DCA10_HUMAN - dbPTM
DCA10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCA10_HUMAN
UniProt AC Q5QP82
Protein Name DDB1- and CUL4-associated factor 10
Gene Name DCAF10
Organism Homo sapiens (Human).
Sequence Length 559
Subcellular Localization
Protein Description May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
Protein Sequence MFPFGPHSPGGDGSAGAGAEEPTPHEGQAAATGPPSPLHPGADATHPPPPARSPRRPGAPSLSPAPRSGELGLPGAPESSTASAPGEPSPPSPPCRRPGPDCRAKSRGRHGLGAGLGGPGARLFGWLKERSLGRGLFVDPARDNFRTMTSLYGSIHPADSVYLSTRTHGAVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHKKFFHTRFLMRMRLTPDCSKMLISTSSGYLLILHDLDLTKSLEVGSYPILRARRTTSSSDLTTSSSSSGPRVSGSPCHHSDSNSSEKHMSRASQREGVSPRNSLEVVTPEVLGESDHGNCITSLQLHPKGWATLLRCSSNSDDEECTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCFSPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMFPFGPHSPGGDGSA
CCCCCCCCCCCCCCC		28.5120068231
14PhosphorylationHSPGGDGSAGAGAEE
CCCCCCCCCCCCCCC		28.4120068231
23PhosphorylationGAGAEEPTPHEGQAA
CCCCCCCCCCCCCHH		40.3220068231
32PhosphorylationHEGQAAATGPPSPLH
CCCCHHCCCCCCCCC		45.5626074081
36PhosphorylationAAATGPPSPLHPGAD
HHCCCCCCCCCCCCC		43.1320068231
45PhosphorylationLHPGADATHPPPPAR
CCCCCCCCCCCCCCC		35.1520068231
53PhosphorylationHPPPPARSPRRPGAP
CCCCCCCCCCCCCCC		25.5125921289
61PhosphorylationPRRPGAPSLSPAPRS
CCCCCCCCCCCCCCC		40.7329255136
63PhosphorylationRPGAPSLSPAPRSGE
CCCCCCCCCCCCCCC		24.2930266825
68PhosphorylationSLSPAPRSGELGLPG
CCCCCCCCCCCCCCC		35.2426552605
79PhosphorylationGLPGAPESSTASAPG
CCCCCCCCCCCCCCC		31.7430576142
80PhosphorylationLPGAPESSTASAPGE
CCCCCCCCCCCCCCC		26.7430278072
81PhosphorylationPGAPESSTASAPGEP
CCCCCCCCCCCCCCC		33.6326552605
83PhosphorylationAPESSTASAPGEPSP
CCCCCCCCCCCCCCC		34.7830576142
89PhosphorylationASAPGEPSPPSPPCR
CCCCCCCCCCCCCCC		45.1823401153
92PhosphorylationPGEPSPPSPPCRRPG
CCCCCCCCCCCCCCC		44.8723401153
128 (in isoform 1)Ubiquitination-44.5721890473
128 (in isoform 2)Ubiquitination-44.5721890473
128UbiquitinationARLFGWLKERSLGRG
HHHHHHHHHCCCCCC		44.5721890473
134MethylationLKERSLGRGLFVDPA
HHHCCCCCCCCCCCC		43.8924129315
181PhosphorylationLEYSPDGSVLTVACE
EEECCCCCEEEEEEE		22.7229888752
184PhosphorylationSPDGSVLTVACEQTE
CCCCCEEEEEEECCE		12.1429888752
190PhosphorylationLTVACEQTEVLLFDP
EEEEEECCEEEEECC		13.0329888752
204UbiquitinationPISSKHIKTLSEAHE
CCCHHHHHHHHHHCH		43.03-
245UbiquitinationDLRKLNTKVCTLHGH
EHHHCCCEEEEECCC		33.95-
338PhosphorylationTKSLEVGSYPILRAR
CCCEECCCCCEEEEE		32.6727499020
339PhosphorylationKSLEVGSYPILRARR
CCEECCCCCEEEEEC		6.5927499020
347PhosphorylationPILRARRTTSSSDLT
CEEEEECCCCCCCCC		26.0227794612
348PhosphorylationILRARRTTSSSDLTT
EEEEECCCCCCCCCC		25.4619413330
349PhosphorylationLRARRTTSSSDLTTS
EEEECCCCCCCCCCC		27.5123911959
350 (in isoform 2)Phosphorylation-26.2725262027
350PhosphorylationRARRTTSSSDLTTSS
EEECCCCCCCCCCCC		26.2723911959
351PhosphorylationARRTTSSSDLTTSSS
EECCCCCCCCCCCCC		36.0823911959
351 (in isoform 2)Phosphorylation-36.0825262027
354PhosphorylationTTSSSDLTTSSSSSG
CCCCCCCCCCCCCCC		29.6228450419
354 (in isoform 2)Phosphorylation-29.6225262027
355PhosphorylationTSSSDLTTSSSSSGP
CCCCCCCCCCCCCCC		33.6330576142
356PhosphorylationSSSDLTTSSSSSGPR
CCCCCCCCCCCCCCC		24.0028450419
357PhosphorylationSSDLTTSSSSSGPRV
CCCCCCCCCCCCCCC		31.9528450419
358PhosphorylationSDLTTSSSSSGPRVS
CCCCCCCCCCCCCCC		28.4330576142
360PhosphorylationLTTSSSSSGPRVSGS
CCCCCCCCCCCCCCC		55.56-
365PhosphorylationSSSGPRVSGSPCHHS
CCCCCCCCCCCCCCC		34.5327794612
367PhosphorylationSGPRVSGSPCHHSDS
CCCCCCCCCCCCCCC		19.4925849741
372PhosphorylationSGSPCHHSDSNSSEK
CCCCCCCCCCCCCHH		21.0430576142
374PhosphorylationSPCHHSDSNSSEKHM
CCCCCCCCCCCHHHH		41.4427794612
376PhosphorylationCHHSDSNSSEKHMSR
CCCCCCCCCHHHHHH		43.7727794612
377PhosphorylationHHSDSNSSEKHMSRA
CCCCCCCCHHHHHHH		55.7227794612
421UbiquitinationTSLQLHPKGWATLLR
EEEEECCCCEEEEEE		57.23-
430PhosphorylationWATLLRCSSNSDDEE
EEEEEECCCCCCCCC		26.5628348404
431PhosphorylationATLLRCSSNSDDEEC
EEEEECCCCCCCCCE		43.9328348404
433PhosphorylationLLRCSSNSDDEECTC
EEECCCCCCCCCEEE		48.6822210691
439PhosphorylationNSDDEECTCVYEFQE
CCCCCCEEEEEEECC		14.3222210691
442PhosphorylationDEECTCVYEFQEGAP
CCCEEEEEEECCCCC		17.1122210691
454PhosphorylationGAPVRPVSPRCSLRL
CCCCCCCCCCCEEEE		14.8726074081
458PhosphorylationRPVSPRCSLRLTHYI
CCCCCCCEEEEEEHH		20.1526074081
472MethylationIEEANVGRGYIKELC
HHHCCCCCCHHEEEE		30.3854560527
476UbiquitinationNVGRGYIKELCFSPD
CCCCCHHEEEEECCC		35.83-
481PhosphorylationYIKELCFSPDGRMIS
HHEEEEECCCCCEEC		22.5321815630
489PhosphorylationPDGRMISSPHGYGIR
CCCCEECCCCCCCEE		15.25-
502UbiquitinationIRLLGFDKQCSELVD
EEEEEECHHHHHHHH		51.44-
513UbiquitinationELVDCLPKEASPLRV
HHHHHCCCCCCHHHH		53.62-
516PhosphorylationDCLPKEASPLRVIRS
HHCCCCCCHHHHHHH		26.0924702127
523PhosphorylationSPLRVIRSLYSHNDV
CHHHHHHHHHHCCCE		22.1222496350
525PhosphorylationLRVIRSLYSHNDVVL
HHHHHHHHHCCCEEE		14.7720068231
526PhosphorylationRVIRSLYSHNDVVLT
HHHHHHHHCCCEEEE		22.5520068231
535UbiquitinationNDVVLTTKFSPTHCQ
CCEEEEECCCCCCCC		38.31-
537PhosphorylationVVLTTKFSPTHCQIA
EEEEECCCCCCCCCC		30.3728555341
539PhosphorylationLTTKFSPTHCQIASG
EEECCCCCCCCCCCC		33.80-
549PhosphorylationQIASGCLSGRVSLYQ
CCCCCCCCCCEEEEC		28.73-
555PhosphorylationLSGRVSLYQPKF---
CCCCEEEECCCC---		18.4427642862
558UbiquitinationRVSLYQPKF------
CEEEECCCC------		48.45-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCA10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCA10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCA10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPW_HUMANCCT6Bphysical
28514442
TCPG_HUMANCCT3physical
28514442
EIF3I_HUMANEIF3Iphysical
28514442
TCPB_HUMANCCT2physical
28514442
TCPD_HUMANCCT4physical
28514442
PRI1_HUMANPRIM1physical
28514442
TCPA_HUMANTCP1physical
28514442
TCPH_HUMANCCT7physical
28514442
PRI2_HUMANPRIM2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCA10_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory