ARRD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARRD1_HUMAN
• UniProt AC: Q8N5I2
• Protein Name: Arrestin domain-containing protein 1 {ECO:0000305}
• Gene Name: ARRDC1 {ECO:0000312|HGNC:HGNC:28633}
• Organism: Homo sapiens (Human).
• Sequence Length: 433
• Subcellular Localization: Cell membrane . Also found in extracellular vesicles different from exosomes.
• Protein Description: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. [PubMed: 23886940]
• Protein Sequence: MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVGQALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEVEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKAPEATVTLPVFIGNIAVNHAPVSPRPGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCPQDGSPASHPLHPPLCISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYEAPPSYEQSCGGVEPSLTPES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	PGEPLAGTVRVRLGA CCCCCCEEEEEECCC	10.26	26853621
58	Phosphorylation	VSNKANDTAWVVEEG CCCCCCCCEEEEEEC	23.40	-
69	Phosphorylation	VEEGYFNSSLSLADK EEECCCCCCCCCCCC	23.82	28348404
117	Phosphorylation	QVRAAIHTPRFSKDH HHHHHHCCCCCCCCC	15.28	28348404
121	Phosphorylation	AIHTPRFSKDHKCSL HHCCCCCCCCCCCEE	38.15	24719451
153	Phosphorylation	QPNVASATKKFSYKL CCCCCHHCCCCEEEE	32.07	24275569
157	Phosphorylation	ASATKKFSYKLVKTG CHHCCCCEEEEEECC	30.18	29496963
198	Phosphorylation	NQSGKDTSPVVASLL CCCCCCCHHHHHHHH	26.32	25627689
207	Ubiquitination	VVASLLQKVSYKAKR HHHHHHHHHCHHHHH	32.87	29967540
231	Ubiquitination	EVEGAGVKAWRRAQW EECCCCHHHHHHHHH	41.11	-
276	Phosphorylation	KAPEATVTLPVFIGN CCCCCEEEEEEEECC	22.46	23663014
292	Phosphorylation	AVNHAPVSPRPGLGL EECCCCCCCCCCCCC	17.71	29255136
337	Ubiquitination	DPVFLSTKSHSQRQP CCEEECCCCCCCCCC	42.68	33845483
405	Phosphorylation	TLILPPEYSSWGYPY EEEECCCHHCCCCCC	17.49	22817900
426	Ubiquitination	EQSCGGVEPSLTPES HCCCCCCCCCCCCCC	32.23	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARRD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARRD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARRD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWP1_HUMAN	WWP1	physical	21191027
TS101_HUMAN	TSG101	physical	21191027
PDC6I_HUMAN	PDCD6IP	physical	21191027
WWP2_HUMAN	WWP2	physical	21191027
NEDD4_HUMAN	NEDD4	physical	21191027
ITCH_HUMAN	ITCH	physical	21191027
TS101_HUMAN	TSG101	physical	22315426
A4_HUMAN	APP	physical	21832049
WWP2_HUMAN	WWP2	physical	23236378
ITCH_HUMAN	ITCH	physical	23236378
ADRB2_HUMAN	ADRB2	physical	21982743
KDM1A_HUMAN	KDM1A	physical	26186194
AN13A_HUMAN	ANKRD13A	physical	26186194
GLMN_HUMAN	GLMN	physical	26186194
NXN_HUMAN	NXN	physical	26186194
TOPK_HUMAN	PBK	physical	26186194
NEDD4_HUMAN	NEDD4	physical	26186194
ITCH_HUMAN	ITCH	physical	26186194
NED4L_HUMAN	NEDD4L	physical	26186194
KCTD2_HUMAN	KCTD2	physical	26186194
KCD17_HUMAN	KCTD17	physical	26186194
KCTD5_HUMAN	KCTD5	physical	26186194
RCOR1_HUMAN	RCOR1	physical	26186194
RCOR3_HUMAN	RCOR3	physical	26186194
ZMYM2_HUMAN	ZMYM2	physical	26186194
OSBL6_HUMAN	OSBPL6	physical	26186194
ABRX2_HUMAN	FAM175B	physical	26186194
EPN1_HUMAN	EPN1	physical	26186194
HECW2_HUMAN	HECW2	physical	26186194
KIBRA_HUMAN	WWC1	physical	26186194
VP37A_HUMAN	VPS37A	physical	26186194
OSBL3_HUMAN	OSBPL3	physical	26186194
CUED1_HUMAN	CUEDC1	physical	26186194
YAP1_HUMAN	YAP1	physical	26186194
WIPI3_HUMAN	WDR45B	physical	26186194
VPS28_HUMAN	VPS28	physical	26186194
TOPK_HUMAN	PBK	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
VP37A_HUMAN	VPS37A	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
KIBRA_HUMAN	WWC1	physical	28514442
HECW2_HUMAN	HECW2	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
KCD17_HUMAN	KCTD17	physical	28514442
OSBL6_HUMAN	OSBPL6	physical	28514442
ITCH_HUMAN	ITCH	physical	28514442
CUED1_HUMAN	CUEDC1	physical	28514442
VPS28_HUMAN	VPS28	physical	28514442
ZMYM2_HUMAN	ZMYM2	physical	28514442
KCTD2_HUMAN	KCTD2	physical	28514442
YAP1_HUMAN	YAP1	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
EPN1_HUMAN	EPN1	physical	28514442
NXN_HUMAN	NXN	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442
WIPI3_HUMAN	WDR45B	physical	28514442
AN13A_HUMAN	ANKRD13A	physical	28514442
ABRX2_HUMAN	FAM175B	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
KDM1A_HUMAN	KDM1A	physical	28514442
WWP1_HUMAN	WWP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.