F161A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F161A_HUMAN
• UniProt AC: Q3B820
• Protein Name: Protein FAM161A
• Gene Name: FAM161A
• Organism: Homo sapiens (Human).
• Sequence Length: 660
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium . Localized to the region between the outer and inner photoreceptor segments, corresponding to the photoreceptor connecting cilium.
• Protein Description: Involved in ciliogenesis..
• Protein Sequence: MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRELEEREEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	ATSHRVAKLVASSLQ CCHHHHHHHHHHHCC	40.41	29967540
13	Phosphorylation	RVAKLVASSLQTPVN HHHHHHHHHCCCCCC	24.89	25693802
14	Phosphorylation	VAKLVASSLQTPVNP HHHHHHHHCCCCCCC	18.11	25693802
17	Phosphorylation	LVASSLQTPVNPITG HHHHHCCCCCCCCCC	34.20	25693802
37	Ubiquitination	YEREDPLKALAAAEA CCCCCHHHHHHHHHH	46.90	29967540
61	Phosphorylation	VAQPAGASADLNTSF HCCCCCCCCCCCCCC	22.77	26471730
66	Phosphorylation	GASADLNTSFSGVDE CCCCCCCCCCCCCCC	38.15	28348404
67	Phosphorylation	ASADLNTSFSGVDEH CCCCCCCCCCCCCCC	19.15	28348404
69	Phosphorylation	ADLNTSFSGVDEHAP CCCCCCCCCCCCCCC	37.36	28348404
78	Phosphorylation	VDEHAPISYEDFVNF CCCCCCCCHHHHCCC	22.78	26471730
79	Phosphorylation	DEHAPISYEDFVNFP CCCCCCCHHHHCCCC	21.90	26471730
135	Phosphorylation	PVVIREDSLSDSSRS CEEEECCCCCCCCCC	25.64	20363803
137	Phosphorylation	VIREDSLSDSSRSVS EEECCCCCCCCCCHH	39.12	20363803
139	Phosphorylation	REDSLSDSSRSVSEK ECCCCCCCCCCHHHC	25.03	29978859
140	Phosphorylation	EDSLSDSSRSVSEKN CCCCCCCCCCHHHCC	33.30	29978859
258	Phosphorylation	KKEESMKSKSDIEMV HHHHHHCCHHHHHHH	28.84	30622161
260	Phosphorylation	EESMKSKSDIEMVHK HHHHCCHHHHHHHHH	51.41	30622161
278	Phosphorylation	KQEEDPEYKKKFRAN HCCCCHHHHHHHCCC	33.23	-
279	Acetylation	QEEDPEYKKKFRANP CCCCHHHHHHHCCCC	48.07	20167786
281	Acetylation	EDPEYKKKFRANPVP CCHHHHHHHCCCCCC	35.61	20167786
296	Phosphorylation	ASVFLPLYHDLVKQK HHHHHHHHHHHHHHH	7.43	-
309	Phosphorylation	QKEERRRSLKEKSKE HHHHHHHHHHHHHHH	41.82	-
363	Phosphorylation	KARPIPRSTYGSTTN CCCCCCHHHCCCCCC	22.19	30622161
364	Phosphorylation	ARPIPRSTYGSTTND CCCCCHHHCCCCCCH	32.93	30622161
365	Phosphorylation	RPIPRSTYGSTTNDK CCCCHHHCCCCCCHH	15.43	30622161
367	Phosphorylation	IPRSTYGSTTNDKLK CCHHHCCCCCCHHHC	22.96	30622161
368	Phosphorylation	PRSTYGSTTNDKLKE CHHHCCCCCCHHHCH	25.84	30622161
369	Phosphorylation	RSTYGSTTNDKLKEE HHHCCCCCCHHHCHH	43.02	30622161
374	Ubiquitination	STTNDKLKEEELYRN CCCCHHHCHHHHHHH	69.67	29967540
379	Phosphorylation	KLKEEELYRNLRTQL HHCHHHHHHHHHHHH	10.75	24043423
384	Phosphorylation	ELYRNLRTQLRAQEH HHHHHHHHHHHHHHH	34.81	24043423
395	Phosphorylation	AQEHLQNSSPLPCRS HHHHHHCCCCCCCHH	22.00	30266825
396	Phosphorylation	QEHLQNSSPLPCRSA HHHHHCCCCCCCHHH	37.70	30266825
428	Phosphorylation	KHKVRCPTPDFEDLP CCCCCCCCCCHHHCH	38.83	22617229
438	Phosphorylation	FEDLPERYQKHLSEH HHHCHHHHHHHHHHC	21.91	-
447	Phosphorylation	KHLSEHKSPKLLTVC HHHHHCCCCHHEEEE	29.22	24706070
462	Phosphorylation	KPFDLHASPHASIKR CCCCCCCCCCCCCCH	13.38	30576142
466	Phosphorylation	LHASPHASIKREKIL CCCCCCCCCCHHHHH	26.13	25159151
468	Sumoylation	ASPHASIKREKILAD CCCCCCCCHHHHHHH	52.59	28112733
468	Sumoylation	ASPHASIKREKILAD CCCCCCCCHHHHHHH	52.59	-
484	Ubiquitination	EADEENLKETRWPYL HCCHHHHHHCCCCCC	69.49	29967540
484	Sumoylation	EADEENLKETRWPYL HCCHHHHHHCCCCCC	69.49	28112733
492	Phosphorylation	ETRWPYLSPRRKSPV HCCCCCCCCCCCCCC	15.54	28985074
497	Phosphorylation	YLSPRRKSPVRCAGV CCCCCCCCCCCCCCC	27.15	23090842
538	Phosphorylation	EKERMREYQRELEER HHHHHHHHHHHHHHH	11.51	-
560 (in isoform 3)	Phosphorylation	-	22.35	-
570	Acetylation	NARMAAEKHYSNTLK HHHHHHHHHHHHHHH	43.02	25953088
577	Ubiquitination	KHYSNTLKALGISDE HHHHHHHHHCCCCHH	39.26	29967540
582	Phosphorylation	TLKALGISDEFVSKK HHHHCCCCHHHHHCC	29.32	27050516
587	Phosphorylation	GISDEFVSKKGQSGK CCCHHHHHCCCCCCC	33.69	23312004
588	Ubiquitination	ISDEFVSKKGQSGKV CCHHHHHCCCCCCCE	56.47	29967540
588	Acetylation	ISDEFVSKKGQSGKV CCHHHHHCCCCCCCE	56.47	12435317
589	Acetylation	SDEFVSKKGQSGKVL CHHHHHCCCCCCCEE	55.46	12435325
598	Phosphorylation	QSGKVLEYFNNQETK CCCCEEHHHCCCCCC	13.88	25839225
608	Phosphorylation	NQETKSVTEDKESFN CCCCCCCCCCHHHCC	45.62	30108239
613	Phosphorylation	SVTEDKESFNEEEKI CCCCCHHHCCHHHHH	38.83	30108239
636	Phosphorylation	NYFIDTNSQDSYKEK CEEECCCCCCHHHHH	37.14	28985074
639	Phosphorylation	IDTNSQDSYKEKDEA ECCCCCCHHHHHHHH	30.39	22468782
640	Phosphorylation	DTNSQDSYKEKDEAN CCCCCCHHHHHHHHH	31.30	22468782
644	Ubiquitination	QDSYKEKDEANEESE CCHHHHHHHHHHHCH	62.42	29967540
650	Phosphorylation	KDEANEESEEEKSVE HHHHHHHCHHHHHHH	44.09	25849741
655	Phosphorylation	EESEEEKSVEESH-- HHCHHHHHHHHCC--	37.73	30108239
659	Phosphorylation	EEKSVEESH------ HHHHHHHCC------	22.46	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F161A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F161A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F161A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPM1F_HUMAN	PPM1F	physical	16169070
F161A_HUMAN	FAM161A	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
TRI15_HUMAN	TRIM15	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956
POC5_HUMAN	POC5	physical	25416956
MIPO1_HUMAN	MIPOL1	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
TXLNB_HUMAN	TXLNB	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
NUTM1_HUMAN	NUTM1	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
POC1B_HUMAN	POC1B	physical	25018096
LCA5_HUMAN	LCA5	physical	25018096
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606068: Retinitis pigmentosa 28 (RP28)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.