AP180_HUMAN - dbPTM
AP180_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP180_HUMAN
UniProt AC O60641
Protein Name Clathrin coat assembly protein AP180
Gene Name SNAP91
Organism Homo sapiens (Human).
Sequence Length 907
Subcellular Localization Cell membrane. Membrane, coated pit
Peripheral membrane protein
Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane..
Protein Description Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity)..
Protein Sequence MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQPDFSSGGAAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATASASASTTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATATTAPPALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQPAPVSMVPPSPAMAASKALGSDLDSSLASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGQTLTDR
------CCCCCHHHH		39.3420068231
5Phosphorylation---MSGQTLTDRIAA
---CCCCCHHHHHHH		34.8424043423
7Phosphorylation-MSGQTLTDRIAAAQ
-CCCCCHHHHHHHHH		26.9824043423
15PhosphorylationDRIAAAQYSVTGSAV
HHHHHHHCCCHHHHH		10.6125884760
16PhosphorylationRIAAAQYSVTGSAVA
HHHHHHCCCHHHHHH		10.9224043423
18PhosphorylationAAAQYSVTGSAVARA
HHHHCCCHHHHHHHH		21.3429978859
20PhosphorylationAQYSVTGSAVARAVC
HHCCCHHHHHHHHHH		15.3729978859
30PhosphorylationARAVCKATTHEVMGP
HHHHHHHHCCCCCCC		17.74-
31PhosphorylationRAVCKATTHEVMGPK
HHHHHHHCCCCCCCC		22.39-
44PhosphorylationPKKKHLDYLIQATNE
CCHHHHHHHHHHCCC		16.44-
49PhosphorylationLDYLIQATNETNVNI
HHHHHHHCCCCCCCC		19.74-
52PhosphorylationLIQATNETNVNIPQM
HHHHCCCCCCCCHHH		46.68-
62PhosphorylationNIPQMADTLFERATN
CCHHHHHHHHHHHCC		24.65-
102PhosphorylationQYLASRNTLFNLSNF
HHHHHCCCHHHHHHH		31.4524076635
107PhosphorylationRNTLFNLSNFLDKSG
CCCHHHHHHHHCCCC		27.0020068231
237Nitrated tyrosineCKDALEIYKRFLTRM
HHHHHHHHHHHHHHH		6.17-
237NitrationCKDALEIYKRFLTRM
HHHHHHHHHHHHHHH		6.17-
284 (in isoform 3)Phosphorylation-32.3325307156
296PhosphorylationKPGNNEGSGAPSPLS
CCCCCCCCCCCCCCC		26.1325307156
298 (in isoform 4)Phosphorylation-11.7725307156
298PhosphorylationGNNEGSGAPSPLSKS
CCCCCCCCCCCCCCC		11.7724719451
300PhosphorylationNEGSGAPSPLSKSSP
CCCCCCCCCCCCCCC		37.6320886841
303PhosphorylationSGAPSPLSKSSPATT
CCCCCCCCCCCCCCE		33.6024117733
305PhosphorylationAPSPLSKSSPATTVT
CCCCCCCCCCCCEEC		37.8727732954
306PhosphorylationPSPLSKSSPATTVTS
CCCCCCCCCCCEECC		23.4527732954
309PhosphorylationLSKSSPATTVTSPNS
CCCCCCCCEECCCCC		25.7827732954
309O-linked_GlycosylationLSKSSPATTVTSPNS
CCCCCCCCEECCCCC		25.7828657654
310PhosphorylationSKSSPATTVTSPNST
CCCCCCCEECCCCCC		24.7227732954
310O-linked_GlycosylationSKSSPATTVTSPNST
CCCCCCCEECCCCCC		24.7228657654
312PhosphorylationSSPATTVTSPNSTPA
CCCCCEECCCCCCCC		36.0527732954
312O-linked_GlycosylationSSPATTVTSPNSTPA
CCCCCEECCCCCCCC		36.0528657654
313PhosphorylationSPATTVTSPNSTPAK
CCCCEECCCCCCCCC		20.1115345747
316PhosphorylationTTVTSPNSTPAKTID
CEECCCCCCCCCCCC		38.8727732954
317PhosphorylationTVTSPNSTPAKTIDT
EECCCCCCCCCCCCC		33.6327732954
321PhosphorylationPNSTPAKTIDTSPPV
CCCCCCCCCCCCCCC		26.6220886841
324PhosphorylationTPAKTIDTSPPVDLF
CCCCCCCCCCCCCEE		39.0020886841
325PhosphorylationPAKTIDTSPPVDLFA
CCCCCCCCCCCCEEE		24.3720886841
333PhosphorylationPPVDLFATASAAVPV
CCCCEEEECCCCCCC		17.5127732954
335PhosphorylationVDLFATASAAVPVST
CCEEEECCCCCCCCC		16.6527732954
341O-linked_GlycosylationASAAVPVSTSKPSSD
CCCCCCCCCCCCCCC		22.3928657654
596PhosphorylationFSTDAFSSPPQGASP
ECCCCCCCCCCCCCC		33.86-
602PhosphorylationSSPPQGASPVPESSL
CCCCCCCCCCCHHHC		33.00-
623PhosphorylationVDAFAAPSPATTASP
CCCCCCCCCCCCCCC		23.57-
626O-linked_GlycosylationFAAPSPATTASPAKV
CCCCCCCCCCCCCCC		26.6928657654
627O-linked_GlycosylationAAPSPATTASPAKVD
CCCCCCCCCCCCCCC		27.5228657654
629PhosphorylationPSPATTASPAKVDSS
CCCCCCCCCCCCCCC		24.25-
629O-linked_GlycosylationPSPATTASPAKVDSS
CCCCCCCCCCCCCCC		24.2528657654
755PhosphorylationAASKALGSDLDSSLA
HHHHHHCCCHHHHHH		35.5324076635
759PhosphorylationALGSDLDSSLASLVG
HHCCCHHHHHHHHHH		34.2523879269
763PhosphorylationDLDSSLASLVGNLGI
CHHHHHHHHHHHCCC		28.9624076635
773PhosphorylationGNLGISGTTTKKGDL
HHCCCCCCCCCCCCE		25.2224114839
775PhosphorylationLGISGTTTKKGDLQW
CCCCCCCCCCCCEEE		30.5124114839
865MethylationMFAQPMMRPPFGAAA
EEEECCCCCCCCCCC		29.50-
865Asymmetric dimethylarginineMFAQPMMRPPFGAAA
EEEECCCCCCCCCCC		29.50-
886PhosphorylationSPSPTPASQSPKKPP
CCCCCCCCCCCCCCC		32.1825332170
888PhosphorylationSPTPASQSPKKPPAK
CCCCCCCCCCCCCCC		35.8725332170
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP180_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
310TPhosphorylation

-
310TPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP180_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EPS15_HUMANEPS15physical
12807910
AP1B1_HUMANAP1B1physical
12538641
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP180_HUMAN

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Related Literatures of Post-Translational Modification
Nitration
ReferencePubMed
"The human pituitary nitroproteome: detection of nitrotyrosyl-proteinswith two-dimensional Western blotting, and amino acid sequencedetermination with mass spectrometry.";
Zhan X., Desiderio D.M.;
Biochem. Biophys. Res. Commun. 325:1180-1186(2004).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-237, AND MASS SPECTROMETRY.

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