| UniProt ID | BAG1_HUMAN | |
|---|---|---|
| UniProt AC | Q99933 | |
| Protein Name | BAG family molecular chaperone regulator 1 | |
| Gene Name | BAG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 345 | |
| Subcellular Localization |
Isoform 1: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus. Isoform 2: Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock. Isoform 4: Cytoplasm. Nucleus. I |
|
| Protein Description | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. [PubMed: 27474739] | |
| Protein Sequence | MAQRGGARRPRGDRERLGSRLRALRPGREPRQSEPPAQRGPPPSGRPPARSTASGHDRPTRGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATWSEEATQSEEATQGEEMNRSQEVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRVMLIGKKNSPQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 (in isoform 4) | Phosphorylation | - | 35.65 | 26425664 | |
| 33 | Phosphorylation | PGREPRQSEPPAQRG CCCCCCCCCCCHHCC | 54.04 | 28555341 | |
| 52 | Phosphorylation | GRPPARSTASGHDRP CCCCCCCCCCCCCCC | 21.20 | 24719451 | |
| 54 | Phosphorylation | PPARSTASGHDRPTR CCCCCCCCCCCCCCC | 36.43 | 24719451 | |
| 58 | Methylation | STASGHDRPTRGAAA CCCCCCCCCCCCCCC | 28.90 | - | |
| 61 | Methylation | SGHDRPTRGAAAGAR CCCCCCCCCCCCCCC | 35.12 | - | |
| 68 | Methylation | RGAAAGARRPRMKKK CCCCCCCCCHHHCHH | 48.49 | - | |
| 80 | Phosphorylation | KKKTRRRSTRSEELT CHHHHCCCCCHHHHH | 26.76 | 25159151 | |
| 81 | Phosphorylation | KKTRRRSTRSEELTR HHHHCCCCCHHHHHH | 36.08 | 27251275 | |
| 83 | Phosphorylation | TRRRSTRSEELTRSE HHCCCCCHHHHHHHH | 35.20 | 33259812 | |
| 87 | Phosphorylation | STRSEELTRSEELTL CCCHHHHHHHHHCCC | 35.11 | 23312004 | |
| 93 | Ubiquitination | LTRSEELTLSEEATW HHHHHHCCCCCCCCC | 31.36 | 33845483 | |
| 116 | Ubiquitination | EATQGEEMNRSQEVT HHHCHHHCHHHHCCC | 4.37 | 33845483 | |
| 119 | Phosphorylation | QGEEMNRSQEVTRDE CHHHCHHHHCCCCCH | 26.20 | 25159151 | |
| 123 | Phosphorylation | MNRSQEVTRDEESTR CHHHHCCCCCHHHHC | 31.48 | 29083192 | |
| 127 | Ubiquitination | QEVTRDEESTRSEEV HCCCCCHHHHCCHHH | 62.79 | 29967540 | |
| 128 | Phosphorylation | EVTRDEESTRSEEVT CCCCCHHHHCCHHHH | 27.37 | 21815630 | |
| 129 | Phosphorylation | VTRDEESTRSEEVTR CCCCHHHHCCHHHHH | 41.30 | 22985185 | |
| 131 | Phosphorylation | RDEESTRSEEVTREE CCHHHHCCHHHHHHH | 37.89 | 21815630 | |
| 135 | Ubiquitination | STRSEEVTREEMAAA HHCCHHHHHHHHHHC | 35.33 | 33845483 | |
| 137 | Ubiquitination | RSEEVTREEMAAAGL CCHHHHHHHHHHCCC | 42.64 | 29967540 | |
| 145 | Phosphorylation | EMAAAGLTVTVTHSN HHHHCCCEEEEEECC | 17.14 | 20068231 | |
| 149 | Ubiquitination | AGLTVTVTHSNEKHD CCCEEEEEECCCEEE | 15.38 | 29967540 | |
| 149 | Phosphorylation | AGLTVTVTHSNEKHD CCCEEEEEECCCEEE | 15.38 | 20068231 | |
| 158 (in isoform 4) | Ubiquitination | - | 27.20 | 21890473 | |
| 158 | Ubiquitination | SNEKHDLHVTSQQGS CCCEEEEEEEECCCC | 27.20 | 23000965 | |
| 160 | Ubiquitination | EKHDLHVTSQQGSSE CEEEEEEEECCCCCC | 15.29 | 33845483 | |
| 164 | Ubiquitination | LHVTSQQGSSEPVVQ EEEEECCCCCCHHHH | 26.04 | 23000965 | |
| 187 | Ubiquitination | VIGVPQSFQKLIFKG HHCCCHHHHHHHHCC | 6.64 | 29967540 | |
| 196 | Phosphorylation | KLIFKGKSLKEMETP HHHHCCCCHHHCCCC | 54.03 | 28857561 | |
| 202 | Ubiquitination | KSLKEMETPLSALGI CCHHHCCCCHHHCCC | 28.37 | 33845483 | |
| 202 | Phosphorylation | KSLKEMETPLSALGI CCHHHCCCCHHHCCC | 28.37 | 28857561 | |
| 202 (in isoform 3) | Ubiquitination | - | 28.37 | 21890473 | |
| 205 | Phosphorylation | KEMETPLSALGIQDG HHCCCCHHHCCCCCC | 23.74 | 28857561 | |
| 220 | Acetylation | CRVMLIGKKNSPQEE CEEEEEECCCCCHHH | 41.61 | 25953088 | |
| 223 | Phosphorylation | MLIGKKNSPQEEVEL EEEECCCCCHHHHHH | 36.52 | 25159151 | |
| 231 | Ubiquitination | PQEEVELKKLKHLEK CHHHHHHHHHHHHHH | 42.42 | 33845483 | |
| 231 | Acetylation | PQEEVELKKLKHLEK CHHHHHHHHHHHHHH | 42.42 | 23749302 | |
| 238 | Acetylation | KKLKHLEKSVEKIAD HHHHHHHHHHHHHHH | 67.19 | 25953088 | |
| 242 | Ubiquitination | HLEKSVEKIADQLEE HHHHHHHHHHHHHHH | 40.83 | 29967540 | |
| 252 | Ubiquitination | DQLEELNKELTGIQQ HHHHHHHHHHHHCCC | 67.72 | 29967540 | |
| 264 | Ubiquitination | IQQGFLPKDLQAEAL CCCCCCCHHHHHHHH | 73.54 | 29967540 | |
| 273 | Ubiquitination | LQAEALCKLDRRVKA HHHHHHHHHHHHHHH | 55.03 | 23000965 | |
| 273 (in isoform 1) | Ubiquitination | - | 55.03 | 21890473 | |
| 273 (in isoform 2) | Ubiquitination | - | 55.03 | 21890473 | |
| 279 | Ubiquitination | CKLDRRVKATIEQFM HHHHHHHHHHHHHHH | 37.69 | 23000965 | |
| 302 | Ubiquitination | LILPENFKDSRLKRK HHCCCCCCCHHHHHH | 67.39 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:11676916 |
| - | K | Ubiquitination | E3 ubiquitin ligase | SIAH1 | Q8IUQ4 | PMID:22199232 |
| - | K | Ubiquitination | E3 ubiquitin ligase | SIAH2 | O43255 | PMID:22199232 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BAG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BAG1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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