dbPTM

PDC6I_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDC6I_HUMAN
UniProt AC	Q8WUM4
Protein Name	Programmed cell death 6-interacting protein
Gene Name	PDCD6IP
Organism	Homo sapiens (Human).
Sequence Length	868
Subcellular Localization	Cytoplasm, cytosol . Melanosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Secreted, exosome . Cell junction, tight junction . Midbody, Midbody ring . Identified by mass spectrometry in melanosome fractions from stage I to
Protein Description	Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. [PubMed: 14739459 The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis]
Protein Sequence	MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPPQQSYYPQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATFISVQL ------CCEEEEEEE	15.95	22223895
3	Phosphorylation	-----MATFISVQLK -----CCEEEEEEEC	21.87	23401153
6	Phosphorylation	--MATFISVQLKKTS --CCEEEEEEECCCC	10.30	23401153
10	Methylation	TFISVQLKKTSEVDL EEEEEEECCCCCCCH	36.59	-
11	Malonylation	FISVQLKKTSEVDLA EEEEEECCCCCCCHH	66.91	26320211
11 (in isoform 2)	Malonylation	-	66.91	26320211
12	Phosphorylation	ISVQLKKTSEVDLAK EEEEECCCCCCCHHH	28.65	20873877
13	Phosphorylation	SVQLKKTSEVDLAKP EEEECCCCCCCHHHH	44.49	25849741
13 (in isoform 2)	Phosphorylation	-	44.49	27251275
19	Ubiquitination	TSEVDLAKPLVKFIQ CCCCCHHHHHHHHHH	46.30	21890473
19	Ubiquitination	TSEVDLAKPLVKFIQ CCCCCHHHHHHHHHH	46.30	21890473
19	Acetylation	TSEVDLAKPLVKFIQ CCCCCHHHHHHHHHH	46.30	23236377
19	Malonylation	TSEVDLAKPLVKFIQ CCCCCHHHHHHHHHH	46.30	26320211
19	Ubiquitination	TSEVDLAKPLVKFIQ CCCCCHHHHHHHHHH	46.30	23000965
19 (in isoform 2)	Malonylation	-	46.30	26320211
23	Ubiquitination	DLAKPLVKFIQQTYP CHHHHHHHHHHHHCC	44.42	21890473
23	Ubiquitination	DLAKPLVKFIQQTYP CHHHHHHHHHHHHCC	44.42	21890473
23	Acetylation	DLAKPLVKFIQQTYP CHHHHHHHHHHHHCC	44.42	25953088
23	Ubiquitination	DLAKPLVKFIQQTYP CHHHHHHHHHHHHCC	44.42	23000965
25	Ubiquitination	AKPLVKFIQQTYPSG HHHHHHHHHHHCCCC	2.16	22817900
39	Phosphorylation	GGEEQAQYCRAAEEL CHHHHHHHHHHHHHH	6.21	22817900
40	Glutathionylation	GEEQAQYCRAAEELS HHHHHHHHHHHHHHH	1.26	22555962
40	S-nitrosylation	GEEQAQYCRAAEELS HHHHHHHHHHHHHHH	1.26	2212679
48	Acetylation	RAAEELSKLRRAAVG HHHHHHHHHHHHHHC	59.65	19608861
48	Malonylation	RAAEELSKLRRAAVG HHHHHHHHHHHHHHC	59.65	26320211
48	Ubiquitination	RAAEELSKLRRAAVG HHHHHHHHHHHHHHC	59.65	33845483
48 (in isoform 2)	Malonylation	-	59.65	26320211
60	Acetylation	AVGRPLDKHEGALET HHCCCCCCCCCHHHH	51.76	23749302
60	Ubiquitination	AVGRPLDKHEGALET HHCCCCCCCCCHHHH	51.76	-
95	Ubiquitination	QICLTFTWKDAFDKG EEEEEEEEHHCCCCC	7.73	24816145
100	Ubiquitination	FTWKDAFDKGSLFGG EEEHHCCCCCCCCCH	57.01	24816145
101	Ubiquitination	TWKDAFDKGSLFGGS EEHHCCCCCCCCCHH	43.90	21890473
101	Ubiquitination	TWKDAFDKGSLFGGS EEHHCCCCCCCCCHH	43.90	21890473
101	Acetylation	TWKDAFDKGSLFGGS EEHHCCCCCCCCCHH	43.90	23236377
101	Ubiquitination	TWKDAFDKGSLFGGS EEHHCCCCCCCCCHH	43.90	27667366
103	O-linked_Glycosylation	KDAFDKGSLFGGSVK HHCCCCCCCCCHHHH	26.68	23301498
103	Phosphorylation	KDAFDKGSLFGGSVK HHCCCCCCCCCHHHH	26.68	62168483
108	Phosphorylation	KGSLFGGSVKLALAS CCCCCCHHHHHHHHH	19.23	23684312
108 (in isoform 2)	Phosphorylation	-	19.23	24719451
113	Ubiquitination	GGSVKLALASLGYEK CHHHHHHHHHCCCCC	4.88	24816145
115	Phosphorylation	SVKLALASLGYEKSC HHHHHHHHCCCCCHH	24.15	28152594
118	Phosphorylation	LALASLGYEKSCVLF HHHHHCCCCCHHHHH	26.02	28152594
118	Ubiquitination	LALASLGYEKSCVLF HHHHHCCCCCHHHHH	26.02	24816145
122	Ubiquitination	SLGYEKSCVLFNCAA HCCCCCHHHHHHHHH	4.58	24816145
123	Ubiquitination	LGYEKSCVLFNCAAL CCCCCHHHHHHHHHH	9.86	24816145
127	Ubiquitination	KSCVLFNCAALASQI CHHHHHHHHHHHHHH	1.51	24816145
128	Ubiquitination	SCVLFNCAALASQIA HHHHHHHHHHHHHHH	13.45	24816145
157	Phosphorylation	AKHYQFASGAFLHIK HHHHHHCCCCCHHHH	31.76	28348404
160	Ubiquitination	YQFASGAFLHIKETV HHHCCCCCHHHHHHH	6.10	21890473
165	Ubiquitination	GAFLHIKETVLSALS CCCHHHHHHHHHHHH	43.47	21890473
166	Phosphorylation	AFLHIKETVLSALSR CCHHHHHHHHHHHHC	23.03	19413330
167	Ubiquitination	FLHIKETVLSALSRE CHHHHHHHHHHHHCC	4.11	23503661
169	Phosphorylation	HIKETVLSALSREPT HHHHHHHHHHHCCCC	23.87	21712546
172	Ubiquitination	ETVLSALSREPTVDI HHHHHHHHCCCCCCC	34.02	23503661
184	Ubiquitination	VDISPDTVGTLSLIM CCCCCCCHHHHHHHH	7.80	24816145
186	Phosphorylation	ISPDTVGTLSLIMLA CCCCCHHHHHHHHHH	14.61	46162323
189	Ubiquitination	DTVGTLSLIMLAQAQ CCHHHHHHHHHHHHH	2.76	24816145
209	Malonylation	KATRDKMKDAIIAKL HHCHHHHHHHHHHHH	50.15	26320211
209	Ubiquitination	KATRDKMKDAIIAKL HHCHHHHHHHHHHHH	50.15	33845483
209 (in isoform 2)	Malonylation	-	50.15	26320211
215	Ubiquitination	MKDAIIAKLANQAAD HHHHHHHHHHHHHHH	37.41	21890473
215	Acetylation	MKDAIIAKLANQAAD HHHHHHHHHHHHHHH	37.41	19608861
215	Ubiquitination	MKDAIIAKLANQAAD HHHHHHHHHHHHHHH	37.41	22817900
223	Phosphorylation	LANQAADYFGDAFKQ HHHHHHHHHHHHHHH	12.53	28152594
229	Acetylation	DYFGDAFKQCQYKDT HHHHHHHHHCCCCCC	52.46	25953088
229	Ubiquitination	DYFGDAFKQCQYKDT HHHHHHHHHCCCCCC	52.46	32015554
234	Ubiquitination	AFKQCQYKDTLPKEV HHHHCCCCCCCCHHH	20.54	-
239	Ubiquitination	QYKDTLPKEVFPVLA CCCCCCCHHHHHHHH	70.40	29967540
258	Phosphorylation	IMQANAEYHQSILAK HHHCCHHHHHHHHHH	11.62	46162341
269	Acetylation	ILAKQQKKFGEEIAR HHHHHHHHHHHHHHH	55.02	25953088
269	Ubiquitination	ILAKQQKKFGEEIAR HHHHHHHHHHHHHHH	55.02	29967540
274	Ubiquitination	QKKFGEEIARLQHAA HHHHHHHHHHHHHHH	2.05	29967540
285	Acetylation	QHAAELIKTVASRYD HHHHHHHHHHHHHCH	49.96	25953088
285	Malonylation	QHAAELIKTVASRYD HHHHHHHHHHHHHCH	49.96	26320211
285	Ubiquitination	QHAAELIKTVASRYD HHHHHHHHHHHHHCH	49.96	32015554
290	Ubiquitination	LIKTVASRYDEYVNV HHHHHHHHCHHCCCH	32.93	32015554
290 (in isoform 2)	Malonylation	-	32.93	26320211
294	Phosphorylation	VASRYDEYVNVKDFS HHHHCHHCCCHHHHH	8.40	27251275
296	Ubiquitination	SRYDEYVNVKDFSDK HHCHHCCCHHHHHHH	33.93	23000965
298	Acetylation	YDEYVNVKDFSDKIN CHHCCCHHHHHHHHH	48.10	23236377
298	Ubiquitination	YDEYVNVKDFSDKIN CHHCCCHHHHHHHHH	48.10	32015554
299 (in isoform 2)	Phosphorylation	-	43.96	27642862
301	Ubiquitination	YVNVKDFSDKINRAL CCCHHHHHHHHHHHH	48.40	23000965
303	Acetylation	NVKDFSDKINRALAA CHHHHHHHHHHHHHH	40.45	26822725
303	Malonylation	NVKDFSDKINRALAA CHHHHHHHHHHHHHH	40.45	26320211
303	Ubiquitination	NVKDFSDKINRALAA CHHHHHHHHHHHHHH	40.45	32015554
308	Ubiquitination	SDKINRALAAAKKDN HHHHHHHHHHHHHCC	2.77	24816145
308 (in isoform 2)	Malonylation	-	2.77	26320211
311	Ubiquitination	INRALAAAKKDNDFI HHHHHHHHHHCCCCC	17.52	21890473
312	Ubiquitination	NRALAAAKKDNDFIY HHHHHHHHHCCCCCC	56.80	24816145
313	Malonylation	RALAAAKKDNDFIYH HHHHHHHHCCCCCCC	57.97	26320211
313	Ubiquitination	RALAAAKKDNDFIYH HHHHHHHHCCCCCCC	57.97	24816145
316	Ubiquitination	AAAKKDNDFIYHDRV HHHHHCCCCCCCCCC	41.26	21890473
317	Ubiquitination	AAKKDNDFIYHDRVP HHHHCCCCCCCCCCC	8.18	24816145
318	Ubiquitination	AKKDNDFIYHDRVPD HHHCCCCCCCCCCCC	3.13	33845483
318 (in isoform 2)	Malonylation	-	3.13	26320211
319	Phosphorylation	KKDNDFIYHDRVPDL HHCCCCCCCCCCCCH	9.54	27259358
322	Methylation	NDFIYHDRVPDLKDL CCCCCCCCCCCHHHC	28.67	-
324 (in isoform 2)	Phosphorylation	-	41.95	27642862
327	Acetylation	HDRVPDLKDLDPIGK CCCCCCHHHCCCCCC	64.72	25953088
327	Ubiquitination	HDRVPDLKDLDPIGK CCCCCCHHHCCCCCC	64.72	32015554
332	Ubiquitination	DLKDLDPIGKATLVK CHHHCCCCCCEEEEE	9.86	32015554
334	Acetylation	KDLDPIGKATLVKST HHCCCCCCEEEEECC	38.63	25953088
334	Ubiquitination	KDLDPIGKATLVKST HHCCCCCCEEEEECC	38.63	29967540
339	Acetylation	IGKATLVKSTPVNVP CCCEEEEECCCCCCC	52.29	23236377
339	Malonylation	IGKATLVKSTPVNVP CCCEEEEECCCCCCC	52.29	26320211
339	Ubiquitination	IGKATLVKSTPVNVP CCCEEEEECCCCCCC	52.29	32015554
340	Phosphorylation	GKATLVKSTPVNVPI CCEEEEECCCCCCCC	30.39	25627689
341	Phosphorylation	KATLVKSTPVNVPIS CEEEEECCCCCCCCH	26.07	25627689
344	Ubiquitination	LVKSTPVNVPISQKF EEECCCCCCCCHHHH	34.74	32015554
344 (in isoform 2)	Malonylation	-	34.74	26320211
350	Acetylation	VNVPISQKFTDLFEK CCCCCHHHHHHHHHH	43.36	23236377
350	Ubiquitination	VNVPISQKFTDLFEK CCCCCHHHHHHHHHH	43.36	23000965
355	Ubiquitination	SQKFTDLFEKMVPVS HHHHHHHHHHHCCCC	10.63	21890473
355	Ubiquitination	SQKFTDLFEKMVPVS HHHHHHHHHHHCCCC	10.63	23000965
357	Ubiquitination	KFTDLFEKMVPVSVQ HHHHHHHHHCCCCHH	37.55	21906983
362	Ubiquitination	FEKMVPVSVQQSLAA HHHHCCCCHHHHHHH	14.24	23503661
366	Phosphorylation	VPVSVQQSLAAYNQR CCCCHHHHHHHHHHH	11.68	50564661
370	Phosphorylation	VQQSLAAYNQRKADL HHHHHHHHHHHHHHH	13.25	50564669
374	Ubiquitination	LAAYNQRKADLVNRS HHHHHHHHHHHHHHH	36.17	24816145
379	Ubiquitination	QRKADLVNRSIAQMR HHHHHHHHHHHHHHH	39.00	24816145
416	Phosphorylation	SGDTVPQSILTKSRS CCCCCCHHHHHHCCH	17.31	24719451
421	Phosphorylation	PQSILTKSRSVIEQG CHHHHHHCCHHHHHC	25.26	29514088
423	Phosphorylation	SILTKSRSVIEQGGI HHHHHCCHHHHHCCH	34.24	29514088
438	Ubiquitination	QTVDQLIKELPELLQ HHHHHHHHHHHHHHH	62.89	29967540
443	Ubiquitination	LIKELPELLQRNREI HHHHHHHHHHHHHHH	4.69	29967540
448	Ubiquitination	PELLQRNREILDESL HHHHHHHHHHHHHHH	34.22	21963094
450	Ubiquitination	LLQRNREILDESLRL HHHHHHHHHHHHHHH	5.47	27667366
453	Ubiquitination	RNREILDESLRLLDE HHHHHHHHHHHHCCH	48.50	21963094
455	Ubiquitination	REILDESLRLLDEEE HHHHHHHHHHCCHHH	4.15	27667366
456	Methylation	EILDESLRLLDEEEA HHHHHHHHHCCHHHC	42.35	-
464	Phosphorylation	LLDEEEATDNDLRAK HCCHHHCCCHHHHHH	38.32	110755291
464	Ubiquitination	LLDEEEATDNDLRAK HCCHHHCCCHHHHHH	38.32	25015289
469	Ubiquitination	EATDNDLRAKFKERW HCCCHHHHHHHHHHH	38.30	25015289
471	Ubiquitination	TDNDLRAKFKERWQR CCHHHHHHHHHHHHC	51.00	29967540
476	Ubiquitination	RAKFKERWQRTPSNE HHHHHHHHHCCCCCC	7.97	29967540
479	Phosphorylation	FKERWQRTPSNELYK HHHHHHCCCCCCCCH	18.90	25159151
481	Phosphorylation	ERWQRTPSNELYKPL HHHHCCCCCCCCHHH	42.18	25159151
481	Ubiquitination	ERWQRTPSNELYKPL HHHHCCCCCCCCHHH	42.18	23503661
484 (in isoform 2)	Phosphorylation	-	8.56	24719451
485	Phosphorylation	RTPSNELYKPLRAEG CCCCCCCCHHHHCCC	12.37	28258704
485	Ubiquitination	RTPSNELYKPLRAEG CCCCCCCCHHHHCCC	12.37	23503661
486	Acetylation	TPSNELYKPLRAEGT CCCCCCCHHHHCCCC	50.64	23954790
486	Malonylation	TPSNELYKPLRAEGT CCCCCCCHHHHCCCC	50.64	26320211
486	Succinylation	TPSNELYKPLRAEGT CCCCCCCHHHHCCCC	50.64	23954790
486	Ubiquitination	TPSNELYKPLRAEGT CCCCCCCHHHHCCCC	50.64	23000965
490	Ubiquitination	ELYKPLRAEGTNFRT CCCHHHHCCCCCHHH	27.53	23503661
490 (in isoform 2)	Phosphorylation	-	27.53	27642862
491	Ubiquitination	LYKPLRAEGTNFRTV CCHHHHCCCCCHHHH	61.18	23000965
491 (in isoform 2)	Malonylation	-	61.18	26320211
500	Ubiquitination	TNFRTVLDKAVQADG CCHHHHHHHHHHCCC	32.31	24816145
501	Acetylation	NFRTVLDKAVQADGQ CHHHHHHHHHHCCCC	46.42	25953088
501	Ubiquitination	NFRTVLDKAVQADGQ CHHHHHHHHHHCCCC	46.42	23000965
505	Ubiquitination	VLDKAVQADGQVKEC HHHHHHHCCCCHHHH	19.12	24816145
506	Ubiquitination	LDKAVQADGQVKECY HHHHHHCCCCHHHHH	30.85	21890473
506	Ubiquitination	LDKAVQADGQVKECY HHHHHHCCCCHHHHH	30.85	23000965
510	Ubiquitination	VQADGQVKECYQSHR HHCCCCHHHHHHHCC	33.89	29967540
512	Glutathionylation	ADGQVKECYQSHRDT CCCCHHHHHHHCCCE	2.87	22555962
515	Ubiquitination	QVKECYQSHRDTIVL CHHHHHHHCCCEEEE	8.26	29967540
517	Ubiquitination	KECYQSHRDTIVLLC HHHHHHCCCEEEEEE	48.27	23000965
522	Ubiquitination	SHRDTIVLLCKPEPE HCCCEEEEEECCCHH	4.03	23000965
524	Glutathionylation	RDTIVLLCKPEPELN CCEEEEEECCCHHHC	6.38	22555962
525	Acetylation	DTIVLLCKPEPELNA CEEEEEECCCHHHCC	53.00	26051181
541	Ubiquitination	IPSANPAKTMQGSEV CCCCCCCCCCCHHHH	45.87	32015554
543	Sulfoxidation	SANPAKTMQGSEVVN CCCCCCCCCHHHHHH	4.13	21406390
546	Ubiquitination	PAKTMQGSEVVNVLK CCCCCCHHHHHHHHH	15.44	32015554
554	Phosphorylation	EVVNVLKSLLSNLDE HHHHHHHHHHHCHHH	30.31	28348404
557	Phosphorylation	NVLKSLLSNLDEVKK HHHHHHHHCHHHHHH	40.41	20860994
561	Ubiquitination	SLLSNLDEVKKEREG HHHHCHHHHHHHHHH	60.44	21890473
563	Ubiquitination	LSNLDEVKKEREGLE HHCHHHHHHHHHHHH	47.04	29967540
564	Ubiquitination	SNLDEVKKEREGLEN HCHHHHHHHHHHHHH	68.15	-
566	Ubiquitination	LDEVKKEREGLENDL HHHHHHHHHHHHHHH	52.76	21890473
568	Ubiquitination	EVKKEREGLENDLKS HHHHHHHHHHHHHHH	44.50	29967540
575	Phosphorylation	GLENDLKSVNFDMTS HHHHHHHHCCHHHHH	29.59	25159151
580	Sulfoxidation	LKSVNFDMTSKFLTA HHHCCHHHHHHHHHH	3.89	30846556
581	Phosphorylation	KSVNFDMTSKFLTAL HHCCHHHHHHHHHHH	30.52	27470641
606	Methylation	LSVTELDRVYGGLTT CCHHHHHHHHCCHHH	35.86	-
608	Phosphorylation	VTELDRVYGGLTTKV HHHHHHHHCCHHHHH	13.33	28152594
612	Phosphorylation	DRVYGGLTTKVQESL HHHHCCHHHHHHHHH	28.04	24719451
613	Phosphorylation	RVYGGLTTKVQESLK HHHCCHHHHHHHHHH	33.97	24719451
613 (in isoform 2)	Phosphorylation	-	33.97	24719451
614	Ubiquitination	VYGGLTTKVQESLKK HHCCHHHHHHHHHHH	36.36	29967540
617 (in isoform 2)	Phosphorylation	-	62.11	24719451
618 (in isoform 2)	Phosphorylation	-	28.53	24719451
619	Ubiquitination	TTKVQESLKKQEGLL HHHHHHHHHHCCCHH	8.70	29967540
620	Acetylation	TKVQESLKKQEGLLK HHHHHHHHHCCCHHH	62.78	25953088
627	Ubiquitination	KKQEGLLKNIQVSHQ HHCCCHHHHHHHCHH	57.98	29967540
632	Ubiquitination	LLKNIQVSHQEFSKM HHHHHHHCHHHHHHH	11.77	29967540
638	Neddylation	VSHQEFSKMKQSNNE HCHHHHHHHHHCCCH	56.27	32015554
638	Ubiquitination	VSHQEFSKMKQSNNE HCHHHHHHHHHCCCH	56.27	21906983
640	Ubiquitination	HQEFSKMKQSNNEAN HHHHHHHHHCCCHHH	55.07	21906983
643	Neddylation	FSKMKQSNNEANLRE HHHHHHCCCHHHHHH	48.11	32015554
643	Ubiquitination	FSKMKQSNNEANLRE HHHHHHCCCHHHHHH	48.11	27667366
645	Ubiquitination	KMKQSNNEANLREEV HHHHCCCHHHHHHHH	43.09	27667366
654	Ubiquitination	NLREEVLKNLATAYD HHHHHHHHHHHHHHH	55.90	25015289
659	Ubiquitination	VLKNLATAYDNFVEL HHHHHHHHHHHHHHH	12.22	25015289
671	Ubiquitination	VELVANLKEGTKFYN HHHHHHHHCCCCHHH	54.64	23503661
675	Ubiquitination	ANLKEGTKFYNELTE HHHHCCCCHHHHHHH	57.62	23503661
676	Ubiquitination	NLKEGTKFYNELTEI HHHCCCCHHHHHHHH	8.76	23503661
680	Ubiquitination	GTKFYNELTEILVRF CCCHHHHHHHHHHHH	4.66	23503661
690	Ubiquitination	ILVRFQNKCSDIVFA HHHHHHHHCCCCEEE	25.08	24816145
692	Phosphorylation	VRFQNKCSDIVFARK HHHHHHCCCCEEECC	31.79	166220823
695	Ubiquitination	QNKCSDIVFARKTER HHHCCCCEEECCHHH	3.54	24816145
695 (in isoform 2)	Malonylation	-	3.54	32601280
707	Acetylation	TERDELLKDLQQSIA HHHHHHHHHHHHHHH	69.85	25953088
707	Ubiquitination	TERDELLKDLQQSIA HHHHHHHHHHHHHHH	69.85	23000965
712	Ubiquitination	LLKDLQQSIAREPSA HHHHHHHHHHHCCCC	12.78	21890473
712	Phosphorylation	LLKDLQQSIAREPSA HHHHHHHHHHHCCCC	12.78	29255136
712	Ubiquitination	LLKDLQQSIAREPSA HHHHHHHHHHHCCCC	12.78	23000965
718	Phosphorylation	QSIAREPSAPSIPTP HHHHHCCCCCCCCCC	48.32	23898821
721	Phosphorylation	AREPSAPSIPTPAYQ HHCCCCCCCCCCCCC	40.70	69009511
723 (in isoform 2)	Phosphorylation	-	36.35	27251275
724	Phosphorylation	PSAPSIPTPAYQSSP CCCCCCCCCCCCCCC	20.91	30278072
726 (in isoform 2)	Phosphorylation	-	19.92	27251275
727	Phosphorylation	PSIPTPAYQSSPAGG CCCCCCCCCCCCCCC	15.33	30278072
729	Phosphorylation	IPTPAYQSSPAGGHA CCCCCCCCCCCCCCC	26.13	23401153
730	Phosphorylation	PTPAYQSSPAGGHAP CCCCCCCCCCCCCCC	11.84	30278072
732 (in isoform 2)	Phosphorylation	-	38.25	27642862
734 (in isoform 2)	Phosphorylation	-	18.85	27251275
735	Phosphorylation	QSSPAGGHAPTPPTP CCCCCCCCCCCCCCC	27.84	32142685
738	O-linked_Glycosylation	PAGGHAPTPPTPAPR CCCCCCCCCCCCCCC	42.56	OGP
738	Phosphorylation	PAGGHAPTPPTPAPR CCCCCCCCCCCCCCC	42.56	30278072
741	Phosphorylation	GHAPTPPTPAPRTMP CCCCCCCCCCCCCCC	33.03	25159151
745	Methylation	TPPTPAPRTMPPTKP CCCCCCCCCCCCCCC	45.84	24129315
746	Phosphorylation	PPTPAPRTMPPTKPQ CCCCCCCCCCCCCCC	32.73	18669648
751	Acetylation	PRTMPPTKPQPPARP CCCCCCCCCCCCCCC	47.64	23954790
751	Methylation	PRTMPPTKPQPPARP CCCCCCCCCCCCCCC	47.64	-
751	Ubiquitination	PRTMPPTKPQPPARP CCCCCCCCCCCCCCC	47.64	23000965
756	Ubiquitination	PTKPQPPARPPPPVL CCCCCCCCCCCCCCC	43.21	21890473
756	Ubiquitination	PTKPQPPARPPPPVL CCCCCCCCCCCCCCC	43.21	21890473
757	Methylation	TKPQPPARPPPPVLP CCCCCCCCCCCCCCC	50.46	-
767	Methylation	PPVLPANRAPSATAP CCCCCCCCCCCCCCC	50.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SH3RF1	Q7Z6J0	PMID:19393081
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:20519395

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDC6I_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDC6I_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDCD6_HUMAN	PDCD6	physical	9880530
PGFRB_HUMAN	PDGFRB	physical	17082185
NEDD4_HUMAN	NEDD4	physical	20519395
SH3G2_HUMAN	SH3GL2	physical	15456872
SH3R1_HUMAN	SH3RF1	physical	19393081
TS101_HUMAN	TSG101	physical	17229889
ARRD1_HUMAN	ARRDC1	physical	21191027
ARRD3_HUMAN	ARRDC3	physical	21191027
SH3K1_HUMAN	SH3KBP1	physical	21191027
CHM4A_HUMAN	CHMP4A	physical	21191027
PAR1_HUMAN	F2R	physical	22547407
SH3K1_HUMAN	SH3KBP1	physical	17428861
SH3G1_HUMAN	SH3GL1	physical	17428861
CD2AP_HUMAN	CD2AP	physical	17428861
SGSM3_HUMAN	SGSM3	physical	17174262
CHM4B_HUMAN	CHMP4B	physical	17174262
TS101_HUMAN	TSG101	physical	17174262
SH3G2_HUMAN	SH3GL2	physical	17174262
SH3K1_HUMAN	SH3KBP1	physical	17174262
ALG2_HUMAN	ALG2	physical	17174262
PTN23_HUMAN	PTPN23	physical	17174262
SRC_HUMAN	SRC	physical	15557335
TS101_HUMAN	TSG101	physical	14505570
PDC6I_HUMAN	PDCD6IP	physical	14505570
TS101_HUMAN	TSG101	physical	19520058
ALG2_HUMAN	ALG2	physical	19520058
GAG_HV1H2	gag	physical	19282983
CEP55_HUMAN	CEP55	physical	17853893
CD2AP_HUMAN	CD2AP	physical	17853893
TS101_HUMAN	TSG101	physical	16004603
PDC6I_HUMAN	PDCD6IP	physical	16004603
ALG2_HUMAN	ALG2	physical	16004603
CHM4A_HUMAN	CHMP4A	physical	14505569
TS101_HUMAN	TSG101	physical	14505569
GAG_HV1H2	gag	physical	14505569
CHM4B_HUMAN	CHMP4B	physical	20929444
PDC6I_HUMAN	PDCD6IP	physical	20929444
SRC_HUMAN	SRC	physical	20929444
TS101_HUMAN	TSG101	physical	20929444
CEP55_HUMAN	CEP55	physical	18948538
PDC6I_HUMAN	PDCD6IP	physical	18641129
TS101_HUMAN	TSG101	physical	18641129
CHM4A_HUMAN	CHMP4A	physical	18641129
SH3K1_HUMAN	SH3KBP1	physical	18641129
ALG2_HUMAN	ALG2	physical	18256029
CEP55_HUMAN	CEP55	physical	18940611
PDCD6_HUMAN	PDCD6	physical	18940611
VPS4B_HUMAN	VPS4B	physical	22939629
PEF1_HUMAN	PEF1	physical	22939629
CHM4B_HUMAN	CHMP4B	physical	23895345
TNIP2_HUMAN	TNIP2	physical	21988832
SH3G1_HUMAN	SH3GL1	physical	21988832
EZRI_HUMAN	EZR	physical	22863883
IPO9_HUMAN	IPO9	physical	22863883
MCTS1_HUMAN	MCTS1	physical	22863883
NEF_HV1H2	nef	physical	25118280
CEP55_HUMAN	CEP55	physical	25416956
SDCB1_HUMAN	SDCBP	physical	22660413
ENOA_HUMAN	ENO1	physical	26344197
ESTD_HUMAN	ESD	physical	26344197
AATC_HUMAN	GOT1	physical	26344197
MIF_HUMAN	MIF	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26490116
GAG_SIVG1	gag-pol	physical	27839950

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDC6I_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48 AND LYS-215, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730; THR-738 ANDTHR-741, AND MASS SPECTROMETRY.	18669648 [Abstract]