SNX12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX12_HUMAN
• UniProt AC: Q9UMY4
• Protein Name: Sorting nexin-12
• Gene Name: SNX12
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: May be involved in several stages of intracellular trafficking..
• Protein Sequence: MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKSLAVSCPGWSAVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDTAVADT ------CCCCHHHCH	43.60	29255136
2 (in isoform 2)	Phosphorylation	-	43.60	24719451
2 (in isoform 2)	Acetylation	-	43.60	-
2	Acetylation	------MSDTAVADT ------CCCCHHHCH	43.60	22814378
4	Phosphorylation	----MSDTAVADTRR ----CCCCHHHCHHH	18.74	29255136
10	Methylation	DTAVADTRRLNSKPQ CCHHHCHHHHCCCCC	41.45	115917421
14	Phosphorylation	ADTRRLNSKPQDLTD HCHHHHCCCCCCCHH	50.75	29978859
14 (in isoform 2)	Phosphorylation	-	50.75	27251275
20	Phosphorylation	NSKPQDLTDAYGPPS CCCCCCCHHCCCCCC	27.20	29978859
23	Phosphorylation	PQDLTDAYGPPSNFL CCCCHHCCCCCCCCE	32.73	29978859
23 (in isoform 2)	Phosphorylation	-	32.73	-
27 (in isoform 2)	Phosphorylation	-	43.26	24719451
27	Phosphorylation	TDAYGPPSNFLEIDI HHCCCCCCCCEEEEE	43.26	29978859
48	Phosphorylation	GVGRARFTTYEVRMR CCCCEECEEEEEEHH	23.94	26074081
49	Phosphorylation	VGRARFTTYEVRMRT CCCEECEEEEEEHHC	18.25	26074081
50	Phosphorylation	GRARFTTYEVRMRTN CCEECEEEEEEHHCC	14.90	26074081
56	Phosphorylation	TYEVRMRTNLPIFKL EEEEEHHCCCCEEEC	31.59	26074081
62 (in isoform 2)	Ubiquitination	-	60.41	21890473
62 (in isoform 1)	Ubiquitination	-	60.41	21890473
62	Ubiquitination	RTNLPIFKLKESCVR HCCCCEEECHHHHHH	60.41	21890473
64	Ubiquitination	NLPIFKLKESCVRRR CCCEEECHHHHHHHC	48.44	-
72	Phosphorylation	ESCVRRRYSDFEWLK HHHHHHCCCCHHHHH	15.69	30266825
73	Phosphorylation	SCVRRRYSDFEWLKN HHHHHCCCCHHHHHH	33.73	22167270
73 (in isoform 2)	Phosphorylation	-	33.73	24719451
79	Ubiquitination	YSDFEWLKNELERDS CCCHHHHHHHHHCCC	49.83	-
87	Ubiquitination	NELERDSKIVVPPLP HHHHCCCCEECCCCC	43.75	-
114	Phosphorylation	DEGIFEESFIEERRQ CCCCCCHHHHHHHHH	25.07	21712546
153	Methylation	LQEEAIDRNYVPGKS HHHHHHHCCCCCCCE	30.20	115917425
160	Phosphorylation	RNYVPGKSLAVSCPG CCCCCCCEEEEECCC	27.72	19413330
169	Phosphorylation	AVSCPGWSAVA---- EEECCCCCCCC----	20.84	19413330

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AK1A1_HUMAN	AKR1A1	physical	26344197
GNPI2_HUMAN	GNPDA2	physical	26344197
PIN1_HUMAN	PIN1	physical	26344197
PPIL3_HUMAN	PPIL3	physical	26344197
TAGL_HUMAN	TAGLN	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, AND MASSSPECTROMETRY.
PubMed: 17081983

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-23, AND MASSSPECTROMETRY.
PubMed: 15592455