GNPI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNPI2_HUMAN
• UniProt AC: Q8TDQ7
• Protein Name: Glucosamine-6-phosphate isomerase 2
• Gene Name: GNPDA2
• Organism: Homo sapiens (Human).
• Sequence Length: 276
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGHLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	CNRIIQFKPGQDRYF HHHHCEECCCCCCEE	31.68	21906983
28 (in isoform 3)	Ubiquitination	-	31.68	21890473
28 (in isoform 2)	Ubiquitination	-	31.68	21890473
28 (in isoform 1)	Ubiquitination	-	31.68	21890473
36	Phosphorylation	PGQDRYFTLGLPTGS CCCCCEEEECCCCCC	15.81	25072903
41	Phosphorylation	YFTLGLPTGSTPLGC EEEECCCCCCCCCHH	49.13	25072903
43	Phosphorylation	TLGLPTGSTPLGCYK EECCCCCCCCCHHHH	29.36	25072903
44	Phosphorylation	LGLPTGSTPLGCYKK ECCCCCCCCCHHHHH	24.71	25072903
49	Phosphorylation	GSTPLGCYKKLIEYH CCCCCHHHHHHHHHH	14.90	25072903
50	Acetylation	STPLGCYKKLIEYHK CCCCHHHHHHHHHHH	45.22	11924457
50 (in isoform 3)	Ubiquitination	-	45.22	21890473
50 (in isoform 2)	Ubiquitination	-	45.22	21890473
50 (in isoform 1)	Ubiquitination	-	45.22	21890473
50	Ubiquitination	STPLGCYKKLIEYHK CCCCHHHHHHHHHHH	45.22	21890473
50	Ubiquitination	STPLGCYKKLIEYHK CCCCHHHHHHHHHHH	45.22	21890473
50	Ubiquitination	STPLGCYKKLIEYHK CCCCHHHHHHHHHHH	45.22	-
51	Acetylation	TPLGCYKKLIEYHKN CCCHHHHHHHHHHHC	28.37	10985217
51	Ubiquitination	TPLGCYKKLIEYHKN CCCHHHHHHHHHHHC	28.37	-
62	Phosphorylation	YHKNGHLSFKYVKTF HHHCCCEEEEEEEEE	17.64	24719451
64	Ubiquitination	KNGHLSFKYVKTFNM HCCCEEEEEEEEECH	45.84	-
64	Acetylation	KNGHLSFKYVKTFNM HCCCEEEEEEEEECH	45.84	-
67 (in isoform 1)	Ubiquitination	-	44.29	21890473
67 (in isoform 2)	Ubiquitination	-	44.29	21890473
67	Ubiquitination	HLSFKYVKTFNMDEY CEEEEEEEEECHHHC	44.29	21890473
67	Ubiquitination	HLSFKYVKTFNMDEY CEEEEEEEEECHHHC	44.29	21890473
67	Ubiquitination	HLSFKYVKTFNMDEY CEEEEEEEEECHHHC	44.29	-
67 (in isoform 3)	Ubiquitination	-	44.29	21890473
68	Phosphorylation	LSFKYVKTFNMDEYV EEEEEEEEECHHHCC	15.36	-
71	Sulfoxidation	KYVKTFNMDEYVGLP EEEEEECHHHCCCCC	3.46	31801345
74	Phosphorylation	KTFNMDEYVGLPRNH EEECHHHCCCCCCCC	8.78	-
124	Ubiquitination	ECDAFENKIKEAGGI HHHHHHHHHHHHCCC	48.21	-
126	Ubiquitination	DAFENKIKEAGGIDL HHHHHHHHHHCCCCE	43.02	-
151	Phosphorylation	IAFNEPGSSLVSRTR EECCCCCCCHHCHHH	31.08	23879269
152	Phosphorylation	AFNEPGSSLVSRTRL ECCCCCCCHHCHHHH	38.41	23879269
155	Phosphorylation	EPGSSLVSRTRLKTL CCCCCHHCHHHHHHH	32.97	23879269
157	Phosphorylation	GSSLVSRTRLKTLAM CCCHHCHHHHHHHHH	32.61	23879269
160 (in isoform 3)	Ubiquitination	-	37.90	21890473
160 (in isoform 1)	Ubiquitination	-	37.90	21890473
160 (in isoform 2)	Ubiquitination	-	37.90	21890473
160	Ubiquitination	LVSRTRLKTLAMDTI HHCHHHHHHHHHHHH	37.90	21906983
161	Phosphorylation	VSRTRLKTLAMDTIL HCHHHHHHHHHHHHH	25.09	28348404
164	Sulfoxidation	TRLKTLAMDTILANA HHHHHHHHHHHHHCC	5.41	21406390
172	Ubiquitination	DTILANAKYFDGDLS HHHHHCCCCCCCCHH	46.38	21890473
172 (in isoform 3)	Ubiquitination	-	46.38	21890473
172 (in isoform 1)	Ubiquitination	-	46.38	21890473
172	Methylation	DTILANAKYFDGDLS HHHHHCCCCCCCCHH	46.38	-
172	Ubiquitination	DTILANAKYFDGDLS HHHHHCCCCCCCCHH	46.38	21890473
172	"N6,N6-dimethyllysine"	DTILANAKYFDGDLS HHHHHCCCCCCCCHH	46.38	-
172 (in isoform 2)	Ubiquitination	-	46.38	21890473
172	Ubiquitination	DTILANAKYFDGDLS HHHHHCCCCCCCCHH	46.38	21890473
183	Phosphorylation	GDLSKVPTMALTVGV CCHHHCCCEEEEECC	20.33	22210691
187	Phosphorylation	KVPTMALTVGVGTVM HCCCEEEEECCCCEE	12.99	20068231
192	Phosphorylation	ALTVGVGTVMDAREV EEEECCCCEECHHHH	15.39	22210691
213 (in isoform 2)	Phosphorylation	-	8.57	22210691
226 (in isoform 2)	Phosphorylation	-	1.99	22210691
243 (in isoform 2)	Phosphorylation	-	16.43	22210691
251	Phosphorylation	TLELRVKTVKYFKGL CEEEEHHHHHHHCHH	21.26	-
253	Ubiquitination	ELRVKTVKYFKGLMH EEEHHHHHHHCHHHH	50.64	-
254	Phosphorylation	LRVKTVKYFKGLMHV EEHHHHHHHCHHHHH	13.24	28509920
259	Sulfoxidation	VKYFKGLMHVHNKLV HHHHCHHHHHHHHHH	4.18	30846556
271	Phosphorylation	KLVDPLFSMKDGN-- HHHCCHHCCCCCC--	32.38	24719451
272 (in isoform 2)	Ubiquitination	-	3.43	21890473
273 (in isoform 1)	Ubiquitination	-	62.38	21890473
273	Ubiquitination	VDPLFSMKDGN---- HCCHHCCCCCC----	62.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNPI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNPI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNPI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOL3_HUMAN	NOL3	physical	22863883
MTND_HUMAN	ADI1	physical	26344197
CK054_HUMAN	C11orf54	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.