WDCP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDCP_HUMAN
• UniProt AC: Q9H6R7
• Protein Name: WD repeat and coiled-coil-containing protein {ECO:0000305}
• Gene Name: WDCP {ECO:0000312|HGNC:HGNC:26157}
• Organism: Homo sapiens (Human).
• Sequence Length: 721
• Protein Sequence: MELGKGKLLRTGLNALHQAVHPIHGLAWTDGNQVVLTDLRLHSGEVKFGDSKVIGQFECVCGLSWAPPVADDTPVLLAVQHEKHVTVWQLCPSPMESSKWLTSQTCEIRGSLPILPQGCVWHPKCAILTVLTAQDVSIFPNVHSDDSQVKADINTQGRIHCACWTQDGLRLVVAVGSSLHSYIWDSAQKTLHRCSSCLVFDVDSHVCSITATVDSQVAIATELPLDKICGLNASETFNIPPNSKDMTPYALPVIGEVRSMDKEATDSETNSEVSVSSSYLEPLDLTHIHFNQHKSEGNSLICLRKKDYLTGTGQDSSHLVLVTFKKAVTMTRKVTIPGILVPDLIAFNLKAHVVAVASNTCNIILIYSVIPSSVPNIQQIRLENTERPKGICFLTDQLLLILVGKQKLTDTTFLPSSKSDQYAISLIVREIMLEEEPSITSGESQTTYSTFSAPLNKANRKKLIESLSPDFCHQNKGLLLTVNTSSQNGRPGRTLIKEIQSPLSSICDGSIALDAEPVTQPASLPRHSSTPDHTSTLEPPRLPQRKNLQSEKETYQLSKEVEILSRNLVEMQRCLSELTNRLHNGKKSSSVYPLSQDLPYVHIIYQKPYYLGPVVEKRAVLLCDGKLRLSTVQQTFGLSLIEMLHDSHWILLSADSEGFIPLTFTATQEIIIRDGSLSRSDVFRDSFSHSPGAVSSLKVFTGLAAPSLDTTGCCNHVDGMA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELGKGKL -------CCCCCCHH		22814378
5	Ubiquitination	---MELGKGKLLRTG ---CCCCCCHHHHHH		24816145
7	Ubiquitination	-MELGKGKLLRTGLN -CCCCCCHHHHHHHH		-
47	Ubiquitination	RLHSGEVKFGDSKVI EECCCEEEECCCCEE		29967540
111	Phosphorylation	QTCEIRGSLPILPQG CCEEEECCCCCCCCC		29449344
247	Phosphorylation	PPNSKDMTPYALPVI CCCCCCCCCCCHHEE		21945579
249	Phosphorylation	NSKDMTPYALPVIGE CCCCCCCCCHHEEEE		21945579
259	Phosphorylation	PVIGEVRSMDKEATD HEEEEEECCCCCCCC		22199227
265	Phosphorylation	RSMDKEATDSETNSE ECCCCCCCCCCCCCE		20873877
267	Phosphorylation	MDKEATDSETNSEVS CCCCCCCCCCCCEEE		20873877
269	Phosphorylation	KEATDSETNSEVSVS CCCCCCCCCCEEEEC		20873877
271	Phosphorylation	ATDSETNSEVSVSSS CCCCCCCCEEEECHH		20873877
274	Phosphorylation	SETNSEVSVSSSYLE CCCCCEEEECHHHCC		20873877
276	Phosphorylation	TNSEVSVSSSYLEPL CCCEEEECHHHCCCC		20873877
277	Phosphorylation	NSEVSVSSSYLEPLD CCEEEECHHHCCCCC		20873877
278	Phosphorylation	SEVSVSSSYLEPLDL CEEEECHHHCCCCCC		20873877
279	Phosphorylation	EVSVSSSYLEPLDLT EEEECHHHCCCCCCC		20873877
294	Ubiquitination	HIHFNQHKSEGNSLI EEEECCCCCCCCEEE		29967540
295	Phosphorylation	IHFNQHKSEGNSLIC EEECCCCCCCCEEEE		25159151
299	Phosphorylation	QHKSEGNSLICLRKK CCCCCCCEEEEEEEC		25159151
310	Phosphorylation	LRKKDYLTGTGQDSS EEECCCCCCCCCCCC		26503514
312	Phosphorylation	KKDYLTGTGQDSSHL ECCCCCCCCCCCCEE		26503514
317	Phosphorylation	TGTGQDSSHLVLVTF CCCCCCCCEEEEEEE		26503514
326	Acetylation	LVLVTFKKAVTMTRK EEEEEECCCCCCCCC		7365143
326	Ubiquitination	LVLVTFKKAVTMTRK EEEEEECCCCCCCCC		29967540
329	Phosphorylation	VTFKKAVTMTRKVTI EEECCCCCCCCCCCC		-
331	Phosphorylation	FKKAVTMTRKVTIPG ECCCCCCCCCCCCCC		-
333	Acetylation	KAVTMTRKVTIPGIL CCCCCCCCCCCCCEE		7365153
358	Phosphorylation	AHVVAVASNTCNIIL CEEEEEECCCCCEEE		24043423
360	Phosphorylation	VVAVASNTCNIILIY EEEEECCCCCEEEEE		24043423
367	Phosphorylation	TCNIILIYSVIPSSV CCCEEEEEECCCCCC		24043423
368	Phosphorylation	CNIILIYSVIPSSVP CCEEEEEECCCCCCC		24043423
372	Phosphorylation	LIYSVIPSSVPNIQQ EEEECCCCCCCCHHE		24043423
373	Phosphorylation	IYSVIPSSVPNIQQI EEECCCCCCCCHHEE		24043423
416	Phosphorylation	TDTTFLPSSKSDQYA CCCCCCCCCCCHHHH		25627689
417	Phosphorylation	DTTFLPSSKSDQYAI CCCCCCCCCCHHHHH		21815630
418	Ubiquitination	TTFLPSSKSDQYAIS CCCCCCCCCHHHHHH		-
422	Phosphorylation	PSSKSDQYAISLIVR CCCCCHHHHHHHHHH		-
452	Phosphorylation	QTTYSTFSAPLNKAN CCCEEECCCCCCHHH		25159151
457	Ubiquitination	TFSAPLNKANRKKLI ECCCCCCHHHHHHHH		-
466	Phosphorylation	NRKKLIESLSPDFCH HHHHHHHHCCHHHHH		23401153
468	Phosphorylation	KKLIESLSPDFCHQN HHHHHHCCHHHHHCC		22167270
481	Phosphorylation	QNKGLLLTVNTSSQN CCCCEEEEEECCCCC		29214152
485	Phosphorylation	LLLTVNTSSQNGRPG EEEEEECCCCCCCCC		28555341
486	Phosphorylation	LLTVNTSSQNGRPGR EEEEECCCCCCCCCC		21712546
501	Phosphorylation	TLIKEIQSPLSSICD HHHHHCCCCHHHHCC		30278072
504	Phosphorylation	KEIQSPLSSICDGSI HHCCCCHHHHCCCCE		28464451
505	Phosphorylation	EIQSPLSSICDGSIA HCCCCHHHHCCCCEE		26552605
510	Phosphorylation	LSSICDGSIALDAEP HHHHCCCCEEECCCC		21082442
519	Phosphorylation	ALDAEPVTQPASLPR EECCCCCCCCCCCCC		27080861
523	Phosphorylation	EPVTQPASLPRHSST CCCCCCCCCCCCCCC		21712546
528	Phosphorylation	PASLPRHSSTPDHTS CCCCCCCCCCCCCCC		25159151
529	Phosphorylation	ASLPRHSSTPDHTST CCCCCCCCCCCCCCC		25159151
530	Phosphorylation	SLPRHSSTPDHTSTL CCCCCCCCCCCCCCC		25159151
534	Phosphorylation	HSSTPDHTSTLEPPR CCCCCCCCCCCCCCC		25159151
535	Phosphorylation	SSTPDHTSTLEPPRL CCCCCCCCCCCCCCC		25159151
536	Phosphorylation	STPDHTSTLEPPRLP CCCCCCCCCCCCCCC		27732954
552	Ubiquitination	RKNLQSEKETYQLSK CCCCCCHHHHHHHHH		29967540
565	Phosphorylation	SKEVEILSRNLVEMQ HHHHHHHHHHHHHHH		24719451
680	Phosphorylation	RDGSLSRSDVFRDSF CCCCCCHHHHCHHHC		27422710
686	Phosphorylation	RSDVFRDSFSHSPGA HHHHCHHHCCCCCCH		30266825
688	Phosphorylation	DVFRDSFSHSPGAVS HHCHHHCCCCCCHHC		23927012
690	Phosphorylation	FRDSFSHSPGAVSSL CHHHCCCCCCHHCCC		29255136
695	Phosphorylation	SHSPGAVSSLKVFTG CCCCCHHCCCEEECC		23927012
696	Phosphorylation	HSPGAVSSLKVFTGL CCCCHHCCCEEECCC		23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
686	S	Phosphorylation	Kinase	PLK1	P53350	PSP
695	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDCP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDCP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED31_HUMAN	MED31	physical	16169070
RUVB1_HUMAN	RUVBL1	physical	18218781
RUVB2_HUMAN	RUVBL2	physical	18218781
PAPS1_HUMAN	PAPSS1	physical	28514442
GNL1_HUMAN	GNL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.