STX8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STX8_HUMAN
• UniProt AC: Q9UNK0
• Protein Name: Syntaxin-8
• Gene Name: STX8
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Subcellular Localization: Membrane; Single-pass type IV membrane protein. Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity)..
• Protein Description: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER..
• Protein Sequence: MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTIRALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMVDRKSASCGMIMVILLLLVAIVVVAVWPTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Glutathionylation	FSTYDSTCQIAQEIA CCCCHHHHHHHHHHH	2.97	22555962
39	Ubiquitination	RKGEKAPKLTVTIRA HCCCCCCCHHHHHHH	62.74	33845483
43	Phosphorylation	KAPKLTVTIRALLQN CCCCHHHHHHHHHHH	10.26	24719451
52	Ubiquitination	RALLQNLKEKIALLK HHHHHHHHHHHHHHH	65.59	33845483
54	2-Hydroxyisobutyrylation	LLQNLKEKIALLKDL HHHHHHHHHHHHHHH	31.52	-
54	Ubiquitination	LLQNLKEKIALLKDL HHHHHHHHHHHHHHH	31.52	22817900
59	Ubiquitination	KEKIALLKDLLLRAV HHHHHHHHHHHHHHH	47.37	21906983
62	Ubiquitination	IALLKDLLLRAVSTH HHHHHHHHHHHHHHH	4.33	24816145
67	Phosphorylation	DLLLRAVSTHQITQL HHHHHHHHHHHHHHC	21.13	26471730
68	Phosphorylation	LLLRAVSTHQITQLE HHHHHHHHHHHHHCC	15.94	26471730
72	Phosphorylation	AVSTHQITQLEGDRR HHHHHHHHHCCCHHH	22.11	26471730
91	Ubiquitination	DDLVTRERLLLASFK HHHHHHHHHHHHHHC	27.61	21890473
96	Phosphorylation	RERLLLASFKNEGAE HHHHHHHHHCCCCCC	36.40	30266825
98	Ubiquitination	RLLLASFKNEGAEPD HHHHHHHCCCCCCHH	52.15	23000965
109	Phosphorylation	AEPDLIRSSLMSEEA CCHHHHHHHHCCHHH	22.34	22210691
110	Phosphorylation	EPDLIRSSLMSEEAK CHHHHHHHHCCHHHH	20.45	22210691
117	Ubiquitination	SLMSEEAKRGAPNPW HHCCHHHHCCCCCCC	55.43	33845483
132	Phosphorylation	LFEEPEETRGLGFDE CCCCCHHHCCCCHHH	28.51	22210691
146	Ubiquitination	EIRQQQQKIIQEQDA HHHHHHHHHHHHHHH	37.12	21906983
159	Phosphorylation	DAGLDALSSIISRQK HHHHHHHHHHHHHHH	22.63	29514088
160	Phosphorylation	AGLDALSSIISRQKQ HHHHHHHHHHHHHHH	25.45	29514088
163	Phosphorylation	DALSSIISRQKQMGQ HHHHHHHHHHHHHHH	27.30	30108239
214	S-palmitoylation	VDRKSASCGMIMVIL CCHHHHHHHHHHHHH	4.25	18980942

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	HECTD3	Q5T447	PMID:18821010

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STX8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STX8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VTI1B_HUMAN	VTI1B	physical	16189514
CREB3_HUMAN	CREB3	physical	16189514
VTI1B_HUMAN	VTI1B	physical	10683148
SNAA_HUMAN	NAPA	physical	10683148
STX7_HUMAN	STX7	physical	11101518
VTI1A_HUMAN	VTI1A	physical	11101518
VAMP8_HUMAN	VAMP8	physical	11101518

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.