IQUB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IQUB_HUMAN
• UniProt AC: Q8NA54
• Protein Name: IQ and ubiquitin-like domain-containing protein
• Gene Name: IQUB
• Organism: Homo sapiens (Human).
• Sequence Length: 791
• Protein Description: May play roles in cilia formation and/or maintenance..
• Protein Sequence: MSNQQEKYEAQNIVNSTEESDDAFDTVTIPVPSEEPQESDQTEEHESGIEQFSESHAIHVEEQSDQSFSSLEPDNEQLMEEVISPRQVSYTPQHHEKQYAMQRPNDDSLAFLDKIKSVKESLQESVEDSLATVKVVLIPVGQEIVIPFKVDTILKYLKDHFSHLLGIPHSVLQIRYSGKILKNNETLVQHGVKPQEIVQVEIFSTNPDLYPVRRIDGLTDVSQIITVTVQTGLDQYQQVPVEIVKSDFHKPFLGGFRHKVTGVEYHNAGTQTVPKRIPERLSIFCRDTQTVFQKKNLQQTTNTTSTQMTNIGVYVSNMTDKLVTPGKYFSAAEYHAQRLKAVIVIQTYYRQWHAKIFVENLRRQKSLRLEWETQQELRKIREKEEWIKLDYHRRHNPKTNEDFEFLYNALEFWRQEELTRINQSFTGAERKAALCELLEKETQIIASIGRHRYIAYMANQEAAIQAFLDKCSAPKIWRTPNGKTIEMDTQFTIRARELQNIYKCIMLKNISQDERLDVLLTLKHTVKEHECKLTQEILELIDREVDLMMRGVKHHNLEGLRKRIATLFFHYIKTPLFNPEVAKYLKVPQDPLKFYKKIYFCHSCQLYLPSTEFSVSSTSRRIYRCRNCINLQNEAQKRESFLKYKCLLQQLYYTEADYEDDSKIAFLMQLQDIQYLTENIWASQSVLSACDNLSDLVMVRWNKSLEWSPWNCILLTKDEAAAHLKLTSIEEGYERSFIHKIKHKHILAKNYFSQVPVLASFILDDGEIDEIRWKYHSDTTPKIIESQRPPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
324	Phosphorylation	NMTDKLVTPGKYFSA ECCCCCCCCCCCCCH	36.44	-
475	Acetylation	LDKCSAPKIWRTPNG HHHCCCCCEEECCCC	55.40	20167786
479	Phosphorylation	SAPKIWRTPNGKTIE CCCCEEECCCCCEEE	13.20	30622161
492	Phosphorylation	IEMDTQFTIRARELQ EEECCCCEEEHHHHH	10.35	24719451
502	Phosphorylation	ARELQNIYKCIMLKN HHHHHHHHHHHEECC	13.83	-
640	Phosphorylation	NEAQKRESFLKYKCL CHHHHHHHHHHHHHH	39.65	24719451
736	Phosphorylation	IEEGYERSFIHKIKH HHHHHHHHHHHHHHH	19.33	-
775	Phosphorylation	IDEIRWKYHSDTTPK CEEEEEEECCCCCCC	10.29	30206219
777	Phosphorylation	EIRWKYHSDTTPKII EEEEEECCCCCCCHH	33.30	30206219
779	Phosphorylation	RWKYHSDTTPKIIES EEEECCCCCCCHHHC	48.27	30206219
780	Phosphorylation	WKYHSDTTPKIIESQ EEECCCCCCCHHHCC	27.81	30206219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IQUB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IQUB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IQUB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IQUB_HUMAN	IQUB	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
KR124_HUMAN	KRTAP12-4	physical	25416956
TLR6_HUMAN	TLR6	physical	28514442
BTBD1_HUMAN	BTBD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.