dbPTM

CYLD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CYLD_HUMAN
UniProt AC	Q9NQC7
Protein Name	Ubiquitin carboxyl-terminal hydrolase CYLD
Gene Name	CYLD {ECO:0000303\|PubMed:12917689, ECO:0000312\|HGNC:HGNC:2584}
Organism	Homo sapiens (Human).
Sequence Length	956
Subcellular Localization	Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleto
Protein Description	Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. [PubMed: 12917689]
Protein Sequence	MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGVYQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFACVESTILLHINDIIPALSESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNGSSVDSQPQSKSKNTWYIDEVAEDPAKSLTEISTDFDRSSPPLQPPPVNSLTTENRFHSLPFSLTKMPNTNGSIGHSPLSLSAQSVMEELNTAPVQESPPLAMPPGNSHGLEVGSLAEVKENPPFYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSGLWSQE ------CCCCCCCCC	32.87	29514088
3	Phosphorylation	-----MSSGLWSQEK -----CCCCCCCCCC	36.28	29514088
10	Ubiquitination	SGLWSQEKVTSPYWE CCCCCCCCCCCCHHH	43.08	-
12	Phosphorylation	LWSQEKVTSPYWEER CCCCCCCCCCHHHHH	34.74	29523821
13	Phosphorylation	WSQEKVTSPYWEERI CCCCCCCCCHHHHHH	20.98	25159151
15	Phosphorylation	QEKVTSPYWEERIFY CCCCCCCHHHHHHHH	25.81	25159151
22	Phosphorylation	YWEERIFYLLLQECS HHHHHHHHHHHHHCC	8.28	-
29	Phosphorylation	YLLLQECSVTDKQTQ HHHHHHCCCCHHHHH	27.57	-
31	Phosphorylation	LLQECSVTDKQTQKL HHHHCCCCHHHHHHH	22.61	-
35	Phosphorylation	CSVTDKQTQKLLKVP CCCCHHHHHHHHCCC	33.15	-
40	Ubiquitination	KQTQKLLKVPKGSIG HHHHHHHCCCCCCHH	67.91	-
43	Ubiquitination	QKLLKVPKGSIGQYI HHHHCCCCCCHHHHC	69.17	-
45	Phosphorylation	LLKVPKGSIGQYIQD HHCCCCCCHHHHCCC	29.67	-
62	Phosphorylation	VGHSRIPSAKGKKNQ CCCCCCCCCCCCCCC	40.00	24719451
73	Ubiquitination	KKNQIGLKILEQPHA CCCCHHCHHHCCCCE	39.78	-
111	Phosphorylation	TNCEERFSLFKNRNR HCCHHHHHHHCCCCC	38.83	24719451
114	Ubiquitination	EERFSLFKNRNRLSK HHHHHHHCCCCCCCC	61.36	-
121	Ubiquitination	KNRNRLSKGLQIDVG CCCCCCCCCCEEECC	69.13	-
132	Ubiquitination	IDVGCPVKVQLRSGE EECCCCEEEEECCCC	14.92	-
141	Ubiquitination	QLRSGEEKFPGVVRF EECCCCCCCCCEEEE	53.18	-
287	Phosphorylation	FDGVQLCSFACVEST CCCEEEEHHEEEEEH	25.19	24275569
318	Ubiquitination	TQERRPPKLAFMSRG CCCCCCCCCEEECCC	55.95	-
333	Phosphorylation	VGDKGSSSHNKPKAT CCCCCCCCCCCCCCC	32.54	26657352
343	Phosphorylation	KPKATGSTSDPGNRN CCCCCCCCCCCCCCC	38.19	24275569
344	Phosphorylation	PKATGSTSDPGNRNR CCCCCCCCCCCCCCH	43.43	24275569
352	Phosphorylation	DPGNRNRSELFYTLN CCCCCCHHHEEEEEC	42.05	21945579
356	Phosphorylation	RNRSELFYTLNGSSV CCHHHEEEEECCCCC	23.96	21945579
357	Phosphorylation	NRSELFYTLNGSSVD CHHHEEEEECCCCCC	13.35	21945579
361	Phosphorylation	LFYTLNGSSVDSQPQ EEEEECCCCCCCCCC	26.56	28348404
362	Phosphorylation	FYTLNGSSVDSQPQS EEEECCCCCCCCCCC	31.20	28985074
365	Phosphorylation	LNGSSVDSQPQSKSK ECCCCCCCCCCCCCC	41.42	27251275
369	Phosphorylation	SVDSQPQSKSKNTWY CCCCCCCCCCCCEEE	45.65	27251275
372	Ubiquitination	SQPQSKSKNTWYIDE CCCCCCCCCEEEEHH	63.23	-
376	Phosphorylation	SKSKNTWYIDEVAED CCCCCEEEEHHHHCC	9.10	-
387	Phosphorylation	VAEDPAKSLTEISTD HHCCHHHHHHEECCC	42.50	29255136
389	Phosphorylation	EDPAKSLTEISTDFD CCHHHHHHEECCCCC	38.06	29255136
392	Phosphorylation	AKSLTEISTDFDRSS HHHHHEECCCCCCCC	18.72	29255136
393	Phosphorylation	KSLTEISTDFDRSSP HHHHEECCCCCCCCC	46.47	23401153
398	Phosphorylation	ISTDFDRSSPPLQPP ECCCCCCCCCCCCCC	49.38	23401153
399	Phosphorylation	STDFDRSSPPLQPPP CCCCCCCCCCCCCCC	31.28	30266825
409	Phosphorylation	LQPPPVNSLTTENRF CCCCCCCCCCCCCCC	27.59	30242111
411	Phosphorylation	PPPVNSLTTENRFHS CCCCCCCCCCCCCCC	31.70	30242111
412	Phosphorylation	PPVNSLTTENRFHSL CCCCCCCCCCCCCCC	36.23	30242111
418	Phosphorylation	TTENRFHSLPFSLTK CCCCCCCCCCCCCEE	34.72	29255136
422	Phosphorylation	RFHSLPFSLTKMPNT CCCCCCCCCEECCCC	32.94	29255136
424	Phosphorylation	HSLPFSLTKMPNTNG CCCCCCCEECCCCCC	24.89	29255136
432	Phosphorylation	KMPNTNGSIGHSPLS ECCCCCCCCCCCCCC	27.71	22817900
436	Phosphorylation	TNGSIGHSPLSLSAQ CCCCCCCCCCCCCHH	23.48	22817900
439	Phosphorylation	SIGHSPLSLSAQSVM CCCCCCCCCCHHHHH	24.54	22817900
441	Phosphorylation	GHSPLSLSAQSVMEE CCCCCCCCHHHHHHH	22.38	22817900
444	Phosphorylation	PLSLSAQSVMEELNT CCCCCHHHHHHHHCC	24.13	22817900
523	Phosphorylation	GTFRGTRYFTCALKK CCCCCHHHHHHHHHH	11.77	29496907
530	Ubiquitination	YFTCALKKALFVKLK HHHHHHHHHHEEEEH	51.69	-
547	Phosphorylation	RPDSRFASLQPVSNQ CCCCCCCCCCCCCHH	25.48	28857561
552	Phosphorylation	FASLQPVSNQIERCN CCCCCCCCHHHHHHH	29.69	26657352
560	Phosphorylation	NQIERCNSLAFGGYL HHHHHHHHHCCCCHH	25.38	26657352
566	Phosphorylation	NSLAFGGYLSEVVEE HHHCCCCHHHHHHHH	13.87	27080861
568	Phosphorylation	LAFGGYLSEVVEENT HCCCCHHHHHHHHCC	21.62	27080861
627	Ubiquitination	VLLRPKEKNDVEYYS HCCCCCCCCCCCCHH	65.65	-
668	Ubiquitination	KLRKILEKVEAASGF HHHHHHHHHHHHCCC	41.76	-
701	Ubiquitination	LRVEPLLKIRSAGQK HHHHCCHHHHCCCCC	43.70	-
761	Ubiquitination	IQMPRFGKDFKLFKK EECCCCCCCHHHHHH	58.23	-
768	Ubiquitination	KDFKLFKKIFPSLEL CCHHHHHHHHCCCCC	42.09	-
772	Phosphorylation	LFKKIFPSLELNITD HHHHHHCCCCCCHHH	24.59	-
818	Ubiquitination	GKIKQFCKTCNTQVH HHHHHHHHHCCCEEE	58.35	-
829	Ubiquitination	TQVHLHPKRLNHKYN CEEEECHHHCCCCCC	59.79	-
834	Ubiquitination	HPKRLNHKYNPVSLP CHHHCCCCCCCCCCC	45.72	-
842	Ubiquitination	YNPVSLPKDLPDWDW CCCCCCCCCCCCCCC	76.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
362	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
418	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
418	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
422	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
432	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
436	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
439	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
441	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
444	S	Phosphorylation	Kinase	IKBKB	O14920	GPS
772	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	MIB2	Q96AX9	PMID:25565632

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CYLD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CYLD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLK1_HUMAN	PLK1	physical	17495026
KCC2D_HUMAN	CAMK2D	physical	19615732
MYO6_HUMAN	MYO6	physical	19615732
SPAT2_HUMAN	SPATA2	physical	19615732
OGA_HUMAN	MGEA5	physical	19615732
SPA2L_HUMAN	SPATA2L	physical	19615732
TRPA1_HUMAN	TRPA1	physical	16500080
HDAC6_HUMAN	HDAC6	physical	19893491
TRAIP_HUMAN	TRAIP	physical	14676304
NEMO_HUMAN	IKBKG	physical	12917691
TRAF2_HUMAN	TRAF2	physical	12917691
TRAF6_HUMAN	TRAF6	physical	12917691
NEMO_HUMAN	IKBKG	physical	16627981
OPTN_HUMAN	OPTN	physical	21408173
RIPK1_HUMAN	RIPK1	physical	21408173
DVL1_HUMAN	DVL1	physical	20227366
SQSTM_HUMAN	SQSTM1	physical	19201866
ITCH_HUMAN	ITCH	physical	22057290
UBC_HUMAN	UBC	physical	17851586
UBC_HUMAN	UBC	physical	20622874
UBE2S_HUMAN	UBE2S	physical	20622874
TRAF6_HUMAN	TRAF6	physical	20622874
UBC_HUMAN	UBC	physical	19373254
RIPK1_HUMAN	RIPK1	physical	22848449
TBA1A_HUMAN	TUBA1A	physical	18222923
AURKB_HUMAN	AURKB	physical	20593489
HDAC6_HUMAN	HDAC6	physical	20593489
ARHGC_HUMAN	ARHGEF12	physical	23405219
IKKE_HUMAN	IKBKE	physical	23453969
AKT1_HUMAN	AKT1	physical	23300340
NEMO_HUMAN	IKBKG	physical	21988832
CE350_HUMAN	CEP350	physical	25134987
MARE1_HUMAN	MAPRE1	physical	24552808
MARE1_HUMAN	MAPRE1	genetic	24552808
TRAF6_HUMAN	TRAF6	physical	26056944
CLIP3_HUMAN	CLIP3	physical	26017671
MIB2_HUMAN	MIB2	physical	25565632
NEMO_HUMAN	IKBKG	physical	26802121
RNF31_HUMAN	RNF31	physical	26670046
SHRPN_HUMAN	SHARPIN	physical	26670046
KCC2A_HUMAN	CAMK2A	physical	24614225
SDC4_HUMAN	SDC4	physical	27279133
HRSL4_HUMAN	RARRES3	physical	27279133
P53_HUMAN	TP53	physical	27561390
CYLD_HUMAN	CYLD	physical	28187457
SPAT2_HUMAN	SPATA2	physical	27458237
RNF31_HUMAN	RNF31	physical	27591049
SPAT2_HUMAN	SPATA2	physical	27591049
CYLD_HUMAN	CYLD	physical	27591049
IF4E_HUMAN	EIF4E	physical	27591049
SPA2L_HUMAN	SPATA2L	physical	27591049
BIRC2_HUMAN	BIRC2	physical	27591049
THIL_HUMAN	ACAT1	physical	27591049
CC170_HUMAN	CCDC170	physical	27591049
TRAF2_HUMAN	TRAF2	physical	27591049
TFAM_HUMAN	TFAM	physical	27591049
RHG31_HUMAN	ARHGAP31	physical	27591049
RS23_HUMAN	RPS23	physical	27591049
CCSE1_HUMAN	CCSER1	physical	27591049
CO1A2_HUMAN	COL1A2	physical	27591049
K1C25_HUMAN	KRT25	physical	27591049
MICU3_HUMAN	MICU3	physical	27591049
PGK1_HUMAN	PGK1	physical	27591049
FLNC_HUMAN	FLNC	physical	27591049
MDHM_HUMAN	MDH2	physical	27591049
ADT3_HUMAN	SLC25A6	physical	27591049
RL10_HUMAN	RPL10	physical	27591049
SETX_HUMAN	SETX	physical	27591049
K1C23_HUMAN	KRT23	physical	27591049
FHL2_HUMAN	FHL2	physical	27591049
ACAP2_HUMAN	ACAP2	physical	27591049
RL4_HUMAN	RPL4	physical	27591049
SFPQ_HUMAN	SFPQ	physical	27591049
PAP1L_HUMAN	PABPC1L	physical	27591049
TAB3_HUMAN	TAB3	physical	27591049
THOC4_HUMAN	ALYREF	physical	27591049
ATAT_HUMAN	ATAT1	physical	27591049
GRP78_HUMAN	HSPA5	physical	27591049
RBBP4_HUMAN	RBBP4	physical	27591049
FYCO1_HUMAN	FYCO1	physical	27591049
DCD_HUMAN	DCD	physical	27591049
F262_HUMAN	PFKFB2	physical	27591049
PAIRB_HUMAN	SERBP1	physical	27591049
AF1Q_HUMAN	MLLT11	physical	27591049
EF1A2_HUMAN	EEF1A2	physical	27591049
SYFA_HUMAN	FARSA	physical	27591049
RS21_HUMAN	RPS21	physical	27591049
K2C78_HUMAN	KRT78	physical	27591049
CASPE_HUMAN	CASP14	physical	27591049
PIP_HUMAN	PIP	physical	27591049
COF1_HUMAN	CFL1	physical	27591049
MGAP_HUMAN	MGA	physical	27591049
CBPA4_HUMAN	CPA4	physical	27591049
TAB2_HUMAN	TAB2	physical	27591049
TRFL_HUMAN	LTF	physical	27591049
K1C17_HUMAN	KRT17	physical	27591049
PRDX2_HUMAN	PRDX2	physical	27591049
AHNK_HUMAN	AHNAK	physical	27591049
1433B_HUMAN	YWHAB	physical	27591049
SSA27_HUMAN	SSSCA1	physical	27591049
RL30_HUMAN	RPL30	physical	27591049
DNJB6_HUMAN	DNAJB6	physical	27591049
ACSL3_HUMAN	ACSL3	physical	27591049
NP1L1_HUMAN	NAP1L1	physical	27591049
RAB3D_HUMAN	RAB3D	physical	27591049
STK38_HUMAN	STK38	physical	27591049
DCTN2_HUMAN	DCTN2	physical	27591049
ZYX_HUMAN	ZYX	physical	27591049
ROCK2_HUMAN	ROCK2	physical	27591049
GRP75_HUMAN	HSPA9	physical	27591049
HNRPD_HUMAN	HNRNPD	physical	27591049
MTMRE_HUMAN	MTMR14	physical	27591049
CG050_HUMAN	C7orf50	physical	27591049
EF1B_HUMAN	EEF1B2	physical	27591049
MUCL1_HUMAN	MUCL1	physical	27591049
EIF3G_HUMAN	EIF3G	physical	27591049
BRAF_HUMAN	BRAF	physical	27591049
BLMH_HUMAN	BLMH	physical	27591049
IMDH2_HUMAN	IMPDH2	physical	27591049
PHB2_HUMAN	PHB2	physical	27591049
LEG1_HUMAN	LGALS1	physical	27591049
CLH1_HUMAN	CLTC	physical	27591049
K2C1B_HUMAN	KRT77	physical	27591049
HSP76_HUMAN	HSPA6	physical	27591049
CNCG_HUMAN	PDE6H	physical	27591049
RENT1_HUMAN	UPF1	physical	27591049
CNTP3_HUMAN	CNTNAP3	physical	27591049
G3BP1_HUMAN	G3BP1	physical	27591049
RU2B_HUMAN	SNRPB2	physical	27591049
ZN609_HUMAN	ZNF609	physical	27591049
SYWC_HUMAN	WARS	physical	27591049
DSC3_HUMAN	DSC3	physical	27591049
RS12_HUMAN	RPS12	physical	27591049
RS14_HUMAN	RPS14	physical	27591049
PCBP1_HUMAN	PCBP1	physical	27591049
ANXA2_HUMAN	ANXA2	physical	27591049
HNRH2_HUMAN	HNRNPH2	physical	27591049
YBOX1_HUMAN	YBX1	physical	27591049
K2C8_HUMAN	KRT8	physical	27591049
ML12A_HUMAN	MYL12A	physical	27591049
RS19_HUMAN	RPS19	physical	27591049
HSP74_HUMAN	HSPA4	physical	27591049
ACOC_HUMAN	ACO1	physical	27591049
FAS_HUMAN	FASN	physical	27591049
SPTN1_HUMAN	SPTAN1	physical	27591049
K1C10_HUMAN	KRT10	physical	27591049
NADAP_HUMAN	SLC4A1AP	physical	27591049
PHB_HUMAN	PHB	physical	27591049
ANM5_HUMAN	PRMT5	physical	27591049
FILA_HUMAN	FLG	physical	27591049
TBA4A_HUMAN	TUBA4A	physical	27591049
IF4G1_HUMAN	EIF4G1	physical	27591049
AIMP1_HUMAN	AIMP1	physical	27591049
HNRPF_HUMAN	HNRNPF	physical	27591049
SRSF3_HUMAN	SRSF3	physical	27591049
FBX50_HUMAN	NCCRP1	physical	27591049
S10A8_HUMAN	S100A8	physical	27591049
RLA1_HUMAN	RPLP1	physical	27591049
MCM5_HUMAN	MCM5	physical	27591049
CO1A1_HUMAN	COL1A1	physical	27591049
K1C12_HUMAN	KRT12	physical	27591049
SLAI2_HUMAN	SLAIN2	physical	27591049
RLA2_HUMAN	RPLP2	physical	27591049
AT2A3_HUMAN	ATP2A3	physical	27591049
RCN2_HUMAN	RCN2	physical	27591049
EIF3D_HUMAN	EIF3D	physical	27591049
NPM_HUMAN	NPM1	physical	27591049
S61A1_HUMAN	SEC61A1	physical	27591049
RS5_HUMAN	RPS5	physical	27591049
HSPB1_HUMAN	HSPB1	physical	27591049
RS6_HUMAN	RPS6	physical	27591049
G3P_HUMAN	GAPDH	physical	27591049
MYH13_HUMAN	MYH13	physical	27591049
RL23_HUMAN	RPL23	physical	27591049
EF1D_HUMAN	EEF1D	physical	27591049
GRSF1_HUMAN	GRSF1	physical	27591049
SND1_HUMAN	SND1	physical	27591049
KIF11_HUMAN	KIF11	physical	27591049
HORN_HUMAN	HRNR	physical	27591049
TCPE_HUMAN	CCT5	physical	27591049
HUTH_HUMAN	HAL	physical	27591049
G3BP2_HUMAN	G3BP2	physical	27591049
KCTD2_HUMAN	KCTD2	physical	27591049
CCD87_HUMAN	CCDC87	physical	27591049
PRDX1_HUMAN	PRDX1	physical	27591049
UBQL1_HUMAN	UBQLN1	physical	27591049
RS3_HUMAN	RPS3	physical	27591049
TBB4B_HUMAN	TUBB4B	physical	27591049
SF3B6_HUMAN	SF3B6	physical	27591049
EIF3I_HUMAN	EIF3I	physical	27591049
TBB2B_HUMAN	TUBB2B	physical	27591049
RS17_HUMAN	RPS17	physical	27591049
K1C16_HUMAN	KRT16	physical	27591049
SERPH_HUMAN	SERPINH1	physical	27591049
TADBP_HUMAN	TARDBP	physical	27591049
TBB6_HUMAN	TUBB6	physical	27591049
XP32_HUMAN	C1orf68	physical	27591049
ATPA_HUMAN	ATP5A1	physical	27591049
GSDMA_HUMAN	GSDMA	physical	27591049
HS105_HUMAN	HSPH1	physical	27591049
EFTU_HUMAN	TUFM	physical	27591049
DNJA1_HUMAN	DNAJA1	physical	27591049
DNJB2_HUMAN	DNAJB2	physical	27591049
TCPG_HUMAN	CCT3	physical	27591049
1433E_HUMAN	YWHAE	physical	27591049
1433Z_HUMAN	YWHAZ	physical	27591049
KCTD5_HUMAN	KCTD5	physical	27591049
RL10A_HUMAN	RPL10A	physical	27591049
ROAA_HUMAN	HNRNPAB	physical	27591049
DNJA2_HUMAN	DNAJA2	physical	27591049
EIF3H_HUMAN	EIF3H	physical	27591049
TRIP6_HUMAN	TRIP6	physical	27591049
NUCL_HUMAN	NCL	physical	27591049
ACTB_HUMAN	ACTB	physical	27591049
RS7_HUMAN	RPS7	physical	27591049
TBB3_HUMAN	TUBB3	physical	27591049
YBOX3_HUMAN	YBX3	physical	27591049
K1C9_HUMAN	KRT9	physical	27591049
IF4B_HUMAN	EIF4B	physical	27591049
RU2A_HUMAN	SNRPA1	physical	27591049
HNRH1_HUMAN	HNRNPH1	physical	27591049
E2F7_HUMAN	E2F7	physical	27591049
DSG1_HUMAN	DSG1	physical	27591049
RAN_HUMAN	RAN	physical	27591049
TBA1C_HUMAN	TUBA1C	physical	27591049
TERA_HUMAN	VCP	physical	27591049
PRS10_HUMAN	PSMC6	physical	27591049
PRS6A_HUMAN	PSMC3	physical	27591049
P3C2B_HUMAN	PIK3C2B	physical	27591049
CO6A5_HUMAN	COL6A5	physical	27591049
RS27A_HUMAN	RPS27A	physical	27591049
CATA_HUMAN	CAT	physical	27591049
RL22_HUMAN	RPL22	physical	27591049
RL11_HUMAN	RPL11	physical	27591049
ILK_HUMAN	ILK	physical	27591049
C1TM_HUMAN	MTHFD1L	physical	27591049
RL12_HUMAN	RPL12	physical	27591049
MERL_HUMAN	NF2	physical	27591049
NS1BP_HUMAN	IVNS1ABP	physical	27591049
IF2A_HUMAN	EIF2S1	physical	27591049
PGAM5_HUMAN	PGAM5	physical	27591049
PDIA6_HUMAN	PDIA6	physical	27591049
C1QBP_HUMAN	C1QBP	physical	27591049
ERH_HUMAN	ERH	physical	27591049
RM13_HUMAN	MRPL13	physical	27591049
ALBU_HUMAN	ALB	physical	27591049
HSP7C_HUMAN	HSPA8	physical	27591049
ENOB_HUMAN	ENO3	physical	27591049
ACTZ_HUMAN	ACTR1A	physical	27591049
ATPB_HUMAN	ATP5B	physical	27591049
RACK1_HUMAN	GNB2L1	physical	27591049
ECM1_HUMAN	ECM1	physical	27591049
CH60_HUMAN	HSPD1	physical	27591049
EIF3B_HUMAN	EIF3B	physical	27591049
PRS7_HUMAN	PSMC2	physical	27591049
NOP2_HUMAN	NOP2	physical	27591049
ICLN_HUMAN	CLNS1A	physical	27591049
FUS_HUMAN	FUS	physical	27591049
LEG3_HUMAN	LGALS3	physical	27591049
DSC1_HUMAN	DSC1	physical	27591049
METK2_HUMAN	MAT2A	physical	27591049
SF3B2_HUMAN	SF3B2	physical	27591049
PPIB_HUMAN	PPIB	physical	27591049
ELAV1_HUMAN	ELAVL1	physical	27591049
DIM1_HUMAN	DIMT1	physical	27591049
ERLN2_HUMAN	ERLIN2	physical	27591049
MEP50_HUMAN	WDR77	physical	27591049
MOB1B_HUMAN	MOB1B	physical	27591049
SPIN3_HUMAN	SPIN3	physical	27591049
CTRO_HUMAN	CIT	physical	27591049
RSMN_HUMAN	SNRPN	physical	27591049
RL27_HUMAN	RPL27	physical	27591049
SF3B3_HUMAN	SF3B3	physical	27591049
RM12_HUMAN	MRPL12	physical	27591049
TBB5_HUMAN	TUBB	physical	27591049
HNRDL_HUMAN	HNRNPDL	physical	27591049
SPB12_HUMAN	SERPINB12	physical	27591049
RTCB_HUMAN	RTCB	physical	27591049
M3K7_HUMAN	MAP3K7	physical	27591049
SPS2L_HUMAN	SPATS2L	physical	27591049
K22E_HUMAN	KRT2	physical	27591049
HNRPK_HUMAN	HNRNPK	physical	27591049
DDB1_HUMAN	DDB1	physical	27591049
PSMD4_HUMAN	PSMD4	physical	27591049
SF3A1_HUMAN	SF3A1	physical	27591049
4F2_HUMAN	SLC3A2	physical	27591049
TBB4A_HUMAN	TUBB4A	physical	27591049
PSB5_HUMAN	PSMB5	physical	27591049
PSMD2_HUMAN	PSMD2	physical	27591049
DESP_HUMAN	DSP	physical	27591049
HNRPM_HUMAN	HNRNPM	physical	27591049
DOC10_HUMAN	DOCK10	physical	27591049
CDSN_HUMAN	CDSN	physical	27591049
SYMC_HUMAN	MARS	physical	27591049
RUXF_HUMAN	SNRPF	physical	27591049
PSA7_HUMAN	PSMA7	physical	27591049
K2C80_HUMAN	KRT80	physical	27591049
AT1A1_HUMAN	ATP1A1	physical	27591049
S10AE_HUMAN	S100A14	physical	27591049
EIF3K_HUMAN	EIF3K	physical	27591049
FA98B_HUMAN	FAM98B	physical	27591049
MCM7_HUMAN	MCM7	physical	27591049
K2C72_HUMAN	KRT72	physical	27591049
EF2_HUMAN	EEF2	physical	27591049
MPCP_HUMAN	SLC25A3	physical	27591049
K2C5_HUMAN	KRT5	physical	27591049
RM46_HUMAN	MRPL46	physical	27591049
SYK_HUMAN	KARS	physical	27591049
WDR5_HUMAN	WDR5	physical	27591049
OTUD4_HUMAN	OTUD4	physical	27591049
STAU1_HUMAN	STAU1	physical	27591049
LA_HUMAN	SSB	physical	27591049
FILA2_HUMAN	FLG2	physical	27591049
RS26_HUMAN	RPS26	physical	27591049
CAZA1_HUMAN	CAPZA1	physical	27591049
RL18A_HUMAN	RPL18A	physical	27591049
RM39_HUMAN	MRPL39	physical	27591049
PABP1_HUMAN	PABPC1	physical	27591049
PPM1B_HUMAN	PPM1B	physical	27591049
DJB11_HUMAN	DNAJB11	physical	27591049
SYQ_HUMAN	QARS	physical	27591049
UBP15_HUMAN	USP15	physical	27591049
RSSA_HUMAN	RPSA	physical	27591049
TGM3_HUMAN	TGM3	physical	27591049
TAB1_HUMAN	TAB1	physical	27591049
SMD1_HUMAN	SNRPD1	physical	27591049
IF4A2_HUMAN	EIF4A2	physical	27591049
ATD3A_HUMAN	ATAD3A	physical	27591049
SPIN1_HUMAN	SPIN1	physical	27591049
RM43_HUMAN	MRPL43	physical	27591049
SNUT1_HUMAN	SART1	physical	27591049
PYRG1_HUMAN	CTPS1	physical	27591049
K2C71_HUMAN	KRT71	physical	27591049
ADT2_HUMAN	SLC25A5	physical	27591049
HBB_HUMAN	HBB	physical	27591049
LAT1_HUMAN	SLC7A5	physical	27591049
HS90B_HUMAN	HSP90AB1	physical	27591049
SFXN3_HUMAN	SFXN3	physical	27591049
RL13_HUMAN	RPL13	physical	27591049
MYOME_HUMAN	PDE4DIP	physical	27591049
DDX3X_HUMAN	DDX3X	physical	27591049
SMD3_HUMAN	SNRPD3	physical	27591049
RL35A_HUMAN	RPL35A	physical	27591049
SPB3_HUMAN	SERPINB3	physical	27591049
CMC2_HUMAN	SLC25A13	physical	27591049
OGT1_HUMAN	OGT	physical	27591049
CK084_HUMAN	C11orf84	physical	27591049
SYRC_HUMAN	RARS	physical	27591049
TGM1_HUMAN	TGM1	physical	27591049
RS3A_HUMAN	RPS3A	physical	27591049
PSA6_HUMAN	PSMA6	physical	27591049
TIM21_HUMAN	TIMM21	physical	27591049
AT1A4_HUMAN	ATP1A4	physical	27591049
1433T_HUMAN	YWHAQ	physical	27591049
LYSC_HUMAN	LYZ	physical	27591049
SSRD_HUMAN	SSR4	physical	27591049
RL31_HUMAN	RPL31	physical	27591049
CDC37_HUMAN	CDC37	physical	27591049
RM04_HUMAN	MRPL4	physical	27591049
DHCR7_HUMAN	DHCR7	physical	27591049
ARGI1_HUMAN	ARG1	physical	27591049
TMM33_HUMAN	TMEM33	physical	27591049
PRP31_HUMAN	PRPF31	physical	27591049
ECHB_HUMAN	HADHB	physical	27591049
RM03_HUMAN	MRPL3	physical	27591049
ST38L_HUMAN	STK38L	physical	27591049
TCPH_HUMAN	CCT7	physical	27591049
S10A9_HUMAN	S100A9	physical	27591049
PPM1A_HUMAN	PPM1A	physical	27591049
RL7A_HUMAN	RPL7A	physical	27591049
GHC1_HUMAN	SLC25A22	physical	27591049
RS27_HUMAN	RPS27	physical	27591049
RS24_HUMAN	RPS24	physical	27591049
XPO2_HUMAN	CSE1L	physical	27591049
PSA3_HUMAN	PSMA3	physical	27591049
K1C14_HUMAN	KRT14	physical	27591049
K2C1_HUMAN	KRT1	physical	27591049
RS11_HUMAN	RPS11	physical	27591049
DYHC1_HUMAN	DYNC1H1	physical	27591049
PSA4_HUMAN	PSMA4	physical	27591049
RL5_HUMAN	RPL5	physical	27591049
F263_HUMAN	PFKFB3	physical	27591049
DHX9_HUMAN	DHX9	physical	27591049
RS15A_HUMAN	RPS15A	physical	27591049
EIF3F_HUMAN	EIF3F	physical	27591049
IF2B_HUMAN	EIF2S2	physical	27591049
RM02_HUMAN	MRPL2	physical	27591049
RS20_HUMAN	RPS20	physical	27591049
RS15_HUMAN	RPS15	physical	27591049
DX39B_HUMAN	DDX39B	physical	27591049
RL9_HUMAN	RPL9	physical	27591049
LCN1_HUMAN	LCN1	physical	27591049
ROA1_HUMAN	HNRNPA1	physical	27591049
MYH9_HUMAN	MYH9	physical	27591049
ACTY_HUMAN	ACTR1B	physical	27591049
RL36_HUMAN	RPL36	physical	27591049
ANFY1_HUMAN	ANKFY1	physical	27591049
SPF27_HUMAN	BCAS2	physical	27591049
KPRP_HUMAN	KPRP	physical	27591049
PRKDC_HUMAN	PRKDC	physical	27591049
RM49_HUMAN	MRPL49	physical	27591049
RL32_HUMAN	RPL32	physical	27591049
RS9_HUMAN	RPS9	physical	27591049
RS29_HUMAN	RPS29	physical	27591049
PRS4_HUMAN	PSMC1	physical	27591049
SYVC_HUMAN	VARS	physical	27591049
RS8_HUMAN	RPS8	physical	27591049
RL15_HUMAN	RPL15	physical	27591049
RL19_HUMAN	RPL19	physical	27591049
RM44_HUMAN	MRPL44	physical	27591049
RM37_HUMAN	MRPL37	physical	27591049
RS25_HUMAN	RPS25	physical	27591049
NONO_HUMAN	NONO	physical	27591049
K2C6A_HUMAN	KRT6A	physical	27591049
RN213_HUMAN	RNF213	physical	27591049
PSD13_HUMAN	PSMD13	physical	27591049
PABP4_HUMAN	PABPC4	physical	27591049
SMD2_HUMAN	SNRPD2	physical	27591049
KCD17_HUMAN	KCTD17	physical	27591049
IPO8_HUMAN	IPO8	physical	27591049
K1C27_HUMAN	KRT27	physical	27591049
RM22_HUMAN	MRPL22	physical	27591049
PCBP2_HUMAN	PCBP2	physical	27591049
RL27A_HUMAN	RPL27A	physical	27591049
FLNA_HUMAN	FLNA	physical	27591049
EIF3L_HUMAN	EIF3L	physical	27591049
SYIC_HUMAN	IARS	physical	27591049
SF3B4_HUMAN	SF3B4	physical	27591049
SRP14_HUMAN	SRP14	physical	27591049
DRG1_HUMAN	DRG1	physical	27591049
RO52_HUMAN	TRIM21	physical	27591049
CYTA_HUMAN	CSTA	physical	27591049
TCPB_HUMAN	CCT2	physical	27591049
LX12B_HUMAN	ALOX12B	physical	27591049
RM15_HUMAN	MRPL15	physical	27591049
MSH6_HUMAN	MSH6	physical	27591049
RBM10_HUMAN	RBM10	physical	27591049
RM01_HUMAN	MRPL1	physical	27591049
RS2_HUMAN	RPS2	physical	27591049
ABLM1_HUMAN	ABLIM1	physical	27591049
LEG7_HUMAN	LGALS7	physical	27591049
PYR1_HUMAN	CAD	physical	27591049
PRP16_HUMAN	DHX38	physical	27591049
BMS1_HUMAN	BMS1	physical	27591049
FABP5_HUMAN	FABP5	physical	27591049
PRS8_HUMAN	PSMC5	physical	27591049
PSD11_HUMAN	PSMD11	physical	27591049
SYDC_HUMAN	DARS	physical	27591049
PKP1_HUMAN	PKP1	physical	27591049
PCNA_HUMAN	PCNA	physical	27591049
ZA2G_HUMAN	AZGP1	physical	27591049
PSB1_HUMAN	PSMB1	physical	27591049
SRRM2_HUMAN	SRRM2	physical	27591049
HNRPL_HUMAN	HNRNPL	physical	27591049
RL14_HUMAN	RPL14	physical	27591049
PLAK_HUMAN	JUP	physical	27591049
SBSN_HUMAN	SBSN	physical	27591049
SYEP_HUMAN	EPRS	physical	27591049
PSB6_HUMAN	PSMB6	physical	27591049
RL34_HUMAN	RPL34	physical	27591049
TCPZ_HUMAN	CCT6A	physical	27591049
PSA1_HUMAN	PSMA1	physical	27591049
SRSF6_HUMAN	SRSF6	physical	27591049
PRC2A_HUMAN	PRRC2A	physical	27591049
ILF2_HUMAN	ILF2	physical	27591049
RL28_HUMAN	RPL28	physical	27591049
AFG32_HUMAN	AFG3L2	physical	27591049
SRSF5_HUMAN	SRSF5	physical	27591049
ROCK1_HUMAN	ROCK1	physical	27591049
EIF3E_HUMAN	EIF3E	physical	27591049
DCTN1_HUMAN	DCTN1	physical	27591049
CEPT1_HUMAN	CEPT1	physical	27591049
BAG2_HUMAN	BAG2	physical	27591049
HNRPQ_HUMAN	SYNCRIP	physical	27591049
POF1B_HUMAN	POF1B	physical	27591049
CCAR2_HUMAN	CCAR2	physical	27591049
TCPD_HUMAN	CCT4	physical	27591049
TCPA_HUMAN	TCP1	physical	27591049
SF3B1_HUMAN	SF3B1	physical	27591049
SPTB2_HUMAN	SPTBN1	physical	27591049
LMNA_HUMAN	LMNA	physical	27591049
PSMD1_HUMAN	PSMD1	physical	27591049
K2C6B_HUMAN	KRT6B	physical	27591049
HNRPU_HUMAN	HNRNPU	physical	27591049
RS4X_HUMAN	RPS4X	physical	27591049
RL3_HUMAN	RPL3	physical	27591049
CHERP_HUMAN	CHERP	physical	27591049
RM21_HUMAN	MRPL21	physical	27591049
GALK1_HUMAN	GALK1	physical	27591049
EF1G_HUMAN	EEF1G	physical	27591049
CAPR1_HUMAN	CAPRIN1	physical	27591049
MAP1B_HUMAN	MAP1B	physical	27591049
RL8_HUMAN	RPL8	physical	27591049
MYO1B_HUMAN	MYO1B	physical	27591049
RUVB2_HUMAN	RUVBL2	physical	27591049
MVP_HUMAN	MVP	physical	27591049
HNRPR_HUMAN	HNRNPR	physical	27591049
ILF3_HUMAN	ILF3	physical	27591049
TCPQ_HUMAN	CCT8	physical	27591049
EIF3C_HUMAN	EIF3C	physical	27591049
SPF45_HUMAN	RBM17	physical	27591049
EIF3A_HUMAN	EIF3A	physical	27591049
HDX_HUMAN	HDX	physical	27591049
UBIM_HUMAN	FAU	physical	27591049
KRBA2_HUMAN	KRBA2	physical	27591049
RL35_HUMAN	RPL35	physical	27591049
RM11_HUMAN	MRPL11	physical	27591049
ANM1_HUMAN	PRMT1	physical	27591049
RM18_HUMAN	MRPL18	physical	27591049
RL29_HUMAN	RPL29	physical	27591049
RL7_HUMAN	RPL7	physical	27591049
PSB2_HUMAN	PSMB2	physical	27591049
RT30_HUMAN	MRPS30	physical	27591049
RL17_HUMAN	RPL17	physical	27591049
CYBP_HUMAN	CACYBP	physical	27591049
RL18_HUMAN	RPL18	physical	27591049
ICT1_HUMAN	ICT1	physical	27591049
IF2B2_HUMAN	IGF2BP2	physical	27591049
DDX5_HUMAN	DDX5	physical	27591049
SGT1_HUMAN	SUGT1	physical	27591049
EIF3M_HUMAN	EIF3M	physical	27591049
FMR1_HUMAN	FMR1	physical	27591049
SR140_HUMAN	U2SURP	physical	27591049
K1C19_HUMAN	KRT19	physical	27591049
RS16_HUMAN	RPS16	physical	27591049
RL23A_HUMAN	RPL23A	physical	27591049
RS10_HUMAN	RPS10	physical	27591049
RS18_HUMAN	RPS18	physical	27591049
HS90A_HUMAN	HSP90AA1	physical	27591049
JAK1_HUMAN	JAK1	physical	27591049
RM47_HUMAN	MRPL47	physical	27591049
RBMX_HUMAN	RBMX	physical	27591049
UN45A_HUMAN	UNC45A	physical	27591049
DHX30_HUMAN	DHX30	physical	27591049
RT18A_HUMAN	MRPS18A	physical	27591049
RS13_HUMAN	RPS13	physical	27591049
PARP1_HUMAN	PARP1	physical	27591049
DDX17_HUMAN	DDX17	physical	27591049
PSMD3_HUMAN	PSMD3	physical	27591049
AIFM1_HUMAN	AIFM1	physical	27591049
CFA44_HUMAN	CFAP44	physical	27591049
RL21_HUMAN	RPL21	physical	27591049
MATR3_HUMAN	MATR3	physical	27591049
SRSF1_HUMAN	SRSF1	physical	27591049
DHX15_HUMAN	DHX15	physical	27591049
HNRL1_HUMAN	HNRNPUL1	physical	27591049
PRP19_HUMAN	PRPF19	physical	27591049
RM20_HUMAN	MRPL20	physical	27591049
RL6_HUMAN	RPL6	physical	27591049
H10_HUMAN	H1F0	physical	27591049
TR150_HUMAN	THRAP3	physical	27591049
PRC2C_HUMAN	PRRC2C	physical	27591049
DDX47_HUMAN	DDX47	physical	27591049
UBP10_HUMAN	USP10	physical	27591049
IF2G_HUMAN	EIF2S3	physical	27591049
MAGB2_HUMAN	MAGEB2	physical	27591049
RL13A_HUMAN	RPL13A	physical	27591049
RL37A_HUMAN	RPL37A	physical	27591049
KRT34_HUMAN	KRT34	physical	27591049
RS4Y1_HUMAN	RPS4Y1	physical	27591049
BASI_HUMAN	BSG	physical	27591049
CALL5_HUMAN	CALML5	physical	27591049
RM17_HUMAN	MRPL17	physical	27591049
FACR1_HUMAN	FAR1	physical	27591049
RM16_HUMAN	MRPL16	physical	27591049
H14_HUMAN	HIST1H1E	physical	27591049
CDC5L_HUMAN	CDC5L	physical	27591049
PTBP1_HUMAN	PTBP1	physical	27591049
MAGD2_HUMAN	MAGED2	physical	27591049
PLEC_HUMAN	PLEC	physical	27591049
H1X_HUMAN	H1FX	physical	27591049
BCLF1_HUMAN	BCLAF1	physical	27591049
ODR4_HUMAN	C1orf27	physical	27591049
HNRPC_HUMAN	HNRNPC	physical	27591049
K1C13_HUMAN	KRT13	physical	27591049
K2C7_HUMAN	KRT7	physical	27591049
TRA2B_HUMAN	TRA2B	physical	27591049
MYL1_HUMAN	MYL1	physical	27591049
VIME_HUMAN	VIM	physical	27591049
H2A1H_HUMAN	HIST1H2AH	physical	27591049
U5S1_HUMAN	EFTUD2	physical	27591049
DJC13_HUMAN	DNAJC13	physical	27591049
H12_HUMAN	HIST1H1C	physical	27591049
H2B1K_HUMAN	HIST1H2BK	physical	27591049
H2B1B_HUMAN	HIST1H2BB	physical	27591049
KRT84_HUMAN	KRT84	physical	27591049

Drug and Disease Associations

Kegg Disease
H00827	Brooke-Spiegler syndrome
H00828	Familial cylindromatosis
H00829	Multiple familial trichoepithelioma
OMIM Disease
132700	Cylindromatosis, familial (FCYL)
601606	Multiple familial trichoepithelioma 1 (MFT1)
605041	Brooke-Spiegler syndrome (BRSS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CYLD_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Regulation of the deubiquitinating enzyme CYLD by IkappaB kinasegamma-dependent phosphorylation."; Reiley W., Zhang M., Wu X., Granger E., Sun S.C.; Mol. Cell. Biol. 25:3886-3895(2005). Cited for: FUNCTION, INTERACTION WITH TRAF2, ENZYME REGULATION, MUTAGENESIS OFSER-418; SER-422; SER-432; SER-436; SER-439; SER-441 AND SER-444, ANDPHOSPHORYLATION AT SER-418.	15870263 [Abstract]