCCCCCCCCCCCCCC	11.93	29255136
481	Phosphorylation	VKGSPHLSDSACLGQ CCCCCCCCCCCCCCC	26.87	29255136
483	Phosphorylation	GSPHLSDSACLGQQR CCCCCCCCCCCCCCC	19.94	29255136
503	Phosphorylation	ELVGTMMTSNTPERT EEEEEEEECCCCCCC	14.17	27251275
504	Phosphorylation	LVGTMMTSNTPERTS EEEEEEECCCCCCCC	22.32	27690223
506	Phosphorylation	GTMMTSNTPERTSQG EEEEECCCCCCCCCC	26.71	25850435
518	Phosphorylation	SQGGAGVSPLLVKEE CCCCCCCCCEEEECC	14.65	28102081
523	Sumoylation	GVSPLLVKEEPKEDN CCCCEEEECCCCCCC	57.22	-
523	Sumoylation	GVSPLLVKEEPKEDN CCCCEEEECCCCCCC	57.22	25218447
549	Sumoylation	DRPANHTKLKDPSEY CCCCCCCCCCCHHHH	46.09	28112733
560	Phosphorylation	PSEYVANSASALFSQ HHHHHHHHHHHHHCC	17.54	30631047
566	Phosphorylation	NSASALFSQDISVKM HHHHHHHCCCCHHHH	28.00	30631047
570	Phosphorylation	ALFSQDISVKMASDF HHHCCCCHHHHHHHH	24.79	30631047
575	Phosphorylation	DISVKMASDFLMKLS CCHHHHHHHHHHHHH	25.95	24247654
580	Sumoylation	MASDFLMKLSAANQK HHHHHHHHHHHCCCC	41.24	28112733
587	Sumoylation	KLSAANQKEPMNLNF HHHHCCCCCCCCCCE	64.69	28112733
597	Sumoylation	MNLNFKVKEEPKEGE CCCCEEEECCCCCCC	57.88	-
597	Sumoylation	MNLNFKVKEEPKEGE CCCCEEEECCCCCCC	57.88	25755297
613	Phosphorylation	LSTTLPRSSYVFSPE CCCCCCCCCEECCCC	24.87	27732954
614	Phosphorylation	STTLPRSSYVFSPES CCCCCCCCEECCCCH	26.96	27732954
615	Phosphorylation	TTLPRSSYVFSPESE CCCCCCCEECCCCHH	13.53	23312004
618	Phosphorylation	PRSSYVFSPESEVSA CCCCEECCCCHHCCC	20.08	22199227
621	Phosphorylation	SYVFSPESEVSAPGV CEECCCCHHCCCCCC	46.83	22199227
624	Phosphorylation	FSPESEVSAPGVSED CCCCHHCCCCCCCCC	25.37	27732954
629	Phosphorylation	EVSAPGVSEDALKPQ HCCCCCCCCCCCCCC	35.36	23312004
634	Sumoylation	GVSEDALKPQEGKGS CCCCCCCCCCCCCCC	46.50	28112733
639	Sumoylation	ALKPQEGKGSVLRRD CCCCCCCCCCCHHCH	47.46	28112733
658	Sumoylation	AASELLMKLSAESYK HHHHHHHHHCHHHHC	38.98	28112733
660	Phosphorylation	SELLMKLSAESYKET HHHHHHHCHHHHCCC	25.19	26471730
663	Phosphorylation	LMKLSAESYKETQMV HHHHCHHHHCCCCCE	41.02	26471730
667	O-linked_Glycosylation	SAESYKETQMVKIKE CHHHHCCCCCEECCC	20.15	30379171
673	Sumoylation	ETQMVKIKEEPMEVD CCCCEECCCCCCCCC	50.75	-
673	Sumoylation	ETQMVKIKEEPMEVD CCCCEECCCCCCCCC	50.75	25114211
684	Phosphorylation	MEVDIQDSHVSISPS CCCCCCCCCCEECCC	14.93	29255136
687	Phosphorylation	DIQDSHVSISPSRNV CCCCCCCEECCCCCC	16.36	29255136
689	Phosphorylation	QDSHVSISPSRNVGY CCCCCEECCCCCCCC	14.87	29255136
691	Phosphorylation	SHVSISPSRNVGYST CCCEECCCCCCCCCC	29.69	29255136
704	Sumoylation	STLIGREKTEPLQKM CCCCCCCCCCCHHCC	57.75	28112733
710	Sumoylation	EKTEPLQKMPEGRVP CCCCCHHCCCCCCCC	65.19	28112733
724	Phosphorylation	PPERNLFSQDISVKM CCCCCCCCCHHHHHH	30.06	25159151
742	Sumoylation	LLFQLSEKVSKEHNH HHHHHHHHHHHHCCC	48.73	28112733
757	Phosphorylation	TKENTIRTTTSPFFS CCCCCEECCCCCCCC	30.49	23403867
758	Phosphorylation	KENTIRTTTSPFFSE CCCCEECCCCCCCCC	18.54	23403867
759	Phosphorylation	ENTIRTTTSPFFSED CCCEECCCCCCCCCC	33.51	29255136
760	Phosphorylation	NTIRTTTSPFFSEDT CCEECCCCCCCCCCC	20.02	23401153
764	Phosphorylation	TTTSPFFSEDTFRQS CCCCCCCCCCCCCCC	34.64	23403867
767	Phosphorylation	SPFFSEDTFRQSPFT CCCCCCCCCCCCCCC	19.37	28348404
771	Phosphorylation	SEDTFRQSPFTSNSK CCCCCCCCCCCCCCC	20.09	28985074
778	Sumoylation	SPFTSNSKELLPSDS CCCCCCCCCCCCCCC	57.54	28112733
798	Sumoylation	ISAPETEKIVLEAGN CCCCCCEEEEEECCC	45.60	28112733
837	Phosphorylation	QTLSRHLSLHTEERK HHHHHHHHCCCCCCC	16.39	22985185
840	Phosphorylation	SRHLSLHTEERKYKC HHHHHCCCCCCCCCC	44.85	28555341
868	Phosphorylation	NQHLTVHSVKLVSTD CCCCEEEEEEEEECC	19.33	28555341
870	Sumoylation	HLTVHSVKLVSTDTE CCEEEEEEEEECCHH	46.30	28112733
891	Sumoylation	TSEGSDGKKHPYYYS CCCCCCCCCCCCEEE	53.55	28112733
953	Phosphorylation	THIGTKHTGEDRKTP HCCCCCCCCCCCCCC	43.77	29449344
958	Sumoylation	KHTGEDRKTPSESNS CCCCCCCCCCCCCCC	76.69	28112733
959	Phosphorylation	HTGEDRKTPSESNSP CCCCCCCCCCCCCCC	32.70	25850435
961	Phosphorylation	GEDRKTPSESNSPSS CCCCCCCCCCCCCCH	59.91	25850435
963	Phosphorylation	DRKTPSESNSPSSSS CCCCCCCCCCCCHHH	47.12	25850435
965	Phosphorylation	KTPSESNSPSSSSLS CCCCCCCCCCHHHHH	35.12	25850435
967	Phosphorylation	PSESNSPSSSSLSAL CCCCCCCCHHHHHHH	42.55	30576142
968	Phosphorylation	SESNSPSSSSLSALS CCCCCCCHHHHHHHH	27.59	25850435
969	Phosphorylation	ESNSPSSSSLSALSD CCCCCCHHHHHHHHH	39.37	25850435
970	Phosphorylation	SNSPSSSSLSALSDS CCCCCHHHHHHHHHC	28.43	25850435
972	Phosphorylation	SPSSSSLSALSDSAN CCCHHHHHHHHHCCC	29.16	27732954
975	Phosphorylation	SSSLSALSDSANSKD HHHHHHHHHCCCCCC	29.27	27732954
977	Phosphorylation	SLSALSDSANSKDDS HHHHHHHCCCCCCCC	26.44	27732954
980	Phosphorylation	ALSDSANSKDDSDGS HHHHCCCCCCCCCCC	36.86	23312004
1014	Sumoylation	PSLNSEEKPEKGFEC CCCCCCCCCCCCEEE	55.19	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN827_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN827_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN827_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P66A_HUMAN	GATAD2A	physical	25150861
P66B_HUMAN	GATAD2B	physical	25150861
RBBP7_HUMAN	RBBP7	physical	25150861
RBBP4_HUMAN	RBBP4	physical	25150861
CHD3_HUMAN	CHD3	physical	25150861
CHD4_HUMAN	CHD4	physical	25150861
MTA1_HUMAN	MTA1	physical	25150861
MTA2_HUMAN	MTA2	physical	25150861
MTA3_HUMAN	MTA3	physical	25150861
HDAC1_HUMAN	HDAC1	physical	25150861
HDAC2_HUMAN	HDAC2	physical	25150861
MCPH1_HUMAN	MCPH1	physical	25150861
BRCA1_HUMAN	BRCA1	physical	25150861

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.