SNAA_HUMAN - dbPTM
SNAA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNAA_HUMAN
UniProt AC P54920
Protein Name Alpha-soluble NSF attachment protein
Gene Name NAPA
Organism Homo sapiens (Human).
Sequence Length 295
Subcellular Localization Cell membrane
Peripheral membrane protein .
Protein Description Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane. [PubMed: 15980433]
Protein Sequence MDNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTESVKEYDSISRLDQWLTTMLLRIKKTIQGDEEDLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDNSGKEA
-------CCCCHHHH		11.2622814378
11SulfoxidationSGKEAEAMALLAEAE
CHHHHHHHHHHHHHH		1.7121406390
22UbiquitinationAEAERKVKNSQSFFS
HHHHHHHHCCHHHHC		54.6521906983
24PhosphorylationAERKVKNSQSFFSGL
HHHHHHCCHHHHCCH		22.8330108239
26PhosphorylationRKVKNSQSFFSGLFG
HHHHCCHHHHCCHHC		28.2530108239
29PhosphorylationKNSQSFFSGLFGGSS
HCCHHHHCCHHCCCH		32.3521712546
35PhosphorylationFSGLFGGSSKIEEAC
HCCHHCCCHHHHHHH		28.9223186163
36PhosphorylationSGLFGGSSKIEEACE
CCHHCCCHHHHHHHH		40.7123186163
45PhosphorylationIEEACEIYARAANMF
HHHHHHHHHHHHHHH		2.8127642862
53AcetylationARAANMFKMAKNWSA
HHHHHHHHHHHCHHH		27.4625953088
56UbiquitinationANMFKMAKNWSAAGN
HHHHHHHHCHHHHHH		56.29-
59PhosphorylationFKMAKNWSAAGNAFC
HHHHHCHHHHHHHHH		20.0328348404
93AcetylationVDAGNAFKKADPQEA
EECCHHHHHCCHHHH		44.6423749302
93UbiquitinationVDAGNAFKKADPQEA
EECCHHHHHCCHHHH		44.64-
94AcetylationDAGNAFKKADPQEAI
ECCHHHHHCCHHHHH		52.12130575
94MalonylationDAGNAFKKADPQEAI
ECCHHHHHCCHHHHH		52.1226320211
105SulfoxidationQEAINCLMRAIEIYT
HHHHHHHHHHHHHHH		2.7221406390
111PhosphorylationLMRAIEIYTDMGRFT
HHHHHHHHHHCCCHH		5.49-
114SulfoxidationAIEIYTDMGRFTIAA
HHHHHHHCCCHHHHH		2.9821406390
118PhosphorylationYTDMGRFTIAAKHHI
HHHCCCHHHHHCCCE		14.3528060719
126PhosphorylationIAAKHHISIAEIYET
HHHCCCEEHHHHHHH		16.0527251275
151PhosphorylationHYEQSADYYKGEESN
HHHHHCCCCCCCCCC		13.5422817900
152PhosphorylationYEQSADYYKGEESNS
HHHHCCCCCCCCCCC		17.05-
153AcetylationEQSADYYKGEESNSS
HHHCCCCCCCCCCCH		54.3326051181
153UbiquitinationEQSADYYKGEESNSS
HHHCCCCCCCCCCCH		54.3321906983
157PhosphorylationDYYKGEESNSSANKC
CCCCCCCCCCHHHHH		37.4026714015
163MalonylationESNSSANKCLLKVAG
CCCCHHHHHHHHHHH		26.4426320211
163AcetylationESNSSANKCLLKVAG
CCCCHHHHHHHHHHH		26.4426051181
163UbiquitinationESNSSANKCLLKVAG
CCCCHHHHHHHHHHH		26.44-
185PhosphorylationYQKAIDIYEQVGTNA
HHHHHHHHHHHCCCC		9.1428060719
190PhosphorylationDIYEQVGTNAMDSPL
HHHHHHCCCCCCCCC		22.4328060719
193SulfoxidationEQVGTNAMDSPLLKY
HHHCCCCCCCCCHHH		5.9430846556
195PhosphorylationVGTNAMDSPLLKYSA
HCCCCCCCCCHHHCH		12.3630278072
199UbiquitinationAMDSPLLKYSAKDYF
CCCCCCHHHCHHHHH		44.86-
203UbiquitinationPLLKYSAKDYFFKAA
CCHHHCHHHHHHHHH		47.2021906983
203AcetylationPLLKYSAKDYFFKAA
CCHHHCHHHHHHHHH		47.2019608861
218SulfoxidationLCHFCIDMLNAKLAV
HHHHHHHHHHHHHHH		1.2530846556
227UbiquitinationNAKLAVQKYEELFPA
HHHHHHHHHHHHHHH		48.2921906983
246UbiquitinationRECKLMKKLLEAHEE
HHHHHHHHHHHHHHH		44.3221906983
259PhosphorylationEEQNVDSYTESVKEY
HHCCHHHHHHHHHHH		15.29-
264UbiquitinationDSYTESVKEYDSISR
HHHHHHHHHHHHHHH		60.8921906983
266PhosphorylationYTESVKEYDSISRLD
HHHHHHHHHHHHHHH		14.8528634298
268PhosphorylationESVKEYDSISRLDQW
HHHHHHHHHHHHHHH		22.8928634298
270PhosphorylationVKEYDSISRLDQWLT
HHHHHHHHHHHHHHH		30.6428634298
277PhosphorylationSRLDQWLTTMLLRIK
HHHHHHHHHHHHHHH		13.7528634298
278PhosphorylationRLDQWLTTMLLRIKK
HHHHHHHHHHHHHHH		12.0328634298
284UbiquitinationTTMLLRIKKTIQGDE
HHHHHHHHHHHCCCH		37.11-
285MalonylationTMLLRIKKTIQGDEE
HHHHHHHHHHCCCHH		48.7932601280
285UbiquitinationTMLLRIKKTIQGDEE
HHHHHHHHHHCCCHH		48.7921906983
295MethylationQGDEEDLR-------
CCCHHHHC-------		57.74115917329
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNAA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNAA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNAA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RTN4_HUMANRTN4physical
16189514
VAMP8_HUMANVAMP8physical
9614193
STX12_HUMANSTX12physical
9507000
STX7_HUMANSTX7physical
9417091
NSF_HUMANNSFphysical
9362506
STX1A_HUMANSTX1Aphysical
7622514
SNP25_HUMANSNAP25physical
7622514
VAMP2_HUMANVAMP2physical
7622514
NSF_HUMANNSFphysical
7622514
A4_HUMANAPPphysical
21832049
VAMP2_HUMANVAMP2physical
22939629
THUM3_HUMANTHUMPD3physical
22939629
STAM2_HUMANSTAM2physical
22939629
NSF_MOUSENsfphysical
11278501
AP2A2_HUMANAP2A2physical
26344197
VATB2_HUMANATP6V1B2physical
26344197
BET1_HUMANBET1physical
26344197
HS74L_HUMANHSPA4Lphysical
26344197
HYOU1_HUMANHYOU1physical
26344197
STX16_HUMANSTX16physical
26344197
TRM6_HUMANTRMT6physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNAA_HUMAN

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Related Literatures of Post-Translational Modification

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