NRDC_HUMAN - dbPTM
NRDC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NRDC_HUMAN
UniProt AC O43847
Protein Name Nardilysin
Gene Name NRDC {ECO:0000312|HGNC:HGNC:7995}
Organism Homo sapiens (Human).
Sequence Length 1150
Subcellular Localization
Protein Description Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs..
Protein Sequence MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARPFPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEGRRGSLSNAGDPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEDDDEDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLADCIIPITDIRAFTTTLNLLPYHKIVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MLRRVTVAAVCAT
--CCCHHHHHHHHHH		11.5626434552
32PhosphorylationAALWGIETRGRCEDS
HHHHCCCCCCCCCCC		36.1823403867
58PhosphorylationPGRNKAKSTCSCPDL
CCCCCCCCCCCCCCC		39.2323927012
59PhosphorylationGRNKAKSTCSCPDLQ
CCCCCCCCCCCCCCC		14.0223927012
61PhosphorylationNKAKSTCSCPDLQPN
CCCCCCCCCCCCCCC		28.8625159151
76PhosphorylationGQDLGENSRVARLGA
CCCCCCCCCCCCCCC		24.6723090842
86PhosphorylationARLGADESEEEGRRG
CCCCCCCCHHCCCCC		51.3529255136
94PhosphorylationEEEGRRGSLSNAGDP
HHCCCCCCCCCCCCH		27.1519664994
96PhosphorylationEGRRGSLSNAGDPEI
CCCCCCCCCCCCHHH		26.7429255136
106PhosphorylationGDPEIVKSPSDPKQY
CCHHHCCCCCCHHHH		20.8123403867
108PhosphorylationPEIVKSPSDPKQYRY
HHHCCCCCCHHHHHE		73.8925850435
111UbiquitinationVKSPSDPKQYRYIKL
CCCCCCHHHHHEEEE		66.02-
113PhosphorylationSPSDPKQYRYIKLQN
CCCCHHHHHEEEECC		16.1224719451
133SulfoxidationLISDLSNMEGKTGNT
HHHHHHCCCCCCCCC		6.8921406390
205 (in isoform 2)Phosphorylation-43.13-
206 (in isoform 2)Phosphorylation-50.49-
208 (in isoform 2)Ubiquitination-47.6721890473
213 (in isoform 2)Phosphorylation-10.9527762562
219 (in isoform 2)Phosphorylation-15.89-
228 (in isoform 2)Ubiquitination-42.6221890473
229 (in isoform 2)Phosphorylation-42.6730206219
230 (in isoform 2)Phosphorylation-2.9430206219
231 (in isoform 2)Phosphorylation-9.4130206219
232 (in isoform 2)Phosphorylation-32.6330206219
233 (in isoform 2)Ubiquitination-7.7221890473
235 (in isoform 2)Phosphorylation-29.0630206219
236 (in isoform 2)Phosphorylation-21.6130206219
237 (in isoform 2)Phosphorylation-1.4930206219
242PhosphorylationEHMVFMGSLKYPDEN
HHHHHHCCCCCCCCC		15.2024719451
242 (in isoform 2)Phosphorylation-15.2030206219
246 (in isoform 2)Phosphorylation-40.63-
256UbiquitinationNGFDAFLKKHGGSDN
CCHHHHHHHCCCCCC		35.9521906983
257UbiquitinationGFDAFLKKHGGSDNA
CHHHHHHHCCCCCCC		50.02-
257 (in isoform 1)Ubiquitination-50.0221890473
283UbiquitinationDVQRKYFKEALDRWA
HHHHHHHHHHHHHHH		38.7021890473
284UbiquitinationVQRKYFKEALDRWAQ
HHHHHHHHHHHHHHH		44.56-
284 (in isoform 1)Ubiquitination-44.5621890473
312PhosphorylationREVEAVDSEYQLARP
HHHHHHCCCCCCCCC		31.4428796482
314PhosphorylationVEAVDSEYQLARPSD
HHHHCCCCCCCCCCC		16.8728796482
320PhosphorylationEYQLARPSDANRKEM
CCCCCCCCCCCHHHH		43.7528555341
324 (in isoform 2)Ubiquitination-37.7221890473
325UbiquitinationRPSDANRKEMLFGSL
CCCCCCHHHHHHHHC		47.4821890473
3262-HydroxyisobutyrylationPSDANRKEMLFGSLA
CCCCCHHHHHHHHCC		37.57-
326UbiquitinationPSDANRKEMLFGSLA
CCCCCHHHHHHHHCC		37.57-
326 (in isoform 1)Ubiquitination-37.5721890473
327SulfoxidationSDANRKEMLFGSLAR
CCCCHHHHHHHHCCC		4.1621406390
331PhosphorylationRKEMLFGSLARPGHP
HHHHHHHHCCCCCCC		16.1220068231
341UbiquitinationRPGHPMGKFFWGNAE
CCCCCCCCCCCCCHH		31.0021890473
342UbiquitinationPGHPMGKFFWGNAET
CCCCCCCCCCCCHHH		5.29-
342 (in isoform 1)Ubiquitination-5.2921890473
351UbiquitinationWGNAETLKHEPRKNN
CCCHHHHCCCCCCCC		54.0321890473
351 (in isoform 2)Ubiquitination-54.0321890473
352UbiquitinationGNAETLKHEPRKNNI
CCHHHHCCCCCCCCC		54.10-
352 (in isoform 1)Ubiquitination-54.1021890473
387PhosphorylationLVVQSKETLDTLEKW
EEEECHHHHHHHHHH		33.4020068231
390PhosphorylationQSKETLDTLEKWVTE
ECHHHHHHHHHHHHH		39.6720068231
391PhosphorylationSKETLDTLEKWVTEI
CHHHHHHHHHHHHHH		6.7720068231
393 (in isoform 2)Ubiquitination-50.5021890473
396PhosphorylationDTLEKWVTEIFSQIP
HHHHHHHHHHHHCCC		23.4228842319
400PhosphorylationKWVTEIFSQIPNNGL
HHHHHHHHCCCCCCC		32.6328842319
409 (in isoform 2)Ubiquitination-43.7821890473
419 (in isoform 2)Ubiquitination-21.2821890473
455AcetylationQQQHYRVKPLHYISW
HHCCCCCCCHHHHHH		32.6326051181
619UbiquitinationSGANEGKCDLKEKWF
ECCCCCCCCCCCCCC		12.46-
667PhosphorylationKYIATDFTLKAFDCP
CEEEECCEEEEECCC		30.1125137130
670UbiquitinationATDFTLKAFDCPETE
EECCEEEEECCCCCC		14.50-
681AcetylationPETEYPVKIVNTPQG
CCCCCCEEEECCCCC		36.1126051181
682UbiquitinationETEYPVKIVNTPQGC
CCCCCEEEECCCCCC		2.69-
693AcetylationPQGCLWYKKDNKFKI
CCCCEEEEECCCCCC		41.9126051181
8142-HydroxyisobutyrylationKPETLAKDVRLLILE
CHHHHHHHHHHHHHH		25.76-
831PhosphorylationRWSMIDKYQALMDGL
HHHHHHHHHHHHCCC		8.6823607784
839PhosphorylationQALMDGLSLESLLSF
HHHHCCCCHHHHHHH		35.3023607784
842PhosphorylationMDGLSLESLLSFVKE
HCCCCHHHHHHHHHH		39.6523607784
845PhosphorylationLSLESLLSFVKEFKS
CCHHHHHHHHHHHHH		33.0323607784
912UbiquitinationCKVKALNKGDANSEV
EEEEEECCCCCCCEE		60.0421906983
913UbiquitinationKVKALNKGDANSEVT
EEEEECCCCCCCEEE		37.88-
913 (in isoform 1)Ubiquitination-37.8821890473
923PhosphorylationNSEVTVYYQSGTRSL
CCEEEEEEECCCCCH		7.58-
925PhosphorylationEVTVYYQSGTRSLRE
EEEEEEECCCCCHHH		26.47-
927PhosphorylationTVYYQSGTRSLREYT
EEEEECCCCCHHHHH		23.49-
954UbiquitinationCFDFLRTKQTLGYHV
HHHHHHCCCCCCCEE		34.55-
9552-HydroxyisobutyrylationFDFLRTKQTLGYHVY
HHHHHCCCCCCCEEC		41.15-
955UbiquitinationFDFLRTKQTLGYHVY
HHHHHCCCCCCCEEC		41.15-
969PhosphorylationYPTCRNTSGILGFSV
CCCCCCCCCCCCEEE		27.64-
980 (in isoform 2)Ubiquitination-15.6421890473
992AcetylationYNSEVVDKKIEEFLS
CCHHHHHHHHHHHHH		44.0023749302
993AcetylationNSEVVDKKIEEFLSS
CHHHHHHHHHHHHHH		51.38-
994UbiquitinationSEVVDKKIEEFLSSF
HHHHHHHHHHHHHHH		8.26-
999PhosphorylationKKIEEFLSSFEEKIE
HHHHHHHHHHHHHHH		38.00-
1000PhosphorylationKIEEFLSSFEEKIEN
HHHHHHHHHHHHHHH		38.5324719451
1001PhosphorylationIEEFLSSFEEKIENL
HHHHHHHHHHHHHHH		14.63-
1024AcetylationVTALIKLKECEDTHL
HHEEEEHHHCCCCCC		56.1526051181
1025UbiquitinationTALIKLKECEDTHLG
HEEEEHHHCCCCCCC		54.28-
1061PhosphorylationHEIEALKSFSKSDLV
HHHHHHHCCCHHHHH		35.2924719451
1061UbiquitinationHEIEALKSFSKSDLV
HHHHHHHCCCHHHHH		35.29-
1064UbiquitinationEALKSFSKSDLVNWF
HHHHCCCHHHHHHHH		46.082190698
1065UbiquitinationALKSFSKSDLVNWFK
HHHCCCHHHHHHHHH		34.67-
1065 (in isoform 1)Ubiquitination-34.6721890473
1101PhosphorylationLEEDGTPSSEDSNSS
ECCCCCCCCCCCCCC		46.3128348404
1102PhosphorylationEEDGTPSSEDSNSSC
CCCCCCCCCCCCCCC		46.7728348404
1105PhosphorylationGTPSSEDSNSSCEVM
CCCCCCCCCCCCEEE		34.2628348404
1107PhosphorylationPSSEDSNSSCEVMQL
CCCCCCCCCCEEEEE		40.0728348404
1108PhosphorylationSSEDSNSSCEVMQLT
CCCCCCCCCEEEEEE		20.6728348404
1115PhosphorylationSCEVMQLTYLPTSPL
CCEEEEEEECCCCHH		13.2028348404
1116PhosphorylationCEVMQLTYLPTSPLL
CEEEEEEECCCCHHH		21.1928348404
1119PhosphorylationMQLTYLPTSPLLADC
EEEEECCCCHHHCCC		40.1428348404
1120PhosphorylationQLTYLPTSPLLADCI
EEEECCCCHHHCCCE		16.1828348404
1132 (in isoform 2)Ubiquitination-29.1521890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NRDC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NRDC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NRDC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HBEGF_HUMANHBEGFphysical
11432822
MD1L1_HUMANMAD1L1physical
22294699
COBL1_HUMANCOBLL1physical
22294699
NCOR1_HUMANNCOR1physical
22294699
UACA_HUMANUACAphysical
22294699
IQGA1_HUMANIQGAP1physical
22294699
HDAC3_HUMANHDAC3physical
22294699
NCOR2_HUMANNCOR2physical
22294699
TBL1X_HUMANTBL1Xphysical
22294699
NRDC_HUMANNRD1physical
19797269
MOB1A_HUMANMOB1Aphysical
18362890
STK3_HUMANSTK3physical
18362890
MOB2_HUMANMOB2physical
16061636
DNJC7_HUMANDNAJC7physical
22863883
PFD1_HUMANPFDN1physical
22863883
TSN_HUMANTSNphysical
22863883
IMA4_HUMANKPNA3physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NRDC_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-94, AND MASSSPECTROMETRY.

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