dbPTM

HERC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HERC1_HUMAN
UniProt AC	Q15751
Protein Name	Probable E3 ubiquitin-protein ligase HERC1
Gene Name	HERC1
Organism	Homo sapiens (Human).
Sequence Length	4861
Subcellular Localization	Membrane Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Recruited onto actin-rich surface protrusions.
Protein Description	Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates..
Protein Sequence	MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARPLLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLLDTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTAACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSPQASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLHMASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQIVERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGELEEEDENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGYGLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEMREEKESKEEEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLLDLTYLTGVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKSENEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPTSPSDEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLGSGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSDTDY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Ubiquitination	PQQVLCLKGPQLPDF CCEEEECCCCCCCCC	68.50	-
133	Phosphorylation	KVKQQQHSPESSSGS CCCCCCCCCCCCCCC	26.48	23090842
136	Phosphorylation	QQQHSPESSSGSADV CCCCCCCCCCCCCCC	32.94	23090842
137	Phosphorylation	QQHSPESSSGSADVH CCCCCCCCCCCCCCC	36.74	23090842
138	Phosphorylation	QHSPESSSGSADVHS CCCCCCCCCCCCCCC	46.15	23090842
140	Phosphorylation	SPESSSGSADVHSVS CCCCCCCCCCCCCCC	24.20	23090842
145	Phosphorylation	SGSADVHSVSERPRS CCCCCCCCCCCCCCC	27.47	23090842
147	Phosphorylation	SADVHSVSERPRSST CCCCCCCCCCCCCCH	30.79	23090842
223	Phosphorylation	PMGLDCLSQVTTFLK CCCHHHHHHHHHHHC	29.00	-
237	Phosphorylation	KGVTIPNSGADTLGR CCCCCCCCCCCHHHH	29.97	-
241	Phosphorylation	IPNSGADTLGRRLAS CCCCCCCHHHHHHHH	30.49	-
260	Phosphorylation	GLAAQRGSLRYLLEW HHHHHHCCHHHHHHH	16.32	24719451
275	Phosphorylation	IEMALGASAVVHTME HHHHHCCCEEEHHHH	21.57	26074081
280	Phosphorylation	GASAVVHTMEKGKLL CCCEEEHHHHCCCCC	18.53	26074081
288	Phosphorylation	MEKGKLLSSQEGMIS HHCCCCCCCCCCCCH	40.17	26074081
289	Phosphorylation	EKGKLLSSQEGMISF HCCCCCCCCCCCCHH	32.02	26074081
312	Phosphorylation	QMRRSLGSSADRSQW HHHHHCCCCCCHHHC	27.87	28348404
313	Phosphorylation	MRRSLGSSADRSQWR HHHHCCCCCCHHHCC	32.18	28348404
317	Phosphorylation	LGSSADRSQWREPTR CCCCCCHHHCCCCCC	34.34	28348404
448	Ubiquitination	NNQSTLKKLTFEPHR CCCHHHHHCCCCCCC	56.74	-
450	Phosphorylation	QSTLKKLTFEPHRSI CHHHHHCCCCCCCCC	34.53	-
466	Phosphorylation	KVSSSKGSDGHTLAF ECCCCCCCCCCEEEE	44.12	30377224
470	Phosphorylation	SKGSDGHTLAFTTEG CCCCCCCEEEEEECC	25.88	30377224
474	Phosphorylation	DGHTLAFTTEGEVFS CCCEEEEEECCCEEE	20.52	30377224
475	Phosphorylation	GHTLAFTTEGEVFSW CCEEEEEECCCEEEE	35.22	30377224
481	Phosphorylation	TTEGEVFSWGDGDYG EECCCEEEECCCCCC	35.01	30377224
487	Phosphorylation	FSWGDGDYGKLGHGN EEECCCCCCCCCCCC	22.99	30377224
495	Phosphorylation	GKLGHGNSSTQKYPK CCCCCCCCCCCCCCC	39.08	30377224
496	Phosphorylation	KLGHGNSSTQKYPKL CCCCCCCCCCCCCCH	38.57	30377224
497	Phosphorylation	LGHGNSSTQKYPKLI CCCCCCCCCCCCCHH	28.97	30377224
499	Ubiquitination	HGNSSTQKYPKLIQG CCCCCCCCCCCHHCC	64.70	-
555	Phosphorylation	SNSRNIPTLVKDISN CCCCCCCCHHEECCC	40.15	-
561	Phosphorylation	PTLVKDISNVGEVSC CCHHEECCCCCEEEC	35.28	26546556
599	Phosphorylation	GKLGHGDTNRVYKPK CCCCCCCCCCCCCHH	29.53	28152594
604	Acetylation	GDTNRVYKPKVIEAL CCCCCCCCHHHHHHH	35.19	26051181
606	Acetylation	TNRVYKPKVIEALQG CCCCCCHHHHHHHHH	52.25	26051181
724	Phosphorylation	GIAIQQISAGTSHSL CEEEEEECCCCCCCE	19.13	22210691
728	Phosphorylation	QQISAGTSHSLAWTA EEECCCCCCCEEEEC	15.34	-
789	Phosphorylation	PSSREHHSFLKLCLK CCCHHHHHHHHHHHH	33.89	24719451
832	Phosphorylation	LLFRLMDSTVPDEIQ HHHHHHCCCCCHHHH	19.83	22210691
833	Phosphorylation	LFRLMDSTVPDEIQE HHHHHCCCCCHHHHH	31.62	22210691
965	Ubiquitination	QAFGELEKNSDKFLL CCHHHHHCCCCCEEE	74.50	-
969	Ubiquitination	ELEKNSDKFLLGTSS HHHCCCCCEEECCCC	37.42	-
1031	Phosphorylation	PHATDIYSRSANLLK HHHHHHHHCCCHHHC	21.79	24719451
1033	Phosphorylation	ATDIYSRSANLLKES HHHHHHCCCHHHCCC	18.63	29978859
1194	Phosphorylation	PQLDKCMSCLLEVAL HHHHHHHHHHHHHHH	15.87	28450419
1202	Phosphorylation	CLLEVALSGNEEQKP HHHHHHHHCCCCCCC	29.81	28450419
1221	Phosphorylation	LRPEIAVYVDLALGC CCHHEEEEEEHHCCC	4.53	22210691
1287	Phosphorylation	QACGESRYQPGKHLS HHHCCCCCCCCCCHH	28.48	24719451
1291	Ubiquitination	ESRYQPGKHLSEVYR CCCCCCCCCHHHHHH	48.32	-
1294	Phosphorylation	YQPGKHLSEVYRCVY CCCCCCHHHHHHHHH	25.41	20068231
1297	Phosphorylation	GKHLSEVYRCVYKVR CCCHHHHHHHHHHHH	8.34	24719451
1311	Ubiquitination	RSRLLACKNLELIQT HHHHHHCCCCCCEEE	59.98	-
1318	Phosphorylation	KNLELIQTRSSSRDR CCCCCEEECCHHHHH	26.06	30576142
1328	Phosphorylation	SSRDRWISENQDSAD HHHHHHCCCCCCCCC	24.44	30266825
1333	Phosphorylation	WISENQDSADVDPQE HCCCCCCCCCCCCCC	19.32	30266825
1342	Phosphorylation	DVDPQEHSFTRTIDE CCCCCCCCCCCCCCH	27.79	25159151
1344	Phosphorylation	DPQEHSFTRTIDEEA CCCCCCCCCCCCHHH	29.89	21712546
1391	Phosphorylation	KIFQCFLSAREVARS HHHHHHHHHHHHHHH	12.67	-
1406	Phosphorylation	RDRDRMNSGAGSGAR CCHHHCCCCCCCCCC	22.22	25849741
1410	Phosphorylation	RMNSGAGSGARADDP HCCCCCCCCCCCCCC	28.84	23090842
1421	Phosphorylation	ADDPPPQSQQERRVS CCCCCCCCHHHHCCC	39.34	-
1428	Phosphorylation	SQQERRVSTDLPEGQ CHHHHCCCCCCCCCC	17.88	23927012
1429	Phosphorylation	QQERRVSTDLPEGQD HHHHCCCCCCCCCCH	38.40	23401153
1438	Phosphorylation	LPEGQDVYTAACNSV CCCCCHHHHHHHHHH	10.03	23403867
1439	Phosphorylation	PEGQDVYTAACNSVI CCCCHHHHHHHHHHH	13.97	23403867
1444	Phosphorylation	VYTAACNSVIHRCAL HHHHHHHHHHHHHHH	23.49	23403867
1489	Phosphorylation	GGGLMTRSESLTAES CCCCCCCCCCCCCCE	23.52	25850435
1491	Phosphorylation	GLMTRSESLTAESRL CCCCCCCCCCCCEEE	32.06	23401153
1493	Phosphorylation	MTRSESLTAESRLVH CCCCCCCCCCEEEEE	37.34	25850435
1496	Phosphorylation	SESLTAESRLVHTSP CCCCCCCEEEEECCC	28.57	29396449
1501	Phosphorylation	AESRLVHTSPNYRLI CCEEEEECCCCCEEE	38.10	30266825
1502	Phosphorylation	ESRLVHTSPNYRLIK CEEEEECCCCCEEEE	9.03	30266825
1505	Phosphorylation	LVHTSPNYRLIKSRS EEECCCCCEEEECCC	15.35	30266825
1510	Phosphorylation	PNYRLIKSRSESDLS CCCEEEECCCHHHCC	33.76	23401153
1512	Phosphorylation	YRLIKSRSESDLSQP CEEEECCCHHHCCCC	48.85	25159151
1514	Phosphorylation	LIKSRSESDLSQPES EEECCCHHHCCCCCC	45.13	23927012
1517	Phosphorylation	SRSESDLSQPESDEE CCCHHHCCCCCCCCC	48.99	17525332
1521	Phosphorylation	SDLSQPESDEEGYAL HHCCCCCCCCCCCCC	57.94	23927012
1526	Phosphorylation	PESDEEGYALSGRRN CCCCCCCCCCCCCCC	13.98	23927012
1529	Phosphorylation	DEEGYALSGRRNVDL CCCCCCCCCCCCCCH	23.29	23927012
1541	Phosphorylation	VDLDLAASHRKRGPM CCHHHHHHHHHCCCC	20.44	25159151
1544	Ubiquitination	DLAASHRKRGPMHSQ HHHHHHHHCCCCHHH	57.17	-
1550	Phosphorylation	RKRGPMHSQLESLSD HHCCCCHHHHHHHHH	30.15	21712546
1556	Phosphorylation	HSQLESLSDSWARLK HHHHHHHHHHHHHHH	38.59	25159151
1558	Phosphorylation	QLESLSDSWARLKHS HHHHHHHHHHHHHHC	21.18	25159151
1573	Phosphorylation	RDWLCNSSYSFESDF CCCCCCCCCCCCCCC	15.71	27251275
1575	Phosphorylation	WLCNSSYSFESDFDL CCCCCCCCCCCCCCC	25.20	28348404
1578	Phosphorylation	NSSYSFESDFDLTKS CCCCCCCCCCCCCHH	41.38	28348404
1649	Phosphorylation	HQILVLLSGMEEKGS HHHHHHHHCCCCCCC	31.75	23898821
1656	Phosphorylation	SGMEEKGSISLAGSR HCCCCCCCEEECCCC	21.77	23898821
1658	Phosphorylation	MEEKGSISLAGSRLS CCCCCCEEECCCCCC	17.54	23898821
1662	Phosphorylation	GSISLAGSRLSSGFQ CCEEECCCCCCCCCC	25.17	23898821
1916	Phosphorylation	VFLRRVVSSKAIQSK HHHHHHHCCHHHHHH	24.22	30622161
1917	Phosphorylation	FLRRVVSSKAIQSKM HHHHHHCCHHHHHHC	17.94	30622161
1918	Ubiquitination	LRRVVSSKAIQSKMA HHHHHCCHHHHHHCC	41.84	-
1926	Phosphorylation	AIQSKMASPKWTEVL HHHHHCCCCHHHHHH	24.42	27282143
1928	Acetylation	QSKMASPKWTEVLLN HHHCCCCHHHHHHHH	65.34	25953088
1930	Phosphorylation	KMASPKWTEVLLNIA HCCCCHHHHHHHHHH	23.49	29449344
1952	Methylation	IPLVGNLRTRLLALH CCCCCHHHHHHHHHH	23.07	115386639
2007	Ubiquitination	AKHAIQIKEKEQEIK HHHHHHCHHHHHHHH	46.49	-
2014	Ubiquitination	KEKEQEIKLQKQGEL HHHHHHHHHHHCCCC	44.08	-
2017	Ubiquitination	EQEIKLQKQGELEEE HHHHHHHHCCCCCCC	71.37	-
2093	Phosphorylation	EGTCVGVSRWPVHDF CCEEEEEEECCCCCC	23.77	-
2231	Phosphorylation	HRTDRWTYCINKKMM HCCCCCEECCCHHHH	5.60	-
2260	Phosphorylation	QKLKKSRSVQSREEN HHHHHCCCCHHHHHH	31.44	23186163
2263	Phosphorylation	KKSRSVQSREENEMR HHCCCCHHHHHHHHH	39.23	23186163
2333	Phosphorylation	KQTGRHATLLGVVKE CCCCCCEEEEEEECC	19.18	23403867
2339	Ubiquitination	ATLLGVVKEGSTSAK EEEEEEECCCCCCCE	54.68	-
2411	Phosphorylation	EDMGKQSTKRHEKKH CCCCCHHHHHHHHHH	29.60	22798277
2422	Phosphorylation	EKKHRHESEEKGDVE HHHHCCCCCCCCCCC	44.95	29255136
2431	Ubiquitination	EKGDVEQKPESESAL CCCCCCCCCCCCCHH	36.93	-
2434	Phosphorylation	DVEQKPESESALDMR CCCCCCCCCCHHHHC	45.43	23186163
2436	Phosphorylation	EQKPESESALDMRTG CCCCCCCCHHHHCCC	43.33	23186163
2442	Phosphorylation	ESALDMRTGLTSDDV CCHHHHCCCCCHHHH	29.88	-
2445	Phosphorylation	LDMRTGLTSDDVKSQ HHHCCCCCHHHHHCC	31.30	28102081
2446	Phosphorylation	DMRTGLTSDDVKSQS HHCCCCCHHHHHCCC	36.53	21082442
2450	Ubiquitination	GLTSDDVKSQSTTSS CCCHHHHHCCCCCCC	50.18	-
2451	Phosphorylation	LTSDDVKSQSTTSSK CCHHHHHCCCCCCCC	29.25	-
2454	Phosphorylation	DDVKSQSTTSSKSEN HHHHCCCCCCCCCHH	24.06	-
2458	Ubiquitination	SQSTTSSKSENEIAS CCCCCCCCCHHCEEE	62.65	-
2467	Phosphorylation	ENEIASFSLDPTLPS HHCEEEEECCCCCCC	29.39	24173317
2474	Phosphorylation	SLDPTLPSVESQHQI ECCCCCCCHHHHHCC	41.45	27251275
2477	Phosphorylation	PTLPSVESQHQITEG CCCCCHHHHHCCCCC	30.70	27251275
2485	Ubiquitination	QHQITEGKRKNHEHM HHCCCCCHHHCCHHH	54.70	-
2510	Phosphorylation	IRAVQLSYLYLGAMK HHHHHHHHHHHHHHH	14.14	18083107
2528	Phosphorylation	ALLGCSKYAELLLIP HHHCCCHHHHHHHHH	6.76	18083107
2545	Phosphorylation	LAENGHNSDCASSPV HHHCCCCCCCCCCCC	28.52	28450419
2549	Phosphorylation	GHNSDCASSPVVHED CCCCCCCCCCCCCCC	41.32	28450419
2550	Phosphorylation	HNSDCASSPVVHEDV CCCCCCCCCCCCCCH	11.82	28450419
2612	Ubiquitination	LEDQFGGKIKQEIDQ HCCCCCCCHHHHHHH	47.30	-
2666	Phosphorylation	TPVTDTETVPASESP CCCCCCCCCCCCCCC	33.60	24275569
2670	Phosphorylation	DTETVPASESPGVMP CCCCCCCCCCCCCCC	32.32	24275569
2672	Phosphorylation	ETVPASESPGVMPLS CCCCCCCCCCCCCHH	25.18	24275569
2679	Phosphorylation	SPGVMPLSLLRQMFS CCCCCCHHHHHHHHH	21.35	24275569
2686	Phosphorylation	SLLRQMFSSYPTTTV HHHHHHHHCCCCCCC	24.50	25907765
2687	Phosphorylation	LLRQMFSSYPTTTVL HHHHHHHCCCCCCCC	24.70	25907765
2688	Phosphorylation	LRQMFSSYPTTTVLP HHHHHHCCCCCCCCC	11.91	25907765
2690	Phosphorylation	QMFSSYPTTTVLPTR HHHHCCCCCCCCCCC	27.19	25907765
2691	Phosphorylation	MFSSYPTTTVLPTRR HHHCCCCCCCCCCCC	15.48	25907765
2692	Phosphorylation	FSSYPTTTVLPTRRA HHCCCCCCCCCCCCC	23.64	25907765
2696	Phosphorylation	PTTTVLPTRRAQTPP CCCCCCCCCCCCCCC	28.73	25907765
2701	Phosphorylation	LPTRRAQTPPISSLP CCCCCCCCCCCCCCC	30.01	29255136
2705	Phosphorylation	RAQTPPISSLPTSPS CCCCCCCCCCCCCCC	31.43	23927012
2706	Phosphorylation	AQTPPISSLPTSPSD CCCCCCCCCCCCCCC	38.80	23927012
2709	Phosphorylation	PPISSLPTSPSDEVG CCCCCCCCCCCCCCC	59.57	23927012
2710	Phosphorylation	PISSLPTSPSDEVGR CCCCCCCCCCCCCCC	22.07	23927012
2712	Phosphorylation	SSLPTSPSDEVGRRQ CCCCCCCCCCCCCCC	46.28	23927012
2720	Phosphorylation	DEVGRRQSLTSPDSQ CCCCCCCCCCCCCCC	31.63	23401153
2722	Phosphorylation	VGRRQSLTSPDSQSA CCCCCCCCCCCCCCC	43.38	29255136
2723	Phosphorylation	GRRQSLTSPDSQSAR CCCCCCCCCCCCCCC	31.81	29255136
2726	Phosphorylation	QSLTSPDSQSARPAN CCCCCCCCCCCCCCC	29.44	29255136
2728	Phosphorylation	LTSPDSQSARPANRT CCCCCCCCCCCCCCC	30.14	23403867
2735	Phosphorylation	SARPANRTALSDPSS CCCCCCCCCCCCCCC	31.58	28102081
2738	Phosphorylation	PANRTALSDPSSRLS CCCCCCCCCCCCCCC	45.04	22985185
2741	Phosphorylation	RTALSDPSSRLSTSP CCCCCCCCCCCCCCC	32.83	23322592
2742	Phosphorylation	TALSDPSSRLSTSPP CCCCCCCCCCCCCCC	42.50	26270265
2745	Phosphorylation	SDPSSRLSTSPPPPA CCCCCCCCCCCCCCC	26.23	27273156
2746	Phosphorylation	DPSSRLSTSPPPPAI CCCCCCCCCCCCCCC	50.25	28464451
2747	Phosphorylation	PSSRLSTSPPPPAIA CCCCCCCCCCCCCCH	31.84	26846344
2763	Phosphorylation	PLLEMGFSLRQIAKA HHHHCCCCHHHHHHH	19.53	20068231
2769	Ubiquitination	FSLRQIAKAMEATGA CCHHHHHHHHHHHCC	50.31	21890473
2821	Phosphorylation	PGAAVLGSGGKSNDP CCCEEECCCCCCCCC	39.96	26270265
2866	Phosphorylation	TENAASGSGPSARGR CCCCCCCCCCCHHCC	45.06	28787133
2881	Ubiquitination	SAVTRRHKFDLAART CHHHHHHHHHHHHHH	38.47	21890473
2888	Phosphorylation	KFDLAARTLLARAAG HHHHHHHHHHHHHHH	22.77	-
2899	Phosphorylation	RAAGLYRSVQAHRNQ HHHHHHHHHHHHHHC	12.67	28555341
3005	Phosphorylation	NHPGCGRSANRQGYR CCCCCCCCCCCCCCC	18.38	-
3013	Phosphorylation	ANRQGYRSNGSYVDG CCCCCCCCCCCCCCC	36.74	23401153
3017	Phosphorylation	GYRSNGSYVDGWFGG CCCCCCCCCCCCCCC	12.17	23401153
3032	Phosphorylation	ECGSGNPYYLLCGTC CCCCCCCEEEEECHH	15.67	23401153
3033	Phosphorylation	CGSGNPYYLLCGTCR CCCCCCEEEEECHHH	8.41	23401153
3042	Ubiquitination	LCGTCREKYLAMKTK EECHHHHHHHHHCCC	26.64	-
3051	Ubiquitination	LAMKTKSKSTSSERY HHHCCCCCCCCCHHH	60.35	-
3059	Ubiquitination	STSSERYKGQAPDLI CCCCHHHCCCCCCCC	51.25	-
3071	Phosphorylation	DLIGKQDSVYEEDWD CCCCCCCCCCCCCCC	24.89	28348404
3188	Phosphorylation	AQVLLARTMVMRALS HHHHHHHHHHHHHHH	14.44	28674151
3205	Phosphorylation	SVSGSSCSLAAGLES HCCCCCCHHHHHHHH	24.00	28674151
3212	Phosphorylation	SLAAGLESLGLTDIR HHHHHHHHCCCCCHH	32.55	28674151
3216	Phosphorylation	GLESLGLTDIRTLVR HHHHCCCCCHHHHHH	27.81	28674151
3236	Phosphorylation	AAGRAGLSTSPSAMA HCHHCCCCCCHHHHC	26.39	23186163
3237	Phosphorylation	AGRAGLSTSPSAMAS CHHCCCCCCHHHHCC	50.10	23186163
3238	Phosphorylation	GRAGLSTSPSAMAST HHCCCCCCHHHHCCC	17.30	23186163
3240	Phosphorylation	AGLSTSPSAMASTSE CCCCCCHHHHCCCCC	30.37	23186163
3242	Sulfoxidation	LSTSPSAMASTSERS CCCCHHHHCCCCCCC	3.38	21406390
3244	Phosphorylation	TSPSAMASTSERSRG CCHHHHCCCCCCCCC	21.27	23186163
3245	Phosphorylation	SPSAMASTSERSRGG CHHHHCCCCCCCCCC	25.68	24719451
3246	Phosphorylation	PSAMASTSERSRGGH HHHHCCCCCCCCCCC	28.63	23186163
3254	Phosphorylation	ERSRGGHSKANKPIS CCCCCCCCCCCCCHH	36.42	-
3311	Ubiquitination	VDDSIQRKFLPSFLR CCHHHHHHHHHHHHH	34.57	21890473
3328	Phosphorylation	AEENKLVTSPNFVVT HHHCCCCCCCCHHHH	49.23	-
3329	Phosphorylation	EENKLVTSPNFVVTQ HHCCCCCCCCHHHHH	15.46	-
3335	Phosphorylation	TSPNFVVTQALVALL CCCCHHHHHHHHHHH	11.65	-
3348	Ubiquitination	LLADKGAKLRPNYDK HHHHCCCCCCCCCCH	54.41	-
3355	Ubiquitination	KLRPNYDKSEVEKKG CCCCCCCHHHHHHCC	37.85	-
3420	Phosphorylation	GGDLRKCSFIKLEAH CCCHHCCCEEEEEEC	32.80	24719451
3440	Ubiquitination	TCVWCNKKGLLATSG EEEEECCCCEEEECC	40.58	-
3459	Ubiquitination	IRVWNVTKKQYSLQQ EEEEEECCCEEEEEC	33.33	-
3460	Ubiquitination	RVWNVTKKQYSLQQT EEEEECCCEEEEECE	45.14	21890473
3462	Phosphorylation	WNVTKKQYSLQQTCV EEECCCEEEEECEEH	21.89	30622161
3463	Phosphorylation	NVTKKQYSLQQTCVF EECCCEEEEECEEHH	19.74	30622161
3467	Phosphorylation	KQYSLQQTCVFNRLE CEEEEECEEHHCCCC	9.55	30622161
3485	Phosphorylation	EESLGSPSDPSFSPV HHHCCCCCCCCCCCC	64.94	28787133
3488	Phosphorylation	LGSPSDPSFSPVSWS CCCCCCCCCCCCCEE	43.26	28787133
3490	Phosphorylation	SPSDPSFSPVSWSIS CCCCCCCCCCCEEEC	28.82	28787133
3611	Ubiquitination	GKLLLGTKEPLEKGG CEEEECCCCCHHHCC	56.38	-
3616	Ubiquitination	GTKEPLEKGGIVLID CCCCCHHHCCEEEEE	70.85	-
3628	Phosphorylation	LIDAHKDTLISMKWD EEECCCCCEEEEEEC	30.69	17287340
3631	Phosphorylation	AHKDTLISMKWDPTG CCCCCEEEEEECCCC	19.88	17287340
3643	Phosphorylation	PTGHILMTCAKEDSV CCCCEEEEEECCCCC	13.08	17287340
3775	Phosphorylation	GGLMNIWSLRDGSVL CCCCHHHHCCCCCEE	15.10	24719451
3837	Ubiquitination	ATCRTALKQQGVLGL HHHHHHHHHCCCCCC	37.80	-
4163	Phosphorylation	FTFGNGDYGRLGLGN EEECCCCCCCCCCCC	12.92	25147952
4232	Ubiquitination	TAKSSPQKIDVLCGI CCCCCCCCCCEEECC	44.23	-
4393	Phosphorylation	YGALREVSIHTVRAR CCCCEEEEHHHHHHH	12.14	-
4396	Phosphorylation	LREVSIHTVRARLRL CEEEEHHHHHHHHHH	15.26	24719451
4459	Phosphorylation	YTLPMVRSIGKTMVQ EEHHHHHHHCCEEEC	25.04	-
4462	Acetylation	PMVRSIGKTMVQGKN HHHHHHCCEEECCCC	31.60	25953088
4462	Ubiquitination	PMVRSIGKTMVQGKN HHHHHHCCEEECCCC	31.60	-
4468	Ubiquitination	GKTMVQGKNYGPQIT CCEEECCCCCCCCEE	29.88	21890473
4477	Acetylation	YGPQITVKRISTRGR CCCCEEEEEECCCCC	35.05	25953088
4487	Ubiquitination	STRGRKCKPIFVQIA CCCCCCCCCHHHHHH	44.15	-
4499	Ubiquitination	QIARQVVKLNASDLR HHHHHHHHCCHHHCC	36.85	-
4503	Phosphorylation	QVVKLNASDLRLPSR HHHHCCHHHCCCCCC	35.78	23401153
4509	Phosphorylation	ASDLRLPSRAWKVKL HHHCCCCCCCEEEEE	38.94	20068231
4672	Phosphorylation	PIIPGGNSIPLTFSN EECCCCCCCCCCCCC	28.94	23911959
4676	Phosphorylation	GGNSIPLTFSNRKEY CCCCCCCCCCCHHHH	21.47	23911959
4678	Phosphorylation	NSIPLTFSNRKEYVE CCCCCCCCCHHHHHH	30.41	23911959
4786	Phosphorylation	RSRLPANTADISQRF CCCCCCCCCCHHHHH	28.01	22210691
4790	Phosphorylation	PANTADISQRFQIMK CCCCCCHHHHHCEEE	18.82	22210691
4797	Ubiquitination	SQRFQIMKVDRPYDS HHHHCEEECCCCCCC	42.48	-
4845	Phosphorylation	RSIDMDNYMLSRNVD CCCCCCCCCCCCCCC	8.65	27642862
4857	Phosphorylation	NVDNAEGSDTDY--- CCCCCCCCCCCC---	28.92	30278072
4859	Phosphorylation	DNAEGSDTDY----- CCCCCCCCCC-----	38.61	30278072
4861	Phosphorylation	AEGSDTDY------- CCCCCCCC-------	23.65	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HERC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HERC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HERC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPYM_HUMAN	PKM	physical	12650930
ARF1_HUMAN	ARF1	physical	8861955
CLH1_HUMAN	CLTC	physical	9233772
SOX9_HUMAN	SOX9	physical	24155239
UB2D3_HUMAN	UBE2D3	physical	24155239
BAK_HUMAN	BAK1	physical	25408501
HERC1_HUMAN	HERC1	physical	26949039
UBE2S_HUMAN	UBE2S	physical	26949039

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HERC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1521 AND THR-2701, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2747, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1510; SER-1512;SER-1517; SER-1521; THR-2701; SER-2706; THR-2709 AND SER-2710, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1428; SER-1502; THR-2701AND SER-2706, AND MASS SPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1517 AND SER-1521, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3628; SER-3631 ANDTHR-3643, AND MASS SPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1514; THR-4786 ANDSER-4790, AND MASS SPECTROMETRY.	17081983 [Abstract]