dbPTM

TBA1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBA1A_HUMAN
UniProt AC	Q71U36
Protein Name	Tubulin alpha-1A chain
Gene Name	TUBA1A
Organism	Homo sapiens (Human).
Sequence Length	451
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
Protein Sequence	MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRECISIHVGQAG --CCCEEEEEECCHH	20.50	-
16	Phosphorylation	VGQAGVQIGNACWEL ECCHHEEECHHHHHC	4.22	32142685
24	Phosphorylation	GNACWELYCLEHGIQ CHHHHHCHHHHCCCC	5.40	-
25	Neddylation	NACWELYCLEHGIQP HHHHHCHHHHCCCCC	5.86	32015554
25	Ubiquitination	NACWELYCLEHGIQP HHHHHCHHHHCCCCC	5.86	32142685
38	Phosphorylation	QPDGQMPSDKTIGGG CCCCCCCCCCCCCCC	46.53	26074081
40	Acetylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
40	Methylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
40	Ubiquitination	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
41	Phosphorylation	GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC	29.82	25463755
48	Phosphorylation	TIGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	19664994
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	29255136
54	Phosphorylation	DSFNTFFSETGAGKH CCHHHCCCCCCCCCC	30.02	25159151
56	Phosphorylation	FNTFFSETGAGKHVP HHHCCCCCCCCCCCC	31.00	23927012
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	21890473
60	Sumoylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Acetylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	19811145
60	Methylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Neddylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	32015554
60	Sumoylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	21906983
61	Methylation	SETGAGKHVPRAVFV CCCCCCCCCCEEEEE	33.62	-
61	Ubiquitination	SETGAGKHVPRAVFV CCCCCCCCCCEEEEE	33.62	27667366
64	Methylation	GAGKHVPRAVFVDLE CCCCCCCEEEEECCC	42.15	-
73	Phosphorylation	VFVDLEPTVIDEVRT EEECCCCEEEHHCCC	22.25	30108239
77	Ubiquitination	LEPTVIDEVRTGTYR CCCEEEHHCCCCCCH	23.83	21963094
80	Phosphorylation	TVIDEVRTGTYRQLF EEEHHCCCCCCHHCC	38.77	28857561
82	Phosphorylation	IDEVRTGTYRQLFHP EHHCCCCCCHHCCCH	18.21	28857561
83	Nitration	DEVRTGTYRQLFHPE HHCCCCCCHHCCCHH	9.56	-
83	Phosphorylation	DEVRTGTYRQLFHPE HHCCCCCCHHCCCHH	9.56	28857561
89	Ubiquitination	TYRQLFHPEQLITGK CCHHCCCHHHHCCCC	24.56	25015289
94	Phosphorylation	FHPEQLITGKEDAAN CCHHHHCCCCHHHHH	51.28	28152594
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	21890473
96	Sumoylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Acetylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	30582623
96	Sumoylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	21906983
103	Nitration	KEDAANNYARGHYTI CHHHHHHCCCCCCCC	9.48	-
103	Phosphorylation	KEDAANNYARGHYTI CHHHHHHCCCCCCCC	9.48	27155012
108	Nitration	NNYARGHYTIGKEII HHCCCCCCCCCHHHH	11.68	-
108	Phosphorylation	NNYARGHYTIGKEII HHCCCCCCCCCHHHH	11.68	25884760
109	Phosphorylation	NYARGHYTIGKEIID HCCCCCCCCCHHHHH	19.99	28796482
112	Ubiquitination	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	21890473
112	Sumoylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	-
112	Acetylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	18528869
112	Sumoylation	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	-
112	Ubiquitination	RGHYTIGKEIIDLVL CCCCCCCHHHHHHHH	41.72	21906983
123	Phosphorylation	DLVLDRIRKLADQCT HHHHHHHHHHHHHCC	28.91	32142685
124	Acetylation	LVLDRIRKLADQCTG HHHHHHHHHHHHCCC	45.73	15611751
124	Ubiquitination	LVLDRIRKLADQCTG HHHHHHHHHHHHCCC	45.73	21906983
128	Acetylation	RIRKLADQCTGLQGF HHHHHHHHCCCCCCE	22.51	19608861
128	Ubiquitination	RIRKLADQCTGLQGF HHHHHHHHCCCCCCE	22.51	27667366
129	Ubiquitination	IRKLADQCTGLQGFL HHHHHHHCCCCCCEE	3.16	27667366
131	Ubiquitination	KLADQCTGLQGFLVF HHHHHCCCCCCEEEE	24.51	22817900
151	Phosphorylation	GTGSGFTSLLMERLS CCCCCHHHHHHHHHC	19.76	-
158	Phosphorylation	SLLMERLSVDYGKKS HHHHHHHCCCCCCCC	21.11	28355574
161	Nitration	MERLSVDYGKKSKLE HHHHCCCCCCCCCEE	28.79	-
161	Phosphorylation	MERLSVDYGKKSKLE HHHHCCCCCCCCCEE	28.79	23911959
163	Ubiquitination	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	21890473
163	Acetylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	19608861
163	Methylation	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	19608861
163	Ubiquitination	RLSVDYGKKSKLEFS HHCCCCCCCCCEEEE	47.87	27667366
164	Ubiquitination	LSVDYGKKSKLEFSI HCCCCCCCCCEEEEE	48.75	21890473
164	Ubiquitination	LSVDYGKKSKLEFSI HCCCCCCCCCEEEEE	48.75	21906983
165	Phosphorylation	SVDYGKKSKLEFSIY CCCCCCCCCEEEEEE	46.06	22817900
166	Ubiquitination	VDYGKKSKLEFSIYP CCCCCCCCEEEEEEE	62.00	22817900
170	Phosphorylation	KKSKLEFSIYPAPQV CCCCEEEEEEECCCC	16.31	23663014
172	Phosphorylation	SKLEFSIYPAPQVST CCEEEEEEECCCCCE	7.67	23663014
178	Phosphorylation	IYPAPQVSTAVVEPY EEECCCCCEEEEECC	12.85	23663014
179	Phosphorylation	YPAPQVSTAVVEPYN EECCCCCEEEEECCC	25.31	23663014
185	Phosphorylation	STAVVEPYNSILTTH CEEEEECCCCCCCCC	14.18	23663014
187	Phosphorylation	AVVEPYNSILTTHTT EEEECCCCCCCCCCC	17.09	23663014
190	Phosphorylation	EPYNSILTTHTTLEH ECCCCCCCCCCCCCC	18.18	23663014
191	Phosphorylation	PYNSILTTHTTLEHS CCCCCCCCCCCCCCC	17.49	23663014
193	Phosphorylation	NSILTTHTTLEHSDC CCCCCCCCCCCCCCE	30.86	23663014
194	Phosphorylation	SILTTHTTLEHSDCA CCCCCCCCCCCCCEE	23.65	23663014
198	Phosphorylation	THTTLEHSDCAFMVD CCCCCCCCCEEEEEC	25.63	26356563
210	Phosphorylation	MVDNEAIYDICRRNL EECHHHHHHHHHCCC	13.30	25884760
223	Phosphorylation	NLDIERPTYTNLNRL CCCCCCCCCCCHHHH	49.55	28796482
224	Nitration	LDIERPTYTNLNRLI CCCCCCCCCCHHHHH	9.05	-
224	Phosphorylation	LDIERPTYTNLNRLI CCCCCCCCCCHHHHH	9.05	19605366
225	Phosphorylation	DIERPTYTNLNRLIG CCCCCCCCCHHHHHH	35.39	28555341
236	Phosphorylation	RLIGQIVSSITASLR HHHHHHHHHHHHHCC	20.04	27732954
237	Phosphorylation	LIGQIVSSITASLRF HHHHHHHHHHHHCCC	17.05	27732954
239	Phosphorylation	GQIVSSITASLRFDG HHHHHHHHHHCCCCC	16.49	27732954
241	Phosphorylation	IVSSITASLRFDGAL HHHHHHHHCCCCCCC	16.07	-
245	Ubiquitination	ITASLRFDGALNVDL HHHHCCCCCCCCCCC	34.71	21963094
253	Phosphorylation	GALNVDLTEFQTNLV CCCCCCCCEEECCCC	30.23	21712546
257	Phosphorylation	VDLTEFQTNLVPYPR CCCCEEECCCCCCCC	35.52	21712546
262	Nitration	FQTNLVPYPRIHFPL EECCCCCCCCCCCCC	9.54	-
262	Phosphorylation	FQTNLVPYPRIHFPL EECCCCCCCCCCCCC	9.54	22817901
269	Neddylation	YPRIHFPLATYAPVI CCCCCCCCCCCCCCC	5.63	32015554
269	Ubiquitination	YPRIHFPLATYAPVI CCCCCCCCCCCCCCC	5.63	21963094
271	Phosphorylation	RIHFPLATYAPVISA CCCCCCCCCCCCCCH	28.09	21945579
272	Nitration	IHFPLATYAPVISAE CCCCCCCCCCCCCHH	11.87	-
272	Phosphorylation	IHFPLATYAPVISAE CCCCCCCCCCCCCHH	11.87	21945579
276	Ubiquitination	LATYAPVISAEKAYH CCCCCCCCCHHHHHH	2.92	21963094
277	Phosphorylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	21945579
280	Ubiquitination	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	21906983
282	Nitrated tyrosine	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
282	Nitration	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
282	Nitration	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
282	Phosphorylation	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	25159151
287	Phosphorylation	KAYHEQLSVAEITNA HHHHHHCCHHHHHHH	20.98	22322096
291	Acetylation	EQLSVAEITNACFEP HHCCHHHHHHHHCCC	2.31	19608861
291	Ubiquitination	EQLSVAEITNACFEP HHCCHHHHHHHHCCC	2.31	27667366
292	Phosphorylation	QLSVAEITNACFEPA HCCHHHHHHHHCCCH	14.31	30576142
295	Glutathionylation	VAEITNACFEPANQM HHHHHHHHCCCHHHC	4.27	22555962
301	Neddylation	ACFEPANQMVKCDPR HHCCCHHHCCCCCCC	39.90	32015554
301	Ubiquitination	ACFEPANQMVKCDPR HHCCCHHHCCCCCCC	39.90	21963094
303	Ubiquitination	FEPANQMVKCDPRHG CCCHHHCCCCCCCCC	3.93	21963094
304	Ubiquitination	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	21890473
304	Neddylation	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	32015554
304	Ubiquitination	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	21963094
311	Ubiquitination	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	21890473
311	Acetylation	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	22632513
311	Ubiquitination	KCDPRHGKYMACCLL CCCCCCCCEEEEHHH	26.23	21906983
312	Phosphorylation	CDPRHGKYMACCLLY CCCCCCCEEEEHHHC	8.44	28152594
314	Phosphorylation	PRHGKYMACCLLYRG CCCCCEEEEHHHCCC	4.27	32142685
315	Glutathionylation	RHGKYMACCLLYRGD CCCCEEEEHHHCCCC	0.67	22555962
317	Ubiquitination	GKYMACCLLYRGDVV CCEEEEHHHCCCCCC	4.78	21963094
319	Phosphorylation	YMACCLLYRGDVVPK EEEEHHHCCCCCCCC	10.29	23917254
326	Ubiquitination	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	21890473
326	Sumoylation	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	-
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	22632523
326	Sumoylation	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	19608861
326	Ubiquitination	YRGDVVPKDVNAAIA CCCCCCCCCCHHHHH	63.80	27667366
334	Phosphorylation	DVNAAIATIKTKRTI CCHHHHHHCCCCCEE	19.52	23401153
335	Neddylation	VNAAIATIKTKRTIQ CHHHHHHCCCCCEEE	3.84	32015554
335	Ubiquitination	VNAAIATIKTKRTIQ CHHHHHHCCCCCEEE	3.84	27667366
336	Sumoylation	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	-
336	Acetylation	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	14497329
336	Neddylation	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	32015554
336	Sumoylation	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	-
336	Ubiquitination	NAAIATIKTKRTIQF HHHHHHCCCCCEEEE	43.57	21906983
337	Phosphorylation	AAIATIKTKRTIQFV HHHHHCCCCCEEEEE	23.16	30266825
338	Methylation	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	14505105
338	Ubiquitination	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	21963094
340	Phosphorylation	ATIKTKRTIQFVDWC HHCCCCCEEEEEEEC	22.23	28857561
347	Glutathionylation	TIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	22555962
347	S-palmitoylation	TIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	29575903
349	Phosphorylation	QFVDWCPTGFKVGIN EEEEECCCCEEEEEE	52.71	21712546
352	Acetylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	13670219
352	Sumoylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	-
352	Ubiquitination	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	21963094
357	Nitration	GFKVGINYQPPTVVP CEEEEEECCCCEECC	22.07	-
357	Phosphorylation	GFKVGINYQPPTVVP CEEEEEECCCCEECC	22.07	27273156
359	Ubiquitination	KVGINYQPPTVVPGG EEEEECCCCEECCCC	19.03	32142685
361	Phosphorylation	GINYQPPTVVPGGDL EEECCCCEECCCCCH	40.60	28152594
366	Acetylation	PPTVVPGGDLAKVQR CCEECCCCCHHHHHH	22.23	19608861
366	Ubiquitination	PPTVVPGGDLAKVQR CCEECCCCCHHHHHH	22.23	21963094
370	Ubiquitination	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	21890473
370	Sumoylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Acetylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	22632503
370	Neddylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	32015554
370	Sumoylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Ubiquitination	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	21906983
376	Glutathionylation	AKVQRAVCMLSNTTA HHHHHHHHHHCCHHH	1.90	22555962
379	Phosphorylation	QRAVCMLSNTTAIAE HHHHHHHCCHHHHHH	12.78	19664995
381	Phosphorylation	AVCMLSNTTAIAEAW HHHHHCCHHHHHHHH	17.77	30108239
382	Phosphorylation	VCMLSNTTAIAEAWA HHHHCCHHHHHHHHH	21.95	30108239
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	21890473
394	Sumoylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	14496259
394	Sumoylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	21906983
395	Ubiquitination	WARLDHKFDLMYAKR HHHCCCCCCHHHEEE	8.60	21963094
399	Phosphorylation	DHKFDLMYAKRAFVH CCCCCHHHEEEHHHH	19.10	28674151
401	Sumoylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	13670207
401	Sumoylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	19608861
401	Ubiquitination	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	21963094
408	Phosphorylation	KRAFVHWYVGEGMEE EEHHHHHHCCCCCCC	5.45	28796482
419	Phosphorylation	GMEEGEFSEAREDMA CCCCCCHHHHHHHHH	26.50	28270605
430	Ubiquitination	EDMAALEKDYEEVGV HHHHHHHHCHHHHCC	67.47	21906983
432	Phosphorylation	MAALEKDYEEVGVDS HHHHHHCHHHHCCCC	25.67	28796482
439	Phosphorylation	YEEVGVDSVEGEGEE HHHHCCCCCCCCCCC	21.47	20201521
445	5-glutamyl polyglutamate	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	-
445	Formation of an isopeptide bond	DSVEGEGEEEGEEY- CCCCCCCCCCCCCC-	48.88	-
451	Nitration	GEEEGEEY------- CCCCCCCC-------	21.39	-
451	Nitration	GEEEGEEY------- CCCCCCCC-------	21.39	10339593
451	Phosphorylation	GEEEGEEY------- CCCCCCCC-------	21.39	28674151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
165	S	Phosphorylation	Kinase	PKCA	P17252	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
40	K	Acetylation	24906155
Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen.
40	K	Methylation	24906155
Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBA1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIS1_HUMAN	PAFAH1B1	physical	9384577
MYC_HUMAN	MYC	physical	20691906
VAV_HUMAN	VAV1	physical	8530437
ZAP70_HUMAN	ZAP70	physical	8530437
ACTN1_HUMAN	ACTN1	physical	18341635
DAG1_HUMAN	DAG1	physical	18341635
MTAP2_HUMAN	MAP2	physical	18341635
ITB1_HUMAN	ITGB1	physical	18341635
PDC6I_HUMAN	PDCD6IP	physical	12771190
CBL_HUMAN	CBL	physical	15878338
IFNE_HUMAN	IFNE	physical	22565157
TAU_HUMAN	MAPT	physical	22565157
SQSTM_HUMAN	SQSTM1	physical	22565157
UBC_HUMAN	UBC	physical	22565157
CYLD_HUMAN	CYLD	physical	18222923
HDAC6_HUMAN	HDAC6	physical	19961433
TBB2A_HUMAN	TUBB2A	physical	22939629
TBA1B_HUMAN	TUBA1B	physical	22939629
TBB5_HUMAN	TUBB	physical	22939629
TBB4B_HUMAN	TUBB4B	physical	22939629
TBB6_HUMAN	TUBB6	physical	22939629
TBB3_HUMAN	TUBB3	physical	22939629
TBA4A_HUMAN	TUBA4A	physical	22939629
VATB2_HUMAN	ATP6V1B2	physical	22939629
MARE1_HUMAN	MAPRE1	physical	16455083
CLIP1_HUMAN	CLIP1	physical	16455083
G3P_HUMAN	GAPDH	physical	22863883
METK2_HUMAN	MAT2A	physical	22863883
MAT2B_HUMAN	MAT2B	physical	22863883
TBA4A_HUMAN	TUBA4A	physical	22863883
TBB6_HUMAN	TUBB6	physical	22863883
TBB5_HUMAN	TUBB	physical	22863883
ATX3_HUMAN	ATXN3	physical	24685680
TBB5_HUMAN	TUBB	physical	24688049
F110C_HUMAN	FAM110C	physical	19698782
TBB4B_HUMAN	TUBB4B	physical	26344197
S10A9_HUMAN	S100A9	physical	15331440
S10A8_HUMAN	S100A8	physical	15331440
T11L2_HUMAN	TCP11L2	physical	28514442
TTC5_HUMAN	TTC5	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
TUSC3_HUMAN	TUSC3	genetic	27453043
CDC73_HUMAN	CDC73	genetic	27453043
ATAD5_HUMAN	ATAD5	genetic	27453043
CHK1_HUMAN	CHEK1	genetic	27453043
L2GL1_HUMAN	LLGL1	genetic	27453043
ING4_HUMAN	ING4	genetic	27453043
ING5_HUMAN	ING5	genetic	27453043
WRN_HUMAN	WRN	genetic	27453043
BLM_HUMAN	BLM	genetic	27453043
XRCC3_HUMAN	XRCC3	genetic	27453043
RB_HUMAN	RB1	genetic	27453043
1433Z_HUMAN	YWHAZ	genetic	27453043
WEE1_HUMAN	WEE1	genetic	27453043
RL11_HUMAN	RPL11	genetic	27453043
TITIN_HUMAN	TTN	genetic	27453043
PHB2_HUMAN	PHB2	genetic	27453043
CC14A_HUMAN	CDC14A	genetic	27453043
MTOR_HUMAN	MTOR	genetic	27453043
CHK2_HUMAN	CHEK2	genetic	27453043

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
611603	Lissencephaly 3 (LIS3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00518	Albendazole
DB00643	Mebendazole
DB00570	Vinblastine

Regulatory Network of TBA1A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48 AND SER-439, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.	17081983 [Abstract]

show

show