VPS36_HUMAN - dbPTM
VPS36_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS36_HUMAN
UniProt AC Q86VN1
Protein Name Vacuolar protein-sorting-associated protein 36
Gene Name VPS36
Organism Homo sapiens (Human).
Sequence Length 386
Subcellular Localization Cytoplasm. Endosome. Late endosome . Membrane. Nucleus . Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Protein Description Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3..
Protein Sequence MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIWRDQKNHECCMAILLSQIVFIEEQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQVPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23UbiquitinationTLVIQQRGVRIYDGE
EEEEEECCEEEECCC		14.5529967540
27PhosphorylationQQRGVRIYDGEEKIK
EECCEEEECCCCEEE		13.8228152594
34AcetylationYDGEEKIKFDAGTLL
ECCCCEEEECHHHHE		48.5425953088
44PhosphorylationAGTLLLSTHRLIWRD
HHHHEEEHHHHHHCC		15.81-
44UbiquitinationAGTLLLSTHRLIWRD
HHHHEEEHHHHHHCC		15.8122817900
44 (in isoform 2)Ubiquitination-15.81-
49 (in isoform 2)Ubiquitination-11.4621890473
49UbiquitinationLSTHRLIWRDQKNHE
EEHHHHHHCCCCCHH		11.4621890473
53UbiquitinationRLIWRDQKNHECCMA
HHHHCCCCCHHHHHH		65.6422817900
72UbiquitinationQIVFIEEQAAGIGKS
HHHHHHHHHCCCCCC		24.5829967540
81UbiquitinationAGIGKSAKIVVHLHP
CCCCCCCEEEEECCC		43.0329967540
93UbiquitinationLHPAPPNKEPGPFQS
CCCCCCCCCCCCCCC		71.6822817900
98UbiquitinationPNKEPGPFQSSKNSY
CCCCCCCCCCCCCCE		15.8621890473
100PhosphorylationKEPGPFQSSKNSYIK
CCCCCCCCCCCCEEE		43.59-
101PhosphorylationEPGPFQSSKNSYIKL
CCCCCCCCCCCEEEE		25.69-
102UbiquitinationPGPFQSSKNSYIKLS
CCCCCCCCCCEEEEE		55.9822817900
104PhosphorylationPFQSSKNSYIKLSFK
CCCCCCCCEEEEEEH		31.78-
107UbiquitinationSSKNSYIKLSFKEHG
CCCCCEEEEEEHHCC		29.8222817900
107 (in isoform 1)Ubiquitination-29.8221890473
109PhosphorylationKNSYIKLSFKEHGQI
CCCEEEEEEHHCCHH		29.3024719451
111UbiquitinationSYIKLSFKEHGQIEF
CEEEEEEHHCCHHHH		45.4822817900
114UbiquitinationKLSFKEHGQIEFYRR
EEEEHHCCHHHHHHH		31.1129967540
123PhosphorylationIEFYRRLSEEMTQRR
HHHHHHHCHHHHHHH		29.6928857561
125UbiquitinationFYRRLSEEMTQRRWE
HHHHHCHHHHHHHHH		44.1229967540
131UbiquitinationEEMTQRRWENMPVSQ
HHHHHHHHHCCCHHH		11.9629967540
137PhosphorylationRWENMPVSQSLQTNR
HHHCCCHHHHCCCCC		14.2628857561
138UbiquitinationWENMPVSQSLQTNRG
HHCCCHHHHCCCCCC		48.6829967540
139PhosphorylationENMPVSQSLQTNRGP
HCCCHHHHCCCCCCC		18.2228857561
147UbiquitinationLQTNRGPQPGRIRAV
CCCCCCCCCCCEEEE		56.7729967540
160UbiquitinationAVGIVGIERKLEEKR
EEEEEEEHHHHHHHH		37.5221890473
160 (in isoform 2)Ubiquitination-37.5221890473
163UbiquitinationIVGIERKLEEKRKET
EEEEHHHHHHHHHHH		14.9229967540
172UbiquitinationEKRKETDKNISEAFE
HHHHHHHCCHHHHHH		64.7029967540
174UbiquitinationRKETDKNISEAFEDL
HHHHHCCHHHHHHHH		4.9229967540
175PhosphorylationKETDKNISEAFEDLS
HHHHCCHHHHHHHHH		32.0627470641
180UbiquitinationNISEAFEDLSKLMIK
CHHHHHHHHHHHHHH		50.1929967540
182PhosphorylationSEAFEDLSKLMIKAK
HHHHHHHHHHHHHHH		35.7423401153
183AcetylationEAFEDLSKLMIKAKE
HHHHHHHHHHHHHHH		49.7424469599
183UbiquitinationEAFEDLSKLMIKAKE
HHHHHHHHHHHHHHH		49.7429967540
187UbiquitinationDLSKLMIKAKEMVEL
HHHHHHHHHHHHHHH		39.1729967540
189UbiquitinationSKLMIKAKEMVELSK
HHHHHHHHHHHHHHH		41.1429967540
195PhosphorylationAKEMVELSKSIANKI
HHHHHHHHHHHHHHH		15.7328258704
196UbiquitinationKEMVELSKSIANKIK
HHHHHHHHHHHHHHH		59.5129967540
197PhosphorylationEMVELSKSIANKIKD
HHHHHHHHHHHHHHH		24.4528258704
203UbiquitinationKSIANKIKDKQGDIT
HHHHHHHHHCCCCCC		61.56-
205UbiquitinationIANKIKDKQGDITED
HHHHHHHCCCCCCCC		51.7029967540
209UbiquitinationIKDKQGDITEDETIR
HHHCCCCCCCCCHHH		6.0921890473
210PhosphorylationKDKQGDITEDETIRF
HHCCCCCCCCCHHHH		41.97-
214PhosphorylationGDITEDETIRFKSYL
CCCCCCCHHHHHHHH		29.7628258704
218UbiquitinationEDETIRFKSYLLSMG
CCCHHHHHHHHHHCC		28.4822817900
218 (in isoform 1)Ubiquitination-28.4821890473
219PhosphorylationDETIRFKSYLLSMGI
CCHHHHHHHHHHCCC		20.5028348404
240 (in isoform 2)Ubiquitination-29.6521890473
240UbiquitinationETYGSGTQYHMQLAK
HHCCCHHHHHHHHHH		29.6521890473
279SulfoxidationLVNRARGMELLSPED
HHHHHCCCCCCCHHH		2.4621406390
289UbiquitinationLSPEDLVNACKMLEA
CCHHHHHHHHHHHHH		47.0921890473
298UbiquitinationCKMLEALKLPLRLRV
HHHHHHCCCCEEEEE		55.9222817900
298 (in isoform 1)Ubiquitination-55.9221890473
304UbiquitinationLKLPLRLRVFDSGVM
CCCCEEEEEECCCEE		22.1829967540
330PhosphorylationMVASALETVSEKGSL
HHHHHHHHHHHHCCC		30.1330631047
348SulfoxidationEFAKLVGMSVLLAKE
HHHHHHHHHHHHHHH		1.6321406390
353UbiquitinationVGMSVLLAKERLLLA
HHHHHHHHHHHHHHH		13.9129967540
362UbiquitinationERLLLAEKMGHLCRD
HHHHHHHHHCHHCCC		44.5729967540
371PhosphorylationGHLCRDDSVEGLRFY
CHHCCCCCCCCCCCC		26.7620873877
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS36_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS36_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS36_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS25_HUMANVPS25physical
16371348
SNF8_HUMANSNF8physical
16371348
VPS20_YEASTVPS20physical
16371348
SNF8_HUMANSNF8physical
18539118
VPS25_HUMANVPS25physical
18539118
UBC_HUMANUBCphysical
17057716
SNF8_HUMANSNF8physical
16973552
VPS36_HUMANVPS36physical
16973552
VPS25_HUMANVPS25physical
16973552
TS101_HUMANTSG101physical
16973552
UBC_HUMANUBCphysical
16973552
CHMP6_HUMANCHMP6physical
14505570
TS101_HUMANTSG101physical
14505570
SPY2_HUMANSPRY2physical
21543492
ZNHI2_HUMANZNHIT2physical
22939629
ATG7_HUMANATG7physical
22863883
PP2BB_HUMANPPP3CBphysical
22863883
SRSF5_HUMANSRSF5physical
22863883
WDR12_HUMANWDR12physical
22863883
SNF8_HUMANSNF8physical
26344197
TRM61_HUMANTRMT61Aphysical
26344197
VPS25_HUMANVPS25physical
26344197
SNF8_HUMANSNF8physical
28514442
VPS25_HUMANVPS25physical
28514442
UBB_HUMANUBBphysical
28514442
HERC1_HUMANHERC1physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS36_HUMAN

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Related Literatures of Post-Translational Modification

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