SYCE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYCE1_HUMAN
• UniProt AC: Q8N0S2
• Protein Name: Synaptonemal complex central element protein 1
• Gene Name: SYCE1
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Nucleus . Chromosome . Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are syn
• Protein Description: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination..
• Protein Sequence: MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVASPKPLKGERPGAAHQAGPDVLIGQEDTLHPDLSPRGFQEIKELF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	LTSKAEPTAGAVDRA CCCCCCCCCCHHHHH	29.27	22985185
28	Phosphorylation	EKAGGQDTSSQKIED HHCCCCCCCHHHHHH	23.53	-
29	Phosphorylation	KAGGQDTSSQKIEDL HCCCCCCCHHHHHHH	38.78	-
30	Phosphorylation	AGGQDTSSQKIEDLM CCCCCCCHHHHHHHH	37.27	-
190	Phosphorylation	KEICALDSSKEQLLK HHHHCCCCCHHHHHC	44.13	18452278
191	Phosphorylation	EICALDSSKEQLLKE HHHCCCCCHHHHHCH	39.62	18452278
197	Sumoylation	SSKEQLLKEEKLVKA CCHHHHHCHHHHHHH	72.86	-
197	Sumoylation	SSKEQLLKEEKLVKA CCHHHHHCHHHHHHH	72.86	-
284	Sumoylation	RLKEELEKHGMQVPA HHHHHHHHCCCCCCH	59.07	-
308	Phosphorylation	AGPGDVASPKPLKGE CCCCCCCCCCCCCCC	33.05	29523821
340	Phosphorylation	DTLHPDLSPRGFQEI CCCCCCCCHHHHHHH	21.67	29523821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYCE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYCE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYCE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MR1L1_HUMAN	MRFAP1L1	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
IQUB_HUMAN	IQUB	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
SKA1_HUMAN	SKA1	physical	25416956
STX19_HUMAN	STX19	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.