| UniProt ID | BTBD1_HUMAN | |
|---|---|---|
| UniProt AC | Q9H0C5 | |
| Protein Name | BTB/POZ domain-containing protein 1 | |
| Gene Name | BTBD1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 482 | |
| Subcellular Localization | Cytoplasm . Localizes to punctate or elongated cytoplasmic bodies. | |
| Protein Description | Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [PubMed: 14528312 Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity] | |
| Protein Sequence | MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIFYT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASLGPAAAG -----CCCCCCCCCC | 32.34 | 26074081 | |
| 14 | Phosphorylation | AAAGEQASGAEAEPG CCCCCCCCCCCCCCC | 37.93 | 26074081 | |
| 30 | Phosphorylation | AGPPPPPSPSSLGPL CCCCCCCCCHHCCCC | 43.09 | 28188228 | |
| 32 | Phosphorylation | PPPPPSPSSLGPLLP CCCCCCCHHCCCCCC | 42.40 | 29116813 | |
| 33 | Phosphorylation | PPPPSPSSLGPLLPL CCCCCCHHCCCCCCC | 40.50 | 29116813 | |
| 46 | Phosphorylation | PLQREPLYNWQATKA CCCCCCCCCHHHCHH | 25.68 | 21945579 | |
| 52 | Ubiquitination | LYNWQATKASLKERF CCCHHHCHHHHHHHH | 38.71 | 21890473 | |
| 52 | Ubiquitination | LYNWQATKASLKERF CCCHHHCHHHHHHHH | 38.71 | 21890473 | |
| 77 | Ubiquitination | DVRFVLGKGRGAAAA CCHHHHCCCCCHHHC | 41.07 | - | |
| 79 | Methylation | RFVLGKGRGAAAAGG HHHHCCCCCHHHCCC | 34.75 | 24129315 | |
| 157 | Ubiquitination | TTLYTAKKYAVPALE HHHHHHHHHHHHHHH | 35.66 | - | |
| 173 | Ubiquitination | HCVEFLTKHLRADNA HHHHHHHHHHCCCCH | 42.67 | - | |
| 202 | Phosphorylation | LASLCLDTIDKSTMD HHHHHHHCCCHHHHH | 20.37 | - | |
| 234 | Phosphorylation | VLERDTLSIRESRLF HHHHCCCHHHHHHHH | 22.99 | 24719451 | |
| 264 | Ubiquitination | LPVTFGNKQKVLGKA CCCCCCCHHHHHHHH | 52.45 | 21890473 | |
| 266 | Ubiquitination | VTFGNKQKVLGKALS CCCCCHHHHHHHHHH | 40.82 | - | |
| 270 | Ubiquitination | NKQKVLGKALSLIRF CHHHHHHHHHHHHHH | 41.83 | 21890473 | |
| 270 | Ubiquitination | NKQKVLGKALSLIRF CHHHHHHHHHHHHHH | 41.83 | 21890473 | |
| 273 | Phosphorylation | KVLGKALSLIRFPLM HHHHHHHHHHHHCCC | 26.98 | 24719451 | |
| 317 | Phosphorylation | NPKPRVEYIDRPRCC CCCCCCEEECCCCEE | 12.79 | 29496907 | |
| 354 | Phosphorylation | TSDRIRFTVNRRISI CCCCEEEEECCCEEE | 13.66 | - | |
| 376 (in isoform 2) | Phosphorylation | - | 19.48 | 27251275 | |
| 378 (in isoform 2) | Phosphorylation | - | 5.77 | 24114839 | |
| 380 (in isoform 2) | Phosphorylation | - | 3.06 | 24114839 | |
| 388 | Ubiquitination | QIIEYEKKQTLGQND EEEEEECCCCCCCCC | 36.25 | - | |
| 423 | Phosphorylation | EILPNVCYTACATLK EECCCEEEEHHHHCC | 7.96 | 26546556 | |
| 428 | Phosphorylation | VCYTACATLKGPDSH EEEEHHHHCCCCCCC | 28.96 | 26546556 | |
| 439 | Ubiquitination | PDSHYGTKGLKKVVH CCCCCCCCCHHHHHC | 58.86 | 21890473 | |
| 443 | Ubiquitination | YGTKGLKKVVHETPA CCCCCHHHHHCCCCC | 55.31 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BTBD1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BTBD1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BTBD1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TOP1_HUMAN | TOP1 | physical | 11818025 | |
| CSN4_HUMAN | COPS4 | physical | 19295130 | |
| LLR1_HUMAN | LRR1 | physical | 25011449 | |
| FMOD_HUMAN | FMOD | physical | 25011449 | |
| BTBD2_HUMAN | BTBD2 | physical | 28514442 | |
| CUL3_HUMAN | CUL3 | physical | 28514442 | |
| CSN7A_HUMAN | COPS7A | physical | 28514442 | |
| CSN4_HUMAN | COPS4 | physical | 28514442 | |
| TPC10_HUMAN | TRAPPC10 | physical | 28514442 | |
| TPPC9_HUMAN | TRAPPC9 | physical | 28514442 | |
| CSN1_HUMAN | GPS1 | physical | 28514442 | |
| TPPC4_HUMAN | TRAPPC4 | physical | 28514442 | |
| TPPC5_HUMAN | TRAPPC5 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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