dbPTM

RCOR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RCOR3_HUMAN
UniProt AC	Q9P2K3
Protein Name	REST corepressor 3
Gene Name	RCOR3
Organism	Homo sapiens (Human).
Sequence Length	495
Subcellular Localization	Nucleus .
Protein Description	May act as a component of a corepressor complex that represses transcription..
Protein Sequence	MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MRVGAEYQARIPEF -CCCCCCCCCCCCCC	13.62	24719451
20	Sumoylation	EFDPGATKYTDKDNG CCCCCCCCEEECCCC	45.69	28112733
20	Ubiquitination	EFDPGATKYTDKDNG CCCCCCCCEEECCCC	45.69	21890473
20 (in isoform 1)	Ubiquitination	-	45.69	21890473
22	Phosphorylation	DPGATKYTDKDNGGM CCCCCCEEECCCCCE	37.82	24719451
24 (in isoform 2)	Phosphorylation	-	45.34	28348404
24 (in isoform 3)	Phosphorylation	-	45.34	28348404
24 (in isoform 4)	Phosphorylation	-	45.34	28348404
33	Phosphorylation	NGGMLVWSPYHSIPD CCCEEEEECCCCCCC	14.22	25159151
34 (in isoform 2)	Phosphorylation	-	18.36	28348404
34 (in isoform 3)	Phosphorylation	-	18.36	28348404
34 (in isoform 4)	Phosphorylation	-	18.36	28348404
35 (in isoform 2)	Phosphorylation	-	11.59	28348404
35 (in isoform 3)	Phosphorylation	-	11.59	28348404
35 (in isoform 4)	Phosphorylation	-	11.59	28348404
36 (in isoform 2)	Phosphorylation	-	23.72	28348404
36 (in isoform 3)	Phosphorylation	-	23.72	28348404
36 (in isoform 4)	Phosphorylation	-	23.72	28348404
42 (in isoform 2)	Phosphorylation	-	64.94	28450419
42 (in isoform 3)	Phosphorylation	-	64.94	28450419
42 (in isoform 4)	Phosphorylation	-	64.94	28450419
43 (in isoform 2)	Phosphorylation	-	6.92	28450419
43 (in isoform 3)	Phosphorylation	-	6.92	28450419
43 (in isoform 4)	Phosphorylation	-	6.92	28450419
46	Phosphorylation	PDAKLDEYIAIAKEK CCCCHHHHHHHHHHH	8.70	-
47 (in isoform 2)	Phosphorylation	-	1.79	28450419
47 (in isoform 3)	Phosphorylation	-	1.79	28450419
47 (in isoform 4)	Phosphorylation	-	1.79	28450419
50 (in isoform 2)	Phosphorylation	-	12.63	28450419
50 (in isoform 3)	Phosphorylation	-	12.63	28450419
50 (in isoform 4)	Phosphorylation	-	12.63	28450419
51	Ubiquitination	DEYIAIAKEKHGYNV HHHHHHHHHHCCCCH	62.27	29901268
51 (in isoform 2)	Phosphorylation	-	62.27	28450419
51 (in isoform 3)	Phosphorylation	-	62.27	28450419
51 (in isoform 4)	Phosphorylation	-	62.27	28450419
74	Ubiquitination	WHKHNIEKSLADLPN HHHHHHHHHHHCCCC	47.15	-
78	Ubiquitination	NIEKSLADLPNFTPF HHHHHHHCCCCCCCC	68.87	21890473
78	Ubiquitination	NIEKSLADLPNFTPF HHHHHHHCCCCCCCC	68.87	21890473
78	Ubiquitination	NIEKSLADLPNFTPF HHHHHHHCCCCCCCC	68.87	21890473
78 (in isoform 2)	Ubiquitination	-	68.87	21890473
78 (in isoform 3)	Ubiquitination	-	68.87	-
79	Ubiquitination	IEKSLADLPNFTPFP HHHHHHCCCCCCCCC	2.88	21890473
83	Phosphorylation	LADLPNFTPFPDEWT HHCCCCCCCCCCCCC	30.57	-
109	Ubiquitination	SFHGKSFHRIQQMLP HCCCHHHHHHHHHCC	32.78	29901268
122	Phosphorylation	LPDKTIASLVKYYYS CCCCHHHHHHHHHHH	29.82	24719451
125	Ubiquitination	KTIASLVKYYYSWKK CHHHHHHHHHHHCHH	32.59	-
126	Phosphorylation	TIASLVKYYYSWKKT HHHHHHHHHHHCHHC	10.52	22817900
127	Phosphorylation	IASLVKYYYSWKKTR HHHHHHHHHHCHHCC	5.82	18083107
128	Phosphorylation	ASLVKYYYSWKKTRS HHHHHHHHHCHHCCC	12.64	18083107
129	Phosphorylation	SLVKYYYSWKKTRSR HHHHHHHHCHHCCCC	19.12	24719451
141	Ubiquitination	RSRTSLMDRQARKLA CCCCHHHHHHHHHHH	44.85	29901268
156	Phosphorylation	NRHNQGDSDDDVEET HHCCCCCCCCCHHHC	50.17	23927012
163	Phosphorylation	SDDDVEETHPMDGND CCCCHHHCCCCCCCC	20.13	23927012
171	Phosphorylation	HPMDGNDSDYDPKKE CCCCCCCCCCCHHHH	41.91	30278072
173	Phosphorylation	MDGNDSDYDPKKEAK CCCCCCCCCHHHHHH	37.79	23927012
183 (in isoform 3)	Ubiquitination	-	56.06	-
193	Sumoylation	EQPVQTSKIGLGRRE CCCCCCCHHCCCHHH	44.15	28112733
193	Ubiquitination	EQPVQTSKIGLGRRE CCCCCCCHHCCCHHH	44.15	29967540
201	Phosphorylation	IGLGRREYQSLQHRH HCCCHHHHHHHHHHH	11.11	22817900
232	Phosphorylation	QEDVVAVSCSPNAAN HHCEEEEECCHHHHH	10.11	23532336
234	Phosphorylation	DVVAVSCSPNAANTI CEEEEECCHHHHHHH	17.43	26074081
240	Phosphorylation	CSPNAANTILRQLDM CCHHHHHHHHHHHCH	19.36	24719451
251	Phosphorylation	QLDMELISLKRQVQN HHCHHHHHHHHHHHC	40.23	24719451
251	Ubiquitination	QLDMELISLKRQVQN HHCHHHHHHHHHHHC	40.23	29967540
256	Ubiquitination	LISLKRQVQNAKQVN HHHHHHHHHCHHHHH	5.71	23000965
262	Ubiquitination	QVQNAKQVNSALKQK HHHCHHHHHHHHHHH	6.35	21890473
282	Phosphorylation	EEFKPPESNQKINAR CCCCCCCCCCCCCCC	50.78	26270265
285	Sumoylation	KPPESNQKINARWTT CCCCCCCCCCCCCCC	42.02	28112733
307	Ubiquitination	QGVRKYGKDFQAIAD HHHHHHCCCHHHHHH	52.89	29967540
319	Ubiquitination	IADVIGNKTVGQVKN HHHHHCCCCHHHHHC	39.10	23000965
325	Ubiquitination	NKTVGQVKNFFVNYR CCCHHHHHCHHHHHH	39.90	23000965
325 (in isoform 1)	Ubiquitination	-	39.90	21890473
351	Ubiquitination	WEAEQGTQASNGDAS HHHHHCCCCCCCCHH	50.01	23000965
352	Ubiquitination	EAEQGTQASNGDAST HHHHCCCCCCCCHHH	12.56	23000965
357	Ubiquitination	TQASNGDASTLGEET CCCCCCCHHHCCHHH	13.05	21890473
358	Ubiquitination	QASNGDASTLGEETK CCCCCCHHHCCHHHC	28.98	21890473
365	Ubiquitination	STLGEETKSASNVPS HHCCHHHCCCCCCCC	47.51	29967540
366	Phosphorylation	TLGEETKSASNVPSG HCCHHHCCCCCCCCC	44.33	30278072
368	Phosphorylation	GEETKSASNVPSGKS CHHHCCCCCCCCCCC	45.51	30278072
372	Phosphorylation	KSASNVPSGKSTDEE CCCCCCCCCCCCCHH	55.35	23401153
375	Phosphorylation	SNVPSGKSTDEEEEA CCCCCCCCCCHHHHH	44.62	23401153
376	Phosphorylation	NVPSGKSTDEEEEAQ CCCCCCCCCHHHHHC	51.41	23401153
377	Ubiquitination	VPSGKSTDEEEEAQT CCCCCCCCHHHHHCC	69.29	23000965
378	Ubiquitination	PSGKSTDEEEEAQTP CCCCCCCHHHHHCCC	68.35	23000965
383	Ubiquitination	TDEEEEAQTPQAPRT CCHHHHHCCCCCCCC	57.92	21890473
383	Ubiquitination	TDEEEEAQTPQAPRT CCHHHHHCCCCCCCC	57.92	21890473
383	Ubiquitination	TDEEEEAQTPQAPRT CCHHHHHCCCCCCCC	57.92	21890473
383 (in isoform 3)	Ubiquitination	-	57.92	-
384	Phosphorylation	DEEEEAQTPQAPRTL CHHHHHCCCCCCCCC	25.15	23927012
384	Ubiquitination	DEEEEAQTPQAPRTL CHHHHHCCCCCCCCC	25.15	21890473
390	Ubiquitination	QTPQAPRTLGPSPPA CCCCCCCCCCCCCCC	34.70	21890473
394	Phosphorylation	APRTLGPSPPAPSST CCCCCCCCCCCCCCC	41.54	26074081
399	Phosphorylation	GPSPPAPSSTPTPTA CCCCCCCCCCCCCCC	49.29	26074081
400	Phosphorylation	PSPPAPSSTPTPTAP CCCCCCCCCCCCCCC	37.03	26074081
401	Phosphorylation	SPPAPSSTPTPTAPI CCCCCCCCCCCCCCC	35.20	26074081
403	Phosphorylation	PAPSSTPTPTAPIAT CCCCCCCCCCCCCCC	33.10	26074081
409	Ubiquitination	PTPTAPIATLNQPPP CCCCCCCCCCCCCCC	12.65	23000965
410	Ubiquitination	TPTAPIATLNQPPPL CCCCCCCCCCCCCCC	27.28	23000965
415	Ubiquitination	IATLNQPPPLLRPTL CCCCCCCCCCCCCCC	23.54	21890473
416	Ubiquitination	ATLNQPPPLLRPTLP CCCCCCCCCCCCCCC	51.19	21890473
429 (in isoform 2)	Phosphorylation	-	28.56	-
430 (in isoform 2)	Phosphorylation	-	52.10	-
434	Phosphorylation	ALHRQPPPLQQQARF HHHCCCCCHHHHHHH	49.86	33259812
434 (in isoform 2)	Phosphorylation	-	49.86	25159151
440	Methylation	PPLQQQARFIQPRPT CCHHHHHHHCCCCCC	25.51	18968907
445	Asymmetric dimethylarginine	QARFIQPRPTLNQPP HHHHCCCCCCCCCCC	22.06	-
445	Methylation	QARFIQPRPTLNQPP HHHHCCCCCCCCCCC	22.06	24129315
457	Asymmetric dimethylarginine	QPPPPLIRPANSMPP CCCCCCCCCCCCCCC	31.77	-
457	Methylation	QPPPPLIRPANSMPP CCCCCCCCCCCCCCC	31.77	24129315
466	Phosphorylation	ANSMPPRLNPRPVLS CCCCCCCCCCCCCEE	14.79	33259812
488	Phosphorylation	PSLIGIQTDSQSSLH CCEEEEECCCCCCCC	35.38	27732954
490	Phosphorylation	LIGIQTDSQSSLH-- EEEEECCCCCCCC--	35.04	27732954
492	Phosphorylation	GIQTDSQSSLH---- EEECCCCCCCC----	38.53	27732954
493	Phosphorylation	IQTDSQSSLH----- EECCCCCCCC-----	23.87	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RCOR3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RCOR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RCOR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP70_HUMAN	CEP70	physical	16189514
A4_HUMAN	APP	physical	21832049
1433T_HUMAN	YWHAQ	physical	21988832
KDM1A_HUMAN	KDM1A	physical	23455924
TRI54_HUMAN	TRIM54	physical	25416956
PRD14_HUMAN	PRDM14	physical	25416956
C102B_HUMAN	CCDC102B	physical	25416956
TSG10_HUMAN	TSGA10	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
MIPO1_HUMAN	MIPOL1	physical	25416956
LCA5_HUMAN	LCA5	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
TRAF2_HUMAN	TRAF2	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RCOR3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156, AND MASSSPECTROMETRY.	17081983 [Abstract]