VTI1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VTI1A_HUMAN
• UniProt AC: Q96AJ9
• Protein Name: Vesicle transport through interaction with t-SNAREs homolog 1A
• Gene Name: VTI1A
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Subcellular Localization: Cytoplasmic vesicle . Golgi apparatus membrane; Single-pass type IV membrane protein.
• Protein Description: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence..
• Protein Sequence: MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRILTGMLRRIIQNRILLVILGIIVVITILMAITFSVRRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSDFEGYE ------CCCCCCCHH	38.32	23663014
3	Phosphorylation	-----MSSDFEGYEQ -----CCCCCCCHHH	45.05	23663014
8	Phosphorylation	MSSDFEGYEQDFAVL CCCCCCCHHHHHHHH	11.83	28464451
16	Phosphorylation	EQDFAVLTAEITSKI HHHHHHHHHHHHHHH	18.69	24719451
35	Ubiquitination	RLPPDEKKQMVANVE CCCCHHHHHHHHHHH	41.39	-
43	Ubiquitination	QMVANVEKQLEEAKE HHHHHHHHHHHHHHH	56.77	23000965
49	Ubiquitination	EKQLEEAKELLEQMD HHHHHHHHHHHHHCC	52.77	23000965
55	Sulfoxidation	AKELLEQMDLEVREI HHHHHHHCCCHHHHC	4.66	21406390
66	Phosphorylation	VREIPPQSRGMYSNR HHHCCCCCCCCCHHH	36.25	-
76	Phosphorylation	MYSNRMRSYKQEMGK CCHHHHHHHHHHHCC	27.60	-
78	Ubiquitination	SNRMRSYKQEMGKLE HHHHHHHHHHHCCCC	40.82	24816145
86	Phosphorylation	QEMGKLETDFKRSRI HHHCCCCCHHHHHHC	58.11	29083192
89	Ubiquitination	GKLETDFKRSRIAYS CCCCCHHHHHHCCCC	52.88	-
91	Phosphorylation	LETDFKRSRIAYSDE CCCHHHHHHCCCCHH	28.73	-
95	Phosphorylation	FKRSRIAYSDEVRNE HHHHHCCCCHHHHHH	17.81	25884760
96	Phosphorylation	KRSRIAYSDEVRNEL HHHHCCCCHHHHHHH	20.48	27486199
110	Phosphorylation	LLGDDGNSSENQRAH HCCCCCCCCHHHHHH	44.55	28450419
111	Phosphorylation	LGDDGNSSENQRAHL CCCCCCCCHHHHHHH	44.56	28450419
122	Phosphorylation	RAHLLDNTERLERSS HHHHHCHHHHHHHHH	23.34	28555341
136	Phosphorylation	SRRLEAGYQIAVETE HHHHHHHHHHEHHHH	12.09	28796482
142	Phosphorylation	GYQIAVETEQIGQEM HHHHEHHHHHHHHHH	26.96	27732954
154	Phosphorylation	QEMLENLSHDREKIQ HHHHHCCCCCHHHHH	34.62	27732954
170	Phosphorylation	ARERLRETDANLGKS HHHHHHHHHCCCCHH	33.70	29083192
176	Ubiquitination	ETDANLGKSSRILTG HHHCCCCHHHHHHHH	48.72	21906983
178	Phosphorylation	DANLGKSSRILTGML HCCCCHHHHHHHHHH	27.16	28348404
183	Ubiquitination	KSSRILTGMLRRIIQ HHHHHHHHHHHHHHH	15.07	27667366
213	Phosphorylation	ILMAITFSVRRH--- HHHHHHHHHHCC---	13.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VTI1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VTI1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VTI1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX7_HUMAN	STX7	physical	11101518
STX8_HUMAN	STX8	physical	11101518
VAMP8_HUMAN	VAMP8	physical	11101518

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.