| UniProt ID | CCAR2_HUMAN | |
|---|---|---|
| UniProt AC | Q8N163 | |
| Protein Name | Cell cycle and apoptosis regulator protein 2 | |
| Gene Name | CCAR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 923 | |
| Subcellular Localization | Nucleus . Cytoplasm . Recruited to chromatin, post-UV irradiation. Sequestered to the cytoplasm in the presence of MCC. Translocated to the cytoplasm during UV-induced apoptosis. | |
| Protein Description | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation. [PubMed: 18235501] | |
| Protein Sequence | MSQFKRQRINPLPGGRNFSGTASTSLLGPPPGLLTPPVATELSQNARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNPGQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFPQKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPRHDLPPYRVHLTPYTVDSPICDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLHHPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYRCCMLFVDDMAEPRETPEHPLKQIKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQTGIDLSGCTKWWRFAEFQYLQPGPPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEAAPPTQEAQGETEPTEQAPDALEQAADTSRRNAETPEATTQQETDTDLPEAPPPPLEPAVIARPGCVNLSLHGIVEDRRPKERISFEVMVLAELFLEMLQRDFGYRVYKMLLSLPEKVVSPPEPEKEEAAKEEATKEEEAIKEEVVKEPKDEAQNEGPATESEAPLKEDGLLPKPLSSGGEEEEKPRGEASEDLCEMALDPELLLLRDDGEEEFAGAKLEDSEVRSVASNQSEMEFSSLQDMPKELDPSAVLPLDCLLAFVFFDANWCGYLHRRDLERILLTLGIRLSAEQAKQLVSRVVTQNICQYRSLQYSRQEGLDGGLPEEVLFGNLDLLPPPGKSTKPGAAPTEHKALVSHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTLAAEMQELRVRLAEAEETARTAERQKSQLQRLLQELRRRLTPLQLEIQRVVEKADSWVEKEEPAPSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 16 | Methylation | INPLPGGRNFSGTAS CCCCCCCCCCCCCCC | - | ||
| 19 | Phosphorylation | LPGGRNFSGTASTSL CCCCCCCCCCCCCCC | 26434776 | ||
| 21 | Phosphorylation | GGRNFSGTASTSLLG CCCCCCCCCCCCCCC | 26434776 | ||
| 23 | Phosphorylation | RNFSGTASTSLLGPP CCCCCCCCCCCCCCC | 26434776 | ||
| 24 | Phosphorylation | NFSGTASTSLLGPPP CCCCCCCCCCCCCCC | 24173317 | ||
| 25 | Phosphorylation | FSGTASTSLLGPPPG CCCCCCCCCCCCCCC | 24173317 | ||
| 35 | Phosphorylation | GPPPGLLTPPVATEL CCCCCCCCCCHHHHH | 26055452 | ||
| 40 | Phosphorylation | LLTPPVATELSQNAR CCCCCHHHHHHHHHH | 28450419 | ||
| 43 | Phosphorylation | PPVATELSQNARHLQ CCHHHHHHHHHHHCC | 29978859 | ||
| 54 | Ubiquitination | RHLQGGEKQRVFTGI HHCCCCCCHHHHHHH | 27667366 | ||
| 54 | 2-Hydroxyisobutyrylation | RHLQGGEKQRVFTGI HHCCCCCCHHHHHHH | - | ||
| 93 | Ubiquitination | RLPQLGEKVLVKAAY CCCCCCCEEEEEECC | 23000965 | ||
| 93 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 93 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 97 | Ubiquitination | LGEKVLVKAAYNPGQ CCCEEEEEECCCCCC | 23000965 | ||
| 100 | Phosphorylation | KVLVKAAYNPGQAVP EEEEEECCCCCCCCC | 28152594 | ||
| 112 | Acetylation | AVPWNAVKVQTLSNQ CCCCCCEEEEECCCC | 24126058 | ||
| 112 | Ubiquitination | AVPWNAVKVQTLSNQ CCCCCCEEEEECCCC | 21906983 | ||
| 112 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 112 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 115 | Phosphorylation | WNAVKVQTLSNQPLL CCCEEEEECCCCCCC | 28464451 | ||
| 117 | Phosphorylation | AVKVQTLSNQPLLKS CEEEEECCCCCCCCC | 29978859 | ||
| 123 | Methylation | LSNQPLLKSPAPPLL CCCCCCCCCCCCCEE | 24129315 | ||
| 123 | Ubiquitination | LSNQPLLKSPAPPLL CCCCCCCCCCCCCEE | 21906983 | ||
| 123 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 123 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 124 | Phosphorylation | SNQPLLKSPAPPLLH CCCCCCCCCCCCEEE | 29255136 | ||
| 138 | Methylation | HVAALGQKQGILGAQ EHHHHCCCCCCCCCC | - | ||
| 138 | Acetylation | HVAALGQKQGILGAQ EHHHHCCCCCCCCCC | 7407619 | ||
| 138 | Ubiquitination | HVAALGQKQGILGAQ EHHHHCCCCCCCCCC | 23000965 | ||
| 162 | Acetylation | IPPLFPQKPLSLFQT CCCCCCCCCCHHHHC | 25953088 | ||
| 180 | Dimethylation | LHLSHLNRFPARGPH EEHHHHHCCCCCCCC | - | ||
| 180 | Methylation | LHLSHLNRFPARGPH EEHHHHHCCCCCCCC | 24129315 | ||
| 184 | Methylation | HLNRFPARGPHGRLD HHHCCCCCCCCCCCC | - | ||
| 195 | Phosphorylation | GRLDQGRSDDYDSKK CCCCCCCCCCCCHHH | 28985074 | ||
| 198 | Phosphorylation | DQGRSDDYDSKKRKQ CCCCCCCCCHHHHHH | - | ||
| 201 | Ubiquitination | RSDDYDSKKRKQRAG CCCCCCHHHHHHHCC | 33845483 | ||
| 206 | Methylation | DSKKRKQRAGGEPWG CHHHHHHHCCCCCCC | - | ||
| 215 | Methylation | GGEPWGAKKPRHDLP CCCCCCCCCCCCCCC | 19608861 | ||
| 215 | Acetylation | GGEPWGAKKPRHDLP CCCCCCCCCCCCCCC | 19608861 | ||
| 215 | Ubiquitination | GGEPWGAKKPRHDLP CCCCCCCCCCCCCCC | 33845483 | ||
| 218 | Methylation | PWGAKKPRHDLPPYR CCCCCCCCCCCCCCE | - | ||
| 232 | Phosphorylation | RVHLTPYTVDSPICD EEECCCCCCCCCHHH | 28348404 | ||
| 235 | Phosphorylation | LTPYTVDSPICDFLE CCCCCCCCCHHHHHH | 23898821 | ||
| 247 | Ubiquitination | FLELQRRYRSLLVPS HHHHHHHHHHHCCCC | 21963094 | ||
| 269 | Ubiquitination | SWLSAFPLSQPFSLH HHHHCCCCCCCCCCC | 23000965 | ||
| 285 | Phosphorylation | PSRIQVSSEKEAAPD CCCEEECCCCCCCCC | 22468782 | ||
| 287 | Acetylation | RIQVSSEKEAAPDAG CEEECCCCCCCCCCC | 87865 | ||
| 287 | Ubiquitination | RIQVSSEKEAAPDAG CEEECCCCCCCCCCC | 21906983 | ||
| 287 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 287 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 302 | Phosphorylation | AEPITADSDPAYSSK CCCCCCCCCHHHCCC | 21601212 | ||
| 304 | Ubiquitination | PITADSDPAYSSKVL CCCCCCCHHHCCCEE | 23000965 | ||
| 306 | Phosphorylation | TADSDPAYSSKVLLL CCCCCHHHCCCEEEC | 22468782 | ||
| 307 | Ubiquitination | ADSDPAYSSKVLLLS CCCCHHHCCCEEECC | 21890473 | ||
| 309 | Ubiquitination | SDPAYSSKVLLLSSP CCHHHCCCEEECCCC | 23000965 | ||
| 309 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 309 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 313 | Ubiquitination | YSSKVLLLSSPGLEE HCCCEEECCCCCHHH | 23000965 | ||
| 314 | Phosphorylation | SSKVLLLSSPGLEEL CCCEEECCCCCHHHH | 21601212 | ||
| 315 | Phosphorylation | SKVLLLSSPGLEELY CCEEECCCCCHHHHH | 21601212 | ||
| 322 | Phosphorylation | SPGLEELYRCCMLFV CCCHHHHHHHHHHHH | - | ||
| 344 | Ubiquitination | ETPEHPLKQIKFLLG CCCCCHHHHHHHHHC | 23000965 | ||
| 347 | Ubiquitination | EHPLKQIKFLLGRKE CCHHHHHHHHHCCCC | 23000965 | ||
| 347 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 347 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 353 | Ubiquitination | IKFLLGRKEEEAVLV HHHHHCCCCCEEEEE | 23000965 | ||
| 401 | Ubiquitination | IDLSGCTKWWRFAEF CCCCCCCCHHEEEEE | - | ||
| 410 | Phosphorylation | WRFAEFQYLQPGPPR HEEEEEEECCCCCCC | 28152594 | ||
| 454 | Phosphorylation | AAEAAPPTQEAQGET HHHHCCCCHHCCCCC | 21955146 | ||
| 461 | Phosphorylation | TQEAQGETEPTEQAP CHHCCCCCCCCCCCC | 28464451 | ||
| 464 | Phosphorylation | AQGETEPTEQAPDAL CCCCCCCCCCCCHHH | 29978859 | ||
| 477 | Phosphorylation | ALEQAADTSRRNAET HHHHHHHHHHHHCCC | 25159151 | ||
| 478 | Phosphorylation | LEQAADTSRRNAETP HHHHHHHHHHHCCCC | 25159151 | ||
| 484 | Phosphorylation | TSRRNAETPEATTQQ HHHHHCCCCCCCCCC | 25159151 | ||
| 488 | Phosphorylation | NAETPEATTQQETDT HCCCCCCCCCCCCCC | 17081983 | ||
| 489 | Phosphorylation | AETPEATTQQETDTD CCCCCCCCCCCCCCC | 28122231 | ||
| 493 | Phosphorylation | EATTQQETDTDLPEA CCCCCCCCCCCCCCC | 17081983 | ||
| 495 | Phosphorylation | TTQQETDTDLPEAPP CCCCCCCCCCCCCCC | 20058876 | ||
| 569 | Phosphorylation | SLPEKVVSPPEPEKE CCCCCCCCCCCHHHH | 29255136 | ||
| 584 | Phosphorylation | EAAKEEATKEEEAIK HHHHHHHHHHHHHHH | 26074081 | ||
| 585 | Acetylation | AAKEEATKEEEAIKE HHHHHHHHHHHHHHH | 30587997 | ||
| 591 | Sumoylation | TKEEEAIKEEVVKEP HHHHHHHHHHHHCCC | - | ||
| 591 | Sumoylation | TKEEEAIKEEVVKEP HHHHHHHHHHHHCCC | 25406032 | ||
| 591 | Ubiquitination | TKEEEAIKEEVVKEP HHHHHHHHHHHHCCC | 33845483 | ||
| 599 | Sumoylation | EEVVKEPKDEAQNEG HHHHCCCCHHHHCCC | - | ||
| 599 | Ubiquitination | EEVVKEPKDEAQNEG HHHHCCCCHHHHCCC | 33845483 | ||
| 609 | Phosphorylation | AQNEGPATESEAPLK HHCCCCCCCCCCCCC | 30108239 | ||
| 611 | Phosphorylation | NEGPATESEAPLKED CCCCCCCCCCCCCCC | 30108239 | ||
| 616 | Ubiquitination | TESEAPLKEDGLLPK CCCCCCCCCCCCCCC | 29967540 | ||
| 623 | Ubiquitination | KEDGLLPKPLSSGGE CCCCCCCCCCCCCCC | 29967540 | ||
| 626 | Phosphorylation | GLLPKPLSSGGEEEE CCCCCCCCCCCCCCC | 29255136 | ||
| 627 | Phosphorylation | LLPKPLSSGGEEEEK CCCCCCCCCCCCCCC | 29255136 | ||
| 627 | Ubiquitination | LLPKPLSSGGEEEEK CCCCCCCCCCCCCCC | 22817900 | ||
| 640 | Phosphorylation | EKPRGEASEDLCEMA CCCCCCCCHHHHHHH | 30278072 | ||
| 667 | Ubiquitination | EEEFAGAKLEDSEVR CCHHCCCCCCCHHHH | 21906983 | ||
| 667 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 667 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 671 | Phosphorylation | AGAKLEDSEVRSVAS CCCCCCCHHHHHHHC | 29255136 | ||
| 674 | Phosphorylation | KLEDSEVRSVASNQS CCCCHHHHHHHCCCC | 32142685 | ||
| 675 | Phosphorylation | LEDSEVRSVASNQSE CCCHHHHHHHCCCCH | 29255136 | ||
| 677 | Phosphorylation | DSEVRSVASNQSEME CHHHHHHHCCCCHHC | 32142685 | ||
| 678 | Phosphorylation | SEVRSVASNQSEMEF HHHHHHHCCCCHHCH | 29255136 | ||
| 680 | Phosphorylation | VRSVASNQSEMEFSS HHHHHCCCCHHCHHH | 32142685 | ||
| 681 | Phosphorylation | RSVASNQSEMEFSSL HHHHCCCCHHCHHHH | 29255136 | ||
| 686 | Phosphorylation | NQSEMEFSSLQDMPK CCCHHCHHHHHCCCC | 29255136 | ||
| 687 | Phosphorylation | QSEMEFSSLQDMPKE CCHHCHHHHHCCCCC | 29255136 | ||
| 702 | Ubiquitination | LDPSAVLPLDCLLAF CCHHHHCCHHHHHHH | 21890473 | ||
| 741 | Ubiquitination | IRLSAEQAKQLVSRV CCCCHHHHHHHHHHH | 21890473 | ||
| 742 | Ubiquitination | RLSAEQAKQLVSRVV CCCHHHHHHHHHHHH | 21890473 | ||
| 742 | 2-Hydroxyisobutyrylation | RLSAEQAKQLVSRVV CCCHHHHHHHHHHHH | - | ||
| 742 | Malonylation | RLSAEQAKQLVSRVV CCCHHHHHHHHHHHH | 26320211 | ||
| 742 | Acetylation | RLSAEQAKQLVSRVV CCCHHHHHHHHHHHH | 25953088 | ||
| 742 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 742 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 756 | Phosphorylation | VTQNICQYRSLQYSR HHHHHHHHHCHHHHH | 25690035 | ||
| 788 | Ubiquitination | DLLPPPGKSTKPGAA CCCCCCCCCCCCCCC | 29967540 | ||
| 790 | Ubiquitination | LPPPGKSTKPGAAPT CCCCCCCCCCCCCCC | 33845483 | ||
| 791 | Ubiquitination | PPPGKSTKPGAAPTE CCCCCCCCCCCCCCC | 33845483 | ||
| 792 | Ubiquitination | PPGKSTKPGAAPTEH CCCCCCCCCCCCCCC | 21890473 | ||
| 797 | Phosphorylation | TKPGAAPTEHKALVS CCCCCCCCCCCHHHC | 24719451 | ||
| 799 | Ubiquitination | PGAAPTEHKALVSHN CCCCCCCCCHHHCCC | 21890473 | ||
| 800 | Ubiquitination | GAAPTEHKALVSHNG CCCCCCCCHHHCCCC | 29967540 | ||
| 804 | Phosphorylation | TEHKALVSHNGSLIN CCCCHHHCCCCCEEE | 28464451 | ||
| 808 | Phosphorylation | ALVSHNGSLINVGSL HHHCCCCCEEEHHHH | 30266825 | ||
| 814 | Phosphorylation | GSLINVGSLLQRAEQ CCEEEHHHHHHHHHH | 30266825 | ||
| 815 | Ubiquitination | SLINVGSLLQRAEQQ CEEEHHHHHHHHHHC | 22817900 | ||
| 824 | Phosphorylation | QRAEQQDSGRLYLEN HHHHHCCCCCEEECC | 30266825 | ||
| 828 | Phosphorylation | QQDSGRLYLENKIHT HCCCCCEEECCCEEE | 30266825 | ||
| 831 | Ubiquitination | SGRLYLENKIHTLEL CCCEEECCCEEEEEE | 21890473 | ||
| 832 | Ubiquitination | GRLYLENKIHTLELK CCEEECCCEEEEEEE | 22817900 | ||
| 832 | Acetylation | GRLYLENKIHTLELK CCEEECCCEEEEEEE | 25953088 | ||
| 832 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 832 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 838 | Ubiquitination | NKIHTLELKLEESHN CCEEEEEEEHHHHCC | 33845483 | ||
| 839 | Ubiquitination | KIHTLELKLEESHNR CEEEEEEEHHHHCCC | 22817900 | ||
| 839 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 839 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 842 | Ubiquitination | TLELKLEESHNRFSA EEEEEHHHHCCCCCH | 24816145 | ||
| 854 | Ubiquitination | FSATEVTNKTLAAEM CCHHHHCCHHHHHHH | 22817900 | ||
| 855 | Ubiquitination | SATEVTNKTLAAEMQ CHHHHCCHHHHHHHH | 21906983 | ||
| 855 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 855 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 865 | Methylation | AAEMQELRVRLAEAE HHHHHHHHHHHHHHH | - | ||
| 876 | Ubiquitination | AEAEETARTAERQKS HHHHHHHHHHHHHHH | 22817900 | ||
| 881 | Ubiquitination | TARTAERQKSQLQRL HHHHHHHHHHHHHHH | 24816145 | ||
| 882 | Ubiquitination | ARTAERQKSQLQRLL HHHHHHHHHHHHHHH | 24816145 | ||
| 897 | Phosphorylation | QELRRRLTPLQLEIQ HHHHHHCCHHHHHHH | 30266825 | ||
| 909 | Acetylation | EIQRVVEKADSWVEK HHHHHHHHHHHHHHC | 23954790 | ||
| 909 | Ubiquitination | EIQRVVEKADSWVEK HHHHHHHHHHHHHHC | - | ||
| 912 | Phosphorylation | RVVEKADSWVEKEEP HHHHHHHHHHHCCCC | 24505115 | ||
| 915 | Ubiquitination | EKADSWVEKEEPAPS HHHHHHHHCCCCCCC | 33845483 | ||
| 916 | Ubiquitination | KADSWVEKEEPAPSN HHHHHHHCCCCCCCC | 22817900 | ||
| 916 | Acetylation | KADSWVEKEEPAPSN HHHHHHHCCCCCCCC | 26051181 | ||
| 916 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 922 | Phosphorylation | EKEEPAPSN------ HCCCCCCCC------ | 21712546 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCAR2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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