CLH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLH1_HUMAN
• UniProt AC: Q00610
• Protein Name: Clathrin heavy chain 1
• Gene Name: CLTC
• Organism: Homo sapiens (Human).
• Sequence Length: 1675
• Subcellular Localization: Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Membrane, coated pit ; Peripheral membrane protein ; Cytoplasmic side . Melanosome . Cytoplasm, cytoskeleton, spindle . Cytoplasmic face of coated pits and vesicles. Iden
• Protein Description: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. [PubMed: 15858577]
• Protein Sequence: MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQILPIRF ------CCCCCCCCH	19.20	22223895
31	Phosphorylation	NIGFSTLTMESDKFI HCCCEEEECCCCEEE	20.98	-
55	Sulfoxidation	AQVVIIDMNDPSNPI EEEEEEECCCCCCCC	4.28	30846556
67	Phosphorylation	NPIRRPISADSAIMN CCCCCCCCCCHHHCC	28.80	30266825
70	Phosphorylation	RRPISADSAIMNPAS CCCCCCCHHHCCCCH	21.29	30266825
73	Sulfoxidation	ISADSAIMNPASKVI CCCCHHHCCCCHHEE	5.00	21406390
77	Phosphorylation	SAIMNPASKVIALKA HHHCCCCHHEEEHHC	28.81	25307156
78	2-Hydroxyisobutyrylation	AIMNPASKVIALKAG HHCCCCHHEEEHHCC	39.50	-
78	Ubiquitination	AIMNPASKVIALKAG HHCCCCHHEEEHHCC	39.50	21906983
78 (in isoform 1)	Ubiquitination	-	39.50	21890473
78 (in isoform 2)	Ubiquitination	-	39.50	21890473
83	Ubiquitination	ASKVIALKAGKTLQI CHHEEEHHCCCEEEE	46.18	-
86	Ubiquitination	VIALKAGKTLQIFNI EEEHHCCCEEEEEEE	51.42	-
86 (in isoform 1)	Ubiquitination	-	51.42	21890473
86 (in isoform 2)	Ubiquitination	-	51.42	21890473
95	Sulfoxidation	LQIFNIEMKSKMKAH EEEEEEECHHHCCCC	5.41	28465586
96	2-Hydroxyisobutyrylation	QIFNIEMKSKMKAHT EEEEEECHHHCCCCC	33.85	-
96	Ubiquitination	QIFNIEMKSKMKAHT EEEEEECHHHCCCCC	33.85	-
96 (in isoform 1)	Ubiquitination	-	33.85	21890473
96 (in isoform 2)	Ubiquitination	-	33.85	21890473
103	Phosphorylation	KSKMKAHTMTDDVTF HHHCCCCCCCCCCCH	26.99	28857561
104	Sulfoxidation	SKMKAHTMTDDVTFW HHCCCCCCCCCCCHH	2.51	30846556
105	Phosphorylation	KMKAHTMTDDVTFWK HCCCCCCCCCCCHHH	30.15	28450419
123	Phosphorylation	LNTVALVTDNAVYHW CCEEEEECCCCEEEE	25.12	28787133
144	Methylation	QPVKMFDRHSSLAGC CCEEEECCCCCCCCC	21.96	-
146	Phosphorylation	VKMFDRHSSLAGCQI EEEECCCCCCCCCEE	28.13	23312004
147	Phosphorylation	KMFDRHSSLAGCQII EEECCCCCCCCCEEE	19.00	23532336
151	S-nitrosocysteine	RHSSLAGCQIINYRT CCCCCCCCEEEECCC	1.87	-
151	Glutathionylation	RHSSLAGCQIINYRT CCCCCCCCEEEECCC	1.87	22555962
151	S-nitrosylation	RHSSLAGCQIINYRT CCCCCCCCEEEECCC	1.87	19483679
158	Phosphorylation	CQIINYRTDAKQKWL CEEEECCCCCCCCEE	29.92	-
163	Acetylation	YRTDAKQKWLLLTGI CCCCCCCCEEEHHCC	38.82	26051181
163	Ubiquitination	YRTDAKQKWLLLTGI CCCCCCCCEEEHHCC	38.82	21890473
163 (in isoform 1)	Ubiquitination	-	38.82	21890473
163 (in isoform 2)	Ubiquitination	-	38.82	21890473
171	Phosphorylation	WLLLTGISAQQNRVV EEEHHCCCCCCCCCC	22.75	21712546
181	Sulfoxidation	QNRVVGAMQLYSVDR CCCCCCCEEEEECCC	2.02	30846556
184	Phosphorylation	VVGAMQLYSVDRKVS CCCCEEEEECCCCCC	6.97	28152594
185	Phosphorylation	VGAMQLYSVDRKVSQ CCCEEEEECCCCCCC	26.57	28152594
189	Malonylation	QLYSVDRKVSQPIEG EEEECCCCCCCCCCC	41.60	26320211
189	Ubiquitination	QLYSVDRKVSQPIEG EEEECCCCCCCCCCC	41.60	-
191	Phosphorylation	YSVDRKVSQPIEGHA EECCCCCCCCCCCCC	33.02	23312004
200	Phosphorylation	PIEGHAASFAQFKME CCCCCCCCEEEEEEE	23.15	28857561
213	Phosphorylation	MEGNAEESTLFCFAV EECCCCCCEEEEEEE	23.16	27732954
214	Phosphorylation	EGNAEESTLFCFAVR ECCCCCCEEEEEEEE	27.42	27732954
227	2-Hydroxyisobutyrylation	VRGQAGGKLHIIEVG EECCCCCEEEEEEEC	35.65	-
227	Acetylation	VRGQAGGKLHIIEVG EECCCCCEEEEEEEC	35.65	25953088
227	Malonylation	VRGQAGGKLHIIEVG EECCCCCEEEEEEEC	35.65	26320211
227	Ubiquitination	VRGQAGGKLHIIEVG EECCCCCEEEEEEEC	35.65	-
235	Phosphorylation	LHIIEVGTPPTGNQP EEEEEECCCCCCCCC	31.13	25159151
238	Phosphorylation	IEVGTPPTGNQPFPK EEECCCCCCCCCCCC	50.39	28450419
245	2-Hydroxyisobutyrylation	TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC	54.46	-
245	Acetylation	TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC	54.46	25953088
245	Malonylation	TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC	54.46	26320211
245	Succinylation	TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC	54.46	23954790
245	Ubiquitination	TGNQPFPKKAVDVFF CCCCCCCCCCEEEEC	54.46	-
246	Ubiquitination	GNQPFPKKAVDVFFP CCCCCCCCCEEEECC	54.61	21906983
246 (in isoform 1)	Ubiquitination	-	54.61	21890473
246 (in isoform 2)	Ubiquitination	-	54.61	21890473
264	Sulfoxidation	QNDFPVAMQISEKHD CCCCCEEEECCCCCC	3.56	31801345
299	Phosphorylation	CIYMNRISGETIFVT EEEEEECCCCEEEEE	27.60	27050516
302	Phosphorylation	MNRISGETIFVTAPH EEECCCCEEEEECCC	24.20	28857561
367	2-Hydroxyisobutyrylation	AEELFARKFNALFAQ HHHHHHHHHHHHHHC	39.27	-
367	Acetylation	AEELFARKFNALFAQ HHHHHHHHHHHHHHC	39.27	25825284
367	Malonylation	AEELFARKFNALFAQ HHHHHHHHHHHHHHC	39.27	26320211
367	Ubiquitination	AEELFARKFNALFAQ HHHHHHHHHHHHHHC	39.27	21890473
367 (in isoform 1)	Ubiquitination	-	39.27	21890473
367 (in isoform 2)	Ubiquitination	-	39.27	21890473
377	Nitration	ALFAQGNYSEAAKVA HHHHCCCHHHHHHHH	18.08	-
377	Phosphorylation	ALFAQGNYSEAAKVA HHHHCCCHHHHHHHH	18.08	28152594
377 (in isoform 2)	Phosphorylation	-	18.08	27642862
378	Phosphorylation	LFAQGNYSEAAKVAA HHHCCCHHHHHHHHH	25.43	28152594
382	Acetylation	GNYSEAAKVAANAPK CCHHHHHHHHHCCCC	39.18	26051181
389	2-Hydroxyisobutyrylation	KVAANAPKGILRTPD HHHHCCCCCCCCCHH	57.06	-
389	Acetylation	KVAANAPKGILRTPD HHHHCCCCCCCCCHH	57.06	26051181
389	Malonylation	KVAANAPKGILRTPD HHHHCCCCCCCCCHH	57.06	26320211
389	Succinylation	KVAANAPKGILRTPD HHHHCCCCCCCCCHH	57.06	23954790
389	Ubiquitination	KVAANAPKGILRTPD HHHHCCCCCCCCCHH	57.06	-
389 (in isoform 2)	Ubiquitination	-	57.06	-
394	Phosphorylation	APKGILRTPDTIRRF CCCCCCCCHHHHHHH	23.28	22617229
397	Phosphorylation	GILRTPDTIRRFQSV CCCCCHHHHHHHCCC	20.00	30266825
403	Phosphorylation	DTIRRFQSVPAQPGQ HHHHHHCCCCCCCCC	27.62	29496963
411	Phosphorylation	VPAQPGQTSPLLQYF CCCCCCCCCHHHHHH	37.92	18691976
412	Phosphorylation	PAQPGQTSPLLQYFG CCCCCCCCHHHHHHH	12.98	22199227
417	Phosphorylation	QTSPLLQYFGILLDQ CCCHHHHHHHEECCC	12.07	20068231
429	Acetylation	LDQGQLNKYESLELC CCCCCCCHHHHHHHH	60.01	21466224
430	Phosphorylation	DQGQLNKYESLELCR CCCCCCHHHHHHHHH	15.07	28152594
450	2-Hydroxyisobutyrylation	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	-
450	Acetylation	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	22644441
450	Malonylation	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	26320211
450	Ubiquitination	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	21890473
450 (in isoform 1)	Ubiquitination	-	58.77	21890473
450 (in isoform 2)	Ubiquitination	-	58.77	21890473
453	Malonylation	QLLEKWLKEDKLECS HHHHHHHHHCCCHHH	63.85	26320211
453	Ubiquitination	QLLEKWLKEDKLECS HHHHHHHHHCCCHHH	63.85	21906983
453 (in isoform 1)	Ubiquitination	-	63.85	21890473
453 (in isoform 2)	Ubiquitination	-	63.85	21890473
456	2-Hydroxyisobutyrylation	EKWLKEDKLECSEEL HHHHHHCCCHHHHHH	47.48	-
456	Acetylation	EKWLKEDKLECSEEL HHHHHHCCCHHHHHH	47.48	69013
456	Ubiquitination	EKWLKEDKLECSEEL HHHHHHCCCHHHHHH	47.48	-
459	Glutathionylation	LKEDKLECSEELGDL HHHCCCHHHHHHHHH	10.07	22555962
473	Phosphorylation	LVKSVDPTLALSVYL HHHCCCCHHHHHHHH	21.87	-
477	Phosphorylation	VDPTLALSVYLRANV CCCHHHHHHHHHCCC	11.78	28152594
479	Phosphorylation	PTLALSVYLRANVPN CHHHHHHHHHCCCCC	6.26	28152594
487	Acetylation	LRANVPNKVIQCFAE HHCCCCCCEEEHHHH	34.34	26051181
491	S-nitrosocysteine	VPNKVIQCFAETGQV CCCCEEEHHHHCCCC	2.10	-
491	Glutathionylation	VPNKVIQCFAETGQV CCCCEEEHHHHCCCC	2.10	22555962
491	S-nitrosylation	VPNKVIQCFAETGQV CCCCEEEHHHHCCCC	2.10	19483679
491	S-palmitoylation	VPNKVIQCFAETGQV CCCCEEEHHHHCCCC	2.10	26865113
500	Acetylation	AETGQVQKIVLYAKK HHCCCCEEEEEEECC	35.61	25953088
500	Malonylation	AETGQVQKIVLYAKK HHCCCCEEEEEEECC	35.61	26320211
500	Ubiquitination	AETGQVQKIVLYAKK HHCCCCEEEEEEECC	35.61	-
506	2-Hydroxyisobutyrylation	QKIVLYAKKVGYTPD EEEEEEECCCCCCHH	34.14	-
506	Acetylation	QKIVLYAKKVGYTPD EEEEEEECCCCCCHH	34.14	54364247
506	Malonylation	QKIVLYAKKVGYTPD EEEEEEECCCCCCHH	34.14	26320211
507	Ubiquitination	KIVLYAKKVGYTPDW EEEEEECCCCCCHHH	32.49	21890473
507 (in isoform 1)	Ubiquitination	-	32.49	21890473
507 (in isoform 2)	Ubiquitination	-	32.49	21890473
510	Phosphorylation	LYAKKVGYTPDWIFL EEECCCCCCHHHHHH	20.34	-
556	Phosphorylation	IVDVFMEYNLIQQCT HHHHHHHHCHHHHHH	11.95	-
587	Sulfoxidation	LQTRLLEMNLMHAPQ HHHHHHHHCCCCHHH	4.75	30846556
590	Sulfoxidation	RLLEMNLMHAPQVAD HHHHHCCCCHHHHHH	1.84	30846556
604	Sulfoxidation	DAILGNQMFTHYDRA HHHHCCCCCCCCCHH	4.92	30846556
617	Glutathionylation	RAHIAQLCEKAGLLQ HHHHHHHHHHHCHHH	3.16	22555962
619	2-Hydroxyisobutyrylation	HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH	46.92	-
619	Acetylation	HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH	46.92	25953088
619	Malonylation	HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH	46.92	26320211
619	Methylation	HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH	46.92	24129315
619	Ubiquitination	HIAQLCEKAGLLQRA HHHHHHHHHCHHHHH	46.92	-
619 (in isoform 1)	Ubiquitination	-	46.92	21890473
619 (in isoform 2)	Ubiquitination	-	46.92	21890473
631	Phosphorylation	QRALEHFTDLYDIKR HHHHHHHHHHHHHHH	27.31	28152594
634	Phosphorylation	LEHFTDLYDIKRAVV HHHHHHHHHHHHHHH	20.59	27273156
634 (in isoform 2)	Phosphorylation	-	20.59	27642862
637	Acetylation	FTDLYDIKRAVVHTH HHHHHHHHHHHHHHH	31.26	25825284
637	Malonylation	FTDLYDIKRAVVHTH HHHHHHHHHHHHHHH	31.26	26320211
637	Ubiquitination	FTDLYDIKRAVVHTH HHHHHHHHHHHHHHH	31.26	19608861
637 (in isoform 1)	Ubiquitination	-	31.26	21890473
637 (in isoform 2)	Ubiquitination	-	31.26	21890473
672	Phosphorylation	ECLRAMLSANIRQNL HHHHHHHHHHHHHHH	13.24	20068231
731	Phosphorylation	DPDVHFKYIQAACKT CCCCHHHHHHHHHHC	9.42	28152594
736	S-nitrosocysteine	FKYIQAACKTGQIKE HHHHHHHHHCCCHHH	4.55	-
736	S-nitrosylation	FKYIQAACKTGQIKE HHHHHHHHHCCCHHH	4.55	19483679
737	2-Hydroxyisobutyrylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	-
737	Malonylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	26320211
737	Succinylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	-
737	Succinylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	-
737	Ubiquitination	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	-
742	2-Hydroxyisobutyrylation	ACKTGQIKEVERICR HHHCCCHHHHHHHHH	48.06	-
742	Acetylation	ACKTGQIKEVERICR HHHCCCHHHHHHHHH	48.06	72629971
742	Ubiquitination	ACKTGQIKEVERICR HHHCCCHHHHHHHHH	48.06	21906983
742 (in isoform 1)	Ubiquitination	-	48.06	21890473
742 (in isoform 2)	Ubiquitination	-	48.06	21890473
751	Phosphorylation	VERICRESNCYDPER HHHHHHHCCCCCHHH	16.91	25159151
760	Ubiquitination	CYDPERVKNFLKEAK CCCHHHHHHHHHHCC	48.48	-
764	2-Hydroxyisobutyrylation	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	-
764	Acetylation	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	22644433
764	Malonylation	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	26320211
764	Ubiquitination	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	19608861
767	2-Hydroxyisobutyrylation	KNFLKEAKLTDQLPL HHHHHHCCCCCCCCE	53.67	-
798	Acetylation	LYRNNLQKYIEIYVQ HHHCCHHHHHHEEEE	51.89	25038526
798	Ubiquitination	LYRNNLQKYIEIYVQ HHHCCHHHHHHEEEE	51.89	21890473
798 (in isoform 1)	Ubiquitination	-	51.89	21890473
798 (in isoform 2)	Ubiquitination	-	51.89	21890473
799	Phosphorylation	YRNNLQKYIEIYVQK HHCCHHHHHHEEEEE	7.27	-
803	Phosphorylation	LQKYIEIYVQKVNPS HHHHHHEEEEECCHH	5.52	-
806	2-Hydroxyisobutyrylation	YIEIYVQKVNPSRLP HHHEEEEECCHHHCC	33.66	-
806	Acetylation	YIEIYVQKVNPSRLP HHHEEEEECCHHHCC	33.66	26051181
806	Ubiquitination	YIEIYVQKVNPSRLP HHHEEEEECCHHHCC	33.66	-
806 (in isoform 1)	Ubiquitination	-	33.66	21890473
806 (in isoform 2)	Ubiquitination	-	33.66	21890473
824	Glutathionylation	GGLLDVDCSEDVIKN ECCCCCCCCHHHHHH	4.88	22555962
825	Phosphorylation	GLLDVDCSEDVIKNL CCCCCCCCHHHHHHH	32.16	21712546
841	Phosphorylation	LVVRGQFSTDELVAE EEECCCCCHHHHHHH	27.36	-
842	Phosphorylation	VVRGQFSTDELVAEV EECCCCCHHHHHHHH	34.48	-
851	2-Hydroxyisobutyrylation	ELVAEVEKRNRLKLL HHHHHHHHHCHHHHH	61.21	-
851	Ubiquitination	ELVAEVEKRNRLKLL HHHHHHHHHCHHHHH	61.21	-
856	2-Hydroxyisobutyrylation	VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH	33.57	-
856	Acetylation	VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH	33.57	19608861
856	Ubiquitination	VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH	33.57	19608861
856 (in isoform 2)	Ubiquitination	-	33.57	-
870	Glutathionylation	EARIHEGCEEPATHN HHHHHCCCCCCCCCC	4.95	22555962
875	Phosphorylation	EGCEEPATHNALAKI CCCCCCCCCCCEEEE	26.78	20068231
881	2-Hydroxyisobutyrylation	ATHNALAKIYIDSNN CCCCCEEEEEECCCC	36.57	-
881	Acetylation	ATHNALAKIYIDSNN CCCCCEEEEEECCCC	36.57	25953088
881	Ubiquitination	ATHNALAKIYIDSNN CCCCCEEEEEECCCC	36.57	-
883	Nitration	HNALAKIYIDSNNNP CCCEEEEEECCCCCH	9.66	-
883	Phosphorylation	HNALAKIYIDSNNNP CCCEEEEEECCCCCH	9.66	17192257
886	Phosphorylation	LAKIYIDSNNNPERF EEEEEECCCCCHHHH	31.72	20860994
899	Phosphorylation	RFLRENPYYDSRVVG HHHCCCCCCCHHHHH	31.33	27273156
899 (in isoform 2)	Phosphorylation	-	31.33	27642862
900	Phosphorylation	FLRENPYYDSRVVGK HHCCCCCCCHHHHHH	14.54	21082442
900 (in isoform 2)	Phosphorylation	-	14.54	27642862
902	Phosphorylation	RENPYYDSRVVGKYC CCCCCCCHHHHHHHH	15.74	28152594
903	Methylation	ENPYYDSRVVGKYCE CCCCCCHHHHHHHHC	25.01	-
907	Acetylation	YDSRVVGKYCEKRDP CCHHHHHHHHCCCCC	34.81	25953088
907	Ubiquitination	YDSRVVGKYCEKRDP CCHHHHHHHHCCCCC	34.81	-
911	Ubiquitination	VVGKYCEKRDPHLAC HHHHHHCCCCCCEEE	59.55	-
918	S-nitrosocysteine	KRDPHLACVAYERGQ CCCCCEEEEEECCCC	1.96	-
918	Glutathionylation	KRDPHLACVAYERGQ CCCCCEEEEEECCCC	1.96	22555962
918	S-nitrosylation	KRDPHLACVAYERGQ CCCCCEEEEEECCCC	1.96	19483679
921	Nitration	PHLACVAYERGQCDL CCEEEEEECCCCCCE	5.93	-
921	Phosphorylation	PHLACVAYERGQCDL CCEEEEEECCCCCCE	5.93	28152594
926	S-nitrosocysteine	VAYERGQCDLELINV EEECCCCCCEEEEEC	7.79	-
926	Glutathionylation	VAYERGQCDLELINV EEECCCCCCEEEEEC	7.79	22555962
926	S-nitrosylation	VAYERGQCDLELINV EEECCCCCCEEEEEC	7.79	19483679
934	S-nitrosocysteine	DLELINVCNENSLFK CEEEEECCCCCHHHH	4.58	-
934	S-nitrosylation	DLELINVCNENSLFK CEEEEECCCCCHHHH	4.58	19483679
938	Phosphorylation	INVCNENSLFKSLSR EECCCCCHHHHHHHH	29.07	21712546
941	Acetylation	CNENSLFKSLSRYLV CCCCHHHHHHHHHHH	56.64	26051181
941	Ubiquitination	CNENSLFKSLSRYLV CCCCHHHHHHHHHHH	56.64	21890473
941 (in isoform 1)	Ubiquitination	-	56.64	21890473
941 (in isoform 2)	Ubiquitination	-	56.64	21890473
951	Acetylation	SRYLVRRKDPELWGS HHHHHHCCCHHHHHH	68.05	26051181
958	Phosphorylation	KDPELWGSVLLESNP CCHHHHHHHHHCCCC	9.67	20071362
996	Sulfoxidation	SVTVKAFMTADLPNE EEEEEEECCCCCCHH	3.45	30846556
1016	Phosphorylation	EKIVLDNSVFSEHRN HHHHCCCCCCCCCCC	24.98	20068231
1019	Phosphorylation	VLDNSVFSEHRNLQN HCCCCCCCCCCCHHH	30.27	20068231
1034	Ubiquitination	LLILTAIKADRTRVM HHHHHHHHCCHHHHH	41.59	21890473
1034 (in isoform 1)	Ubiquitination	-	41.59	21890473
1034 (in isoform 2)	Ubiquitination	-	41.59	21890473
1074	2-Hydroxyisobutyrylation	EAFAIFRKFDVNTSA HHHHHHHHCCCCHHH	34.86	-
1074	Ubiquitination	EAFAIFRKFDVNTSA HHHHHHHHCCCCHHH	34.86	21890473
1074 (in isoform 1)	Ubiquitination	-	34.86	21890473
1074 (in isoform 2)	Ubiquitination	-	34.86	21890473
1096	Phosphorylation	IGNLDRAYEFAERCN HCCHHHHHHHHHHCC	16.69	28152594
1102	Glutathionylation	AYEFAERCNEPAVWS HHHHHHHCCCHHHHH	5.21	22555962
1102	S-nitrosylation	AYEFAERCNEPAVWS HHHHHHHCCCHHHHH	5.21	2212679
1109	Phosphorylation	CNEPAVWSQLAKAQL CCCHHHHHHHHHHHH	14.55	21712546
1118	2-Hydroxyisobutyrylation	LAKAQLQKGMVKEAI HHHHHHHHCCHHHHH	58.53	-
1118	Ubiquitination	LAKAQLQKGMVKEAI HHHHHHHHCCHHHHH	58.53	-
1122	2-Hydroxyisobutyrylation	QLQKGMVKEAIDSYI HHHHCCHHHHHHHHH	32.32	-
1122	Ubiquitination	QLQKGMVKEAIDSYI HHHHCCHHHHHHHHH	32.32	-
1127	Phosphorylation	MVKEAIDSYIKADDP CHHHHHHHHHCCCCH	23.73	28152594
1128	Phosphorylation	VKEAIDSYIKADDPS HHHHHHHHHCCCCHH	11.59	28152594
1130	Ubiquitination	EAIDSYIKADDPSSY HHHHHHHCCCCHHHH	37.21	21906983
1130 (in isoform 1)	Ubiquitination	-	37.21	21890473
1130 (in isoform 2)	Ubiquitination	-	37.21	21890473
1137	Phosphorylation	KADDPSSYMEVVQAA CCCCHHHHHHHHHHH	11.13	-
1138	Sulfoxidation	ADDPSSYMEVVQAAN CCCHHHHHHHHHHHC	3.22	30846556
1155	Acetylation	GNWEELVKYLQMARK CCHHHHHHHHHHHHH	53.52	7407493
1156	Phosphorylation	NWEELVKYLQMARKK CHHHHHHHHHHHHHH	8.49	26074081
1167	Phosphorylation	ARKKARESYVETELI HHHHHHHHHHHHHHH	29.00	26657352
1168	Phosphorylation	RKKARESYVETELIF HHHHHHHHHHHHHHH	9.50	28857561
1179	Ubiquitination	ELIFALAKTNRLAEL HHHHHHHHCCCHHHH	47.37	-
1180	Phosphorylation	LIFALAKTNRLAELE HHHHHHHCCCHHHHH	21.69	-
1206	Phosphorylation	QQVGDRCYDEKMYDA HHHHHHHCCHHHHHH	28.20	27155012
1209	2-Hydroxyisobutyrylation	GDRCYDEKMYDAAKL HHHHCCHHHHHHHHH	39.60	-
1209	Acetylation	GDRCYDEKMYDAAKL HHHHCCHHHHHHHHH	39.60	25953088
1209	Ubiquitination	GDRCYDEKMYDAAKL HHHHCCHHHHHHHHH	39.60	-
1211	Phosphorylation	RCYDEKMYDAAKLLY HHCCHHHHHHHHHHH	17.31	27259358
1215	2-Hydroxyisobutyrylation	EKMYDAAKLLYNNVS HHHHHHHHHHHHCCC	40.52	-
1215	Acetylation	EKMYDAAKLLYNNVS HHHHHHHHHHHHCCC	40.52	26051181
1215	Ubiquitination	EKMYDAAKLLYNNVS HHHHHHHHHHHHCCC	40.52	21890473
1215 (in isoform 1)	Ubiquitination	-	40.52	21890473
1215 (in isoform 2)	Ubiquitination	-	40.52	21890473
1218	Phosphorylation	YDAAKLLYNNVSNFG HHHHHHHHHCCCHHH	18.35	28152594
1222	Phosphorylation	KLLYNNVSNFGRLAS HHHHHCCCHHHHHHH	28.68	21712546
1226	Methylation	NNVSNFGRLASTLVH HCCCHHHHHHHHHHH	23.96	-
1229	Phosphorylation	SNFGRLASTLVHLGE CHHHHHHHHHHHHHC	27.19	28152594
1230	Phosphorylation	NFGRLASTLVHLGEY HHHHHHHHHHHHHCH	27.48	28152594
1237	Nitration	TLVHLGEYQAAVDGA HHHHHHCHHHHHCCC	11.14	-
1237	Phosphorylation	TLVHLGEYQAAVDGA HHHHHHCHHHHHCCC	11.14	28152594
1254	2-Hydroxyisobutyrylation	ANSTRTWKEVCFACV CCCCCCHHHEEEEEC	39.39	-
1254	Acetylation	ANSTRTWKEVCFACV CCCCCCHHHEEEEEC	39.39	26051181
1254	Ubiquitination	ANSTRTWKEVCFACV CCCCCCHHHEEEEEC	39.39	-
1264	2-Hydroxyisobutyrylation	CFACVDGKEFRLAQM EEEECCCCHHHHHHH	49.57	-
1264	Acetylation	CFACVDGKEFRLAQM EEEECCCCHHHHHHH	49.57	25825284
1264	Ubiquitination	CFACVDGKEFRLAQM EEEECCCCHHHHHHH	49.57	-
1271	Sulfoxidation	KEFRLAQMCGLHIVV CHHHHHHHHCCEEEE	1.30	30846556
1318	Phosphorylation	RAHMGMFTELAILYS HHHHCHHHHHHHHHH	22.61	24117733
1324	Phosphorylation	FTELAILYSKFKPQK HHHHHHHHHCCCHHH	12.05	24117733
1325	Phosphorylation	TELAILYSKFKPQKM HHHHHHHHCCCHHHH	28.33	24117733
1341	Phosphorylation	EHLELFWSRVNIPKV HHHHHHHHHCCHHHH	21.01	30108239
1347	2-Hydroxyisobutyrylation	WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH	50.53	-
1347	Malonylation	WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH	50.53	26320211
1347	Ubiquitination	WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH	50.53	21890473
1347 (in isoform 1)	Ubiquitination	-	50.53	21890473
1347 (in isoform 2)	Ubiquitination	-	50.53	21890473
1387	Ubiquitination	NHPTDAWKEGQFKDI CCCCHHHHCCCHHHH	54.40	-
1392	Ubiquitination	AWKEGQFKDIITKVA HHHCCCHHHHHHHHH	39.88	-
1392 (in isoform 1)	Ubiquitination	-	39.88	21890473
1392 (in isoform 2)	Ubiquitination	-	39.88	21890473
1396	Phosphorylation	GQFKDIITKVANVEL CCHHHHHHHHHCHHH	21.57	-
1397	2-Hydroxyisobutyrylation	QFKDIITKVANVELY CHHHHHHHHHCHHHH	29.01	-
1397	Ubiquitination	QFKDIITKVANVELY CHHHHHHHHHCHHHH	29.01	21906983
1397 (in isoform 1)	Ubiquitination	-	29.01	21890473
1397 (in isoform 2)	Ubiquitination	-	29.01	21890473
1404	Phosphorylation	KVANVELYYRAIQFY HHHCHHHHHHHHHHH	4.20	-
1405	Phosphorylation	VANVELYYRAIQFYL HHCHHHHHHHHHHHH	13.24	-
1427	Phosphorylation	NDLLMVLSPRLDHTR HHHHHHHCCCCCCHH	9.14	22210691
1438	Phosphorylation	DHTRAVNYFSKVKQL CCHHHHHHHHHCCCC	11.57	28152594
1440	Phosphorylation	TRAVNYFSKVKQLPL HHHHHHHHHCCCCCC	26.61	28152594
1441	2-Hydroxyisobutyrylation	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	-
1441	Acetylation	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	19608861
1441	Malonylation	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	26320211
1441	Methylation	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	19608861
1441	Succinylation	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	-
1441	Succinylation	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	-
1441	Ubiquitination	RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC	43.48	21890473
1441 (in isoform 1)	Ubiquitination	-	43.48	21890473
1441 (in isoform 2)	Ubiquitination	-	43.48	21890473
1443	Malonylation	VNYFSKVKQLPLVKP HHHHHHCCCCCCCHH	50.26	26320211
1443	Ubiquitination	VNYFSKVKQLPLVKP HHHHHHCCCCCCCHH	50.26	21890473
1443 (in isoform 1)	Ubiquitination	-	50.26	21890473
1443 (in isoform 2)	Ubiquitination	-	50.26	21890473
1449	Acetylation	VKQLPLVKPYLRSVQ CCCCCCCHHHHHHHH	35.31	23749302
1449	Succinylation	VKQLPLVKPYLRSVQ CCCCCCCHHHHHHHH	35.31	23954790
1449	Ubiquitination	VKQLPLVKPYLRSVQ CCCCCCCHHHHHHHH	35.31	21890473
1449 (in isoform 1)	Ubiquitination	-	35.31	21890473
1449 (in isoform 2)	Ubiquitination	-	35.31	21890473
1451	Phosphorylation	QLPLVKPYLRSVQNH CCCCCHHHHHHHHHC	14.72	28152594
1461	Acetylation	SVQNHNNKSVNESLN HHHHCCCCCHHHHHH	62.18	26051181
1461	Ubiquitination	SVQNHNNKSVNESLN HHHHCCCCCHHHHHH	62.18	21906983
1461 (in isoform 1)	Ubiquitination	-	62.18	21890473
1461 (in isoform 2)	Ubiquitination	-	62.18	21890473
1462	Phosphorylation	VQNHNNKSVNESLNN HHHCCCCCHHHHHHH	32.09	20873877
1466	Phosphorylation	NNKSVNESLNNLFIT CCCCHHHHHHHCCCC	31.06	28348404
1473	Phosphorylation	SLNNLFITEEDYQAL HHHHCCCCHHHHHHH	26.45	21552520
1477	Phosphorylation	LFITEEDYQALRTSI CCCCHHHHHHHHHHH	10.04	21082442
1477 (in isoform 2)	Phosphorylation	-	10.04	27642862
1482	Phosphorylation	EDYQALRTSIDAYDN HHHHHHHHHHHHCCC	30.77	21712546
1483	Phosphorylation	DYQALRTSIDAYDNF HHHHHHHHHHHCCCC	16.43	23186163
1487	Phosphorylation	LRTSIDAYDNFDNIS HHHHHHHCCCCCCCC	13.99	21082442
1487 (in isoform 2)	Phosphorylation	-	13.99	27642862
1494	Phosphorylation	YDNFDNISLAQRLEK CCCCCCCCHHHHHHH	24.73	28355574
1501	2-Hydroxyisobutyrylation	SLAQRLEKHELIEFR CHHHHHHHHCHHHHH	47.15	-
1501	Acetylation	SLAQRLEKHELIEFR CHHHHHHHHCHHHHH	47.15	19608861
1501	Malonylation	SLAQRLEKHELIEFR CHHHHHHHHCHHHHH	47.15	26320211
1501	Ubiquitination	SLAQRLEKHELIEFR CHHHHHHHHCHHHHH	47.15	21890473
1501 (in isoform 1)	Ubiquitination	-	47.15	21890473
1501 (in isoform 2)	Ubiquitination	-	47.15	21890473
1513	Phosphorylation	EFRRIAAYLFKGNNR HHHHHHHHHHHCCCH	12.03	28152594
1516	2-Hydroxyisobutyrylation	RIAAYLFKGNNRWKQ HHHHHHHHCCCHHHH	59.12	-
1516	Acetylation	RIAAYLFKGNNRWKQ HHHHHHHHCCCHHHH	59.12	25953088
1516	Succinylation	RIAAYLFKGNNRWKQ HHHHHHHHCCCHHHH	59.12	23954790
1522	2-Hydroxyisobutyrylation	FKGNNRWKQSVELCK HHCCCHHHHHHHHHH	29.47	-
1522	Malonylation	FKGNNRWKQSVELCK HHCCCHHHHHHHHHH	29.47	26320211
1522	Ubiquitination	FKGNNRWKQSVELCK HHCCCHHHHHHHHHH	29.47	-
1522 (in isoform 1)	Ubiquitination	-	29.47	21890473
1522 (in isoform 2)	Ubiquitination	-	29.47	21890473
1524	Phosphorylation	GNNRWKQSVELCKKD CCCHHHHHHHHHHCC	17.52	27251275
1529	2-Hydroxyisobutyrylation	KQSVELCKKDSLYKD HHHHHHHHCCCHHHH	72.71	-
1529	Ubiquitination	KQSVELCKKDSLYKD HHHHHHHHCCCHHHH	72.71	-
1532	Phosphorylation	VELCKKDSLYKDAMQ HHHHHCCCHHHHHHH	42.34	25693802
1534	Phosphorylation	LCKKDSLYKDAMQYA HHHCCCHHHHHHHHH	15.69	25693802
1535	2-Hydroxyisobutyrylation	CKKDSLYKDAMQYAS HHCCCHHHHHHHHHH	44.28	-
1535	Acetylation	CKKDSLYKDAMQYAS HHCCCHHHHHHHHHH	44.28	25825284
1535	Ubiquitination	CKKDSLYKDAMQYAS HHCCCHHHHHHHHHH	44.28	21906983
1535 (in isoform 1)	Ubiquitination	-	44.28	21890473
1535 (in isoform 2)	Ubiquitination	-	44.28	21890473
1538	Sulfoxidation	DSLYKDAMQYASESK CCHHHHHHHHHHCCC	4.49	30846556
1540	Phosphorylation	LYKDAMQYASESKDT HHHHHHHHHHCCCCH	10.06	29083192
1542	Phosphorylation	KDAMQYASESKDTEL HHHHHHHHCCCCHHH	37.15	20860994
1544	Phosphorylation	AMQYASESKDTELAE HHHHHHCCCCHHHHH	33.08	21712546
1604	Acetylation	PYFIQVMKEYLTKVD HHHHHHHHHHHHHHH	44.33	21466224
1608	Phosphorylation	QVMKEYLTKVDKLDA HHHHHHHHHHHHCCH	28.28	-
1609	2-Hydroxyisobutyrylation	VMKEYLTKVDKLDAS HHHHHHHHHHHCCHH	45.93	-
1609	Ubiquitination	VMKEYLTKVDKLDAS HHHHHHHHHHHCCHH	45.93	21890473
1609 (in isoform 1)	Ubiquitination	-	45.93	21890473
1609 (in isoform 2)	Ubiquitination	-	45.93	21890473
1612	2-Hydroxyisobutyrylation	EYLTKVDKLDASESL HHHHHHHHCCHHHHH	51.78	-
1612	Acetylation	EYLTKVDKLDASESL HHHHHHHHCCHHHHH	51.78	25953088
1612	Malonylation	EYLTKVDKLDASESL HHHHHHHHCCHHHHH	51.78	26320211
1612	Ubiquitination	EYLTKVDKLDASESL HHHHHHHHCCHHHHH	51.78	-
1612 (in isoform 1)	Ubiquitination	-	51.78	21890473
1612 (in isoform 2)	Ubiquitination	-	51.78	21890473
1616	Phosphorylation	KVDKLDASESLRKEE HHHHCCHHHHHHHHH	27.64	21815630
1618	Phosphorylation	DKLDASESLRKEEEQ HHCCHHHHHHHHHHH	30.86	25849741
1621	Acetylation	DASESLRKEEEQATE CHHHHHHHHHHHCCC	74.83	7408163
1634	Phosphorylation	TETQPIVYGQPQLML CCCCCCCCCCCEEEE	15.68	-
1634 (in isoform 2)	Phosphorylation	-	15.68	27642862
1638 (in isoform 2)	Phosphorylation	-	31.45	29514088
1642	Phosphorylation	GQPQLMLTAGPSVAV CCCEEEEEECCCEEC	18.66	28348404
1657	Phosphorylation	PPQAPFGYGYTAPPY CCCCCCCCCCCCCCC	13.82	-
1659	Phosphorylation	QAPFGYGYTAPPYGQ CCCCCCCCCCCCCCC	7.40	-
1660	Phosphorylation	APFGYGYTAPPYGQP CCCCCCCCCCCCCCC	28.46	-
1664	Phosphorylation	YGYTAPPYGQPQPGF CCCCCCCCCCCCCCC	27.60	-
1673	Phosphorylation	QPQPGFGYSM----- CCCCCCCCCC-----	10.17	26074081
1674	Phosphorylation	PQPGFGYSM------ CCCCCCCCC------	20.56	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1477	Y	Phosphorylation	Kinase	SRC	P12931	PSP
1477	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HGS_HUMAN	HGS	physical	11532964
SNX5_HUMAN	SNX5	physical	15133132
AUXI_HUMAN	DNAJC6	physical	12732633
AP1B1_HUMAN	AP1B1	physical	9280305
AP2A2_HUMAN	AP2A2	physical	9280305
AP3B2_HUMAN	AP3B2	physical	9545220
EPN2_HUMAN	EPN2	physical	10567358
EPN1_RAT	Epn1	physical	10567358
HGS_HUMAN	HGS	physical	16716190
STAM1_HUMAN	STAM	physical	16716190
DYR1A_HUMAN	DYRK1A	physical	19722700
AMPH_HUMAN	AMPH	physical	10748223
AP180_HUMAN	SNAP91	physical	10748223
AP2B1_HUMAN	AP2B1	physical	10748223
AP2A2_HUMAN	AP2A2	physical	17052248
AP2B1_HUMAN	AP2B1	physical	17052248
AP1G1_HUMAN	AP1G1	physical	17052248
GGA1_HUMAN	GGA1	physical	17052248
XRCC6_HUMAN	XRCC6	physical	15383276
HERC1_HUMAN	HERC1	physical	9233772
TM1L1_HUMAN	TOM1L1	physical	17785434
SRC_HUMAN	SRC	physical	17785434
DNJA3_HUMAN	DNAJA3	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
ARRB2_HUMAN	ARRB2	physical	9169477
ARRB1_HUMAN	ARRB1	physical	16709866
PTAFR_HUMAN	PTAFR	physical	16709866
EP300_HUMAN	EP300	physical	21988832
SYQ_HUMAN	QARS	physical	21988832
STABP_HUMAN	STAMBP	physical	16431367
STAM1_HUMAN	STAM	physical	16431367
CXB5_HUMAN	GJB5	physical	25388970
ZFYV9_HUMAN	ZFYVE9	physical	23222715
AT1A1_HUMAN	ATP1A1	physical	26344197
AT1A2_HUMAN	ATP1A2	physical	26344197
AT1A3_HUMAN	ATP1A3	physical	26344197
ATPG_HUMAN	ATP5C1	physical	26344197
CCD47_HUMAN	CCDC47	physical	26344197
TCPG_HUMAN	CCT3	physical	26344197
TCPZ_HUMAN	CCT6A	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
IF6_HUMAN	EIF6	physical	26344197
COX2_HUMAN	COX2	physical	26344197
PHB_HUMAN	PHB	physical	26344197
PHB2_HUMAN	PHB2	physical	26344197
2AAA_HUMAN	PPP2R1A	physical	26344197
2AAB_HUMAN	PPP2R1B	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
TMCO1_HUMAN	TMCO1	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197
QCR8_HUMAN	UQCRQ	physical	26344197
ARRB1_HUMAN	ARRB1	physical	9169477
ABCA2_HUMAN	ABCA2	physical	26496610
PARP4_HUMAN	PARP4	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2A2_HUMAN	AP2A2	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
VATB2_HUMAN	ATP6V1B2	physical	26496610
VPP1_HUMAN	ATP6V0A1	physical	26496610
CAV1_HUMAN	CAV1	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
KC1A_HUMAN	CSNK1A1	physical	26496610
KC1E_HUMAN	CSNK1E	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
STOM_HUMAN	STOM	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
GAK_HUMAN	GAK	physical	26496610
HIP1_HUMAN	HIP1	physical	26496610
HSP74_HUMAN	HSPA4	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
NDUA9_HUMAN	NDUFA9	physical	26496610
OCRL_HUMAN	OCRL	physical	26496610
CHM1A_HUMAN	CHMP1A	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
SOAT1_HUMAN	SOAT1	physical	26496610
CLH2_HUMAN	CLTCL1	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
PKP4_HUMAN	PKP4	physical	26496610
USO1_HUMAN	USO1	physical	26496610
NUMB_HUMAN	NUMB	physical	26496610
TNK1_HUMAN	TNK1	physical	26496610
RB11A_HUMAN	RAB11A	physical	26496610
HIP1R_HUMAN	HIP1R	physical	26496610
VA0D1_HUMAN	ATP6V0D1	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
SC24C_HUMAN	SEC24C	physical	26496610
MARF1_HUMAN	KIAA0430	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
IST1_HUMAN	IST1	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
MVP_HUMAN	MVP	physical	26496610
TROAP_HUMAN	TROAP	physical	26496610
ACK1_HUMAN	TNK2	physical	26496610
SC24B_HUMAN	SEC24B	physical	26496610
RBM14_HUMAN	RBM14	physical	26496610
SC23A_HUMAN	SEC23A	physical	26496610
VTI1B_HUMAN	VTI1B	physical	26496610
STABP_HUMAN	STAMBP	physical	26496610
TRAD1_HUMAN	TRAFD1	physical	26496610
PKP3_HUMAN	PKP3	physical	26496610
AAK1_HUMAN	AAK1	physical	26496610
BTBD3_HUMAN	BTBD3	physical	26496610
TNR6B_HUMAN	TNRC6B	physical	26496610
EDC4_HUMAN	EDC4	physical	26496610
DUSTY_HUMAN	DSTYK	physical	26496610
PTN23_HUMAN	PTPN23	physical	26496610
NECP1_HUMAN	NECAP1	physical	26496610
TNR6A_HUMAN	TNRC6A	physical	26496610
EPN1_HUMAN	EPN1	physical	26496610
EHD4_HUMAN	EHD4	physical	26496610
EGFL7_HUMAN	EGFL7	physical	26496610
VATD_HUMAN	ATP6V1D	physical	26496610
GTSE1_HUMAN	GTSE1	physical	26496610
PTH2_HUMAN	PTRH2	physical	26496610
PKHA5_HUMAN	PLEKHA5	physical	26496610
CPVL_HUMAN	CPVL	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
DCP1A_HUMAN	DCP1A	physical	26496610
ERBIN_HUMAN	ERBB2IP	physical	26496610
CHM1B_HUMAN	CHMP1B	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
MTUS1_HUMAN	MTUS1	physical	26496610
STALP_HUMAN	STAMBPL1	physical	26496610
DEN1A_HUMAN	DENND1A	physical	26496610
CRTC3_HUMAN	CRTC3	physical	26496610
WNK1_HUMAN	WNK1	physical	26496610
CPSF7_HUMAN	CPSF7	physical	26496610
CJ088_HUMAN	C10orf88	physical	26496610
EDC3_HUMAN	EDC3	physical	26496610
CC115_HUMAN	CCDC115	physical	26496610
FA83A_HUMAN	FAM83A	physical	26496610
REPS1_HUMAN	REPS1	physical	26496610
STON2_HUMAN	STON2	physical	26496610
FCHO2_HUMAN	FCHO2	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
MITD1_HUMAN	MITD1	physical	26496610
CRTC2_HUMAN	CRTC2	physical	26496610
FA83B_HUMAN	FAM83B	physical	26496610
FA83H_HUMAN	FAM83H	physical	26496610
S35B2_HUMAN	SLC35B2	physical	26496610

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-637; LYS-856; LYS-1441 ANDLYS-1501, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1494, AND MASSSPECTROMETRY.
PubMed: 19369195

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND SER-1494, ANDMASS SPECTROMETRY.
PubMed: 15302935

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND TYR-883, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-634 AND TYR-1477, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-634 AND TYR-899, ANDMASS SPECTROMETRY.
PubMed: 18083107