TSG10_HUMAN - dbPTM
TSG10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSG10_HUMAN
UniProt AC Q9BZW7
Protein Name Testis-specific gene 10 protein
Gene Name TSGA10
Organism Homo sapiens (Human).
Sequence Length 698
Subcellular Localization Cytoplasm. Nucleus. Nucleus membrane. The 27 kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail while the 55 kDa peptide localizes to the midpiece..
Protein Description May play a role in the sperm tail fibrous sheath, a major sperm tail structure..
Protein Sequence MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationSKSPRRPSPTARGAN
CCCCCCCCCCCCCCC		32.8323532336
15PhosphorylationSPRRPSPTARGANCD
CCCCCCCCCCCCCCC		33.0730622161
28PhosphorylationCDVELLKTTTRDREE
CCCEEHHCCCCCHHH		33.1125690035
29PhosphorylationDVELLKTTTRDREEL
CCEEHHCCCCCHHHH		20.4625690035
58AcetylationQGNVKVLKSERDKIF
HCCEEEECCHHHHHH		53.9420167786
91PhosphorylationKSCKSPKSTTAHAIL
HHCCCCCCHHHHHHH		34.0830622161
92PhosphorylationSCKSPKSTTAHAILR
HCCCCCCHHHHHHHH		33.8430622161
93PhosphorylationCKSPKSTTAHAILRR
CCCCCCHHHHHHHHH		24.4430622161
137AcetylationQETAFNEKAHLEQRI
HHHHHHHHHHHHHHH		42.0630593123
163PhosphorylationDERMEQMSNMTLMKE
HHHHHHHHHHHHHHH		24.1218669648
166PhosphorylationMEQMSNMTLMKETIS
HHHHHHHHHHHHHHH		28.1318669648
171PhosphorylationNMTLMKETISTVEKE
HHHHHHHHHHHHHHH		18.0818669648
173PhosphorylationTLMKETISTVEKEMK
HHHHHHHHHHHHHHH		33.5430622161
174PhosphorylationLMKETISTVEKEMKS
HHHHHHHHHHHHHHH		28.9129038488
191PhosphorylationRKAMDTESELGRQKA
HHHHHCHHHHHHHHH		39.9730622161
202PhosphorylationRQKAENNSLRLLYEN
HHHHHHCHHHHHHHC		26.8430622161
207PhosphorylationNNSLRLLYENTEKDL
HCHHHHHHHCCCCCC		16.2427067055
210PhosphorylationLRLLYENTEKDLSDT
HHHHHHCCCCCCHHH		32.2627067055
215PhosphorylationENTEKDLSDTQRHLA
HCCCCCCHHHHHHHH		49.0630622161
217PhosphorylationTEKDLSDTQRHLAKK
CCCCCHHHHHHHHHH		24.9130622161
226PhosphorylationRHLAKKKYELQLTQE
HHHHHHHHHHHCHHH		30.6530622161
231PhosphorylationKKYELQLTQEKIMCL
HHHHHHCHHHHHHHH		23.0130622161
246PhosphorylationDEKIDNFTRQNIAQR
HHHHHHHHHHHHHHH		37.2829083192
475PhosphorylationQHLNAERSYKSQIST
HHHHHHHHHHHHHHH		28.5528176443
476PhosphorylationHLNAERSYKSQISTL
HHHHHHHHHHHHHHH		22.3828176443
478PhosphorylationNAERSYKSQISTLHK
HHHHHHHHHHHHHHH		25.2328176443
481PhosphorylationRSYKSQISTLHKSVV
HHHHHHHHHHHHHHH		19.7828176443
520PhosphorylationELCIKLDSSKELLNR
HHHHHCCCCHHHHHH		54.4627461979
521PhosphorylationLCIKLDSSKELLNRQ
HHHHCCCCHHHHHHH		29.8027461979
545PhosphorylationMRENELDSAHSEIEL
HHHHHHHHHHHHHHH		40.2730622161
548PhosphorylationNELDSAHSEIELLRS
HHHHHHHHHHHHHHH		39.7330622161
563PhosphorylationQMANERISMQNLEAL
HHHCCCCCHHHHHHH		22.1225693802
579PhosphorylationVANRDKEYQSQIALQ
HHCCCHHHHHHHHHH		21.1425693802
581PhosphorylationNRDKEYQSQIALQEK
CCCHHHHHHHHHHHC		23.7430622161
590PhosphorylationIALQEKESEIQLLKE
HHHHHCHHHHHHHHH		51.5830622161
636PhosphorylationITKRQLGTERFERER
HHHHHHCCHHHHHHH		32.3624719451
653PhosphorylationQELRRQNYSSNAYHM
HHHHHCCCCCCCCCC		12.7224043423
654PhosphorylationELRRQNYSSNAYHMS
HHHHCCCCCCCCCCC		25.3524043423
655PhosphorylationLRRQNYSSNAYHMSS
HHHCCCCCCCCCCCC		18.3424043423
658PhosphorylationQNYSSNAYHMSSTMK
CCCCCCCCCCCCCCC		11.4224043423
661PhosphorylationSSNAYHMSSTMKPNT
CCCCCCCCCCCCCCC		14.8924043423
662PhosphorylationSNAYHMSSTMKPNTK
CCCCCCCCCCCCCCC		25.5824043423
663PhosphorylationNAYHMSSTMKPNTKC
CCCCCCCCCCCCCCC		23.1624043423
680PhosphorylationPERAHHRSPDRGLDR
CCCCCCCCCCCCCCC		27.1324260401
688PhosphorylationPDRGLDRSLEENLCY
CCCCCCCCHHHHCCC		39.5425693802
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSG10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSG10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSG10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VIME_HUMANVIMphysical
20797700
MYH9_HUMANMYH9physical
20797700
ACTG_HUMANACTG1physical
20797700
OBSL1_HUMANOBSL1physical
20797700
TBB5_HUMANTUBBphysical
20797700
TBA3C_HUMANTUBA3Cphysical
20797700
MYL6_HUMANMYL6physical
20797700
PLEC_HUMANPLECphysical
20797700
FLNA_HUMANFLNAphysical
20797700
TSG10_HUMANTSGA10physical
25416956
CEP44_HUMANCEP44physical
25416956
F161A_HUMANFAM161Aphysical
25416956
ZN587_HUMANZNF587physical
25416956
FBF1_HUMANFBF1physical
25416956
ZN670_HUMANZNF670physical
25416956
ZN417_HUMANZNF417physical
25416956
ZN599_HUMANZNF599physical
25416956
SYT6_HUMANSYT6physical
25416956
PPR18_HUMANPPP1R18physical
25416956
SPERT_HUMANSPERTphysical
25416956
ZBT38_HUMANZBTB38physical
25416956
BCL6B_HUMANBCL6Bphysical
25416956
RTP5_HUMANRTP5physical
25416956
CE57L_HUMANCEP57L1physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSG10_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; THR-166 ANDTHR-171, AND MASS SPECTROMETRY.

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