TPPC9_HUMAN - dbPTM
TPPC9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPPC9_HUMAN
UniProt AC Q96Q05
Protein Name Trafficking protein particle complex subunit 9
Gene Name TRAPPC9
Organism Homo sapiens (Human).
Sequence Length 1148
Subcellular Localization Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm. Processes and cell bodies of neurons..
Protein Description Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi..
Protein Sequence MSVPDYMQCAEDHQTLLVVVQPVGIVSEENFFRIYKRICSVSQISVRDSQRVLYIRYRHHYPPENNEWGDFQTHRKVVGLITITDCFSAKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQGEIVEQPRTDVAFYPNYEDCQTVEKRIEDFIESLFIVLESKRLDRATDKSGDKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDSLVHYHMSVELLRSVNDFLWLGAALEGLCSASVIYHYPGGTGGKSGARRFQGSTLPAEAANRHRPGAQEVLIDPGALTTNGINPDTSTEIGRAKNCLSPEDIIDKYKEAISYYSKYKNAGVIELEACIKAVRVLAIQKRSMEASEFLQNAVYINLRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRACYKLLLETLPGYSLSLDPKDFSRGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVAQSLENYTSKCPGTMEPIALPGGLTLPPVPFTKLPIVRHVKLLNLPASLRPHKMKSLLGQNVSTKSPFIYSPIIAHNRGEERNKKIDFQWVQGDVCEVQLMVYNPMPFELRVENMGLLTSGVEFESLPAALSLPAESGLYPVTLVGVPQTTGTITVNGYHTTVFGVFSDCLLDNLPGIKTSGSTVEVIPALPRLQISTSLPRSAHSLQPSSGDEISTNVSVQLYNGESQQLIIKLENIGMEPLEKLEVTSKVLTTKEKLYGDFLSWKLEETLAQFPLQPGKVATFTINIKVKLDFSCQENLLQDLSDDGISVSGFPLSSPFRQVVRPRVEGKPVNPPESNKAGDYSHVKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVSTRSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQLAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSACLGALLFLYTGDFFLHIRFHEDSTSKELPPSWFCLPSVHVCALEAQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSVPDYMQC
------CCCCCHHHC		54.3723401153
6Phosphorylation--MSVPDYMQCAEDH
--CCCCCHHHCCCCC		5.3023401153
15PhosphorylationQCAEDHQTLLVVVQP
HCCCCCCEEEEEEEE		20.7423401153
27PhosphorylationVQPVGIVSEENFFRI
EEECCCCCHHHHHHH		36.9523401153
35PhosphorylationEENFFRIYKRICSVS
HHHHHHHHHHHHCEE		7.0323401153
39UbiquitinationFRIYKRICSVSQISV
HHHHHHHHCEEEEEE		3.6922817900
41UbiquitinationIYKRICSVSQISVRD
HHHHHHCEEEEEECC		4.1822817900
45PhosphorylationICSVSQISVRDSQRV
HHCEEEEEECCCCEE		11.9423312004
51UbiquitinationISVRDSQRVLYIRYR
EEECCCCEEEEEEEE		25.1023503661
96UbiquitinationAKDWPQTFEKFHVQK
CCCCCHHHHHHHCCH		8.9422817900
98UbiquitinationDWPQTFEKFHVQKEI
CCCHHHHHHHCCHHH		36.2622817900
103UbiquitinationFEKFHVQKEIYGSTL
HHHHHCCHHHHCCCC		45.02-
108UbiquitinationVQKEIYGSTLYDSRL
CCHHHHCCCCCCCEE		9.7723503661
146UbiquitinationEDCQTVEKRIEDFIE
HHHHHHHHHHHHHHH		55.10-
174UbiquitinationATDKSGDKIPLLCVP
CCCCCCCCCCEEEEE		50.1529967540
185UbiquitinationLCVPFEKKDFVGLDT
EEEECCCCCCCCCCC		49.5629967540
196UbiquitinationGLDTDSRHYKKRCQG
CCCCCCHHHHHHHHH		42.5929967540
201UbiquitinationSRHYKKRCQGRMRKH
CHHHHHHHHHHHHHH		7.45-
237UbiquitinationVELLRSVNDFLWLGA
HHHHHCCCHHHHHHH		35.2521890473
242UbiquitinationSVNDFLWLGAALEGL
CCCHHHHHHHHHHHH		3.4922817900
244UbiquitinationNDFLWLGAALEGLCS
CHHHHHHHHHHHHHC		13.50-
272UbiquitinationKSGARRFQGSTLPAE
CCCCCCCCCCCCCHH		43.0229967540
274PhosphorylationGARRFQGSTLPAEAA
CCCCCCCCCCCHHHH		18.9120068231
275PhosphorylationARRFQGSTLPAEAAN
CCCCCCCCCCHHHHH		43.5220068231
283UbiquitinationLPAEAANRHRPGAQE
CCHHHHHCCCCCCCE		23.5929967540
294UbiquitinationGAQEVLIDPGALTTN
CCCEEEECCCCCCCC		31.2721890473
299UbiquitinationLIDPGALTTNGINPD
EECCCCCCCCCCCCC		20.0622817900
306UbiquitinationTTNGINPDTSTEIGR
CCCCCCCCCCCHHHH		49.1229967540
315UbiquitinationSTEIGRAKNCLSPED
CCHHHHHHCCCCHHH		47.0029967540
317UbiquitinationEIGRAKNCLSPEDII
HHHHHHCCCCHHHHH		3.8229967540
319UbiquitinationGRAKNCLSPEDIIDK
HHHHCCCCHHHHHHH		28.5729967540
326UbiquitinationSPEDIIDKYKEAISY
CHHHHHHHHHHHHHH		48.0629967540
327PhosphorylationPEDIIDKYKEAISYY
HHHHHHHHHHHHHHH		15.43-
327UbiquitinationPEDIIDKYKEAISYY
HHHHHHHHHHHHHHH		15.4329967540
328UbiquitinationEDIIDKYKEAISYYS
HHHHHHHHHHHHHHH		46.5429967540
334PhosphorylationYKEAISYYSKYKNAG
HHHHHHHHHHHCCCC		7.59-
336UbiquitinationEAISYYSKYKNAGVI
HHHHHHHHHCCCCCE		44.0929967540
337PhosphorylationAISYYSKYKNAGVIE
HHHHHHHHCCCCCEE		11.97-
350UbiquitinationIELEACIKAVRVLAI
EEHHHHHHHHHHHHH		40.4927667366
359UbiquitinationVRVLAIQKRSMEASE
HHHHHHHHCCCCHHH		40.0827667366
361PhosphorylationVLAIQKRSMEASEFL
HHHHHHCCCCHHHHH		28.1929978859
365PhosphorylationQKRSMEASEFLQNAV
HHCCCCHHHHHHHHH		18.6429978859
373PhosphorylationEFLQNAVYINLRQLS
HHHHHHHHHHHHHCC		5.0229978859
408AcetylationHRKSAFFKRVAAMQC
HHHCHHHHHHHHHHH		39.247663043
413UbiquitinationFFKRVAAMQCVAPSI
HHHHHHHHHHHCHHH		1.9829967540
424UbiquitinationAPSIAEPGWRACYKL
CHHHCCCHHHHHHHH		20.2929967540
426UbiquitinationSIAEPGWRACYKLLL
HHCCCHHHHHHHHHH		22.2429967540
427UbiquitinationIAEPGWRACYKLLLE
HCCCHHHHHHHHHHH		8.4222817900
434UbiquitinationACYKLLLETLPGYSL
HHHHHHHHHCCCCCC		48.5529967540
437UbiquitinationKLLLETLPGYSLSLD
HHHHHHCCCCCCCCC		47.2822817900
437 (in isoform 3)Ubiquitination-47.2821890473
440UbiquitinationLETLPGYSLSLDPKD
HHHCCCCCCCCCHHH		19.8722817900
446UbiquitinationYSLSLDPKDFSRGTH
CCCCCCHHHCCCCCH		71.6922817900
448UbiquitinationLSLDPKDFSRGTHRG
CCCCHHHCCCCCHHH		7.1927667366
457UbiquitinationRGTHRGWAAVQMRLL
CCCHHHHHHHHHHHH		10.6927667366
469PhosphorylationRLLHELVYASRRMGN
HHHHHHHHHHHHCCC		16.1018083107
475UbiquitinationVYASRRMGNPALSVR
HHHHHHCCCCCHHHH		34.8527667366
480PhosphorylationRMGNPALSVRHLSFL
HCCCCCHHHHHHHHH		21.15-
484UbiquitinationPALSVRHLSFLLQTM
CCHHHHHHHHHHHHH		2.4422817900
492UbiquitinationSFLLQTMLDFLSDQE
HHHHHHHHHHCCHHH		4.8429967540
497UbiquitinationTMLDFLSDQEKKDVA
HHHHHCCHHHHHHHH		63.9122817900
501UbiquitinationFLSDQEKKDVAQSLE
HCCHHHHHHHHHHHH		57.6029967540
532UbiquitinationGGLTLPPVPFTKLPI
CCEECCCCCCCCCCE		6.0227667366
535UbiquitinationTLPPVPFTKLPIVRH
ECCCCCCCCCCEEEE		26.1222817900
544UbiquitinationLPIVRHVKLLNLPAS
CCEEEEEHHHCCCHH		40.9222817900
544 (in isoform 2)Ubiquitination-40.9221890473
547UbiquitinationVRHVKLLNLPASLRP
EEEEHHHCCCHHHCH		55.1822817900
549UbiquitinationHVKLLNLPASLRPHK
EEHHHCCCHHHCHHH		20.8022817900
549 (in isoform 3)Ubiquitination-20.8021890473
551PhosphorylationKLLNLPASLRPHKMK
HHHCCCHHHCHHHHH		23.9928188228
556UbiquitinationPASLRPHKMKSLLGQ
CHHHCHHHHHHHCCC		51.1922817900
558UbiquitinationSLRPHKMKSLLGQNV
HHCHHHHHHHCCCCC		42.6321906983
559PhosphorylationLRPHKMKSLLGQNVS
HCHHHHHHHCCCCCC		25.9029978859
559UbiquitinationLRPHKMKSLLGQNVS
HCHHHHHHHCCCCCC		25.9023503661
566PhosphorylationSLLGQNVSTKSPFIY
HHCCCCCCCCCCCCC		37.3523401153
567PhosphorylationLLGQNVSTKSPFIYS
HCCCCCCCCCCCCCC		31.1229970186
568UbiquitinationLGQNVSTKSPFIYSP
CCCCCCCCCCCCCCC		48.9323503661
569PhosphorylationGQNVSTKSPFIYSPI
CCCCCCCCCCCCCCE		25.7321945579
573PhosphorylationSTKSPFIYSPIIAHN
CCCCCCCCCCEECCC		14.5821945579
574PhosphorylationTKSPFIYSPIIAHNR
CCCCCCCCCEECCCC		12.5721945579
599UbiquitinationQWVQGDVCEVQLMVY
EEECCCEEEEEEEEE		5.1529967540
645UbiquitinationAESGLYPVTLVGVPQ
CCCCCEEEEEEEECC		4.0022817900
647UbiquitinationSGLYPVTLVGVPQTT
CCCEEEEEEEECCCC		3.0022817900
654UbiquitinationLVGVPQTTGTITVNG
EEEECCCCCEEEECC		27.3822817900
656UbiquitinationGVPQTTGTITVNGYH
EECCCCCEEEECCEE		16.0422817900
656 (in isoform 2)Ubiquitination-16.0421890473
657PhosphorylationVPQTTGTITVNGYHT
ECCCCCEEEECCEEE		4.2424719451
657UbiquitinationVPQTTGTITVNGYHT
ECCCCCEEEECCEEE		4.2423503661
664PhosphorylationITVNGYHTTVFGVFS
EEECCEEEEEEEEEH		19.0324719451
666UbiquitinationVNGYHTTVFGVFSDC
ECCEEEEEEEEEHHH		4.0623503661
666 (in isoform 2)Ubiquitination-4.06-
667PhosphorylationNGYHTTVFGVFSDCL
CCEEEEEEEEEHHHH		6.9327642862
671PhosphorylationTTVFGVFSDCLLDNL
EEEEEEEHHHHHHCC		25.6327642862
672PhosphorylationTVFGVFSDCLLDNLP
EEEEEEHHHHHHCCC		18.6724719451
739UbiquitinationQQLIIKLENIGMEPL
EEEEEEEEHHCCCCH		41.6329967540
743SulfoxidationIKLENIGMEPLEKLE
EEEEHHCCCCHHHHC		4.2021406390
745UbiquitinationLENIGMEPLEKLEVT
EEHHCCCCHHHHCCC		36.6121890473
745 (in isoform 3)Ubiquitination-36.6121890473
748UbiquitinationIGMEPLEKLEVTSKV
HCCCCHHHHCCCCCE		58.5929967540
750UbiquitinationMEPLEKLEVTSKVLT
CCCHHHHCCCCCEEC		55.6122817900
752PhosphorylationPLEKLEVTSKVLTTK
CHHHHCCCCCEECCH		17.2929083192
752UbiquitinationPLEKLEVTSKVLTTK
CHHHHCCCCCEECCH		17.2929967540
753PhosphorylationLEKLEVTSKVLTTKE
HHHHCCCCCEECCHH		26.4129083192
754UbiquitinationEKLEVTSKVLTTKEK
HHHCCCCCEECCHHH		31.7221890473
754 (in isoform 1)Ubiquitination-31.7221890473
757PhosphorylationEVTSKVLTTKEKLYG
CCCCCEECCHHHHHH		38.5229083192
758PhosphorylationVTSKVLTTKEKLYGD
CCCCEECCHHHHHHH		32.8029083192
759UbiquitinationTSKVLTTKEKLYGDF
CCCEECCHHHHHHHH		47.8422817900
761UbiquitinationKVLTTKEKLYGDFLS
CEECCHHHHHHHHHH		48.8729967540
826UbiquitinationPLSSPFRQVVRPRVE
CCCCCCCCCCCCCCC		38.1429967540
835UbiquitinationVRPRVEGKPVNPPES
CCCCCCCCCCCCCCC		32.0829967540
842PhosphorylationKPVNPPESNKAGDYS
CCCCCCCCCCCCCCC		49.7820873877
843UbiquitinationPVNPPESNKAGDYSH
CCCCCCCCCCCCCCH		36.2121890473
844UbiquitinationVNPPESNKAGDYSHV
CCCCCCCCCCCCCHH		64.1329967540
846UbiquitinationPPESNKAGDYSHVKT
CCCCCCCCCCCHHCC		35.6829967540
848PhosphorylationESNKAGDYSHVKTLE
CCCCCCCCCHHCCHH		10.3528796482
848UbiquitinationESNKAGDYSHVKTLE
CCCCCCCCCHHCCHH		10.3522817900
849PhosphorylationSNKAGDYSHVKTLEA
CCCCCCCCHHCCHHH		26.9228796482
852UbiquitinationAGDYSHVKTLEAVLN
CCCCCHHCCHHHHHC		41.8021890473
852 (in isoform 2)Ubiquitination-41.8021890473
857UbiquitinationHVKTLEAVLNFKYSG
HHCCHHHHHCCCCCC		3.0722817900
859UbiquitinationKTLEAVLNFKYSGGP
CCHHHHHCCCCCCCC		25.4329967540
891PhosphorylationVEPSVFFTRVSTLPA
ECCCEEEEEECCCCC		20.7826434552
933UbiquitinationEALILHAGECQRMAI
CEEEEECHHHHEEEE		26.0129967540
935UbiquitinationLILHAGECQRMAIQV
EEEECHHHHEEEEEE		2.8022817900
935 (in isoform 3)Ubiquitination-2.8021890473
942UbiquitinationCQRMAIQVDKFNFES
HHEEEEEEECCCHHC		7.6529967540
944PhosphorylationRMAIQVDKFNFESFP
EEEEEEECCCHHCCC		43.2732142685
944UbiquitinationRMAIQVDKFNFESFP
EEEEEEECCCHHCCC		43.2722817900
946PhosphorylationAIQVDKFNFESFPES
EEEEECCCHHCCCCC		45.5827642862
948UbiquitinationQVDKFNFESFPESPG
EEECCCHHCCCCCCC		53.2022817900
948 (in isoform 3)Ubiquitination-53.2021890473
949PhosphorylationVDKFNFESFPESPGE
EECCCHHCCCCCCCC		41.8030266825
953PhosphorylationNFESFPESPGEKGQF
CHHCCCCCCCCCCCC		38.1419664994
955UbiquitinationESFPESPGEKGQFAN
HCCCCCCCCCCCCCC		59.5329967540
957UbiquitinationFPESPGEKGQFANPK
CCCCCCCCCCCCCHH		65.0227667366
964UbiquitinationKGQFANPKQLEEERR
CCCCCCHHHHHHHHH		68.2829967540
983UbiquitinationLEIHSKLGICWRIPS
CHHHHHHCEEEECCC		19.4227667366
990PhosphorylationGICWRIPSLKRSGEA
CEEEECCCCCCCCCC		44.1224719451
992UbiquitinationCWRIPSLKRSGEASV
EEECCCCCCCCCCCH		49.1827667366
1033UbiquitinationPCDREAVAACQVGDP
ECCHHHHHHCCCCCC		15.0122817900
1042UbiquitinationCQVGDPVRLEVRLTN
CCCCCCEEEEEEEEC		30.4422817900
1042 (in isoform 2)Ubiquitination-30.4421890473
1046UbiquitinationDPVRLEVRLTNRSPR
CCEEEEEEEECCCCC		26.8122817900
1051PhosphorylationEVRLTNRSPRSVGPF
EEEEECCCCCCCCCE		27.0819664994
1055UbiquitinationTNRSPRSVGPFALTV
ECCCCCCCCCEEEEE		13.7422817900
1055 (in isoform 2)Ubiquitination-13.7421890473
1062UbiquitinationVGPFALTVVPFQDHQ
CCCEEEEEEECCCCC		5.5329967540
1081UbiquitinationNYDLHDTVSFVGSST
CCCCCCCEEECCCCE		5.3527667366
1088PhosphorylationVSFVGSSTFYLDAVQ
EEECCCCEEEEECCC		20.2824719451
1090UbiquitinationFVGSSTFYLDAVQPS
ECCCCEEEEECCCCC		12.0827667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPPC9_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPPC9_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPPC9_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IKKB_HUMANIKBKBphysical
15951441
TPC10_HUMANTRAPPC10physical
21525244
TPC12_HUMANTRAPPC12physical
21525244
TPC2A_HUMANTRAPPC2physical
21525244
TPC2B_HUMANTRAPPC2physical
21525244
TPC10_HUMANTRAPPC10physical
27173435
TPPC3_HUMANTRAPPC3physical
27173435
TPPC4_HUMANTRAPPC4physical
27173435
TPPC1_HUMANTRAPPC1physical
27173435
RAB3I_HUMANRAB3IPphysical
27173435
TPC2L_HUMANTRAPPC2Lphysical
27173435
TM102_HUMANTMEM102physical
27173435
M21D2_HUMANMB21D2physical
27173435
PDLI7_HUMANPDLIM7physical
27173435
R3GEF_HUMANRAB3IL1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613192Mental retardation, autosomal recessive 13 (MRT13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPPC9_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, AND MASSSPECTROMETRY.

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