NUTM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUTM1_HUMAN
• UniProt AC: Q86Y26
• Protein Name: NUT family member 1
• Gene Name: NUTM1
• Organism: Homo sapiens (Human).
• Sequence Length: 1132
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between nucleus and cytoplasm.
• Protein Sequence: MASDGASALPGPDMSMKPSAAPSPSPALPFLPPTSDPPDHPPREPPPQPIMPSVFSPDNPLMLSAFPSSLLVTGDGGPCLSGAGAGKVIVKVKTEGGSAEPSQTQNFILTQTALNSTAPGTPCGGLEGPAPPFVTASNVKTILPSKAVGVSQEGPPGLPPQPPPPVAQLVPIVPLEKAWPGPHGTTGEGGPVATLSKPSLGDRSKISKDVYENFRQWQRYKALARRHLSQSPDTEALSCFLIPVLRSLARLKPTMTLEEGLPLAVQEWEHTSNFDRMIFYEMAERFMEFEAEEMQIQNTQLMNGSQGLSPATPLKLDPLGPLASEVCQQPVYIPKKAASKTRAPRRRQRKAQRPPAPEAPKEIPPEAVKEYVDIMEWLVGTHLATGESDGKQEEEGQQQEEEGMYPDPGLLSYINELCSQKVFVSKVEAVIHPQFLADLLSPEKQRDPLALIEELEQEEGLTLAQLVQKRLMALEEEEDAEAPPSFSGAQLDSSPSGSVEDEDGDGRLRPSPGLQGAGGAACLGKVSSSGKRAREVHGGQEQALDSPRGMHRDGNTLPSPSSWDLQPELAAPQGTPGPLGVERRGSGKVINQVSLHQDGHLGGAGPPGHCLVADRTSEALPLCWQGGFQPESTPSLDAGLAELAPLQGQGLEKQVLGLQKGQQTGGRGVLPQGKEPLAVPWEGSSGAMWGDDRGTPMAQSYDQNPSPRAAGERDDVCLSPGVWLSSEMDAVGLELPVQIEEVIESFQVEKCVTEYQEGCQGLGSRGNISLGPGETLVPGDTESSVIPCGGTVAAAALEKRNYCSLPGPLRANSPPLRSKENQEQSCETVGHPSDLWAEGCFPLLESGDSTLGSSKETLPPTCQGNLLIMGTEDASSLPEASQEAGSRGNSFSPLLETIEPVNILDVKDDCGLQLRVSEDTCPLNVHSYDPQGEGRVDPDLSKPKNLAPLQESQESYTTGTPKATSSHQGLGSTLPRRGTRNAIVPRETSVSKTHRSADRAKGKEKKKKEAEEEDEELSNFAYLLASKLSLSPREHPLSPHHASGGQGSQRASHLLPAGAKGPSKLPYPVAKSGKRALAGGPAPTEKTPHSGAQLGVPREKPLALGVVRPSQPRKRRCDSFVTGRRKKRRRSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	ALPGPDMSMKPSAAP CCCCCCCCCCCCCCC		24719451
53	Phosphorylation	PPQPIMPSVFSPDNP CCCCCCCCCCCCCCC		28857561
56	Phosphorylation	PIMPSVFSPDNPLML CCCCCCCCCCCCCEE		28857561
64	Phosphorylation	PDNPLMLSAFPSSLL CCCCCEECCCCCCEE		28857561
68	Phosphorylation	LMLSAFPSSLLVTGD CEECCCCCCEEEECC		28857561
69	Phosphorylation	MLSAFPSSLLVTGDG EECCCCCCEEEECCC		28857561
73	Phosphorylation	FPSSLLVTGDGGPCL CCCCEEEECCCCCCC		28857561
94	Phosphorylation	KVIVKVKTEGGSAEP CEEEEEECCCCCCCC		-
98	Phosphorylation	KVKTEGGSAEPSQTQ EEECCCCCCCCCCCC		-
145	Phosphorylation	NVKTILPSKAVGVSQ CCEEECCCCCCCCCC		24719451
197	Acetylation	GPVATLSKPSLGDRS CCCCCCCCCCCCCHH		26051181
204	Phosphorylation	KPSLGDRSKISKDVY CCCCCCHHHCCHHHH		-
207	Phosphorylation	LGDRSKISKDVYENF CCCHHHCCHHHHHHH		-
229	Phosphorylation	ALARRHLSQSPDTEA HHHHHHHCCCCCHHH		-
231	Phosphorylation	ARRHLSQSPDTEALS HHHHHCCCCCHHHHH		-
247	Phosphorylation	FLIPVLRSLARLKPT HHHHHHHHHHHCCCC		-
336	Acetylation	QPVYIPKKAASKTRA CCCCCCHHHHCCCCC		70833
339	Phosphorylation	YIPKKAASKTRAPRR CCCHHHHCCCCCCHH		24732914
441	Phosphorylation	QFLADLLSPEKQRDP HHHHHHCCHHHHCCH		25332170
525	Acetylation	GGAACLGKVSSSGKR CCCEECEEECCCCCC		26051181
531	Acetylation	GKVSSSGKRAREVHG EEECCCCCCCCCCCC		26051181
588	Acetylation	VERRGSGKVINQVSL CEECCCCCEEEEEEE		26051181
799	Ubiquitination	VAAAALEKRNYCSLP HHHHHHHHCCCCCCC		25015289
813	Phosphorylation	PGPLRANSPPLRSKE CCCCCCCCCCCCCCC		28634120
817	Ubiquitination	RANSPPLRSKENQEQ CCCCCCCCCCCCHHC		25015289
818	Phosphorylation	ANSPPLRSKENQEQS CCCCCCCCCCCHHCC		-
827	Ubiquitination	ENQEQSCETVGHPSD CCHHCCCCCCCCHHH		25015289
941	Phosphorylation	GRVDPDLSKPKNLAP CCCCCCCCCCCCCCC		24719451
965	Phosphorylation	TGTPKATSSHQGLGS CCCCCCCCCCCCCCC		25954137
966	Phosphorylation	GTPKATSSHQGLGST CCCCCCCCCCCCCCC		25954137
972	Phosphorylation	SSHQGLGSTLPRRGT CCCCCCCCCCCCCCC		24719451
973	Phosphorylation	SHQGLGSTLPRRGTR CCCCCCCCCCCCCCC		25954137
1026	Phosphorylation	NFAYLLASKLSLSPR HHHHHHHHHHCCCCC		22817900
1029	Phosphorylation	YLLASKLSLSPREHP HHHHHHHCCCCCCCC		22817900
1031	Phosphorylation	LASKLSLSPREHPLS HHHHHCCCCCCCCCC		22817900
1046	Methylation	PHHASGGQGSQRASH CCCCCCCCCCCCHHH		26797129
1054	Phosphorylation	GSQRASHLLPAGAKG CCCCHHHCCCCCCCC		-
1057	Phosphorylation	RASHLLPAGAKGPSK CHHHCCCCCCCCCCC		-
1059	Phosphorylation	SHLLPAGAKGPSKLP HHCCCCCCCCCCCCC		-
1122	Phosphorylation	RRCDSFVTGRRKKRR CCCCCCHHCHHHHHH		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUTM1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1026	S	Phosphorylation	Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.	17934517
1029	S	Phosphorylation	Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.	17934517
1031	S	Phosphorylation	Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.	17934517
1046	Q	Methylation	Methylated at Gln-1046 by N6AMT1.	26797129

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUTM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EP300_HUMAN	EP300	physical	20676058
P4HA3_HUMAN	P4HA3	physical	25416956
KANL1_HUMAN	KANSL1	physical	25416956
LHX8_HUMAN	LHX8	physical	25416956
EP300_HUMAN	EP300	physical	24875858

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.