dbPTM

TPC10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPC10_HUMAN
UniProt AC	P48553
Protein Name	Trafficking protein particle complex subunit 10
Gene Name	TRAPPC10
Organism	Homo sapiens (Human).
Sequence Length	1259
Subcellular Localization	Golgi apparatus, cis-Golgi network.
Protein Description	May play a role in vesicular transport from endoplasmic reticulum to Golgi..
Protein Sequence	MDASEEPLPPVIYTMENKPIVTCAGDQNLFTSVYPTLSQQLPREPMEWRRSYGRAPKMIHLESNFVQFKEELLPKEGNKALLTFPFLHIYWTECCDTEVYKATVKDDLTKWQNVLKAHSSVDWLIVIVENDAKKKNKTNILPRTSIVDKIRNDFCNKQSDRCVVLSDPLKDSSRTQESWNAFLTKLRTLLLMSFTKNLGKFEDDMRTLREKRTEPGWSFCEYFMVQEELAFVFEMLQQFEDALVQYDELDALFSQYVVNFGAGDGANWLTFFCQPVKSWNGLILRKPIDMEKRESIQRREATLLDLRSYLFSRQCTLLLFLQRPWEVAQRALELLHNCVQELKLLEVSVPPGALDCWVFLSCLEVLQRIEGCCDRAQIDSNIAHTVGLWSYATEKLKSLGYLCGLVSEKGPNSEDLNRTVDLLAGLGAERPETANTAQSPYKKLKEALSSVEAFEKHYLDLSHATIEMYTSIGRIRSAKFVGKDLAEFYMRKKAPQKAEIYLQGALKNYLAEGWALPITHTRKQLAECQKHLGQIENYLQTSSLLASDHHLTEEERKHFCQEILDFASQPSDSPGHKIVLPMHSFAQLRDLHFDPSNAVVHVGGVLCVEITMYSQMPVPVHVEQIVVNVHFSIEKNSYRKTAEWLTKHKTSNGIINFPPETAPFPVSQNSLPALELYEMFERSPSDNSLNTTGIICRNVHMLLRRQESSSSLEMPSGVALEEGAHVLRCSHVTLEPGANQITFRTQAKEPGTYTLRQLCASVGSVWFVLPHIYPIVQYDVYSQEPQLHVEPLADSLLAGIPQRVKFTVTTGHYTIKNGDSLQLSNAEAMLILCQAESRAVVYSNTREQSSEAALRIQSSDKVTSISLPVAPAYHVIEFELEVLSLPSAPALGGESDMLGMAEPHRKHKDKQRTGRCMVTTDHKVSIDCPWSIYSTVIALTFSVPFRTTHSLLSSGTRKYVQVCVQNLSELDFQLSDSYLVDTGDSTDLQLVPLNTQSQQPIYSKQSVFFVWELKWTEEPPPSLHCRFSVGFSPASEEQLSISLKPYTYEFKVENFFTLYNVKAEIFPPSGMEYCRTGSLCSLEVLITRLSDLLEVDKDEALTESDEHFSTKLMYEVVDNSSNWAVCGKSCGVISMPVAARATHRVHMEVMPLFAGYLPLPDVRLFKYLPHHSAHSSQLDADSWIENDSLSVDKHGDDQPDSSSLKSRGSVHSACSSEHKGLPMPRLQALPAGQVFNSSSGTQVLVIPSQDDHVLEVSVT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	EPMEWRRSYGRAPKM CCCHHHHHHCCCCCE	24.30	-
52	Phosphorylation	PMEWRRSYGRAPKMI CCHHHHHHCCCCCEE	14.60	-
137	Ubiquitination	NDAKKKNKTNILPRT CCHHHCCCCCCCCCC	52.40	-
138	Phosphorylation	DAKKKNKTNILPRTS CHHHCCCCCCCCCCH	36.56	-
149	Ubiquitination	PRTSIVDKIRNDFCN CCCHHHHHHHHCCCC	32.44	29967540
157	Ubiquitination	IRNDFCNKQSDRCVV HHHCCCCCCCCCEEE	52.97	-
166	Phosphorylation	SDRCVVLSDPLKDSS CCCEEEECCCCCCCC	26.10	28985074
170	Ubiquitination	VVLSDPLKDSSRTQE EEECCCCCCCCCCHH	62.04	29967540
173	Phosphorylation	SDPLKDSSRTQESWN CCCCCCCCCCHHHHH	49.86	28985074
178	Phosphorylation	DSSRTQESWNAFLTK CCCCCHHHHHHHHHH	18.80	28985074
188	Phosphorylation	AFLTKLRTLLLMSFT HHHHHHHHHHHHHHH	31.99	27794612
193	Phosphorylation	LRTLLLMSFTKNLGK HHHHHHHHHHCCCCC	29.72	24719451
195	Phosphorylation	TLLLMSFTKNLGKFE HHHHHHHHCCCCCCH	16.24	27794612
200	Ubiquitination	SFTKNLGKFEDDMRT HHHCCCCCCHHHHHH	49.06	29967540
211	Acetylation	DMRTLREKRTEPGWS HHHHHHHHCCCCCCC	59.18	7823047
242	Phosphorylation	MLQQFEDALVQYDEL HHHHHHHHHCCHHHH	11.48	32645325
244	Phosphorylation	QQFEDALVQYDELDA HHHHHHHCCHHHHHH	5.48	32142685
390	Phosphorylation	AHTVGLWSYATEKLK HHHHHHHHHHHHHHH	15.21	24719451
391	Phosphorylation	HTVGLWSYATEKLKS HHHHHHHHHHHHHHH	13.13	24719451
398	Phosphorylation	YATEKLKSLGYLCGL HHHHHHHHHHHHHHH	37.15	-
401	Phosphorylation	EKLKSLGYLCGLVSE HHHHHHHHHHHHHCC	12.24	-
409	Ubiquitination	LCGLVSEKGPNSEDL HHHHHCCCCCCHHHH	72.64	29967540
419	Phosphorylation	NSEDLNRTVDLLAGL CHHHHHHHHHHHHHC	19.80	-
433	Phosphorylation	LGAERPETANTAQSP CCCCCCCCCCCCCCH	28.08	-
439	Phosphorylation	ETANTAQSPYKKLKE CCCCCCCCHHHHHHH	27.94	22817900
445	Ubiquitination	QSPYKKLKEALSSVE CCHHHHHHHHHHHHH	50.23	29967540
489	Phosphorylation	GKDLAEFYMRKKAPQ CHHHHHHHHHHCCCC	6.37	28509920
530	Ubiquitination	KQLAECQKHLGQIEN HHHHHHHHHHHHHHH	53.08	29967540
557	Ubiquitination	HLTEEERKHFCQEIL CCCHHHHHHHHHHHH	44.29	29967540
568	Phosphorylation	QEILDFASQPSDSPG HHHHHHHCCCCCCCC	42.49	20873877
571	Phosphorylation	LDFASQPSDSPGHKI HHHHCCCCCCCCCEE	42.98	21712546
573	Phosphorylation	FASQPSDSPGHKIVL HHCCCCCCCCCEEEE	36.80	20873877
590	Phosphorylation	HSFAQLRDLHFDPSN CCHHHHHHCCCCCCC	53.76	32142685
637	Phosphorylation	HFSIEKNSYRKTAEW EEEECCCCHHHHHHH	37.06	26657352
638	Phosphorylation	FSIEKNSYRKTAEWL EEECCCCHHHHHHHH	26.06	26657352
646	Phosphorylation	RKTAEWLTKHKTSNG HHHHHHHHHCCCCCC	31.98	26657352
647	Ubiquitination	KTAEWLTKHKTSNGI HHHHHHHHCCCCCCC	40.72	29967540
649	Ubiquitination	AEWLTKHKTSNGIIN HHHHHHCCCCCCCCC	56.03	-
650	Phosphorylation	EWLTKHKTSNGIINF HHHHHCCCCCCCCCC	27.43	24905233
651	Phosphorylation	WLTKHKTSNGIINFP HHHHCCCCCCCCCCC	37.55	24905233
661	Phosphorylation	IINFPPETAPFPVSQ CCCCCCCCCCCCCCC	45.46	24905233
667	Phosphorylation	ETAPFPVSQNSLPAL CCCCCCCCCCCCCHH	24.71	24905233
670	Phosphorylation	PFPVSQNSLPALELY CCCCCCCCCCHHHHH	28.26	24905233
677	Phosphorylation	SLPALELYEMFERSP CCCHHHHHHHHHCCC	8.93	24905233
683	Phosphorylation	LYEMFERSPSDNSLN HHHHHHCCCCCCCCC	22.89	28450419
685	Phosphorylation	EMFERSPSDNSLNTT HHHHCCCCCCCCCHH	51.15	27499020
688	Phosphorylation	ERSPSDNSLNTTGII HCCCCCCCCCHHCEE	28.17	25262027
691	Phosphorylation	PSDNSLNTTGIICRN CCCCCCCHHCEEEHH	31.52	30108239
692	Phosphorylation	SDNSLNTTGIICRNV CCCCCCHHCEEEHHH	25.88	30108239
708	Phosphorylation	MLLRRQESSSSLEMP HHHHCCCCCCCCCCC	27.47	23927012
709	Phosphorylation	LLRRQESSSSLEMPS HHHCCCCCCCCCCCC	24.16	23927012
710	Phosphorylation	LRRQESSSSLEMPSG HHCCCCCCCCCCCCC	48.50	23927012
711	Phosphorylation	RRQESSSSLEMPSGV HCCCCCCCCCCCCCE	30.23	23927012
716	Phosphorylation	SSSLEMPSGVALEEG CCCCCCCCCEEECCC	44.59	23927012
748	Ubiquitination	ITFRTQAKEPGTYTL EEEEECCCCCCCCHH	55.41	-
753	Phosphorylation	QAKEPGTYTLRQLCA CCCCCCCCHHHHHHH	15.08	24719451
754	Phosphorylation	AKEPGTYTLRQLCAS CCCCCCCHHHHHHHH	18.46	24719451
807	Phosphorylation	IPQRVKFTVTTGHYT CCCEEEEEEEECCEE	15.95	-
809	Phosphorylation	QRVKFTVTTGHYTIK CEEEEEEEECCEEEE	24.81	-
810	Phosphorylation	RVKFTVTTGHYTIKN EEEEEEEECCEEEEC	20.02	-
884	Phosphorylation	EFELEVLSLPSAPAL EEEEEEECCCCCCCC	43.33	23879269
913	Phosphorylation	KHKDKQRTGRCMVTT CCCCCCCCCCEEEEC	26.87	20068231
933	Phosphorylation	IDCPWSIYSTVIALT ECCCCHHHHHHHHHE	7.86	-
950	Phosphorylation	VPFRTTHSLLSSGTR CCCHHCHHHHCCCCH	28.98	-
1040	Phosphorylation	PASEEQLSISLKPYT CCCHHHEEEEECCEE	15.15	24719451
1042	Phosphorylation	SEEQLSISLKPYTYE CHHHEEEEECCEEEE	27.28	24719451
1057	Phosphorylation	FKVENFFTLYNVKAE EEEECEEEEEEEEEE	24.97	32142685
1076	Phosphorylation	SGMEYCRTGSLCSLE CCCCCCHHCCCCHHH	27.79	28348404
1078	Phosphorylation	MEYCRTGSLCSLEVL CCCCHHCCCCHHHHH	26.11	28348404
1081	Phosphorylation	CRTGSLCSLEVLITR CHHCCCCHHHHHHHH	32.62	28348404
1201	Phosphorylation	HGDDQPDSSSLKSRG CCCCCCCCHHHHCCC	28.63	30576142
1202	Phosphorylation	GDDQPDSSSLKSRGS CCCCCCCHHHHCCCC	47.25	25849741
1203	Phosphorylation	DDQPDSSSLKSRGSV CCCCCCHHHHCCCCH	43.71	25849741
1206	Phosphorylation	PDSSSLKSRGSVHSA CCCHHHHCCCCHHHH	47.36	28857561
1209	Phosphorylation	SSLKSRGSVHSACSS HHHHCCCCHHHHCCC	18.62	28857561
1212	Phosphorylation	KSRGSVHSACSSEHK HCCCCHHHHCCCCCC	28.90	28857561
1215	Phosphorylation	GSVHSACSSEHKGLP CCHHHHCCCCCCCCC	38.18	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TPC10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPC10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPC10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPC10_HUMAN	TRAPPC10	physical	21525244
GPDM_HUMAN	GPD2	physical	26186194
GPDM_HUMAN	GPD2	physical	28514442
LG3BP_HUMAN	LGALS3BP	physical	28514442
M21D2_HUMAN	MB21D2	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPC10_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND MASSSPECTROMETRY.	15302935 [Abstract]