dbPTM

RTN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RTN4_HUMAN
UniProt AC	Q9NQC3
Protein Name	Reticulon-4
Gene Name	RTN4
Organism	Homo sapiens (Human).
Sequence Length	1192
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM3
Protein Description	Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules. [PubMed: 25612671]
Protein Sequence	MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDLDQSP -------CCCCCCCC	40.26	20068231
7	Phosphorylation	-MEDLDQSPLVSSSD -CCCCCCCCCCCCCC	21.62	29255136
11	Phosphorylation	LDQSPLVSSSDSPPR CCCCCCCCCCCCCCC	31.63	29255136
12	Phosphorylation	DQSPLVSSSDSPPRP CCCCCCCCCCCCCCC	30.59	29255136
13	Phosphorylation	QSPLVSSSDSPPRPQ CCCCCCCCCCCCCCC	34.30	29255136
15	Phosphorylation	PLVSSSDSPPRPQPA CCCCCCCCCCCCCCC	38.46	29255136
25	Phosphorylation	RPQPAFKYQFVREPE CCCCCCCEEEECCCC	10.75	28796482
31	Phosphorylation	KYQFVREPEDEEEEE CEEEECCCCCHHHHH	43.72	32142685
33	Phosphorylation	QFVREPEDEEEEEEE EEECCCCCHHHHHHH	78.35	32142685
58	Ubiquitination	ELEVLERKPAAGLSA HHHHHHCCCCCCCCC	29.63	21906983
58 (in isoform 1)	Ubiquitination	-	29.63	21890473
58 (in isoform 2)	Ubiquitination	-	29.63	21890473
58 (in isoform 5)	Ubiquitination	-	29.63	21890473
64	Phosphorylation	RKPAAGLSAAPVPTA CCCCCCCCCCCCCCC	22.82	28857561
70	Phosphorylation	LSAAPVPTAPAAGAP CCCCCCCCCCCCCCC	45.57	29083192
73	Ubiquitination	APVPTAPAAGAPLMD CCCCCCCCCCCCCCC	18.96	33845483
73 (in isoform 3)	Ubiquitination	-	18.96	21890473
79	Sulfoxidation	PAAGAPLMDFGNDFV CCCCCCCCCCCCCCC	3.80	30846556
97	Ubiquitination	PRGPLPAAPPVAPER CCCCCCCCCCCCCCC	13.64	21963094
97 (in isoform 3)	Ubiquitination	-	13.64	21890473
101	Phosphorylation	LPAAPPVAPERQPSW CCCCCCCCCCCCCCC	13.15	32142685
107	Phosphorylation	VAPERQPSWDPSPVS CCCCCCCCCCCCCCC	35.45	25159151
111	Ubiquitination	RQPSWDPSPVSSTVP CCCCCCCCCCCCCCC	35.15	21890473
111	Acetylation	RQPSWDPSPVSSTVP CCCCCCCCCCCCCCC	35.15	19608861
111	Phosphorylation	RQPSWDPSPVSSTVP CCCCCCCCCCCCCCC	35.15	30266825
111	Ubiquitination	RQPSWDPSPVSSTVP CCCCCCCCCCCCCCC	35.15	23000965
111 (in isoform 3)	Ubiquitination	-	35.15	21890473
114	Phosphorylation	SWDPSPVSSTVPAPS CCCCCCCCCCCCCCC	24.55	30266825
115	Phosphorylation	WDPSPVSSTVPAPSP CCCCCCCCCCCCCCC	33.39	30266825
116	Phosphorylation	DPSPVSSTVPAPSPL CCCCCCCCCCCCCCC	24.01	30266825
121	Phosphorylation	SSTVPAPSPLSAAAV CCCCCCCCCCCCCCC	40.35	30266825
124	Phosphorylation	VPAPSPLSAAAVSPS CCCCCCCCCCCCCCC	21.17	30266825
129	Phosphorylation	PLSAAAVSPSKLPED CCCCCCCCCCCCCCC	20.80	25159151
131	Phosphorylation	SAAAVSPSKLPEDDE CCCCCCCCCCCCCCC	39.04	25159151
146	Ubiquitination	PPARPPPPPPASVSP CCCCCCCCCCCCCCC	53.96	22817900
149	Ubiquitination	RPPPPPPASVSPQAE CCCCCCCCCCCCCCC	28.48	22817900
150	Phosphorylation	PPPPPPASVSPQAEP CCCCCCCCCCCCCCC	28.97	29514088
152	Phosphorylation	PPPPASVSPQAEPVW CCCCCCCCCCCCCCC	14.59	25159151
158	Ubiquitination	VSPQAEPVWTPPAPA CCCCCCCCCCCCCCC	7.18	22817900
160	O-linked_Glycosylation	PQAEPVWTPPAPAPA CCCCCCCCCCCCCCC	21.45	OGP
160	Phosphorylation	PQAEPVWTPPAPAPA CCCCCCCCCCCCCCC	21.45	25159151
160	Ubiquitination	PQAEPVWTPPAPAPA CCCCCCCCCCCCCCC	21.45	22817900
166	Ubiquitination	WTPPAPAPAAPPSTP CCCCCCCCCCCCCCC	28.09	32142685
171	Phosphorylation	PAPAAPPSTPAAPKR CCCCCCCCCCCCCCC	46.06	25850435
171 (in isoform 2)	Phosphorylation	-	46.06	25159151
172	Phosphorylation	APAAPPSTPAAPKRR CCCCCCCCCCCCCCC	23.79	25850435
172 (in isoform 2)	Phosphorylation	-	23.79	25159151
178	Ubiquitination	STPAAPKRRGSSGSV CCCCCCCCCCCCCCC	47.32	21890473
178	Ubiquitination	STPAAPKRRGSSGSV CCCCCCCCCCCCCCC	47.32	21890473
178 (in isoform 3)	Ubiquitination	-	47.32	21890473
181	Phosphorylation	AAPKRRGSSGSVDET CCCCCCCCCCCCCHH	29.70	29255136
181	Ubiquitination	AAPKRRGSSGSVDET CCCCCCCCCCCCCHH	29.70	27667366
181 (in isoform 2)	Phosphorylation	-	29.70	23927012
181 (in isoform 3)	Ubiquitination	-	29.70	21890473
182	Phosphorylation	APKRRGSSGSVDETL CCCCCCCCCCCCHHH	37.60	29255136
182 (in isoform 2)	Phosphorylation	-	37.60	23927012
184	Phosphorylation	KRRGSSGSVDETLFA CCCCCCCCCCHHHHC	28.48	29255136
184 (in isoform 2)	Phosphorylation	-	28.48	23927012
186	Ubiquitination	RGSSGSVDETLFALP CCCCCCCCHHHHCCC	44.88	33845483
186 (in isoform 3)	Ubiquitination	-	44.88	21890473
188	Phosphorylation	SSGSVDETLFALPAA CCCCCCHHHHCCCCC	23.78	29255136
190	Ubiquitination	GSVDETLFALPAASE CCCCHHHHCCCCCCC	9.54	21890473
190	Ubiquitination	GSVDETLFALPAASE CCCCHHHHCCCCCCC	9.54	21890473
190 (in isoform 3)	Ubiquitination	-	9.54	21890473
194	Ubiquitination	ETLFALPAASEPVIR HHHHCCCCCCCCCCC	25.19	32142685
195	Ubiquitination	TLFALPAASEPVIRS HHHCCCCCCCCCCCC	16.70	27667366
196	Phosphorylation	LFALPAASEPVIRSS HHCCCCCCCCCCCCC	44.53	23927012
203	Phosphorylation	SEPVIRSSAENMDLK CCCCCCCCHHCCCCC	29.74	32142685
218	Phosphorylation	EQPGNTISAGQEDFP CCCCCCCCCCCCCCC	25.06	25693802
226	Phosphorylation	AGQEDFPSVLLETAA CCCCCCCHHHHHHHH	25.95	25693802
231	Phosphorylation	FPSVLLETAASLPSL CCHHHHHHHHCCCCC	27.74	26074081
234	Phosphorylation	VLLETAASLPSLSPL HHHHHHHCCCCCCCC	38.05	26074081
237	Phosphorylation	ETAASLPSLSPLSAA HHHHCCCCCCCCCHH	46.93	26657352
239	Phosphorylation	AASLPSLSPLSAASF HHCCCCCCCCCHHHH	28.29	26074081
240	Phosphorylation	ASLPSLSPLSAASFK HCCCCCCCCCHHHHC	35.31	32142685
242	Phosphorylation	LPSLSPLSAASFKEH CCCCCCCCHHHHCCC	25.77	26074081
244	Phosphorylation	SLSPLSAASFKEHEY CCCCCCHHHHCCCCH	16.48	32142685
245	Phosphorylation	LSPLSAASFKEHEYL CCCCCHHHHCCCCHH	36.25	26074081
247	Ubiquitination	PLSAASFKEHEYLGN CCCHHHHCCCCHHCC	56.52	33845483
247 (in isoform 2)	Ubiquitination	-	56.52	21890473
251	Phosphorylation	ASFKEHEYLGNLSTV HHHCCCCHHCCCEEE	23.09	28796482
266	Ubiquitination	LPTEGTLQENVSEAS CCCCCCHHHHHHHHH	39.80	33845483
266 (in isoform 5)	Ubiquitination	-	39.80	21890473
271	Ubiquitination	TLQENVSEASKEVSE CHHHHHHHHHHHHHH	53.32	21963094
271 (in isoform 2)	Ubiquitination	-	53.32	21890473
282	Phosphorylation	EVSEKAKTLLIDRDL HHHHHHHHHHHCCCC	31.49	-
285	Ubiquitination	EKAKTLLIDRDLTEF HHHHHHHHCCCCCCC	4.61	21890473
285	Acetylation	EKAKTLLIDRDLTEF HHHHHHHHCCCCCCC	4.61	19608861
285	Ubiquitination	EKAKTLLIDRDLTEF HHHHHHHHCCCCCCC	4.61	23000965
285 (in isoform 2)	Ubiquitination	-	4.61	21890473
290	Ubiquitination	LLIDRDLTEFSELEY HHHCCCCCCCHHCEE	38.99	21963094
290 (in isoform 5)	Ubiquitination	-	38.99	21890473
302	Ubiquitination	LEYSEMGSSFSVSPK CEEECCCCCEECCCC	27.22	32142685
304	Acetylation	YSEMGSSFSVSPKAE EECCCCCEECCCCCC	10.02	19608861
304	Ubiquitination	YSEMGSSFSVSPKAE EECCCCCEECCCCCC	10.02	23000965
304 (in isoform 5)	Ubiquitination	-	10.02	21890473
305	Phosphorylation	SEMGSSFSVSPKAES ECCCCCEECCCCCCC	24.51	26074081
307	Phosphorylation	MGSSFSVSPKAESAV CCCCEECCCCCCCCE	21.34	27422710
307	Ubiquitination	MGSSFSVSPKAESAV CCCCEECCCCCCCCE	21.34	32142685
345	Phosphorylation	NILHNQQELPTALTK CCCCCCCHHHHHHHH	47.13	32142685
351	Phosphorylation	QELPTALTKLVKEDE CHHHHHHHHHHHHCC	21.62	22468782
352	Ubiquitination	ELPTALTKLVKEDEV HHHHHHHHHHHHCCC	52.73	21890473
352	Ubiquitination	ELPTALTKLVKEDEV HHHHHHHHHHHHCCC	52.73	21890473
352 (in isoform 2)	Ubiquitination	-	52.73	21890473
355	Ubiquitination	TALTKLVKEDEVVSS HHHHHHHHHCCCCCC	70.64	27667366
355 (in isoform 2)	Ubiquitination	-	70.64	21890473
360	Ubiquitination	LVKEDEVVSSEKAKD HHHHCCCCCCHHHHH	4.98	33845483
360 (in isoform 2)	Ubiquitination	-	4.98	21890473
361	Phosphorylation	VKEDEVVSSEKAKDS HHHCCCCCCHHHHHC	37.65	21406692
362	Phosphorylation	KEDEVVSSEKAKDSF HHCCCCCCHHHHHCC	31.35	21406692
364	Ubiquitination	DEVVSSEKAKDSFNE CCCCCCHHHHHCCCC	63.79	21890473
364	Ubiquitination	DEVVSSEKAKDSFNE CCCCCCHHHHHCCCC	63.79	33845483
364 (in isoform 2)	Ubiquitination	-	63.79	21890473
366	Ubiquitination	VVSSEKAKDSFNEKR CCCCHHHHHCCCCCC	66.04	22817900
369	Ubiquitination	SEKAKDSFNEKRVAV CHHHHHCCCCCCEEE	22.93	27667366
371	Ubiquitination	KAKDSFNEKRVAVEA HHHHCCCCCCEEEEC	39.98	21890473
371 (in isoform 5)	Ubiquitination	-	39.98	21890473
372	Ubiquitination	AKDSFNEKRVAVEAP HHHCCCCCCEEEECC	53.96	32142685
374	Ubiquitination	DSFNEKRVAVEAPMR HCCCCCCEEEECCCH	11.80	27667366
374 (in isoform 5)	Ubiquitination	-	11.80	21890473
379	Ubiquitination	KRVAVEAPMREEYAD CCEEEECCCHHHHCC	14.62	33845483
379 (in isoform 5)	Ubiquitination	-	14.62	21890473
383	Ubiquitination	VEAPMREEYADFKPF EECCCHHHHCCCCCC	35.34	21890473
383 (in isoform 5)	Ubiquitination	-	35.34	21890473
384	Phosphorylation	EAPMREEYADFKPFE ECCCHHHHCCCCCCC	13.50	28796482
388	Ubiquitination	REEYADFKPFERVWE HHHHCCCCCCCCEEE	49.71	27667366
400	Ubiquitination	VWEVKDSKEDSDMLA EEECCCCCCHHHCHH	75.56	32142685
414	Phosphorylation	AAGGKIESNLESKVD HCCCCHHHHHHHHCC	50.63	28509920
418	Phosphorylation	KIESNLESKVDKKCF CHHHHHHHHCCHHHH	40.94	-
438	Phosphorylation	QTNHEKDSESSNDDT HCCCCCCCCCCCCCC	50.90	27732954
440	Phosphorylation	NHEKDSESSNDDTSF CCCCCCCCCCCCCCC	38.09	30576142
441	Phosphorylation	HEKDSESSNDDTSFP CCCCCCCCCCCCCCC	39.98	25307156
445	Phosphorylation	SESSNDDTSFPSTPE CCCCCCCCCCCCCCC	34.82	21406692
446	Phosphorylation	ESSNDDTSFPSTPEG CCCCCCCCCCCCCCC	42.00	25307156
449	Phosphorylation	NDDTSFPSTPEGIKD CCCCCCCCCCCCCCC	55.36	21406692
450	Phosphorylation	DDTSFPSTPEGIKDR CCCCCCCCCCCCCCC	26.12	21406692
458	Phosphorylation	PEGIKDRSGAYITCA CCCCCCCCCCEEEEC	37.60	28796482
461	Phosphorylation	IKDRSGAYITCAPFN CCCCCCCEEEECCCC	10.57	28796482
462	Ubiquitination	KDRSGAYITCAPFNP CCCCCCEEEECCCCH	2.24	32142685
463	Phosphorylation	DRSGAYITCAPFNPA CCCCCEEEECCCCHH	7.02	28796482
468	Ubiquitination	YITCAPFNPAATESI EEEECCCCHHHCHHH	25.00	29967540
500	Ubiquitination	DEKKIEEKKAQIVTE CHHHHHHHHHHEEEC	40.39	32142685
508	Ubiquitination	KAQIVTEKNTSTKTS HHHEEECCCCCCCCC	57.04	32142685
511	Phosphorylation	IVTEKNTSTKTSNPF EEECCCCCCCCCCCE	36.98	-
513	Ubiquitination	TEKNTSTKTSNPFLV ECCCCCCCCCCCEEE	50.12	32142685
515	Phosphorylation	KNTSTKTSNPFLVAA CCCCCCCCCCEEEEE	44.02	30576142
525	Phosphorylation	FLVAAQDSETDYVTT EEEEECCCCCCCCCC	30.25	19413330
527	Phosphorylation	VAAQDSETDYVTTDN EEECCCCCCCCCCCC	36.26	27642862
529	Phosphorylation	AQDSETDYVTTDNLT ECCCCCCCCCCCCCC	13.71	28796482
531	Phosphorylation	DSETDYVTTDNLTKV CCCCCCCCCCCCCCC	23.39	28796482
532	Phosphorylation	SETDYVTTDNLTKVT CCCCCCCCCCCCCCC	16.91	28796482
536	Phosphorylation	YVTTDNLTKVTEEVV CCCCCCCCCCCHHHH	29.71	32142685
551	Phosphorylation	ANMPEGLTPDLVQEA HCCCCCCCHHHHHHH	26.13	32142685
569	Phosphorylation	ELNEVTGTKIAYETK HHHHHHCCHHHHCCC	15.20	32142685
581	Ubiquitination	ETKMDLVQTSEVMQE CCCCCHHCCHHHHHH	46.75	32142685
591	Ubiquitination	EVMQESLYPAAQLCP HHHHHHHCHHHHHCC	10.49	32142685
600	Phosphorylation	AAQLCPSFEESEATP HHHHCCCCCCCCCCC	7.93	32142685
605	Ubiquitination	PSFEESEATPSPVLP CCCCCCCCCCCCCCC	33.81	32142685
646	Phosphorylation	LEASSVNYESIKHEP CCCCCCCHHHHCCCC	14.64	22817900
654	Phosphorylation	ESIKHEPENPPPYEE HHHCCCCCCCCCHHH	78.40	32142685
659	Phosphorylation	EPENPPPYEEAMSVS CCCCCCCHHHHHHHC	31.98	28796482
668	Ubiquitination	EAMSVSLKKVSGIKE HHHHHCHHHHHCCHH	43.55	32142685
674	Ubiquitination	LKKVSGIKEEIKEPE HHHHHCCHHHHCCCC	53.47	29967540
678	Ubiquitination	SGIKEEIKEPENINA HCCHHHHCCCCHHHH	71.18	32142685
694	Phosphorylation	LQETEAPYISIACDL HHHCCCCCHHHHHHH	17.85	28796482
696	Phosphorylation	ETEAPYISIACDLIK HCCCCCHHHHHHHHH	9.78	24173317
706	Ubiquitination	CDLIKETKLSAEPAP HHHHHHHCCCCCCCC	41.35	32142685
716	Phosphorylation	AEPAPDFSDYSEMAK CCCCCCCCCHHHHHC	42.91	28796482
718	Phosphorylation	PAPDFSDYSEMAKVE CCCCCCCHHHHHCCC	12.82	28796482
719	Phosphorylation	APDFSDYSEMAKVEQ CCCCCCHHHHHCCCC	26.36	28796482
732	Phosphorylation	EQPVPDHSELVEDSS CCCCCCHHHHCCCCC	39.75	21406692
734	Ubiquitination	PVPDHSELVEDSSPD CCCCHHHHCCCCCCC	5.99	32142685
738	Phosphorylation	HSELVEDSSPDSEPV HHHHCCCCCCCCCCC	30.20	21406692
739	Phosphorylation	SELVEDSSPDSEPVD HHHCCCCCCCCCCCC	45.08	21406692
742	Phosphorylation	VEDSSPDSEPVDLFS CCCCCCCCCCCCCCC	47.38	21406692
749	Phosphorylation	SEPVDLFSDDSIPDV CCCCCCCCCCCCCCC	48.05	21406692
752	Phosphorylation	VDLFSDDSIPDVPQK CCCCCCCCCCCCCCC	40.80	21406692
763	Phosphorylation	VPQKQDETVMLVKES CCCCCCCCEEEEEHH	21.36	23663014
763	Ubiquitination	VPQKQDETVMLVKES CCCCCCCCEEEEEHH	21.36	30230243
769	Ubiquitination	ETVMLVKESLTETSF CCEEEEEHHHCCCCH	43.43	32142685
770	Phosphorylation	TVMLVKESLTETSFE CEEEEEHHHCCCCHH	34.57	27690223
772	Phosphorylation	MLVKESLTETSFESM EEEEHHHCCCCHHHH	46.63	23879269
774	Phosphorylation	VKESLTETSFESMIE EEHHHCCCCHHHHHH	33.22	28348404
775	Phosphorylation	KESLTETSFESMIEY EHHHCCCCHHHHHHH	22.30	32142685
777	Phosphorylation	SLTETSFESMIEYEN HHCCCCHHHHHHHCC	38.88	32142685
778	Phosphorylation	LTETSFESMIEYENK HCCCCHHHHHHHCCH	24.05	27690223
782	Phosphorylation	SFESMIEYENKEKLS CHHHHHHHCCHHHHH	17.55	28796482
785	Phosphorylation	SMIEYENKEKLSALP HHHHHCCHHHHHCCC	44.26	32142685
787	Phosphorylation	IEYENKEKLSALPPE HHHCCHHHHHCCCCC	49.72	32142685
787	Ubiquitination	IEYENKEKLSALPPE HHHCCHHHHHCCCCC	49.72	32142685
797	Ubiquitination	ALPPEGGKPYLESFK CCCCCCCCCCHHHCE	41.15	32142685
806	Phosphorylation	YLESFKLSLDNTKDT CHHHCEEEECCCCCC	33.98	32142685
810	Phosphorylation	FKLSLDNTKDTLLPD CEEEECCCCCCCCCH	29.93	26261332
811	Ubiquitination	KLSLDNTKDTLLPDE EEEECCCCCCCCCHH	55.78	32142685
813	Phosphorylation	SLDNTKDTLLPDEVS EECCCCCCCCCHHHH	31.58	26261332
820	Phosphorylation	TLLPDEVSTLSKKEK CCCCHHHHHCCCCCC	22.91	26074081
821	Phosphorylation	LLPDEVSTLSKKEKI CCCHHHHHCCCCCCC	39.98	26074081
823	Phosphorylation	PDEVSTLSKKEKIPL CHHHHHCCCCCCCCC	41.59	24719451
834 (in isoform 4)	Ubiquitination	-	42.55	21890473
840	Phosphorylation	EELSTAVYSNDDLFI HHHHHHHHCCCCCEE	10.17	22817900
856	Phosphorylation	KEAQIRETETFSDSS CCHHEEECCCCCCCC	30.40	28464451
858	Phosphorylation	AQIRETETFSDSSPI HHEEECCCCCCCCCE	35.54	28464451
858 (in isoform 4)	Ubiquitination	-	35.54	21890473
860	Phosphorylation	IRETETFSDSSPIEI EEECCCCCCCCCEEE	43.96	21082442
860	Ubiquitination	IRETETFSDSSPIEI EEECCCCCCCCCEEE	43.96	33845483
860 (in isoform 6)	Ubiquitination	-	43.96	21890473
862	Phosphorylation	ETETFSDSSPIEIID ECCCCCCCCCEEEHH	36.49	28464451
863	Phosphorylation	TETFSDSSPIEIIDE CCCCCCCCCEEEHHH	34.58	21082442
872 (in isoform 4)	Ubiquitination	-	25.01	21890473
873	Phosphorylation	EIIDEFPTLISSKTD EEHHHCCHHHCCCCC	41.88	24117733
876	Phosphorylation	DEFPTLISSKTDSFS HHCCHHHCCCCCHHH	28.97	24117733
877	Phosphorylation	EFPTLISSKTDSFSK HCCHHHCCCCCHHHH	32.36	24117733
879	Phosphorylation	PTLISSKTDSFSKLA CHHHCCCCCHHHHHH	38.53	24719451
881	Phosphorylation	LISSKTDSFSKLARE HHCCCCCHHHHHHHH	36.33	22817900
883	Phosphorylation	SSKTDSFSKLAREYT CCCCCHHHHHHHHHH	30.61	19690332
884	Ubiquitination	SKTDSFSKLAREYTD CCCCHHHHHHHHHHC	44.12	21963094
884 (in isoform 6)	Ubiquitination	-	44.12	21890473
889	Phosphorylation	FSKLAREYTDLEVSH HHHHHHHHHCCCHHC	10.45	28796482
890	Phosphorylation	SKLAREYTDLEVSHK HHHHHHHHCCCHHCH	29.38	22210691
895	Phosphorylation	EYTDLEVSHKSEIAN HHHCCCHHCHHHHCC	18.80	27732954
898	Ubiquitination	DLEVSHKSEIANAPD CCCHHCHHHHCCCCC	28.89	21890473
898	Acetylation	DLEVSHKSEIANAPD CCCHHCHHHHCCCCC	28.89	19608861
898	Ubiquitination	DLEVSHKSEIANAPD CCCHHCHHHHCCCCC	28.89	23000965
898 (in isoform 6)	Ubiquitination	-	28.89	21890473
909	Phosphorylation	NAPDGAGSLPCTELP CCCCCCCCCCCCCCC	28.71	22210691
913	Phosphorylation	GAGSLPCTELPHDLS CCCCCCCCCCCCCCC	38.32	22210691
920	Phosphorylation	TELPHDLSLKNIQPK CCCCCCCCCCCCCCC	43.27	24076635
933	Phosphorylation	PKVEEKISFSDDFSK CCCEECCCCCCCCCC	29.75	27732954
935	Phosphorylation	VEEKISFSDDFSKNG CEECCCCCCCCCCCC	29.49	27732954
939 (in isoform 4)	Ubiquitination	-	32.00	21890473
940	Ubiquitination	SFSDDFSKNGSATSK CCCCCCCCCCCCCCE	66.38	32142685
942 (in isoform 4)	Ubiquitination	-	23.53	21890473
943	Phosphorylation	DDFSKNGSATSKVLL CCCCCCCCCCCEEEE	37.45	18491316
945	Phosphorylation	FSKNGSATSKVLLLP CCCCCCCCCEEEECC	30.67	-
946	Phosphorylation	SKNGSATSKVLLLPP CCCCCCCCEEEECCC	22.08	-
947 (in isoform 4)	Ubiquitination	-	32.33	21890473
951 (in isoform 4)	Ubiquitination	-	5.17	21890473
965	Ubiquitination	LATQAEIESIVKPKV HHCHHHHHHHHCCHH	26.39	21890473
965	Ubiquitination	LATQAEIESIVKPKV HHCHHHHHHHHCCHH	26.39	21890473
965 (in isoform 6)	Ubiquitination	-	26.39	21890473
968	Ubiquitination	QAEIESIVKPKVLVK HHHHHHHHCCHHHHH	13.96	27667366
968 (in isoform 6)	Ubiquitination	-	13.96	21890473
969	Ubiquitination	AEIESIVKPKVLVKE HHHHHHHCCHHHHHH	37.13	30230243
973	Ubiquitination	SIVKPKVLVKEAEKK HHHCCHHHHHHHHHC	5.94	33845483
973 (in isoform 6)	Ubiquitination	-	5.94	21890473
975	Ubiquitination	VKPKVLVKEAEKKLP HCCHHHHHHHHHCCC	47.23	32142685
977	Ubiquitination	PKVLVKEAEKKLPSD CHHHHHHHHHCCCCC	28.35	21890473
977	Ubiquitination	PKVLVKEAEKKLPSD CHHHHHHHHHCCCCC	28.35	21890473
977 (in isoform 6)	Ubiquitination	-	28.35	21890473
982	Ubiquitination	KEAEKKLPSDTEKED HHHHHCCCCCCCCCC	38.75	27667366
983	Phosphorylation	EAEKKLPSDTEKEDR HHHHCCCCCCCCCCC	68.54	32142685
985	Phosphorylation	EKKLPSDTEKEDRSP HHCCCCCCCCCCCCH	53.98	23312004
991	Phosphorylation	DTEKEDRSPSAIFSA CCCCCCCCHHHHHHH	35.21	19664994
993	Phosphorylation	EKEDRSPSAIFSAEL CCCCCCHHHHHHHEC	34.93	25693802
997	Phosphorylation	RSPSAIFSAELSKTS CCHHHHHHHECCCCC	18.08	24117733
1001	Phosphorylation	AIFSAELSKTSVVDL HHHHHECCCCCCEEE	25.95	24117733
1002	Ubiquitination	IFSAELSKTSVVDLL HHHHECCCCCCEEEE	58.40	-
1051	Phosphorylation	ALALLSVTISFRIYK HHHHHHHHHHHHHHH	13.92	23927012
1053	Phosphorylation	ALLSVTISFRIYKGV HHHHHHHHHHHHHHH	10.10	29496963
1066	2-Hydroxyisobutyrylation	GVIQAIQKSDEGHPF HHHHHHHHCCCCCCC	54.48	-
1066	Ubiquitination	GVIQAIQKSDEGHPF HHHHHHHHCCCCCCC	54.48	21906983
1066 (in isoform 1)	Ubiquitination	-	54.48	21890473
1090	Acetylation	ISEELVQKYSNSALG CCHHHHHHHCCCCCC	43.07	26051181
1090	Ubiquitination	ISEELVQKYSNSALG CCHHHHHHHCCCCCC	43.07	21906983
1090 (in isoform 1)	Ubiquitination	-	43.07	21890473
1091	Phosphorylation	SEELVQKYSNSALGH CHHHHHHHCCCCCCC	8.94	26437602
1092	Phosphorylation	EELVQKYSNSALGHV HHHHHHHCCCCCCCC	31.20	28152594
1094	Phosphorylation	LVQKYSNSALGHVNC HHHHHCCCCCCCCCC	20.94	26437602
1101	S-nitrosocysteine	SALGHVNCTIKELRR CCCCCCCCHHHHHHH	3.96	-
1101	S-nitrosylation	SALGHVNCTIKELRR CCCCCCCCHHHHHHH	3.96	2212679
1101	S-palmitoylation	SALGHVNCTIKELRR CCCCCCCCHHHHHHH	3.96	29575903
1104	Acetylation	GHVNCTIKELRRLFL CCCCCHHHHHHHHHC	32.32	19608861
1104	Malonylation	GHVNCTIKELRRLFL CCCCCHHHHHHHHHC	32.32	26320211
1104	Ubiquitination	GHVNCTIKELRRLFL CCCCCHHHHHHHHHC	32.32	23000965
1104 (in isoform 1)	Ubiquitination	-	32.32	21890473
1165	Phosphorylation	HQAQIDHYLGLANKN HHHHHHHHHHHCCCC	9.94	28152594
1171	Malonylation	HYLGLANKNVKDAMA HHHHHCCCCHHHHHH	58.47	26320211
1171	Ubiquitination	HYLGLANKNVKDAMA HHHHHCCCCHHHHHH	58.47	22817900
1171 (in isoform 1)	Ubiquitination	-	58.47	21890473
1174	2-Hydroxyisobutyrylation	GLANKNVKDAMAKIQ HHCCCCHHHHHHHHH	49.52	-
1174	Acetylation	GLANKNVKDAMAKIQ HHCCCCHHHHHHHHH	49.52	26210075
1174	Succinylation	GLANKNVKDAMAKIQ HHCCCCHHHHHHHHH	49.52	23954790
1174	Ubiquitination	GLANKNVKDAMAKIQ HHCCCCHHHHHHHHH	49.52	27667366
1174 (in isoform 1)	Ubiquitination	-	49.52	21890473
1179	2-Hydroxyisobutyrylation	NVKDAMAKIQAKIPG CHHHHHHHHHHHCCC	23.43	-
1179	Acetylation	NVKDAMAKIQAKIPG CHHHHHHHHHHHCCC	23.43	27178108
1179	Ubiquitination	NVKDAMAKIQAKIPG CHHHHHHHHHHHCCC	23.43	21906983
1179 (in isoform 1)	Ubiquitination	-	23.43	21890473
1183	2-Hydroxyisobutyrylation	AMAKIQAKIPGLKRK HHHHHHHHCCCHHHC	32.81	-
1183	Acetylation	AMAKIQAKIPGLKRK HHHHHHHHCCCHHHC	32.81	26210075
1183	Ubiquitination	AMAKIQAKIPGLKRK HHHHHHHHCCCHHHC	32.81	22817900
1183 (in isoform 1)	Ubiquitination	-	32.81	21890473
1188	Ubiquitination	QAKIPGLKRKAE--- HHHCCCHHHCCC---	58.74	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
107	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
694	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RTN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RTN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	11126360
PKHF2_HUMAN	PLEKHF2	physical	16189514
CNTP1_HUMAN	CNTNAP1	physical	14592966
KCNA1_HUMAN	KCNA1	physical	14592966
KCNA2_HUMAN	KCNA2	physical	14592966
DPYL1_HUMAN	CRMP1	physical	16169070
PRR13_HUMAN	PRR13	physical	16169070
B2CL1_HUMAN	BCL2L1	physical	11126360
RT4I1_HUMAN	RTN4IP1	physical	12067236
ZO1_HUMAN	TJP1	physical	22939629
THIM_HUMAN	ACAA2	physical	22939629
TMM65_HUMAN	TMEM65	physical	22939629
SNX12_HUMAN	SNX12	physical	22939629
S10AG_HUMAN	S100A16	physical	22939629
RTN4_HUMAN	RTN4	physical	25416956
ZFY21_HUMAN	ZFYVE21	physical	25416956
SYT16_HUMAN	SYT16	physical	25416956
GOT1B_HUMAN	GOLT1B	physical	26186194
KTN1_HUMAN	KTN1	physical	26186194
DERL2_HUMAN	DERL2	physical	26186194
TMM70_HUMAN	TMEM70	physical	26186194
TBL2_HUMAN	TBL2	physical	26186194
SPD2A_HUMAN	SH3PXD2A	physical	26186194
HSDL1_HUMAN	HSDL1	physical	26186194
NB5R3_HUMAN	CYB5R3	physical	26186194
MET7B_HUMAN	METTL7B	physical	26186194
CD032_HUMAN	C4orf32	physical	26186194
RTN1_HUMAN	RTN1	physical	26186194
RTN2_HUMAN	RTN2	physical	26186194
TMM43_HUMAN	TMEM43	physical	26186194
PRAF3_HUMAN	ARL6IP5	physical	26186194
SCAM1_HUMAN	SCAMP1	physical	26186194
ATLA3_HUMAN	ATL3	physical	26186194
AR6P1_HUMAN	ARL6IP1	physical	26186194
SPOP_HUMAN	SPOP	physical	26186194
SCAM2_HUMAN	SCAMP2	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
F210B_HUMAN	FAM210B	physical	26186194
AT1B1_HUMAN	ATP1B1	physical	26344197
ATPO_HUMAN	ATP5O	physical	26344197
DDX46_HUMAN	DDX46	physical	26344197
GRHPR_HUMAN	GRHPR	physical	26344197
WASC4_HUMAN	KIAA1033	physical	26344197
SNX2_HUMAN	SNX2	physical	26344197
SPOP_HUMAN	SPOP	physical	28514442
AR6P1_HUMAN	ARL6IP1	physical	28514442
PRAF1_HUMAN	RABAC1	physical	28514442
TM208_HUMAN	TMEM208	physical	28514442
MET7B_HUMAN	METTL7B	physical	28514442
RTN2_HUMAN	RTN2	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
NB5R3_HUMAN	CYB5R3	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
SCAM1_HUMAN	SCAMP1	physical	28514442
PRAF3_HUMAN	ARL6IP5	physical	28514442
TM222_HUMAN	TMEM222	physical	28514442
TMM68_HUMAN	TMEM68	physical	28514442
TMM43_HUMAN	TMEM43	physical	28514442
KTN1_HUMAN	KTN1	physical	28514442
RTN3_HUMAN	RTN3	physical	28514442
RNF41_HUMAN	RNF41	physical	27353365

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D10331	Ozanezumab (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RTN4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-7; SER-12 AND SER-15, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1104, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-12 AND SER-15,AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-7; SER-12 AND SER-15, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181; SER-182 ANDSER-184, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-15; SER-107;SER-184 AND THR-188, AND MASS SPECTROMETRY.	17081983 [Abstract]