AGO1_HUMAN - dbPTM
AGO1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGO1_HUMAN
UniProt AC Q9UL18
Protein Name Protein argonaute-1
Gene Name AGO1
Organism Homo sapiens (Human).
Sequence Length 857
Subcellular Localization Cytoplasm, P-body .
Protein Description Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)..
Protein Sequence MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
92PhosphorylationFGDRKPVYDGKKNIY
HCCCCCCCCCCCCEE		27.7522210691
99PhosphorylationYDGKKNIYTVTALPI
CCCCCCEEEEEEEEC		12.4522210691
102PhosphorylationKKNIYTVTALPIGNE
CCCEEEEEEEECCCE		18.0622210691
172PhosphorylationRHLASMRYTPVGRSF
HHHHHCCCCCCCCCC		13.5222210691
173PhosphorylationHLASMRYTPVGRSFF
HHHHCCCCCCCCCCC		10.9222210691
246UbiquitinationRNIDEQPKPLTDSQR
CCCCCCCCCCCHHHC		52.97-
333UbiquitinationLQVGQEQKHTYLPLE
EECCCCCCCCEECHH		36.84-
335PhosphorylationVGQEQKHTYLPLEVC
CCCCCCCCEECHHHH		33.51-
336PhosphorylationGQEQKHTYLPLEVCN
CCCCCCCEECHHHHH		13.1783375
353UbiquitinationAGQRCIKKLTDNQTS
CCCHHHHHCCCCCHH		36.39-
355PhosphorylationQRCIKKLTDNQTSTM
CHHHHHCCCCCHHHH		41.61-
360PhosphorylationKLTDNQTSTMIKATA
HCCCCCHHHHHHHHH		13.25-
364UbiquitinationNQTSTMIKATARSAP
CCHHHHHHHHHHCCC		28.9421906983
382UbiquitinationEEISRLMKNASYNLD
HHHHHHHHHHCCCCC		54.69-
398UbiquitinationYIQEFGIKVKDDMTE
HHHHHCCEECCCCCC		43.54-
438AcetylationGVWDMRGKQFYNGIE
CCCCCCCCEEECCEE		27.2028640537
458UbiquitinationIACFAPQKQCREEVL
EECCCCHHHHHHHHH		50.75-
477UbiquitinationDQLRKISKDAGMPIQ
HHHHHHHHHCCCCCC		55.88-
491UbiquitinationQGQPCFCKYAQGADS
CCCCCCCEECCCCCC		24.30-
509PhosphorylationMFRHLKNTYSGLQLI
HHHHHHHHCCCCEEE		19.9218452278
510PhosphorylationFRHLKNTYSGLQLII
HHHHHHHCCCCEEEE		15.3318452278
511PhosphorylationRHLKNTYSGLQLIIV
HHHHHHCCCCEEEEE		30.8718452278
524PhosphorylationIVILPGKTPVYAEVK
EEECCCCCCCEEEHH		24.7322192793
527PhosphorylationLPGKTPVYAEVKRVG
CCCCCCCEEEHHHHH		9.76-
531UbiquitinationTPVYAEVKRVGDTLL
CCCEEEHHHHHHHHH		32.6321906983
552UbiquitinationVQVKNVVKTSPQTLS
EEEEEEECCCHHHHH		38.72-
621PhosphorylationGSMDAHPSRYCATVR
CCCCCCHHHEEEEEE		26.4750563943
626PhosphorylationHPSRYCATVRVQRPR
CHHHEEEEEEEECCH		12.8050563949
653UbiquitinationELLIQFYKSTRFKPT
HHHHHHHHHCCCCCE		46.79-
702PhosphorylationDYQPGITYIVVQKRH
CCCCCEEEEEEECCC		6.987607403
718UbiquitinationTRLFCADKNERIGKS
EEEEEEECCCCCCCC		42.03-
750PhosphorylationEFDFYLCSHAGIQGT
EEEEEEECCCCCCCC		17.49-
794PhosphorylationTYVRCTRSVSIPAPA
HHCCCCCCCCCCCHH		11.3216094384
796PhosphorylationVRCTRSVSIPAPAYY
CCCCCCCCCCCHHHH		24.89-
802PhosphorylationVSIPAPAYYARLVAF
CCCCCHHHHHHHHHH		9.1526074081
803PhosphorylationSIPAPAYYARLVAFR
CCCCHHHHHHHHHHH		6.3226074081
822PhosphorylationLVDKEHDSGEGSHIS
EECCCCCCCCCCCCC		40.4225159151
826PhosphorylationEHDSGEGSHISGQSN
CCCCCCCCCCCCCCC		17.2237817095
829PhosphorylationSGEGSHISGQSNGRD
CCCCCCCCCCCCCCC		25.9281018045
832PhosphorylationGSHISGQSNGRDPQA
CCCCCCCCCCCCHHH		44.7927251275
850PhosphorylationAVQVHQDTLRTMYFA
HHHHCHHHHHHHCCC		16.15-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AGO1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGO1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGO1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IPO8_HUMANIPO8physical
19167051
TNR6A_HUMANTNRC6Aphysical
19470757
TNR6B_HUMANTNRC6Bphysical
19470757
TNR6C_HUMANTNRC6Cphysical
19470757
TNR6A_HUMANTNRC6Aphysical
19383768
TNR6B_HUMANTNRC6Bphysical
19383768
TNR6C_HUMANTNRC6Cphysical
19383768
HS90A_HUMANHSP90AA1physical
19716330
DICER_HUMANDICER1physical
19716330
TRBP2_HUMANTARBP2physical
19716330
TNR6A_HUMANTNRC6Aphysical
19716330
PABP1_HUMANPABPC1physical
19716330
CNOT7_HUMANCNOT7physical
19716330
TF65_HUMANRELAphysical
21988832
KHDR1_HUMANKHDRBS1physical
21988832
AGO2_HUMANAGO2physical
24086155
RPB1_HUMANPOLR2Aphysical
24086155
AGO2_HUMANAGO2physical
24778252
AIP_HUMANAIPphysical
24778252
WDCP_HUMANC2orf44physical
24778252
DICER_HUMANDICER1physical
24778252
DJB11_HUMANDNAJB11physical
24778252
FKBP5_HUMANFKBP5physical
24778252
GASP2_HUMANGPRASP2physical
24778252
PASK_HUMANPASKphysical
24778252
PP6R1_HUMANPPP6R1physical
24778252
CHIP_HUMANSTUB1physical
24778252
TCF25_HUMANTCF25physical
24778252
TNR6A_HUMANTNRC6Aphysical
24778252
TNR6B_HUMANTNRC6Bphysical
24778252
TNR6C_HUMANTNRC6Cphysical
24778252
P53_HUMANTP53physical
24778252
DCA10_HUMANDCAF10physical
24778252
CYLD_HUMANCYLDphysical
25595906
TAXB1_HUMANTAX1BP1physical
25595906
OTU7B_HUMANOTUD7Bphysical
25595906
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGO1_HUMAN

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Related Literatures of Post-Translational Modification

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