| UniProt ID | HAOX1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UJM8 | |
| Protein Name | Hydroxyacid oxidase 1 | |
| Gene Name | HAO1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 370 | |
| Subcellular Localization | Peroxisome. | |
| Protein Description | Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.. | |
| Protein Sequence | MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | LPKSIYDYYRSGAND CCHHHHHHHHCCCCC | 5.47 | - | |
| 50 | Phosphorylation | AFSRWKLYPRMLRNV HHHHHHHHHHHHHHH | 5.76 | - | |
| 60 | Phosphorylation | MLRNVAETDLSTSVL HHHHHHHCCCCCCCC | 32.28 | 25072903 | |
| 63 | Phosphorylation | NVAETDLSTSVLGQR HHHHCCCCCCCCCCC | 22.80 | 25072903 | |
| 64 | Phosphorylation | VAETDLSTSVLGQRV HHHCCCCCCCCCCCC | 30.10 | 25072903 | |
| 65 | Phosphorylation | AETDLSTSVLGQRVS HHCCCCCCCCCCCCC | 16.39 | 25072903 | |
| 142 | Ubiquitination | KDREVTKKLVRQAEK CCHHHHHHHHHHHHH | 42.73 | - | |
| 153 | Ubiquitination | QAEKMGYKAIFVTVD HHHHCCCEEEEEEEC | 29.31 | - | |
| 184 | Succinylation | LPPQLRMKNFETSTL CCHHHHCCCCEEECC | 52.64 | - | |
| 184 | Succinylation | LPPQLRMKNFETSTL CCHHHHCCCCEEECC | 52.64 | - | |
| 194 | Phosphorylation | ETSTLSFSPEENFGD EEECCEECCCCCCCC | 28.20 | 28192239 | |
| 218 | Phosphorylation | KAIDPSISWEDIKWL HHHCCCCCHHHHHHH | 28.84 | 24275569 | |
| 223 | Acetylation | SISWEDIKWLRRLTS CCCHHHHHHHHHHCC | 53.12 | 20167786 | |
| 229 | Phosphorylation | IKWLRRLTSLPIVAK HHHHHHHCCCCEEEC | 26.80 | 20166139 | |
| 230 | Phosphorylation | KWLRRLTSLPIVAKG HHHHHHCCCCEEECC | 36.42 | 20166139 | |
| 358 | Phosphorylation | NVKVIDKTLVRKNPL CEEEEECHHHCCCCC | 27.08 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HAOX1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HAOX1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HAOX1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCAB2_HUMAN | KCNAB2 | physical | 26186194 | |
| KCAB2_HUMAN | KCNAB2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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