BET1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BET1_HUMAN
• UniProt AC: O15155
• Protein Name: BET1 homolog
• Gene Name: BET1
• Organism: Homo sapiens (Human).
• Sequence Length: 118
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus membrane. Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Grea
• Protein Description: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity)..
• Protein Sequence: MRRAGLGEGVPPGNYGNYGYANSGYSACEEENERLTESLRSKVTAIKSLSIEIGHEVKTQNKLLAEMDSQFDSTTGFLGKTMGKLKILSRGSQTKLLCYMMLFSLFVFFIIYWIIKLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	PPGNYGNYGYANSGY CCCCCCCCCCCCCCC	13.72	19060867
20	Phosphorylation	GNYGNYGYANSGYSA CCCCCCCCCCCCCCC	7.70	19060867
25	Phosphorylation	YGYANSGYSACEEEN CCCCCCCCCCCHHHH	7.91	-
38	Phosphorylation	ENERLTESLRSKVTA HHHHHHHHHHHHHHH	24.69	21815630
41	Phosphorylation	RLTESLRSKVTAIKS HHHHHHHHHHHHHHH	36.45	24702127
42	2-Hydroxyisobutyrylation	LTESLRSKVTAIKSL HHHHHHHHHHHHHHH	36.85	-
42	Ubiquitination	LTESLRSKVTAIKSL HHHHHHHHHHHHHHH	36.85	-
47	Ubiquitination	RSKVTAIKSLSIEIG HHHHHHHHHHHHHHC	42.77	-
48	Phosphorylation	SKVTAIKSLSIEIGH HHHHHHHHHHHHHCC	22.64	23927012
50	Phosphorylation	VTAIKSLSIEIGHEV HHHHHHHHHHHCCCH	25.85	26846344
58	Ubiquitination	IEIGHEVKTQNKLLA HHHCCCHHHHCHHHH	41.21	-
62	Ubiquitination	HEVKTQNKLLAEMDS CCHHHHCHHHHHHHH	34.75	21890473
67	Sulfoxidation	QNKLLAEMDSQFDST HCHHHHHHHHHCCCC	5.10	21406390
69	Phosphorylation	KLLAEMDSQFDSTTG HHHHHHHHHCCCCCC	31.28	30108239
73	Phosphorylation	EMDSQFDSTTGFLGK HHHHHCCCCCCHHHH	29.20	30108239
74	Phosphorylation	MDSQFDSTTGFLGKT HHHHCCCCCCHHHHH	32.55	30108239
75	Phosphorylation	DSQFDSTTGFLGKTM HHHCCCCCCHHHHHH	29.86	30108239
80	Ubiquitination	STTGFLGKTMGKLKI CCCCHHHHHHHHHHH	37.17	-
84	Ubiquitination	FLGKTMGKLKILSRG HHHHHHHHHHHHCCC	35.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BET1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BET1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BET1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USBP1_HUMAN	USHBP1	physical	16189514
B2L13_HUMAN	BCL2L13	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.
PubMed: 17081983