PPIL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIL3_HUMAN
• UniProt AC: Q9H2H8
• Protein Name: Peptidyl-prolyl cis-trans isomerase-like 3
• Gene Name: PPIL3
• Organism: Homo sapiens (Human).
• Sequence Length: 161
• Protein Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing..
• Protein Sequence: MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCIFHRNIKGFMVQTGDPTGTGRGGNSIWGKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVTLHTDV ------CCEEEEECC	24.65	22223895
7	Phosphorylation	-MSVTLHTDVGDIKI -CCEEEEECCCCEEE	35.18	21060948
47 (in isoform 1)	Ubiquitination	-	50.04	21890473
47	Ubiquitination	CIFHRNIKGFMVQTG EEEECCCCEEEEEEC	50.04	21890473
50	Sulfoxidation	HRNIKGFMVQTGDPT ECCCCEEEEEECCCC	2.73	21406390
53	Phosphorylation	IKGFMVQTGDPTGTG CCEEEEEECCCCCCC	31.94	20068231
61	Methylation	GDPTGTGRGGNSIWG CCCCCCCCCCCCCCC	50.08	30988933
69	Acetylation	GGNSIWGKKFEDEYS CCCCCCCCCCHHHHH	39.01	23749302
70	Ubiquitination	GNSIWGKKFEDEYSE CCCCCCCCCHHHHHH	50.47	-
75	Phosphorylation	GKKFEDEYSEYLKHN CCCCHHHHHHHHHHH	21.08	29978859
76	Phosphorylation	KKFEDEYSEYLKHNV CCCHHHHHHHHHHHH	20.09	29978859
78	Phosphorylation	FEDEYSEYLKHNVRG CHHHHHHHHHHHHCC	18.34	29978859
80	Ubiquitination	DEYSEYLKHNVRGVV HHHHHHHHHHHCCEE	32.03	-
120	Ubiquitination	MKYTVFGKVIDGLET CEEEECCEEECCCCC	25.26	-
127	Phosphorylation	KVIDGLETLDELEKL EEECCCCCHHHHHCC	44.55	-
133	Ubiquitination	ETLDELEKLPVNEKT CCHHHHHCCCCCCCC	71.38	2190698
133 (in isoform 1)	Ubiquitination	-	71.38	21890473
137 (in isoform 2)	Ubiquitination	-	43.01	21906983
139	Acetylation	EKLPVNEKTYRPLND HCCCCCCCCCCCCCC	45.73	26051181
139	Ubiquitination	EKLPVNEKTYRPLND HCCCCCCCCCCCCCC	45.73	-
142	Methylation	PVNEKTYRPLNDVHI CCCCCCCCCCCCCEE	34.17	115368667

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPS1_HUMAN	SEPHS1	physical	22939629
SUMO1_HUMAN	SUMO1	physical	22939629
PSA1_HUMAN	PSMA1	physical	22939629
SLD5_HUMAN	GINS4	physical	22939629
SAHH2_HUMAN	AHCYL1	physical	22939629
TMOD3_HUMAN	TMOD3	physical	22939629
RD23B_HUMAN	RAD23B	physical	22939629
SC24C_HUMAN	SEC24C	physical	22939629
RCN1_HUMAN	RCN1	physical	22939629
RPAP1_HUMAN	RPAP1	physical	22939629
SGT1_HUMAN	SUGT1	physical	22939629
SLU7_HUMAN	SLU7	physical	22365833
PCBP1_HUMAN	PCBP1	physical	22365833
BAG1_HUMAN	BAG1	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.