dbPTM

ECM29_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ECM29_HUMAN
UniProt AC	Q5VYK3
Protein Name	Proteasome adapter and scaffold protein ECM29 {ECO:0000305}
Gene Name	ECPAS {ECO:0000312\|HGNC:HGNC:29020}
Organism	Homo sapiens (Human).
Sequence Length	1845
Subcellular Localization	Endoplasmic reticulum . Endoplasmic reticulum-Golgi intermediate compartment . Endosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Endosome, multivesicular body . Cytoplasmic vesicle .
Protein Description	Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis. [PubMed: 15496406 Promotes proteasome dissociation under oxidative stress (By similarity]
Protein Sequence	MAAAAASASQDELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQLPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLLIPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSAQGSSSNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASSDTRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLKIVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNGLTKLINEYKEDPKLLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSMMVGAYSTLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVFPSDHIPSRYLLLLAAGDPREEVHGEAQRVLRCLPGRNRKESTSEQMPSFPEMVYYIQEKASHRMKTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHSAGVVPTSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLLQQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVVVSTVSGNELKSMIEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSEQQDLERNADTLPDQEELIQSATETIGSFLDSTSPLLAIAACTALGEIGRNGPLPIPSEGSGFTKLHLVESLLSRIPSSKETNKMKERAIQTLGYFPVGDGDFPHQKLLLQGLMDSVEAKQIELQFTIGEAITSAAIGTSSVAARDAWQMTEEEYTPPAGAKVNDVVPWVLDVILNKHIISPNPHVRQAACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELGNEQDQQELVSTLVETLMTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELCSLASDLSQPDLVYKFMNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALVTDKSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRPLDDIIDKLPEIWETLFRVQDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAALLPCLLDKGMMSTVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLRATEQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLGTKGGCASVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDSSTEKLLQKLNGWYMEKEEPIYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHEIADEEKSEKEECNLWTEVWQENVPGSFGGIRLYLQELITITQKALQSQSWKMKAQGAIAMASIAKQTSSLVPPYLGMILTALLQGLAGRTWAGKEELLKAIACVVTACSAELEKSVPNQPSTNEILQAVLKECSKENVKYKIVAISCAADILKATKEDRFQEFSNIVIPLIKKNSLESSGVRTTKNEEENEKEKELQLEYLLGAFESLGKAWPRNAETQRCYRQELCKLMCERLKLSTWKVQLGVLQSMNAFFQGLMLLEEEHADPEALAEILLETCKSITYSLENKTYSSVRTEALSVIELLLKKLEESKQWECLTSECRVLLIESLATMEPDSRPELQEKAALLKKTLENLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAASAS ------CCHHHHHCC	19.67	22223895
7	Phosphorylation	-MAAAAASASQDELN -CCHHHHHCCHHHHH	24.59	25693802
9	Phosphorylation	AAAAASASQDELNQL CHHHHHCCHHHHHHH	35.35	25693802
38	Ubiquitination	QLQNIISKFLPPVLL HHHHHHHHHHCHHHH	40.28	-
46	Acetylation	FLPPVLLKLSSTQEG HHCHHHHHCCCCCHH	42.01	26051181
46	Ubiquitination	FLPPVLLKLSSTQEG HHCHHHHHCCCCCHH	42.01	21890473
48	Phosphorylation	PPVLLKLSSTQEGVR CHHHHHCCCCCHHHH	29.74	-
50	Phosphorylation	VLLKLSSTQEGVRKK HHHHCCCCCHHHHHH	27.54	20068231
86	Phosphorylation	VETLLVQYQDPAAVS CEEEEEECCCHHHHH	13.85	22817900
102	Phosphorylation	VTNFTIIYVKMGYPR EECEEEEEEECCCCC	7.09	22817900
107	Phosphorylation	IIYVKMGYPRLPVEK EEEEECCCCCCCHHH	5.02	22817900
144	Phosphorylation	LMHLLIPTLFHMKYP HHHHHHHHHHCCCCC	34.75	-
169	Phosphorylation	NLAEKPKTVQLLLDF CCCCCCHHHHHHHHH	23.24	23607784
185	Phosphorylation	LDVLLMPYGYVLNES HHHHHHHHHHHCCCC	13.71	23607784
187	Phosphorylation	VLLMPYGYVLNESQS HHHHHHHHHCCCCCC	8.91	23607784
192	Phosphorylation	YGYVLNESQSRQNSS HHHHCCCCCCCCCCC	32.17	23607784
194	Phosphorylation	YVLNESQSRQNSSSA HHCCCCCCCCCCCCC	45.15	23607784
198	Phosphorylation	ESQSRQNSSSAQGSS CCCCCCCCCCCCCCC	19.82	25867546
199	Phosphorylation	SQSRQNSSSAQGSSS CCCCCCCCCCCCCCC	36.92	25867546
200	Phosphorylation	QSRQNSSSAQGSSSN CCCCCCCCCCCCCCC	25.16	25867546
204	Phosphorylation	NSSSAQGSSSNSGGG CCCCCCCCCCCCCCC	20.65	25867546
205	Phosphorylation	SSSAQGSSSNSGGGS CCCCCCCCCCCCCCC	40.12	25867546
206	Phosphorylation	SSAQGSSSNSGGGSG CCCCCCCCCCCCCCC	36.39	25867546
208	Phosphorylation	AQGSSSNSGGGSGIP CCCCCCCCCCCCCCC	40.54	25867546
212	Phosphorylation	SSNSGGGSGIPQPPP CCCCCCCCCCCCCCC	36.50	25867546
218	Ubiquitination	GSGIPQPPPGMSFYA CCCCCCCCCCCCEEE	32.60	21890473
222	Phosphorylation	PQPPPGMSFYAAKRV CCCCCCCCEEEEEEH	22.48	25867546
224	Phosphorylation	PPPGMSFYAAKRVIG CCCCCCEEEEEEHHC	9.80	25867546
244	Ubiquitination	PEQLEQCKLGIVKFI HHHHHHCCCCCEEEE	49.82	-
285	Ubiquitination	TAADLELKSKQSLID HHHCHHCCCCCCCCC	46.35	-
287	Ubiquitination	ADLELKSKQSLIDWN HCHHCCCCCCCCCCC	42.17	-
301	Ubiquitination	NNPAIINKMYKVYLG CCHHHHHHHHHHHHC	32.95	-
313	Ubiquitination	YLGDIPLKTKEGAVL HHCCCCCCCCCCCCC	52.80	21890473
315	Ubiquitination	GDIPLKTKEGAVLKP CCCCCCCCCCCCCCH	53.19	-
321	Acetylation	TKEGAVLKPELKRDP CCCCCCCCHHHCCCC	29.82	26051181
336	Malonylation	VSTRVKLKIVPHLLR CCHHHHHHHHHHHHH	35.62	26320211
336	Ubiquitination	VSTRVKLKIVPHLLR CCHHHHHHHHHHHHH	35.62	-
409	Phosphorylation	LTKLINEYKEDPKLL HHHHHHHHCCCHHHH	18.39	-
410	Ubiquitination	TKLINEYKEDPKLLS HHHHHHHCCCHHHHH	49.84	-
414	Ubiquitination	NEYKEDPKLLSMAYS HHHCCCHHHHHHHHH	74.51	21890473
435	Phosphorylation	SRMPHLFTKDIALVQ HCCCCCCHHHHHHHH	33.88	20860994
464	Phosphorylation	LAIQEALSMMVGAYS HHHHHHHHHHHHHHH	16.33	28509920
470	Phosphorylation	LSMMVGAYSTLEGAQ HHHHHHHHHHHHHHH	9.03	28509920
471	Phosphorylation	SMMVGAYSTLEGAQR HHHHHHHHHHHHHHH	26.44	28509920
472	Phosphorylation	MMVGAYSTLEGAQRT HHHHHHHHHHHHHHH	19.02	28509920
485	Ubiquitination	RTLMEALVASYLIKP HHHHHHHHHHHCCCC	4.24	21890473
487	Phosphorylation	LMEALVASYLIKPEV HHHHHHHHHCCCCCC	17.00	-
488	Phosphorylation	MEALVASYLIKPEVQ HHHHHHHHCCCCCCC	11.60	-
491	Acetylation	LVASYLIKPEVQVRQ HHHHHCCCCCCCHHH	32.31	26051181
502	Ubiquitination	QVRQVAVKFASTVFP CHHHHHHHHHHCCCC	26.02	21890473
505	Phosphorylation	QVAVKFASTVFPSDH HHHHHHHHCCCCCCC	28.39	-
506	Phosphorylation	VAVKFASTVFPSDHI HHHHHHHCCCCCCCC	23.80	-
510	Phosphorylation	FASTVFPSDHIPSRY HHHCCCCCCCCCHHH	30.29	-
527	Methylation	LLAAGDPREEVHGEA HHHCCCCHHHHCHHH	58.40	-
549	Phosphorylation	PGRNRKESTSEQMPS CCCCCCCCCCCCCCC	40.02	23401153
550	Phosphorylation	GRNRKESTSEQMPSF CCCCCCCCCCCCCCC	37.06	30576142
551	Phosphorylation	RNRKESTSEQMPSFP CCCCCCCCCCCCCCH	34.80	20873877
556	Phosphorylation	STSEQMPSFPEMVYY CCCCCCCCCHHHHHH	48.36	23401153
586	Ubiquitination	MTGTTVLPFNPAAFG CCCCEEECCCHHHHH	23.72	21890473
606	Phosphorylation	LRMCLAHSAGVVPTS HHHHHHHHCCCCCCC	22.55	23312004
612	Phosphorylation	HSAGVVPTSQSLADM HHCCCCCCCHHHHHH	27.99	23312004
613	Phosphorylation	SAGVVPTSQSLADMQ HCCCCCCCHHHHHHH	16.23	23312004
615	Phosphorylation	GVVPTSQSLADMQDH CCCCCCHHHHHHHHH	25.87	23312004
629	Phosphorylation	HAPAIGRYIRTLMSS HHHHHHHHHHHHHHC	6.91	29396449
632	Phosphorylation	AIGRYIRTLMSSGQM HHHHHHHHHHHCCCC	19.77	29396449
635	Phosphorylation	RYIRTLMSSGQMAPS HHHHHHHHCCCCCCC	34.13	29396449
636	Phosphorylation	YIRTLMSSGQMAPSS HHHHHHHCCCCCCCC	21.05	29396449
642	Phosphorylation	SSGQMAPSSSNKSGE HCCCCCCCCCCCCCC	36.54	29396449
643	Phosphorylation	SGQMAPSSSNKSGET CCCCCCCCCCCCCCC	36.55	29396449
644	Phosphorylation	GQMAPSSSNKSGETN CCCCCCCCCCCCCCC	53.25	29396449
674	Ubiquitination	VGGLPVMYCLLEAVS CCCHHHHHHHHHHHH	4.71	21890473
683	Phosphorylation	LLEAVSVYPEKLATK HHHHHHHCHHHHHHH	9.73	-
689	Phosphorylation	VYPEKLATKFVDKTE HCHHHHHHHHCCHHH	35.14	-
694	2-Hydroxyisobutyrylation	LATKFVDKTEWIKSL HHHHHCCHHHHHHHH	42.94	-
694	Acetylation	LATKFVDKTEWIKSL HHHHHCCHHHHHHHH	42.94	26822725
695	Phosphorylation	ATKFVDKTEWIKSLM HHHHCCHHHHHHHHH	31.89	-
732	Sulfoxidation	SGNELKSMIEQLIKT CHHHHHHHHHHHHHH	3.60	21406390
763	Phosphorylation	LGFTVGRYLAKKKMR HHHHHHHHHHHHHCC	12.70	-
830	Phosphorylation	NGPLPIPSEGSGFTK CCCCCCCCCCCCCCH	56.14	29255136
833	Phosphorylation	LPIPSEGSGFTKLHL CCCCCCCCCCCHHHH	27.04	29255136
836	Phosphorylation	PSEGSGFTKLHLVES CCCCCCCCHHHHHHH	35.90	29255136
837	Ubiquitination	SEGSGFTKLHLVESL CCCCCCCHHHHHHHH	31.48	21906983
843	Phosphorylation	TKLHLVESLLSRIPS CHHHHHHHHHHCCCC	27.42	24719451
846	Phosphorylation	HLVESLLSRIPSSKE HHHHHHHHCCCCCHH	33.19	24719451
852	Ubiquitination	LSRIPSSKETNKMKE HHCCCCCHHHHHHHH	73.27	-
856	Ubiquitination	PSSKETNKMKERAIQ CCCHHHHHHHHHHHH	59.79	-
953	Phosphorylation	ILNKHIISPNPHVRQ HHHCCCCCCCHHHHH	20.30	-
968	Phosphorylation	AACIWLLSLVRKLST HHHHHHHHHHHHHHC	23.73	24719451
974	Phosphorylation	LSLVRKLSTHKEVKS HHHHHHHHCHHHHHH	31.34	28258704
975	Phosphorylation	SLVRKLSTHKEVKSH HHHHHHHCHHHHHHH	47.61	28258704
1009	Ubiquitination	QDVASKGLGLVYELG HHHHHCCCCHHHHCC	5.72	21890473
1034	Phosphorylation	TLVETLMTGKRVKHE HHHHHHHCCCCEEEE	42.54	-
1036	Ubiquitination	VETLMTGKRVKHEVS HHHHHCCCCEEEEEC	44.87	-
1039	Sumoylation	LMTGKRVKHEVSGET HHCCCCEEEEECCCE	37.77	25114211
1039	Ubiquitination	LMTGKRVKHEVSGET HHCCCCEEEEECCCE	37.77	-
1043	Phosphorylation	KRVKHEVSGETVVFQ CCEEEEECCCEEEEE	28.11	30108239
1046	Phosphorylation	KHEVSGETVVFQGGA EEEECCCEEEEECCC	26.04	28450419
1056	Acetylation	FQGGALGKTPDGQGL EECCCCCCCCCCCCC	58.70	26051181
1056	Ubiquitination	FQGGALGKTPDGQGL EECCCCCCCCCCCCC	58.70	2190698
1057	Phosphorylation	QGGALGKTPDGQGLS ECCCCCCCCCCCCCH	25.47	21815630
1067	Acetylation	GQGLSTYKELCSLAS CCCCHHHHHHHHHHC	44.28	7959851
1077	Phosphorylation	CSLASDLSQPDLVYK HHHHCCCCCHHHHHH	44.66	27251275
1099	Ubiquitination	HAMWNSRKGAAFGFN HHHHHCCCCCCCCCE	53.36	-
1143	Phosphorylation	LGIRQAMTSIWNALV CCHHHHHHHHHHHHH	21.78	20068231
1144	Phosphorylation	GIRQAMTSIWNALVT CHHHHHHHHHHHHHC	16.72	20068231
1151	Phosphorylation	SIWNALVTDKSMVDK HHHHHHHCCHHHHHH	38.26	20068231
1172	Phosphorylation	QDLVKNLTSNMWRVR HHHHHHHHHCCHHHH	27.70	21406692
1173	Phosphorylation	DLVKNLTSNMWRVRE HHHHHHHHCCHHHHH	28.05	22210691
1217	2-Hydroxyisobutyrylation	FRVQDDIKESVRKAA HHHCHHHHHHHHHHH	51.43	-
1217	Acetylation	FRVQDDIKESVRKAA HHHCHHHHHHHHHHH	51.43	26051181
1228	Ubiquitination	RKAAELALKTLSKVC HHHHHHHHHHHHHHH	7.33	21890473
1229	Acetylation	KAAELALKTLSKVCV HHHHHHHHHHHHHHH	41.64	25953088
1230	O-linked_Glycosylation	AAELALKTLSKVCVK HHHHHHHHHHHHHHH	36.79	23301498
1232	O-linked_Glycosylation	ELALKTLSKVCVKMC HHHHHHHHHHHHHHC	28.42	23301498
1233	2-Hydroxyisobutyrylation	LALKTLSKVCVKMCD HHHHHHHHHHHHHCC	42.65	-
1237	Malonylation	TLSKVCVKMCDPAKG HHHHHHHHHCCCCCC	28.78	32601280
1257	S-nitrosocysteine	TIAALLPCLLDKGMM HHHHHHHHHHCCCCC	6.26	-
1257	S-nitrosylation	TIAALLPCLLDKGMM HHHHHHHHHHCCCCC	6.26	19483679
1277	Phosphorylation	VRALSINTLVKISKS HHHCCHHHHHHHHHH	31.12	18510355
1282	Phosphorylation	INTLVKISKSAGAML HHHHHHHHHHCCCCC	18.16	30206219
1284	Phosphorylation	TLVKISKSAGAMLKP HHHHHHHHCCCCCCC	25.74	30206219
1324	Ubiquitination	LRATEQEKAAMDSAR CCCCHHHHHHHHHHH	40.93	-
1333	Phosphorylation	AMDSARLSAAKSSPM HHHHHHHHHHHCCHH	22.19	25159151
1337	Phosphorylation	ARLSAAKSSPMMETI HHHHHHHCCHHHHHH	34.64	24043423
1338	Phosphorylation	RLSAAKSSPMMETIN HHHHHHCCHHHHHHH	18.99	24043423
1343	Phosphorylation	KSSPMMETINMCLQY HCCHHHHHHHHHHHH	10.35	24043423
1350	Phosphorylation	TINMCLQYLDVSVLG HHHHHHHHCCHHHHH	7.60	24043423
1354	Phosphorylation	CLQYLDVSVLGELVP HHHHCCHHHHHHHHH	15.99	24043423
1375	O-linked_Glycosylation	RSGVGLGTKGGCASV HHCCCCCCCCCCEEE	31.40	23301498
1403	Phosphorylation	PYSGKLMSALLSGLT CCCHHHHHHHHHCCC	26.63	21406692
1407	Phosphorylation	KLMSALLSGLTDRNS HHHHHHHHCCCCCCH	32.38	21406692
1410	Phosphorylation	SALLSGLTDRNSVIQ HHHHHCCCCCCHHHH	36.12	21406692
1414	Phosphorylation	SGLTDRNSVIQKSCA HCCCCCCHHHHHHHH	22.84	-
1419	Phosphorylation	RNSVIQKSCAFAMGH CCHHHHHHHHHHHHH	8.36	29038488
1434	Phosphorylation	LVRTSRDSSTEKLLQ HHHCCCCCHHHHHHH	37.74	23312004
1435	Phosphorylation	VRTSRDSSTEKLLQK HHCCCCCHHHHHHHH	44.89	22210691
1436	Phosphorylation	RTSRDSSTEKLLQKL HCCCCCHHHHHHHHH	40.88	23312004
1438	Acetylation	SRDSSTEKLLQKLNG CCCCHHHHHHHHHCC	55.36	23236377
1438	Malonylation	SRDSSTEKLLQKLNG CCCCHHHHHHHHHCC	55.36	26320211
1442	Acetylation	STEKLLQKLNGWYME HHHHHHHHHCCCHHC	43.84	23954790
1442	Malonylation	STEKLLQKLNGWYME HHHHHHHHHCCCHHC	43.84	26320211
1450	Acetylation	LNGWYMEKEEPIYKT HCCCHHCCCCCCCCC	51.34	23236377
1455	Phosphorylation	MEKEEPIYKTSCALT HCCCCCCCCCHHHHH	20.94	-
1458	Phosphorylation	EEPIYKTSCALTIHA CCCCCCCHHHHHHHH	8.01	-
1462	Phosphorylation	YKTSCALTIHAIGRY CCCHHHHHHHHHCCC	7.68	-
1524	Phosphorylation	SFGGIRLYLQELITI CCCHHHHHHHHHHHH	9.11	29083192
1530	Phosphorylation	LYLQELITITQKALQ HHHHHHHHHHHHHHH	30.51	29083192
1532	Phosphorylation	LQELITITQKALQSQ HHHHHHHHHHHHHCC	18.50	29083192
1538	Phosphorylation	ITQKALQSQSWKMKA HHHHHHHCCCHHHHH	27.34	29083192
1540	Phosphorylation	QKALQSQSWKMKAQG HHHHHCCCHHHHHHH	33.63	29083192
1558	Phosphorylation	MASIAKQTSSLVPPY HHHHHHHHHCCCHHH	21.41	24043423
1559	Phosphorylation	ASIAKQTSSLVPPYL HHHHHHHHCCCHHHH	21.12	24043423
1560	Phosphorylation	SIAKQTSSLVPPYLG HHHHHHHCCCHHHHH	36.45	24043423
1565	Phosphorylation	TSSLVPPYLGMILTA HHCCCHHHHHHHHHH	15.15	24043423
1571	Phosphorylation	PYLGMILTALLQGLA HHHHHHHHHHHHHHC	12.34	24043423
1585	2-Hydroxyisobutyrylation	AGRTWAGKEELLKAI CCCCCCCHHHHHHHH	40.02	-
1631	Phosphorylation	CSKENVKYKIVAISC HHHCCCCHHEEEEHH	11.15	23403867
1637	Phosphorylation	KYKIVAISCAADILK CHHEEEEHHHHHHHH	6.48	23403867
1646	Phosphorylation	AADILKATKEDRFQE HHHHHHHCCCHHHHH	33.12	29083192
1655	Phosphorylation	EDRFQEFSNIVIPLI CHHHHHHHHCHHHHH	25.54	-
1666	Phosphorylation	IPLIKKNSLESSGVR HHHHHHCCCCCCCCC	42.25	-
1818	Phosphorylation	CRVLLIESLATMEPD HHHHHHHHHHCCCCC	19.13	22199227
1821	Phosphorylation	LLIESLATMEPDSRP HHHHHHHCCCCCCCH	27.62	22199227
1826	Phosphorylation	LATMEPDSRPELQEK HHCCCCCCCHHHHHH	61.52	22199227
1840	Phosphorylation	KAALLKKTLENLE-- HHHHHHHHHHCCC--	37.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ECM29_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ECM29_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ECM29_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCD57_HUMAN	CCDC57	physical	20682791
PCY1B_HUMAN	PCYT1B	physical	20682791
FBX2_HUMAN	FBXO2	physical	20682791
GOGB1_HUMAN	GOLGB1	physical	20682791
CYTSA_HUMAN	SPECC1L	physical	20682791
KINH_HUMAN	KIF5B	physical	20682791
MYH7_HUMAN	MYH7	physical	20682791
MYH10_HUMAN	MYH10	physical	20682791
SYNE1_HUMAN	SYNE1	physical	20682791
PRS6B_HUMAN	PSMC4	physical	20682791
PSMD4_HUMAN	PSMD4	physical	20682791
TBA1A_HUMAN	TUBA1A	physical	20682791
TBB4B_HUMAN	TUBB4B	physical	20682791
TBB5_HUMAN	TUBB	physical	20682791
MYO1B_HUMAN	MYO1B	physical	20682791
MYO10_HUMAN	MYO10	physical	20682791
KIF1B_HUMAN	KIF1B	physical	20682791
VPS36_HUMAN	VPS36	physical	20682791
VP26A_HUMAN	VPS26A	physical	20682791
TMED4_HUMAN	TMED4	physical	20682791
RN217_HUMAN	RNF217	physical	20682791
MARH5_HUMAN	MARCH5	physical	20682791
KDM2B_HUMAN	KDM2B	physical	20682791
KDM2A_HUMAN	KDM2A	physical	20682791
FBX44_HUMAN	FBXO44	physical	20682791
CE152_HUMAN	CEP152	physical	20682791
RCN2_HUMAN	RCN2	physical	20682791
PRS7_HUMAN	PSMC2	physical	20682791
VPS11_HUMAN	VPS11	physical	20682791
RABE1_HUMAN	RABEP1	physical	20682791
PSMD1_HUMAN	PSMD1	physical	20682791
PRS10_HUMAN	PSMC6	physical	20682791
DCTN1_HUMAN	DCTN1	physical	20682791
DC1I1_HUMAN	DYNC1I1	physical	20682791
PSA6_HUMAN	PSMA6	physical	20682791
FLOT1_HUMAN	FLOT1	physical	20682791
FLOT2_HUMAN	FLOT2	physical	20682791
SPTN1_HUMAN	SPTAN1	physical	22939629
PHOCN_HUMAN	MOB4	physical	22863883
PRS8_HUMAN	PSMC5	physical	22863883
PSD11_HUMAN	PSMD11	physical	22863883
PSD12_HUMAN	PSMD12	physical	22863883
PSD13_HUMAN	PSMD13	physical	22863883
PSDE_HUMAN	PSMD14	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
PSMD8_HUMAN	PSMD8	physical	22863883
RS23_HUMAN	RPS23	physical	22863883
RS26_HUMAN	RPS26	physical	22863883
TSR1_HUMAN	TSR1	physical	22863883
TXNL1_HUMAN	TXNL1	physical	22863883
UBR4_HUMAN	UBR4	physical	22863883
UCHL5_HUMAN	UCHL5	physical	22863883
WDR26_HUMAN	WDR26	physical	22863883
ATRAP_HUMAN	AGTRAP	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956
CARF_HUMAN	CDKN2AIP	physical	26344197
DDX1_HUMAN	DDX1	physical	26344197
DNJB1_HUMAN	DNAJB1	physical	26344197
DNJB4_HUMAN	DNAJB4	physical	26344197
IF4H_HUMAN	EIF4H	physical	26344197
SYFA_HUMAN	FARSA	physical	26344197
HNRH1_HUMAN	HNRNPH1	physical	26344197
MA2B1_HUMAN	MAN2B1	physical	26344197
PSMD1_HUMAN	PSMD1	physical	26344197
PSD12_HUMAN	PSMD12	physical	26344197
TIM8B_HUMAN	TIMM8B	physical	26344197
ATRAP_HUMAN	AGTRAP	physical	21516116
AT1A1_HUMAN	ATP1A1	physical	26496610
AAAT_HUMAN	SLC1A5	physical	26496610
USP9X_HUMAN	USP9X	physical	26496610
NOP14_HUMAN	NOP14	physical	26496610
SPD2A_HUMAN	SH3PXD2A	physical	26496610
ICE1_HUMAN	ICE1	physical	26496610
HIG1A_HUMAN	HIGD1A	physical	26496610
SPICE_HUMAN	SPICE1	physical	26496610
PLBL2_HUMAN	PLBD2	physical	26496610

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ECM29_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-833, AND MASSSPECTROMETRY.	15302935 [Abstract]