MYO1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO1B_HUMAN
• UniProt AC: O43795
• Protein Name: Unconventional myosin-Ib
• Gene Name: MYO1B
• Organism: Homo sapiens (Human).
• Sequence Length: 1136
• Protein Description: Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport..
• Protein Sequence: MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	ISVNPYRSLPIYSPE EEECCCCCCCCCCHH	32.43	28112733
65	Phosphorylation	YRSLPIYSPEKVEEY CCCCCCCCHHHHHHH	27.57	23312004
68	Acetylation	LPIYSPEKVEEYRNR CCCCCHHHHHHHHHC	59.33	26051181
68	Ubiquitination	LPIYSPEKVEEYRNR CCCCCHHHHHHHHHC	59.33	-
78	Phosphorylation	EYRNRNFYELSPHIF HHHHCCHHHHCCHHE	21.36	27259358
100	Acetylation	RSLRDQDKDQCILIT HHHCCCCCCCEEEEE	44.03	26051181
100	Ubiquitination	RSLRDQDKDQCILIT HHHCCCCCCCEEEEE	44.03	-
107	Phosphorylation	KDQCILITGESGAGK CCCEEEEECCCCCCH	31.30	-
110	Phosphorylation	CILITGESGAGKTEA EEEEECCCCCCHHHH	34.98	-
114	Ubiquitination	TGESGAGKTEASKLV ECCCCCCHHHHHHHH	42.53	-
115	Phosphorylation	GESGAGKTEASKLVM CCCCCCHHHHHHHHH	35.55	23879269
118	Phosphorylation	GAGKTEASKLVMSYV CCCHHHHHHHHHHHH	21.93	23879269
123	Phosphorylation	EASKLVMSYVAAVCG HHHHHHHHHHHHHHC	14.69	25072903
124	Phosphorylation	ASKLVMSYVAAVCGK HHHHHHHHHHHHHCC	3.97	25072903
131	Ubiquitination	YVAAVCGKGAEVNQV HHHHHHCCCHHHHHH	50.23	-
139	Ubiquitination	GAEVNQVKEQLLQSN CHHHHHHHHHHHHCC	29.94	21906983
139 (in isoform 1)	Ubiquitination	-	29.94	21890473
139 (in isoform 2)	Ubiquitination	-	29.94	21890473
145	Phosphorylation	VKEQLLQSNPVLEAF HHHHHHHCCHHHHHH	42.97	-
156	Ubiquitination	LEAFGNAKTVRNDNS HHHHCCCEEECCCCC	52.10	21906983
156 (in isoform 1)	Ubiquitination	-	52.10	21890473
156 (in isoform 2)	Ubiquitination	-	52.10	21890473
163	Phosphorylation	KTVRNDNSSRFGKYM EEECCCCCCCCEEEE	26.25	29514088
164	Phosphorylation	TVRNDNSSRFGKYMD EECCCCCCCCEEEEE	37.57	29514088
192	Ubiquitination	ISNYLLEKSRVVKQP HHHHHHHHHCCCCCC	43.46	-
209	Phosphorylation	ERNFHVFYQLLSGAS CCCHHHHHHHHHCCC	9.36	20068231
213	Phosphorylation	HVFYQLLSGASEELL HHHHHHHHCCCHHHH	40.69	20068231
213 (in isoform 2)	Phosphorylation	-	40.69	-
216	Phosphorylation	YQLLSGASEELLNKL HHHHHCCCHHHHHHH	34.82	20068231
216 (in isoform 2)	Phosphorylation	-	34.82	-
232	Phosphorylation	LERDFSRYNYLSLDS CCCCHHHCCCCCCHH	13.63	20071362
234	Phosphorylation	RDFSRYNYLSLDSAK CCHHHCCCCCCHHCC	6.69	27642862
239	Phosphorylation	YNYLSLDSAKVNGVD CCCCCCHHCCCCCCC	34.97	20071362
241	Ubiquitination	YLSLDSAKVNGVDDA CCCCHHCCCCCCCCH	39.94	21906983
241 (in isoform 1)	Ubiquitination	-	39.94	21890473
241 (in isoform 2)	Ubiquitination	-	39.94	21890473
287	Sumoylation	KLGNIEFKPESRVNG HHCCCCCCCHHHCCC	34.78	-
287	Acetylation	KLGNIEFKPESRVNG HHCCCCCCCHHHCCC	34.78	26051181
287	Malonylation	KLGNIEFKPESRVNG HHCCCCCCCHHHCCC	34.78	26320211
287	Sumoylation	KLGNIEFKPESRVNG HHCCCCCCCHHHCCC	34.78	25114211
287	Ubiquitination	KLGNIEFKPESRVNG HHCCCCCCCHHHCCC	34.78	-
299	Ubiquitination	VNGLDESKIKDKNEL CCCCCHHHCCCHHHH	52.29	21906983
299 (in isoform 1)	Ubiquitination	-	52.29	21890473
299 (in isoform 2)	Ubiquitination	-	52.29	21890473
303	Ubiquitination	DESKIKDKNELKEIC CHHHCCCHHHHHHHH	47.52	-
307	Ubiquitination	IKDKNELKEICELTG CCCHHHHHHHHHHHC	38.56	-
325	Phosphorylation	SVLERAFSFRTVEAK HHHHHHHHCCCCCCC	16.91	25159151
337	Phosphorylation	EAKQEKVSTTLNVAQ CCCHHHHHCHHHHHH	27.09	25072903
338	Phosphorylation	AKQEKVSTTLNVAQA CCHHHHHCHHHHHHH	37.99	25072903
339	Phosphorylation	KQEKVSTTLNVAQAY CHHHHHCHHHHHHHH	14.61	25072903
346	Phosphorylation	TLNVAQAYYARDALA HHHHHHHHHHHHHHH	5.88	25072903
347	Phosphorylation	LNVAQAYYARDALAK HHHHHHHHHHHHHHH	9.74	25072903
354	2-Hydroxyisobutyrylation	YARDALAKNLYSRLF HHHHHHHHHHHHHHH	48.62	-
354	Ubiquitination	YARDALAKNLYSRLF HHHHHHHHHHHHHHH	48.62	21906983
354 (in isoform 1)	Ubiquitination	-	48.62	21890473
354 (in isoform 2)	Ubiquitination	-	48.62	21890473
358	Phosphorylation	ALAKNLYSRLFSWLV HHHHHHHHHHHHHHH	26.18	24719451
373	Ubiquitination	NRINESIKAQTKVRK HHHHHHHHHHHHHHH	43.66	-
503	Phosphorylation	CSRFLNDTSLPHSCF HHHHHCCCCCCCHHH	30.96	28857561
504	Phosphorylation	SRFLNDTSLPHSCFR HHHHCCCCCCCHHHH	42.65	28857561
508	Phosphorylation	NDTSLPHSCFRIQHY CCCCCCCHHHHHHHC	17.01	20068231
521	Phosphorylation	HYAGKVLYQVEGFVD HCCCCEEEEEEECCC	17.32	27642862
535	Phosphorylation	DKNNDLLYRDLSQAM CCCCCCHHHHHHHHH	14.91	-
551	Ubiquitination	KASHALIKSLFPEGN HHHHHHHHHHCCCCC	41.79	-
561	Malonylation	FPEGNPAKINLKRPP CCCCCCCCEECCCCC	33.12	26320211
561	Ubiquitination	FPEGNPAKINLKRPP CCCCCCCCEECCCCC	33.12	-
565	Malonylation	NPAKINLKRPPTAGS CCCCEECCCCCCCCH	59.37	26320211
565	Ubiquitination	NPAKINLKRPPTAGS CCCCEECCCCCCCCH	59.37	-
569	Phosphorylation	INLKRPPTAGSQFKA EECCCCCCCCHHHHH	46.46	-
575	Methylation	PTAGSQFKASVATLM CCCCHHHHHHHHHHH	31.92	115973521
575	Ubiquitination	PTAGSQFKASVATLM CCCCHHHHHHHHHHH	31.92	-
577	Phosphorylation	AGSQFKASVATLMKN CCHHHHHHHHHHHHH	16.93	21406692
580	Phosphorylation	QFKASVATLMKNLQT HHHHHHHHHHHHHCC	25.81	27422710
582	Sulfoxidation	KASVATLMKNLQTKN HHHHHHHHHHHCCCC	2.05	30846556
588	Ubiquitination	LMKNLQTKNPNYIRC HHHHHCCCCCCCEEE	58.40	21906983
588 (in isoform 1)	Ubiquitination	-	58.40	21890473
588 (in isoform 2)	Ubiquitination	-	58.40	21890473
618	Phosphorylation	LVCHQIRYLGLLENV HHHHHHHHHHHHHHH	13.52	28152594
632	Phosphorylation	VRVRRAGYAFRQAYE HHHHHHHHHHHHHHH	11.11	28152594
695	Ubiquitination	RNPRTLFKLEDLRKQ CCHHHEEEHHHHHHH	54.82	-
747	Phosphorylation	RYAQQKRYQQTKSSA HHHHHHHHHHHHHHH	16.41	30576142
750	Phosphorylation	QQKRYQQTKSSALVI HHHHHHHHHHHHHHH	19.85	30576142
753	Phosphorylation	RYQQTKSSALVIQSY HHHHHHHHHHHHHHH	27.46	30576142
759	Phosphorylation	SSALVIQSYIRGWKA HHHHHHHHHHHHHHH	16.05	28152594
760	Phosphorylation	SALVIQSYIRGWKAR HHHHHHHHHHHHHHH	4.36	28152594
784 (in isoform 2)	Phosphorylation	-	21.38	20068231
785 (in isoform 2)	Phosphorylation	-	11.30	20068231
789	Phosphorylation	AVTTIAAYWHGTQAR HHHHHHHHHHHHHHH	6.74	22461510
789 (in isoform 2)	Phosphorylation	-	6.74	20068231
793	Phosphorylation	IAAYWHGTQARRELR HHHHHHHHHHHHHHH	13.23	20068231
793 (in isoform 2)	Phosphorylation	-	13.23	20068231
799 (in isoform 2)	Phosphorylation	-	3.51	20068231
833 (in isoform 2)	Phosphorylation	-	62.57	-
870	Phosphorylation	ANAGKKIYEFTLQRI HCCCCHHHHHHHHHH	17.55	21406692
873	Phosphorylation	GKKIYEFTLQRIVQK CCHHHHHHHHHHHHH	15.27	21406692
880	Acetylation	TLQRIVQKYFLEMKN HHHHHHHHHHHHHHH	27.37	133227
880	Ubiquitination	TLQRIVQKYFLEMKN HHHHHHHHHHHHHHH	27.37	-
880 (in isoform 2)	Phosphorylation	-	27.37	-
891	Phosphorylation	EMKNKMPSLSPIDKN HHHHCCCCCCCCCCC	37.67	20068231
893	Phosphorylation	KNKMPSLSPIDKNWP HHCCCCCCCCCCCCC	24.93	25159151
894 (in isoform 2)	Ubiquitination	-	44.05	21890473
901	Phosphorylation	PIDKNWPSRPYLFLD CCCCCCCCCCEEEEC	37.19	26074081
904	Phosphorylation	KNWPSRPYLFLDSTH CCCCCCCEEEECCCH	14.69	26074081
909	Phosphorylation	RPYLFLDSTHKELKR CCEEEECCCHHHHHH	34.26	26074081
910	Phosphorylation	PYLFLDSTHKELKRI CEEEECCCHHHHHHH	36.31	26074081
914 (in isoform 2)	Ubiquitination	-	5.57	21890473
928 (in isoform 2)	Ubiquitination	-	44.87	21890473
935	Ubiquitination	DQFTDQQKLIYEEKL HCCCHHHHHHHHHHH	31.08	-
938	Phosphorylation	TDQQKLIYEEKLEAS CHHHHHHHHHHHHHH	28.59	20068231
945	Phosphorylation	YEEKLEASELFKDKK HHHHHHHHHHHCCCC	26.00	20068231
949	Ubiquitination	LEASELFKDKKALYP HHHHHHHCCCCCCCC	79.75	-
952	Ubiquitination	SELFKDKKALYPSSV HHHHCCCCCCCCCCC	54.48	21890473
952 (in isoform 1)	Ubiquitination	-	54.48	21890473
967	Phosphorylation	GQPFQGAYLEINKNP CCCCCCCEEEECCCC	16.22	27259358
972	Acetylation	GAYLEINKNPKYKKL CCEEEECCCCCHHHH	79.06	26051181
972	Ubiquitination	GAYLEINKNPKYKKL CCEEEECCCCCHHHH	79.06	21890473
972 (in isoform 1)	Ubiquitination	-	79.06	21890473
980	Ubiquitination	NPKYKKLKDAIEEKI CCCHHHHHHHHHHHH	54.73	-
986	Ubiquitination	LKDAIEEKIIIAEVV HHHHHHHHHHHHHHH	26.81	21890473
986 (in isoform 1)	Ubiquitination	-	26.81	21890473
995	Ubiquitination	IIAEVVNKINRANGK HHHHHHHHHHHHCCC	29.73	-
1004	Phosphorylation	NRANGKSTSRIFLLT HHHCCCCCCEEEEEC	26.05	25137130
1005	Phosphorylation	RANGKSTSRIFLLTN HHCCCCCCEEEEECC	30.39	25137130
1021	Ubiquitination	NLLLADQKSGQIKSE CEEECCCCCCCCCCC	58.04	-
1022	Phosphorylation	LLLADQKSGQIKSEV EEECCCCCCCCCCCC	30.23	25137130
1026	Ubiquitination	DQKSGQIKSEVPLVD CCCCCCCCCCCEEEE	32.45	-
1028 (in isoform 2)	Ubiquitination	-	43.06	21890473
1086	2-Hydroxyisobutyrylation	RTTLSQTKQKLNIEI HHHHHHHHHHHCCEE	37.49	-
1086	Ubiquitination	RTTLSQTKQKLNIEI HHHHHHHHHHHCCEE	37.49	2190698
1086 (in isoform 1)	Ubiquitination	-	37.49	21890473
1109	Acetylation	RQDKVCVKFIQGNQK CCCCEEEEEECCCCC	31.46	26051181
1109	Ubiquitination	RQDKVCVKFIQGNQK CCCCEEEEEECCCCC	31.46	-
1116	Ubiquitination	KFIQGNQKNGSVPTC EEECCCCCCCCCCCC	68.24	-
1119	Phosphorylation	QGNQKNGSVPTCKRK CCCCCCCCCCCCCCC	34.03	20068231
1122	Phosphorylation	QKNGSVPTCKRKNNR CCCCCCCCCCCCCCE	28.62	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO1B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO1B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.