PPM1F_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPM1F_HUMAN
• UniProt AC: P49593
• Protein Name: Protein phosphatase 1F
• Gene Name: PPM1F
• Organism: Homo sapiens (Human).
• Sequence Length: 454
• Protein Description: Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis..
• Protein Sequence: MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAELAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREEEEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVVFLRDPQELLEGGNQGEGDPQAEGRRQDLPSSLPEPETQAPPRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSGAPQKS ------CCCCCCCCC	37.16	26074081
3	Phosphorylation	-----MSSGAPQKSS -----CCCCCCCCCC	37.36	26074081
9	Phosphorylation	SSGAPQKSSPMASGA CCCCCCCCCCCCCCC	34.13	20068231
10	Phosphorylation	SGAPQKSSPMASGAE CCCCCCCCCCCCCCC	26.23	20068231
14	Phosphorylation	QKSSPMASGAEETPG CCCCCCCCCCCCCCC	32.08	26074081
19	Phosphorylation	MASGAEETPGFLDTL CCCCCCCCCCHHHHH	21.88	20068231
70	Ubiquitination	MGFLGSRKAPPPLAA HHHHCCCCCCHHHHH	67.93	-
100	Methylation	SEFRKLPREEEEEEE HHHHCCCHHHHHHCC	74.52	115488349
128	Phosphorylation	DAQSLAQSFFNRLWE HHHHHHHHHHHHHHH	26.63	23186163
142	Ubiquitination	EVAGQWQKQVPLAAR HHHCHHHHHHCHHHH	50.75	-
158	Phosphorylation	SQRQWLVSIHAIRNT HHHHHHHHHHHHHHH	13.39	-
165	Phosphorylation	SIHAIRNTRRKMEDR HHHHHHHHHHHHHHC	23.23	-
334	Ubiquitination	AIGDVFQKPYVSGEA HHHHHHCCCCCCCCC	27.18	2190698
345	Phosphorylation	SGEADAASRALTGSE CCCCHHHHHHHHCCC	21.58	-
441	Phosphorylation	GRRQDLPSSLPEPET CCCCCCCCCCCCCCC	52.37	23312004
442	Phosphorylation	RRQDLPSSLPEPETQ CCCCCCCCCCCCCCC	46.10	23312004
448	Phosphorylation	SSLPEPETQAPPRS- CCCCCCCCCCCCCC-	40.52	30266825
448	O-linked_Glycosylation	SSLPEPETQAPPRS- CCCCCCCCCCCCCC-	40.52	55821237
454	Phosphorylation	ETQAPPRS------- CCCCCCCC-------	50.80	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPM1F_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPM1F_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPM1F_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARHG7_HUMAN	ARHGEF7	physical	11864573
FEM3_CAEEL	fem-3	physical	11559703
FEM1B_HUMAN	FEM1B	physical	11559703
AAPK2_HUMAN	PRKAA2	physical	20801214
AAPK1_HUMAN	PRKAA1	physical	20801214
KCC2A_HUMAN	CAMK2A	physical	11559703

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.