dbPTM

TNR6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNR6B_HUMAN
UniProt AC	Q9UPQ9
Protein Name	Trinucleotide repeat-containing gene 6B protein
Gene Name	TNRC6B
Organism	Homo sapiens (Human).
Sequence Length	1833
Subcellular Localization	Cytoplasm, P-body . Mammalian P-bodies are also known as GW bodies (GWBs).
Protein Description	Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes..
Protein Sequence	MREKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGPPPCTAPGANPNNAQVTGALLQSESGTAPDSTLGGAAASNYANSTWGSGASSNNGTSPNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSTLPGSTTSNKGKGSQCQSASSGNECNLGVWKSDPKAKSVQSSNSTTENNNGLGNWRNVSGQDRIGPGSGFSNFNPNSNPSAWPALVQEGTSRKGALETDNSNSSAQVSTVGQTSREQQSKMENAGVNFVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTGSVGSWGAARGPSGTDTVSGQSNSGNNGNNGKEREDSWKGASVQKSTGSKNDSWDNNNRSTGGSWNFGPQDSNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSTGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPTHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKNTGGWNDYKNNNSSNWGGGRPDEKTPSSWNENPSKDQGWGGGRQPNQGWSSGKNGWGEEVDQTKNSNWESSASKPVSGWGEGGQNEIGTWGNGGNASLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQPPQQPPPPQPEASGSWGGPPPPPPGNVRPSNSSWSSGPQPATPKDEEPSGWEEPSPQSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTSKSASVWSKSTPPAPDNGTSAWGEPNESSPGWGEMDDTGASTTGWGNTPANAPNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEEDGGVWNTTGSQGSASSHNSASWGQGGKKQMKCSLKGGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVGSLSDKKFDVDKRAMNLGDFNDIMRKDRSGFRPPNSKDMGTTDSGPYFEKLTLPFSNQDGCLGDEAPCSPFSPSPSYKLSPSGSTLPNVSLGAIGTGLNPQNFAARQGGSHGLFGNSTAQSRGLHTPVQPLNSSPSLRAQVPPQFISPQVSASMLKQFPNSGLSPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQRQPGMKHSPSHPVGPKPHLDNMVPNALNVGLPDLQTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPSSPWSSTAPRSVRGWGTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPSAPAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGASLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13 (in isoform 2)	Phosphorylation	-	6.64	-
14 (in isoform 2)	Phosphorylation	-	75.23	-
29	Phosphorylation	DKKKKEATQKVTEQK HHHHHHHHHHHHHHH	29.98	29978859
29 (in isoform 2)	Phosphorylation	-	29.98	26657352
33	Phosphorylation	KEATQKVTEQKTKVP HHHHHHHHHHHHCCC	39.47	29978859
36 (in isoform 2)	Phosphorylation	-	44.04	20068231
54	Phosphorylation	LSQPTAASPIGSSPS CCCCCCCCCCCCCCC	18.00	25159151
58	Phosphorylation	TAASPIGSSPSPPVN CCCCCCCCCCCCCCC	39.53	25159151
59	Phosphorylation	AASPIGSSPSPPVNG CCCCCCCCCCCCCCC	24.96	25159151
61	Phosphorylation	SPIGSSPSPPVNGGN CCCCCCCCCCCCCCC	43.73	28348404
71	Acetylation	VNGGNNAKRVAVPNG CCCCCCCCEEECCCC	49.91	26051181
82	Phosphorylation	VPNGQPPSAARYMPR CCCCCCCCHHHHCCC	41.04	28555341
85	Dimethylation	GQPPSAARYMPREVP CCCCCHHHHCCCCCC	28.18	-
85	Methylation	GQPPSAARYMPREVP CCCCCHHHHCCCCCC	28.18	24410327
195	Phosphorylation	DKVIVDGSDMEEWPC EEEEECCCCCCCCCE	29.35	26074081
205	Phosphorylation	EEWPCIASKDTESSS CCCCEEEECCCCCCC	15.91	26074081
212	Phosphorylation	SKDTESSSENTTDNN ECCCCCCCCCCCCCC	44.11	28985074
234	Phosphorylation	EKSTLPGSTTSNKGK CCCCCCCCCCCCCCC	26.94	30576142
235	Phosphorylation	KSTLPGSTTSNKGKG CCCCCCCCCCCCCCC	39.91	30576142
236	Phosphorylation	STLPGSTTSNKGKGS CCCCCCCCCCCCCCC	31.81	30576142
243	Phosphorylation	TSNKGKGSQCQSASS CCCCCCCCCCCCCCC	31.13	29978859
247	Phosphorylation	GKGSQCQSASSGNEC CCCCCCCCCCCCCCC	37.43	30576142
249	Phosphorylation	GSQCQSASSGNECNL CCCCCCCCCCCCCCC	43.98	29978859
250	Phosphorylation	SQCQSASSGNECNLG CCCCCCCCCCCCCCE	45.41	30576142
261	Phosphorylation	CNLGVWKSDPKAKSV CCCEEECCCCCCCCC	43.35	29978859
327	Phosphorylation	SRKGALETDNSNSSA CCCCCEECCCCCCCC	41.13	-
360	Phosphorylation	AGVNFVVSGREQAQI CCCCEEECCCCCEEE	27.16	30387612
378	Phosphorylation	DGPKNGNTNSLNLSS CCCCCCCCCCCCCCC	27.81	26074081
380	Phosphorylation	PKNGNTNSLNLSSPN CCCCCCCCCCCCCCC	19.32	28450419
384	Phosphorylation	NTNSLNLSSPNPMEN CCCCCCCCCCCCCCC	42.55	25159151
385	Phosphorylation	TNSLNLSSPNPMENK CCCCCCCCCCCCCCC	31.68	25159151
387 (in isoform 2)	Phosphorylation	-	50.96	21552520
403	Phosphorylation	FGMGLGNTSRSTDAP CCCCCCCCCCCCCCC	24.58	28555341
404	Phosphorylation	GMGLGNTSRSTDAPS CCCCCCCCCCCCCCC	28.38	28555341
406	Phosphorylation	GLGNTSRSTDAPSQS CCCCCCCCCCCCCCC	30.33	17192257
407	Phosphorylation	LGNTSRSTDAPSQST CCCCCCCCCCCCCCC	34.76	17192257
419	Phosphorylation	QSTGDRKTGSVGSWG CCCCCCCCCCCCCCC	35.27	26852163
421	Phosphorylation	TGDRKTGSVGSWGAA CCCCCCCCCCCCCCC	28.65	25159151
424	Phosphorylation	RKTGSVGSWGAARGP CCCCCCCCCCCCCCC	21.85	26852163
432	Phosphorylation	WGAARGPSGTDTVSG CCCCCCCCCCCCCCC	58.09	20068231
434	Phosphorylation	AARGPSGTDTVSGQS CCCCCCCCCCCCCCC	32.60	20068231
436	Phosphorylation	RGPSGTDTVSGQSNS CCCCCCCCCCCCCCC	19.19	20068231
438	Phosphorylation	PSGTDTVSGQSNSGN CCCCCCCCCCCCCCC	32.96	20068231
441	Phosphorylation	TDTVSGQSNSGNNGN CCCCCCCCCCCCCCC	36.17	20068231
443	Phosphorylation	TVSGQSNSGNNGNNG CCCCCCCCCCCCCCC	48.41	20068231
456	Phosphorylation	NGKEREDSWKGASVQ CCCCCCCCCCCCCCC	26.40	-
503	Phosphorylation	WGEGNKMTSGVSQGE CCCCCCCCCCCCCCC	24.76	-
504	Phosphorylation	GEGNKMTSGVSQGEW CCCCCCCCCCCCCCC	33.43	-
507	Phosphorylation	NKMTSGVSQGEWKQP CCCCCCCCCCCCCCC	35.67	-
561	Phosphorylation	QAPCWGRSSSSTGSE CCCCCCCCCCCCCCC	30.54	23403867
562	Phosphorylation	APCWGRSSSSTGSEV CCCCCCCCCCCCCCC	27.26	23403867
563	Phosphorylation	PCWGRSSSSTGSEVG CCCCCCCCCCCCCCC	32.92	25159151
564	Phosphorylation	CWGRSSSSTGSEVGG CCCCCCCCCCCCCCC	38.44	25159151
565	Phosphorylation	WGRSSSSTGSEVGGQ CCCCCCCCCCCCCCC	46.83	22115753
567	Phosphorylation	RSSSSTGSEVGGQST CCCCCCCCCCCCCCC	29.24	25159151
573	Phosphorylation	GSEVGGQSTGSNHKA CCCCCCCCCCCCCCC	37.70	23403867
574	Phosphorylation	SEVGGQSTGSNHKAG CCCCCCCCCCCCCCC	36.42	23403867
576	Phosphorylation	VGGQSTGSNHKAGSS CCCCCCCCCCCCCCC	35.53	23403867
583	Phosphorylation	SNHKAGSSDSHNSGR CCCCCCCCCCCCCCC	42.06	-
588	Phosphorylation	GSSDSHNSGRRSYRP CCCCCCCCCCCCCCC	28.40	-
592	Phosphorylation	SHNSGRRSYRPTHPD CCCCCCCCCCCCCHH	24.92	25159151
593	Phosphorylation	HNSGRRSYRPTHPDC CCCCCCCCCCCCHHH	20.85	28555341
596	Phosphorylation	GRRSYRPTHPDCQAV CCCCCCCCCHHHHHH	36.72	26434776
606	Phosphorylation	DCQAVLQTLLSRTDL HHHHHHHHHHHCCCC	26.04	23312004
609	Phosphorylation	AVLQTLLSRTDLDPR HHHHHHHHCCCCCHH	35.93	24719451
650	Phosphorylation	EGKSDKGTEGWESAA CCCCCCCCCCHHHCC	36.75	-
655	Phosphorylation	KGTEGWESAATQTKN CCCCCHHHCCCCCCC	19.39	-
658	Phosphorylation	EGWESAATQTKNSGG CCHHHCCCCCCCCCC	36.17	-
660	Phosphorylation	WESAATQTKNSGGWG HHHCCCCCCCCCCCC	28.04	-
671	Phosphorylation	GGWGDAPSQSNQMKS CCCCCCCCCCCCCCC	48.22	24043423
673	Phosphorylation	WGDAPSQSNQMKSGW CCCCCCCCCCCCCCC	33.11	24043423
684	Phosphorylation	KSGWGELSASTEWKD CCCCCCCCCCCCCCC	18.83	27251275
686	Phosphorylation	GWGELSASTEWKDPK CCCCCCCCCCCCCCC	24.39	27251275
687	Phosphorylation	WGELSASTEWKDPKN CCCCCCCCCCCCCCC	45.65	27251275
766	Phosphorylation	SNWESSASKPVSGWG CCCCCCCCCCCCCCC	39.17	20068231
770	Phosphorylation	SSASKPVSGWGEGGQ CCCCCCCCCCCCCCC	37.04	28111955
782	Phosphorylation	GGQNEIGTWGNGGNA CCCCCCCCCCCCCCC	35.54	28111955
790	Phosphorylation	WGNGGNASLASKGGW CCCCCCCHHHHCCCH	28.59	28111955
793	Phosphorylation	GGNASLASKGGWEDC CCCCHHHHCCCHHHH	36.81	28111955
803	Phosphorylation	GWEDCKRSPAWNETG CHHHHCCCCCCCCCC	12.40	25159151
809	Phosphorylation	RSPAWNETGRQPNSW CCCCCCCCCCCCCCC	34.16	27794612
854	Phosphorylation	PPGNVRPSNSSWSSG CCCCCCCCCCCCCCC	38.49	28111955
866	Phosphorylation	SSGPQPATPKDEEPS CCCCCCCCCCCCCCC	37.24	28111955
873	Phosphorylation	TPKDEEPSGWEEPSP CCCCCCCCCCCCCCC	60.87	23663014
879	Phosphorylation	PSGWEEPSPQSISRK CCCCCCCCCHHHCCC	38.56	19664994
882	Phosphorylation	WEEPSPQSISRKMDI CCCCCCHHHCCCCCC	26.39	30266825
884	Phosphorylation	EPSPQSISRKMDIDD CCCCHHHCCCCCCCC	30.97	22167270
914	Phosphorylation	VNLWDKNSQGGPAPR CCCCCCCCCCCCCCC	35.62	-
927	Phosphorylation	PREPNLPTPMTSKSA CCCCCCCCCCCCCCC	28.94	22210691
933	Phosphorylation	PTPMTSKSASVWSKS CCCCCCCCCCCCCCC	26.08	-
933 (in isoform 1)	Phosphorylation	-	26.08	-
935 (in isoform 1)	Phosphorylation	-	31.07	-
937 (in isoform 1)	Phosphorylation	-	9.50	-
992	Phosphorylation	AMKPNSKSMQDGWGE CCCCCCCCCCCCCCC	22.84	25159151
1011	Phosphorylation	VTGARHPSWEEEEDG CCCCCCCCCCCCCCC	40.78	29507054
1026	Phosphorylation	GVWNTTGSQGSASSH CCEECCCCCCCCCCC	29.31	20068231
1051	Methylation	KQMKCSLKGGNNDSW EEECEECCCCCCCCC	48.77	115979775
1057	Phosphorylation	LKGGNNDSWMNPLAK CCCCCCCCCHHHHHH	30.28	28555341
1067	Phosphorylation	NPLAKQFSNMGLLSQ HHHHHHHCCCCCCCC	24.34	27251275
1081 (in isoform 1)	Phosphorylation	-	33.00	21552520
1086	Phosphorylation	PSSKMDLSVGSLSDK CCCCCCCCCCCCCCC	21.84	21815630
1089	Phosphorylation	KMDLSVGSLSDKKFD CCCCCCCCCCCCCCC	23.65	22199227
1091	Phosphorylation	DLSVGSLSDKKFDVD CCCCCCCCCCCCCCC	49.43	21815630
1110	Phosphorylation	NLGDFNDIMRKDRSG HCCCHHHHHHHCCCC	2.78	20068231
1128	Phosphorylation	PNSKDMGTTDSGPYF CCCCCCCCCCCCCCE	22.31	23403867
1129	Phosphorylation	NSKDMGTTDSGPYFE CCCCCCCCCCCCCEE	23.57	23403867
1131	Phosphorylation	KDMGTTDSGPYFEKL CCCCCCCCCCCEEEE	39.31	23403867
1134	Phosphorylation	GTTDSGPYFEKLTLP CCCCCCCCEEEEECC	28.09	23403867
1177	Phosphorylation	GSTLPNVSLGAIGTG CCCCCCCEECCCCCC	27.94	22210691
1197	Phosphorylation	FAARQGGSHGLFGNS HHHHCCCCCCCCCCC	22.62	22210691
1209	Methylation	GNSTAQSRGLHTPVQ CCCHHHHCCCCCCCC	39.34	115918709
1213	Phosphorylation	AQSRGLHTPVQPLNS HHHCCCCCCCCCCCC	30.14	22199227
1220	Phosphorylation	TPVQPLNSSPSLRAQ CCCCCCCCCCCHHHC	51.84	22199227
1221	Phosphorylation	PVQPLNSSPSLRAQV CCCCCCCCCCHHHCC	19.89	22199227
1223	Phosphorylation	QPLNSSPSLRAQVPP CCCCCCCCHHHCCCC	32.22	22199227
1225	Methylation	LNSSPSLRAQVPPQF CCCCCCHHHCCCCHH	27.58	97799251
1226	Phosphorylation	NSSPSLRAQVPPQFI CCCCCHHHCCCCHHC	21.73	19651622
1302	Phosphorylation	LQNQRKISQAVRQQQ HHHHHHHHHHHHHHH	18.34	24719451
1306	Methylation	RKISQAVRQQQEQQL HHHHHHHHHHHHHHH	31.44	115368777
1315	Methylation	QQEQQLARMVSALQQ HHHHHHHHHHHHHHH	34.33	81453737
1318	Phosphorylation	QQLARMVSALQQQQQ HHHHHHHHHHHHHHH	17.58	28555341
1322	Phosphorylation	RMVSALQQQQQQQQR HHHHHHHHHHHHHHH	43.85	18669648
1324	Phosphorylation	VSALQQQQQQQQRQP HHHHHHHHHHHHHCC	38.42	18669648
1336	Phosphorylation	RQPGMKHSPSHPVGP HCCCCCCCCCCCCCC	23.68	25159151
1338	Phosphorylation	PGMKHSPSHPVGPKP CCCCCCCCCCCCCCC	43.36	25159151
1351	Phosphorylation	KPHLDNMVPNALNVG CCCHHHCCCCCCCCC	4.08	18669648
1364	Phosphorylation	VGLPDLQTKGPIPGY CCCCCCCCCCCCCCC	45.31	20068231
1377	Phosphorylation	GYGSGFSSGGMDYGM CCCCCCCCCCCCCCC	36.79	23879269
1382	Phosphorylation	FSSGGMDYGMVGGKE CCCCCCCCCCCCCHH	9.76	21945579
1392	Phosphorylation	VGGKEAGTESRFKQW CCCHHCCCHHHHHHH	37.52	-
1394	Phosphorylation	GKEAGTESRFKQWTS CHHCCCHHHHHHHHH	42.74	-
1401	Phosphorylation	SRFKQWTSMMEGLPS HHHHHHHHHHHCCCC	17.11	20068231
1408	Phosphorylation	SMMEGLPSVATQEAN HHHHCCCCHHHHHHH	29.44	29759185
1411	Phosphorylation	EGLPSVATQEANMHK HCCCCHHHHHHHHCC	25.45	29759185
1426	Phosphorylation	NGAIVAPGKTRGGSP CCCEECCCCCCCCCC	33.94	18669648
1427	Acetylation	GAIVAPGKTRGGSPY CCEECCCCCCCCCCC	33.71	25953088
1428	Phosphorylation	AIVAPGKTRGGSPYN CEECCCCCCCCCCCC	40.22	25159151
1429	Methylation	IVAPGKTRGGSPYNQ EECCCCCCCCCCCCC	51.46	115389403
1429	Phosphorylation	IVAPGKTRGGSPYNQ EECCCCCCCCCCCCC	51.46	18669648
1432	Phosphorylation	PGKTRGGSPYNQFDI CCCCCCCCCCCCCCC	27.34	23401153
1434	Phosphorylation	KTRGGSPYNQFDIIP CCCCCCCCCCCCCCC	24.24	22617229
1444	Phosphorylation	FDIIPGDTLGGHTGP CCCCCCCCCCCCCCC	32.97	23663014
1449	Phosphorylation	GDTLGGHTGPAGDSW CCCCCCCCCCCCCCC	48.40	23663014
1455	Phosphorylation	HTGPAGDSWLPAKSP CCCCCCCCCCCCCCC	29.60	22115753
1460	Phosphorylation	GDSWLPAKSPPTNKI CCCCCCCCCCCCCCC	62.65	20068231
1461	Phosphorylation	DSWLPAKSPPTNKIG CCCCCCCCCCCCCCC	37.91	23401153
1464	Phosphorylation	LPAKSPPTNKIGSKS CCCCCCCCCCCCCCC	53.15	27794612
1496	Phosphorylation	IQNIDPESDPYVTPG CCCCCCCCCCCCCCC	49.64	29978859
1499	Phosphorylation	IDPESDPYVTPGSVL CCCCCCCCCCCCCCC	23.19	27259358
1501	Phosphorylation	PESDPYVTPGSVLGG CCCCCCCCCCCCCCC	18.98	28450419
1504	Phosphorylation	DPYVTPGSVLGGTAT CCCCCCCCCCCCCCC	18.51	28450419
1509	Phosphorylation	PGSVLGGTATSPIVD CCCCCCCCCCCCCCC	25.60	25159151
1511	Phosphorylation	SVLGGTATSPIVDTD CCCCCCCCCCCCCCC	34.57	25159151
1512	Phosphorylation	VLGGTATSPIVDTDH CCCCCCCCCCCCCCC	15.34	25159151
1517	Phosphorylation	ATSPIVDTDHQLLRD CCCCCCCCCCHHHCC	25.20	28450419
1526	Phosphorylation	HQLLRDNTTGSNSSL CHHHCCCCCCCCCCC	36.50	28450419
1527	Phosphorylation	QLLRDNTTGSNSSLN HHHCCCCCCCCCCCC	44.88	28450419
1529	Phosphorylation	LRDNTTGSNSSLNTS HCCCCCCCCCCCCCC	31.29	28450419
1531	Phosphorylation	DNTTGSNSSLNTSLP CCCCCCCCCCCCCCC	37.59	28450419
1532	Phosphorylation	NTTGSNSSLNTSLPS CCCCCCCCCCCCCCC	29.86	28450419
1535	Phosphorylation	GSNSSLNTSLPSPGA CCCCCCCCCCCCCCC	36.61	28450419
1536	Phosphorylation	SNSSLNTSLPSPGAW CCCCCCCCCCCCCCC	36.89	28450419
1539	Phosphorylation	SLNTSLPSPGAWPYS CCCCCCCCCCCCCCC	41.06	28450419
1545	Phosphorylation	PSPGAWPYSASDNSF CCCCCCCCCCCCCCC	13.23	28450419
1546	Phosphorylation	SPGAWPYSASDNSFT CCCCCCCCCCCCCCC	19.74	28450419
1548	Phosphorylation	GAWPYSASDNSFTNV CCCCCCCCCCCCCCC	31.24	28450419
1551	Phosphorylation	PYSASDNSFTNVHST CCCCCCCCCCCCCCC	38.14	28450419
1553	Phosphorylation	SASDNSFTNVHSTSA CCCCCCCCCCCCCCC	35.83	28450419
1557	Phosphorylation	NSFTNVHSTSAKFPD CCCCCCCCCCCCCCC	21.55	28450419
1558	Phosphorylation	SFTNVHSTSAKFPDY CCCCCCCCCCCCCCC	20.16	28450419
1559	Phosphorylation	FTNVHSTSAKFPDYK CCCCCCCCCCCCCCC	32.26	28450419
1565	Phosphorylation	TSAKFPDYKSTWSPD CCCCCCCCCCCCCCC	13.69	29759185
1567	Phosphorylation	AKFPDYKSTWSPDPI CCCCCCCCCCCCCCC	28.95	20068231
1568	Phosphorylation	KFPDYKSTWSPDPIG CCCCCCCCCCCCCCC	26.30	29978859
1570	Phosphorylation	PDYKSTWSPDPIGHN CCCCCCCCCCCCCCC	21.36	25159151
1595	Phosphorylation	NHISSRNTTPLPRPP HCCCCCCCCCCCCCC	28.78	21712546
1596	Phosphorylation	HISSRNTTPLPRPPP CCCCCCCCCCCCCCC	26.78	25159151
1611	Phosphorylation	GLTNPKPSSPWSSTA CCCCCCCCCCCCCCC	55.98	24719451
1612	Phosphorylation	LTNPKPSSPWSSTAP CCCCCCCCCCCCCCC	38.63	22199227
1615	Phosphorylation	PKPSSPWSSTAPRSV CCCCCCCCCCCCCCC	22.61	22199227
1616	Phosphorylation	KPSSPWSSTAPRSVR CCCCCCCCCCCCCCC	25.39	-
1623	Methylation	STAPRSVRGWGTQDS CCCCCCCCCCCCCCC	36.07	12020405
1627	Phosphorylation	RSVRGWGTQDSRLAS CCCCCCCCCCCCCCC	23.77	30576142
1648	Phosphorylation	GGSVRPSYWLVLHNL CCCCCHHEEEEEECC	12.87	20090780
1706	Phosphorylation	AQTALHMCVLGNTTI HHHHHHHHHHCCCEE	1.27	19664995
1720	Phosphorylation	ILAEFATDDEVSRFL EEEECCCHHHHHHHH	46.79	20068231
1722	Phosphorylation	AEFATDDEVSRFLAQ EECCCHHHHHHHHHH	45.24	20068231
1807	Phosphorylation	SSLWGVPTVEDPHRM CCCCCCCCCCCCCCC	33.84	26074081
1816	Phosphorylation	EDPHRMGSPAPLLPG CCCCCCCCCCCCCCC	14.46	30266825
1830	Phosphorylation	GDLLGGGSDSI---- CCCCCCCCCCC----	31.31	30278072
1832	Phosphorylation	LLGGGSDSI------ CCCCCCCCC------	31.71	10470851

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TNR6B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNR6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNR6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGO1_HUMAN	AGO1	physical	17891150
AGO2_HUMAN	AGO2	physical	17891150
PABP1_HUMAN	PABPC1	physical	21063388
AGO1_HUMAN	AGO1	physical	19470757
AGO2_HUMAN	AGO2	physical	19470757
AGO3_HUMAN	AGO3	physical	19470757
AGO4_HUMAN	AGO4	physical	19470757
AGO2_HUMAN	AGO2	physical	19838187
AGO2_HUMAN	AGO2	physical	24778252
CARM1_HUMAN	CARM1	physical	24778252
APBA3_HUMAN	APBA3	physical	24778252
CSK_HUMAN	CSK	physical	24778252
FBRS_HUMAN	FBRS	physical	24778252
GUAA_HUMAN	GMPS	physical	24778252
NU155_HUMAN	NUP155	physical	24778252
FAD1_HUMAN	FLAD1	physical	24778252
AGO3_HUMAN	AGO3	physical	24778252
AGO1_HUMAN	AGO1	physical	24778252
CHK1_HUMAN	CHEK1	physical	24778252
GARS_HUMAN	GARS	physical	24778252
TRI65_HUMAN	TRIM65	physical	24778252
PUR4_HUMAN	PFAS	physical	24778252
CNOT1_HUMAN	CNOT1	physical	21981923
CNOT2_HUMAN	CNOT2	physical	21981923
CNOT6_HUMAN	CNOT6	physical	21981923
CNO6L_HUMAN	CNOT6L	physical	21981923
CNOT7_HUMAN	CNOT7	physical	21981923
CNOT8_HUMAN	CNOT8	physical	21981923
CNOT3_HUMAN	CNOT3	physical	21981923
PAN3_HUMAN	PAN3	physical	21981923

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNR6B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1432 AND SER-1816, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1816, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND THR-407, ANDMASS SPECTROMETRY.	18691976 [Abstract]