dbPTM

LG3BP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LG3BP_HUMAN
UniProt AC	Q08380
Protein Name	Galectin-3-binding protein
Gene Name	LGALS3BP
Organism	Homo sapiens (Human).
Sequence Length	585
Subcellular Localization	Secreted . Secreted, extracellular space, extracellular matrix .
Protein Description	Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells..
Protein Sequence	MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVPTDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQFNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTDSSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSLVYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGWKAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	QGRVEIFYRGQWGTV CCEEEEEECCCCCCC	21.35	-
69	N-linked_Glycosylation	CRALGFENATQALGR HHHCCCCCHHHHHHH	46.13	15084671
69	N-linked_Glycosylation	CRALGFENATQALGR HHHCCCCCHHHHHHH	46.13	15084671
110	Ubiquitination	CKSLGWLKSNCRHER HHHHCHHHHHCCCCC	32.87	-
125	N-linked_Glycosylation	DAGVVCTNETRSTHT CCCEEECCCCCCCCC	43.44	17623646
125	N-linked_Glycosylation	DAGVVCTNETRSTHT CCCEEECCCCCCCCC	43.44	16335952
136	Phosphorylation	STHTLDLSRELSEAL CCCCHHHHHHHHHHH	24.31	29759185
192	N-linked_Glycosylation	LWKEPGSNVTMSVDA HHCCCCCCEEEEECC	38.91	17623646
192	N-linked_Glycosylation	LWKEPGSNVTMSVDA HHCCCCCCEEEEECC	38.91	16335952
220	Phosphorylation	YSRRIDITLSSVKCF HHHCCCEEHHHHHHH	19.48	20068231
229	Ubiquitination	SSVKCFHKLASAYGA HHHHHHHHHHHHHCH	26.04	-
256	Phosphorylation	ILLPQDPSFQMPLDL HHCCCCCCCCCCHHH	36.08	-
323	Ubiquitination	PSELALLKAVDTWSW CCHHHHHHHHHHCCC	47.41	-
345	Ubiquitination	EVEGLVEKIRFPMML HHHHHHHHHCCCCCC	31.53	-
345	2-Hydroxyisobutyrylation	EVEGLVEKIRFPMML HHHHHHHHHCCCCCC	31.53	-
362	N-linked_Glycosylation	ELFELQFNLSLYWSH HHHHCHHHHHHEECH	18.76	UniProtKB CARBOHYD
376	Ubiquitination	HEALFQKKTLQALEF HHHHHCCHHHHHHHH	43.62	-
395	Ubiquitination	FQLLARYKGLNLTED HHHHHHHCCCCCCCC	51.90	-
398	N-linked_Glycosylation	LARYKGLNLTEDTYK HHHHCCCCCCCCCCC	54.29	17623646
398	N-linked_Glycosylation	LARYKGLNLTEDTYK HHHHCCCCCCCCCCC	54.29	17623646
405	Ubiquitination	NLTEDTYKPRIYTSP CCCCCCCCCCEECCC	29.88	-
411	Phosphorylation	YKPRIYTSPTWSAFV CCCCEECCCCCEEEE	11.89	-
413	O-linked_Glycosylation	PRIYTSPTWSAFVTD CCEECCCCCEEEECC	31.64	OGP
413	Phosphorylation	PRIYTSPTWSAFVTD CCEECCCCCEEEECC	31.64	-
415	Phosphorylation	IYTSPTWSAFVTDSS EECCCCCEEEECCCC	17.82	-
427	Ubiquitination	DSSWSARKSQLVYQS CCCHHHCHHHHHEEE	42.12	-
428	Phosphorylation	SSWSARKSQLVYQSR CCHHHCHHHHHEEEC	24.16	20639409
432	Phosphorylation	ARKSQLVYQSRRGPL HCHHHHHEEECCCCC	14.90	-
434	Phosphorylation	KSQLVYQSRRGPLVK HHHHHEEECCCCCEE	13.27	20639409
441	Acetylation	SRRGPLVKYSSDYFQ ECCCCCEECCCCCCC	47.28	26051181
441	Ubiquitination	SRRGPLVKYSSDYFQ ECCCCCEECCCCCCC	47.28	21890473
442	Phosphorylation	RRGPLVKYSSDYFQA CCCCCEECCCCCCCC	13.11	20639409
443	Phosphorylation	RGPLVKYSSDYFQAP CCCCEECCCCCCCCC	15.83	25884760
443	O-linked_Glycosylation	RGPLVKYSSDYFQAP CCCCEECCCCCCCCC	15.83	OGP
444	Phosphorylation	GPLVKYSSDYFQAPS CCCEECCCCCCCCCC	32.99	26657352
444	O-linked_Glycosylation	GPLVKYSSDYFQAPS CCCEECCCCCCCCCC	32.99	55817675
446	Phosphorylation	LVKYSSDYFQAPSDY CEECCCCCCCCCCCC	10.27	20639409
451	O-linked_Glycosylation	SDYFQAPSDYRYYPY CCCCCCCCCCCCCCC	50.74	OGP
451	Phosphorylation	SDYFQAPSDYRYYPY CCCCCCCCCCCCCCC	50.74	20639409
453	Phosphorylation	YFQAPSDYRYYPYQS CCCCCCCCCCCCCCC	12.59	20639409
458	Phosphorylation	SDYRYYPYQSFQTPQ CCCCCCCCCCCCCCC	10.73	-
463	Phosphorylation	YPYQSFQTPQHPSFL CCCCCCCCCCCCCCC	23.94	-
474	Ubiquitination	PSFLFQDKRVSWSLV CCCCCCCCCCEEEEE	43.87	21890473
550	O-linked_Glycosylation	AIPSALDTNSSKSTS HCCCCCCCCCCCCCC	37.54	23301498
551	N-linked_Glycosylation	IPSALDTNSSKSTSS CCCCCCCCCCCCCCC	43.91	18638581
551	N-linked_Glycosylation	IPSALDTNSSKSTSS CCCCCCCCCCCCCCC	43.91	18780401
554	Ubiquitination	ALDTNSSKSTSSFPC CCCCCCCCCCCCCCC	58.54	-
580	N-linked_Glycosylation	IRPFYLTNSSGVD-- EEEEECCCCCCCC--	31.42	16740002

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LG3BP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LG3BP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LG3BP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LEG1_HUMAN	LGALS1	physical	11146440
LEG3_HUMAN	LGALS3	physical	11146440
CD9_HUMAN	CD9	physical	20581239
CD82_HUMAN	CD82	physical	20581239
LEG3_HUMAN	LGALS3	physical	16518858
LYAM2_HUMAN	SELE	physical	22970241
ACTB_HUMAN	ACTB	physical	23443559
BAG2_HUMAN	BAG2	physical	23443559
PRC2C_HUMAN	PRRC2C	physical	23443559
TCPB_HUMAN	CCT2	physical	23443559
TCPG_HUMAN	CCT3	physical	23443559
TCPD_HUMAN	CCT4	physical	23443559
TCPE_HUMAN	CCT5	physical	23443559
TCPZ_HUMAN	CCT6A	physical	23443559
TCPH_HUMAN	CCT7	physical	23443559
TCPQ_HUMAN	CCT8	physical	23443559
CEP55_HUMAN	CEP55	physical	23443559
CRTC2_HUMAN	CRTC2	physical	23443559
TBB5_HUMAN	TUBB	physical	23443559
ENAH_HUMAN	ENAH	physical	23443559
TRAP1_HUMAN	TRAP1	physical	23443559
RL23_HUMAN	RPL23	physical	23443559
MOGS_HUMAN	MOGS	physical	23443559
GGYF2_HUMAN	GIGYF2	physical	23443559
HNRPU_HUMAN	HNRNPU	physical	23443559
HS90A_HUMAN	HSP90AA1	physical	23443559
HS90B_HUMAN	HSP90AB1	physical	23443559
GRP78_HUMAN	HSPA5	physical	23443559
HSP7C_HUMAN	HSPA8	physical	23443559
CH60_HUMAN	HSPD1	physical	23443559
IRS4_HUMAN	IRS4	physical	23443559
MAGD2_HUMAN	MAGED2	physical	23443559
RAVR1_HUMAN	RAVER1	physical	23443559
RL38_HUMAN	RPL38	physical	23443559
RS4X_HUMAN	RPS4X	physical	23443559
TCPA_HUMAN	TCP1	physical	23443559
TBA1A_HUMAN	TUBA1A	physical	23443559
TBA1C_HUMAN	TUBA1C	physical	23443559
TBB4B_HUMAN	TUBB4B	physical	23443559
XRN2_HUMAN	XRN2	physical	23443559
GCP3_HUMAN	TUBGCP3	physical	23443559
LG3BP_HUMAN	LGALS3BP	physical	25320078
PYR1_HUMAN	CAD	physical	26496610
NRDC_HUMAN	NRD1	physical	26496610
SURF4_HUMAN	SURF4	physical	26496610
TBG1_HUMAN	TUBG1	physical	26496610
RAE1L_HUMAN	RAE1	physical	26496610
SEP15_HUMAN	SEP15	physical	26496610
MVP_HUMAN	MVP	physical	26496610
GCP3_HUMAN	TUBGCP3	physical	26496610
GCP2_HUMAN	TUBGCP2	physical	26496610
TEST_HUMAN	PRSS21	physical	26496610
MYCB2_HUMAN	MYCBP2	physical	26496610
ZC3H3_HUMAN	ZC3H3	physical	26496610
GANAB_HUMAN	GANAB	physical	26496610
MYOF_HUMAN	MYOF	physical	26496610
NDK7_HUMAN	NME7	physical	26496610
T161A_HUMAN	TMEM161A	physical	26496610
NKRF_HUMAN	NKRF	physical	26496610
UGGG1_HUMAN	UGGT1	physical	26496610
VCIP1_HUMAN	VCPIP1	physical	26496610
CE290_HUMAN	CEP290	physical	26496610
SPRY3_HUMAN	SPRYD3	physical	26496610
GCP6_HUMAN	TUBGCP6	physical	26496610
FBSP1_HUMAN	FBXO45	physical	26496610
MZT2A_HUMAN	MZT2A	physical	26496610
LEG3_HUMAN	LGALS3	physical	26168351
LEG1_HUMAN	LGALS1	physical	26168351
SPRY3_HUMAN	SPRYD3	physical	28514442
DJC13_HUMAN	DNAJC13	physical	28514442
HELZ2_HUMAN	HELZ2	physical	28514442
MZT2A_HUMAN	MZT2A	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
GLCNE_HUMAN	GNE	physical	28514442
FBSP1_HUMAN	FBXO45	physical	28514442
FINC_HUMAN	FN1	physical	28514442
GCP5_HUMAN	TUBGCP5	physical	28514442
KIF7_HUMAN	KIF7	physical	28514442
GCP6_HUMAN	TUBGCP6	physical	28514442
FXR1_HUMAN	FXR1	physical	28514442
KPBB_HUMAN	PHKB	physical	28514442
ACACA_HUMAN	ACACA	physical	28514442
NEUL4_HUMAN	NEURL4	physical	28514442
GCP3_HUMAN	TUBGCP3	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
DPOE1_HUMAN	POLE	physical	28514442
TPPC9_HUMAN	TRAPPC9	physical	28514442
MIO_HUMAN	MIOS	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
GEPH_HUMAN	GPHN	physical	28514442
LENG8_HUMAN	LENG8	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
TBG1_HUMAN	TUBG1	physical	28514442
RAE1L_HUMAN	RAE1	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
NKRF_HUMAN	NKRF	physical	28514442
N42L2_HUMAN	N4BP2L2	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
FA83H_HUMAN	FAM83H	physical	28514442
CUL7_HUMAN	CUL7	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LG3BP_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69; ASN-125; ASN-192;ASN-398 AND ASN-551, AND MASS SPECTROMETRY.	19159218 [Abstract]
"Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry."; Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.; Proteomics 8:3833-3847(2008). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69 AND ASN-551, AND MASSSPECTROMETRY.	18780401 [Abstract]
"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry."; Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.; J. Proteome Res. 5:1493-1503(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69; ASN-398; ASN-551 ANDASN-580, AND MASS SPECTROMETRY.	16740002 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69; ASN-125; ASN-192;ASN-398; ASN-551 AND ASN-580, AND MASS SPECTROMETRY.	16335952 [Abstract]
"A proteomic analysis of human bile."; Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H.,Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.; Mol. Cell. Proteomics 3:715-728(2004). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69, AND MASS SPECTROMETRY.	15084671 [Abstract]