dbPTM

COBL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COBL1_HUMAN
UniProt AC	Q53SF7
Protein Name	Cordon-bleu protein-like 1
Gene Name	COBLL1
Organism	Homo sapiens (Human).
Sequence Length	1204
Subcellular Localization
Protein Description
Protein Sequence	MCGRAAEAAASSRTPGREMGQAVTRRLGAGARAAPRRAMDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVELSVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGMLEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKCEFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTISVNGRSRLSHSMSPDAQDGH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	PPAETKYTDVSSAAD CCCCCCCCCHHHHHH	31.33	27251789
72	Phosphorylation	ETKYTDVSSAADSVE CCCCCCHHHHHHHHH	19.64	27251789
139	Phosphorylation	NPSSYTIDLLSAEQN CCHHHHEEEHHHHHC	33.48	24719451
159	Phosphorylation	PNTPIGMLEVEKVIL CCCCCCCEEEEEEEE	5.86	24719451
164	Phosphorylation	GMLEVEKVILKPKML CCEEEEEEEECHHHC	3.81	24719451
167	Ubiquitination	EVEKVILKPKMLDKK EEEEEEECHHHCCCC	31.31	-
177	Phosphorylation	MLDKKKPTPIIPEKT HCCCCCCCCCCCCCE	35.68	23403867
178	Phosphorylation	LDKKKPTPIIPEKTV CCCCCCCCCCCCCEE	30.92	24719451
192	Phosphorylation	VRVVINFKKTQKTIV EEEEEEECCCCCEEE	50.88	-
197	Phosphorylation	NFKKTQKTIVRVSPH EECCCCCEEEEECCC	18.19	28857561
202	Phosphorylation	QKTIVRVSPHASLQE CCEEEEECCCCCHHH	10.62	26657352
204	Phosphorylation	TIVRVSPHASLQELA EEEEECCCCCHHHHH	22.05	24719451
206	Phosphorylation	VRVSPHASLQELAPI EEECCCCCHHHHHHH	27.79	28857561
212	Phosphorylation	ASLQELAPIICSKCE CCHHHHHHHHHHCCC	29.15	-
216	Phosphorylation	ELAPIICSKCEFDPL HHHHHHHHCCCCCCH	29.90	24719451
217	Phosphorylation	LAPIICSKCEFDPLH HHHHHHHCCCCCCHH	33.11	27251275
221	Phosphorylation	ICSKCEFDPLHTLLL HHHCCCCCCHHHHHH	23.66	27251275
222	Phosphorylation	CSKCEFDPLHTLLLK HHCCCCCCHHHHHHH	31.21	24719451
226	Phosphorylation	EFDPLHTLLLKDYQS CCCCHHHHHHHCCCC	3.52	24719451
231	Phosphorylation	HTLLLKDYQSQEPLD HHHHHHCCCCCCCCH	14.42	28102081
233	Phosphorylation	LLLKDYQSQEPLDLT HHHHCCCCCCCCHHC	30.22	26471730
242	Phosphorylation	EPLDLTKSLNDLGLR CCCHHCHHHHHHCHH	27.46	25850435
247	Phosphorylation	TKSLNDLGLRELYAM CHHHHHHCHHHHHEE	26.08	24719451
256	Phosphorylation	RELYAMDVNRESCQI HHHHEEECCHHHCHH	4.70	24719451
257	Phosphorylation	ELYAMDVNRESCQIS HHHEEECCHHHCHHH	37.42	27251275
260	Phosphorylation	AMDVNRESCQISQNL EEECCHHHCHHHHCC	14.21	18669648
264	Phosphorylation	NRESCQISQNLDIMK CHHHCHHHHCCHHHH	6.27	24719451
268	Phosphorylation	CQISQNLDIMKEKEN CHHHHCCHHHHHHHH	46.62	27251275
273	Phosphorylation	NLDIMKEKENKGFFS CCHHHHHHHHCCHHH	62.15	24719451
276	Phosphorylation	IMKEKENKGFFSFFQ HHHHHHHCCHHHHHH	59.18	27251275
280	Phosphorylation	KENKGFFSFFQRSKK HHHCCHHHHHHHHHH	23.92	23403867
284	Phosphorylation	GFFSFFQRSKKKRDQ CHHHHHHHHHHHHCC	45.33	23186163
285	Phosphorylation	FFSFFQRSKKKRDQT HHHHHHHHHHHHCCC	37.74	23403867
292	Phosphorylation	SKKKRDQTASAPATP HHHHHCCCCCCCCCC	27.20	30266825
294	Phosphorylation	KKRDQTASAPATPLV HHHCCCCCCCCCCCC	37.87	29255136
298	Phosphorylation	QTASAPATPLVNKHR CCCCCCCCCCCCCCC	18.98	29255136
305	Phosphorylation	TPLVNKHRPTFTRSN CCCCCCCCCCCCCCC	33.30	24719451
307	Phosphorylation	LVNKHRPTFTRSNTI CCCCCCCCCCCCCCC	37.28	29514088
309	Phosphorylation	NKHRPTFTRSNTISK CCCCCCCCCCCCCCC	35.35	29514088
311	Phosphorylation	HRPTFTRSNTISKPY CCCCCCCCCCCCCCC	34.96	23927012
313	Phosphorylation	PTFTRSNTISKPYIS CCCCCCCCCCCCCCC	28.07	23927012
315	Phosphorylation	FTRSNTISKPYISNT CCCCCCCCCCCCCCC	26.07	23927012
318	Phosphorylation	SNTISKPYISNTLPS CCCCCCCCCCCCCCC	22.25	23927012
319	Phosphorylation	NTISKPYISNTLPSD CCCCCCCCCCCCCCC	3.29	24719451
320	Phosphorylation	TISKPYISNTLPSDA CCCCCCCCCCCCCCC	20.23	29255136
322	Phosphorylation	SKPYISNTLPSDAPK CCCCCCCCCCCCCCC	33.00	19664994
324	Phosphorylation	PYISNTLPSDAPKKR CCCCCCCCCCCCCCC	28.29	24719451
325	Phosphorylation	YISNTLPSDAPKKRR CCCCCCCCCCCCCCC	49.90	29255136
326	Phosphorylation	ISNTLPSDAPKKRRA CCCCCCCCCCCCCCC	66.02	20068231
333	Phosphorylation	DAPKKRRAPLPPMPA CCCCCCCCCCCCCCC	17.64	24719451
339	Phosphorylation	RAPLPPMPASQSVPQ CCCCCCCCCCCCCCH	34.24	-
341	Phosphorylation	PLPPMPASQSVPQDL CCCCCCCCCCCCHHH	19.67	25849741
343	Phosphorylation	PPMPASQSVPQDLAH CCCCCCCCCCHHHHH	33.02	25849741
344	Phosphorylation	PMPASQSVPQDLAHI CCCCCCCCCHHHHHH	3.70	23186163
346	Phosphorylation	PASQSVPQDLAHIQE CCCCCCCHHHHHHHH	57.08	-
348	Phosphorylation	SQSVPQDLAHIQERP CCCCCHHHHHHHHCC	2.92	-
350	Phosphorylation	SVPQDLAHIQERPAS CCCHHHHHHHHCCCC	29.57	19664994
356	Phosphorylation	AHIQERPASCIVKSM HHHHHCCCCEEEEEC	24.21	24719451
357	Phosphorylation	HIQERPASCIVKSMS HHHHCCCCEEEEECC	13.68	29978859
362	Phosphorylation	PASCIVKSMSVDETD CCCEEEEECCCCCCC	12.85	23927012
364	Phosphorylation	SCIVKSMSVDETDKS CEEEEECCCCCCCCC	33.24	23401153
366	Phosphorylation	IVKSMSVDETDKSPC EEEECCCCCCCCCCC	45.85	24719451
368	Phosphorylation	KSMSVDETDKSPCEA EECCCCCCCCCCCCC	44.24	23927012
369	Phosphorylation	SMSVDETDKSPCEAG ECCCCCCCCCCCCCC	47.60	27251275
371	Phosphorylation	SVDETDKSPCEAGRV CCCCCCCCCCCCCCC	37.28	23927012
382	Phosphorylation	AGRVRAGSLQLSSMS CCCCCCCCEECEECC	16.38	23927012
385	Phosphorylation	VRAGSLQLSSMSAGN CCCCCEECEECCCCC	5.06	27251275
386	Phosphorylation	RAGSLQLSSMSAGNS CCCCEECEECCCCCC	15.84	23927012
387	Phosphorylation	AGSLQLSSMSAGNSS CCCEECEECCCCCCH	25.91	23927012
389	Phosphorylation	SLQLSSMSAGNSSLR CEECEECCCCCCHHH	34.67	30266825
390	Phosphorylation	LQLSSMSAGNSSLRR EECEECCCCCCHHHC	16.73	20166139
392	Phosphorylation	LSSMSAGNSSLRRTK CEECCCCCCHHHCCC	28.30	20166139
393	Phosphorylation	SSMSAGNSSLRRTKR EECCCCCCHHHCCCC	29.81	30266825
394	Phosphorylation	SMSAGNSSLRRTKRK ECCCCCCHHHCCCCC	29.87	30266825
399	Phosphorylation	NSSLRRTKRKAPSPP CCHHHCCCCCCCCCC	50.52	27251275
404	Phosphorylation	RTKRKAPSPPSKIPP CCCCCCCCCCCCCCC	55.06	23927012
407	Phosphorylation	RKAPSPPSKIPPHQS CCCCCCCCCCCCCCC	46.75	23403867
410	Phosphorylation	PSPPSKIPPHQSDEN CCCCCCCCCCCCCCC	24.85	27251275
414	Phosphorylation	SKIPPHQSDENSRVT CCCCCCCCCCCCCEE	43.81	26330541
415	Phosphorylation	KIPPHQSDENSRVTA CCCCCCCCCCCCEEE	53.15	27251275
417	Phosphorylation	PPHQSDENSRVTALQ CCCCCCCCCCEEEEE	39.86	27251275
421	Phosphorylation	SDENSRVTALQPVDG CCCCCCEEEEEECCC	22.12	-
422	Phosphorylation	DENSRVTALQPVDGV CCCCCEEEEEECCCC	11.01	-
432	Phosphorylation	PVDGVPPDSASEANS ECCCCCCCCHHHCCC	51.25	27251275
438	Phosphorylation	PDSASEANSPEELSS CCCHHHCCCHHHHCC	54.79	24275569
441	Phosphorylation	ASEANSPEELSSPET HHHCCCHHHHCCCCC	71.97	24275569
461	Phosphorylation	SSQEQCTAPKLMEET CCHHHCCCCHHHCCC	13.57	-
471	Phosphorylation	LMEETSVFECPGTPE HHCCCCCEECCCCHH	8.84	-
474	Phosphorylation	ETSVFECPGTPEAAI CCCCEECCCCHHHHH	42.36	-
480	Phosphorylation	CPGTPEAAITSLTSG CCCCHHHHHHHHHCC	12.16	24719451
487	Phosphorylation	AITSLTSGISSDYSL HHHHHHCCCCCCCCH	20.68	24719451
515	Phosphorylation	KVEAENISPKSQDIP CCCHHHCCCCCCCCC	37.55	19664994
518	Phosphorylation	AENISPKSQDIPFVS HHHCCCCCCCCCEEE	36.15	29255136
522	Phosphorylation	SPKSQDIPFVSTDII CCCCCCCCEEEHHHH	31.69	24719451
525	Phosphorylation	SQDIPFVSTDIINTL CCCCCEEEHHHHHHH	22.27	28857561
526	Phosphorylation	QDIPFVSTDIINTLK CCCCEEEHHHHHHHH	26.39	28857561
531	Phosphorylation	VSTDIINTLKNDPDS EEHHHHHHHHCCCCC	28.80	28857561
538	Phosphorylation	TLKNDPDSALGNGSG HHHCCCCCCCCCCCC	30.68	-
543	Phosphorylation	PDSALGNGSGEFSQN CCCCCCCCCCCCCCC	34.92	19664994
544	Phosphorylation	DSALGNGSGEFSQNS CCCCCCCCCCCCCCC	38.87	28348404
546	Phosphorylation	ALGNGSGEFSQNSME CCCCCCCCCCCCCHH	43.77	18077418
548	Phosphorylation	GNGSGEFSQNSMEEK CCCCCCCCCCCHHHH	24.93	22199227
551	Phosphorylation	SGEFSQNSMEEKQET CCCCCCCCHHHHHHH	21.67	22199227
553	Phosphorylation	EFSQNSMEEKQETKS CCCCCCHHHHHHHCC	62.96	27251275
560	Phosphorylation	EEKQETKSTDGQEPH HHHHHHCCCCCCCCC	38.87	21945579
561	Phosphorylation	EKQETKSTDGQEPHS HHHHHCCCCCCCCCC	45.78	21945579
563	Phosphorylation	QETKSTDGQEPHSVV HHHCCCCCCCCCCEE	33.56	-
568	Phosphorylation	TDGQEPHSVVYDTSN CCCCCCCCEEEECCC	24.80	21945579
571	Phosphorylation	QEPHSVVYDTSNGKK CCCCCEEEECCCCEE	16.02	21945579
572	Phosphorylation	EPHSVVYDTSNGKKV CCCCEEEECCCCEEH	31.86	27251275
573	Phosphorylation	PHSVVYDTSNGKKVV CCCEEEECCCCEEHH	13.35	21945579
574	Phosphorylation	HSVVYDTSNGKKVVD CCEEEECCCCEEHHH	40.46	21945579
579	Phosphorylation	DTSNGKKVVDSIRNL ECCCCEEHHHHHHHH	7.05	27251275
582	Phosphorylation	NGKKVVDSIRNLKSL CCEEHHHHHHHHHHH	16.31	27251275
584	Phosphorylation	KKVVDSIRNLKSLGP EEHHHHHHHHHHHCC	46.51	-
588	Phosphorylation	DSIRNLKSLGPNQEN HHHHHHHHHCCCCCC	41.55	27251275
599	Phosphorylation	NQENVQNEIIVYPEN CCCCCCCEEEECCCC	19.59	-
603	Phosphorylation	VQNEIIVYPENTEDN CCCEEEECCCCCCCH	8.40	29978859
607	Phosphorylation	IIVYPENTEDNMKNG EEECCCCCCCHHHCC	42.95	29978859
610	Phosphorylation	YPENTEDNMKNGVKK CCCCCCCHHHCCCEE	36.78	27251275
618	Phosphorylation	MKNGVKKTEINVEGV HHCCCEECEECEEHH	36.06	20068231
627	Acetylation	INVEGVAKNNNIDME ECEEHHHHCCCCCCE	58.77	19816355
632	Phosphorylation	VAKNNNIDMEVERPS HHHCCCCCCEEECCC	29.34	-
639	Phosphorylation	DMEVERPSNSEAHET CCEEECCCCCCCCCC	60.24	-
647	Phosphorylation	NSEAHETDTAISYKE CCCCCCCCCCCCHHH	31.02	20068231
660	Phosphorylation	KENHLAASSVPDQKL HHHHCCCCCCCCCCC	26.68	-
671	Phosphorylation	DQKLNQPSAEKTKDA CCCCCCCCHHHHHCC	39.02	21815630
675	Phosphorylation	NQPSAEKTKDAAIQT CCCCHHHHHCCCHHC	26.17	23403867
682	Phosphorylation	TKDAAIQTTPSCNSF HHCCCHHCCCCCCCC	34.26	26657352
683	Phosphorylation	KDAAIQTTPSCNSFD HCCCHHCCCCCCCCC	9.24	21815630
685	Phosphorylation	AAIQTTPSCNSFDGK CCHHCCCCCCCCCCC	24.68	26657352
688	Phosphorylation	QTTPSCNSFDGKHQD HCCCCCCCCCCCCCC	29.10	25159151
710	Phosphorylation	VEECVQTSNNNISTQ HHHHHHCCCCCCCHH	22.07	27251275
712	Phosphorylation	ECVQTSNNNISTQHS HHHHCCCCCCCHHHH	47.16	27251275
714	Phosphorylation	VQTSNNNISTQHSCL HHCCCCCCCHHHHHC	5.25	27251275
715	Phosphorylation	QTSNNNISTQHSCLS HCCCCCCCHHHHHCC	24.92	27251275
716	Phosphorylation	TSNNNISTQHSCLSS CCCCCCCHHHHHCCC	26.89	27251275
717	Phosphorylation	SNNNISTQHSCLSSQ CCCCCCHHHHHCCCC	21.50	27251275
719	Phosphorylation	NNISTQHSCLSSQDS CCCCHHHHHCCCCCC	13.61	27251275
722	Phosphorylation	STQHSCLSSQDSVNT CHHHHHCCCCCCCCC	30.22	27251275
723	Phosphorylation	TQHSCLSSQDSVNTS HHHHHCCCCCCCCCC	25.67	27251275
726	Phosphorylation	SCLSSQDSVNTSREF HHCCCCCCCCCCHHH	15.05	27251275
751	Phosphorylation	EDPLTVKDPICAHGN CCCCCCCCCCCCCCC	33.20	27251275
776	Phosphorylation	DKNSTASYLKNYPLY CCCCCHHHHHCCCCC	21.16	-
780	Phosphorylation	TASYLKNYPLYRQDY CHHHHHCCCCCCCCC	7.94	-
786	Phosphorylation	NYPLYRQDYNPKPKP CCCCCCCCCCCCCCC	35.86	24275569
787	Phosphorylation	YPLYRQDYNPKPKPS CCCCCCCCCCCCCCC	25.65	-
809	Phosphorylation	IPKIGMTTYKIVPPK CCCCCCEEEEECCCC	17.58	-
810	Phosphorylation	PKIGMTTYKIVPPKS CCCCCEEEEECCCCH	6.91	-
813	Phosphorylation	GMTTYKIVPPKSLEI CCEEEEECCCCHHCC	6.09	-
814	Phosphorylation	MTTYKIVPPKSLEIS CEEEEECCCCHHCCC	33.79	24275569
817	Phosphorylation	YKIVPPKSLEISKDW EEECCCCHHCCCCCC	36.69	29802988
821	Phosphorylation	PPKSLEISKDWQSET CCCHHCCCCCCCCCE	18.39	24275569
826	Phosphorylation	EISKDWQSETIEYKD CCCCCCCCCEEEECC	32.24	24719451
828	Phosphorylation	SKDWQSETIEYKDDQ CCCCCCCEEEECCCH	25.10	28348404
852	Phosphorylation	THENVKETAIQTEDS CCHHHHHHEEECCCC	24.28	28857561
856	Phosphorylation	VKETAIQTEDSAISE HHHHEEECCCCCCCC	35.33	28857561
859	Phosphorylation	TAIQTEDSAISESPE HEEECCCCCCCCCCC	22.67	25850435
862	Phosphorylation	QTEDSAISESPEEPL ECCCCCCCCCCCCCC	31.57	26657352
864	Phosphorylation	EDSAISESPEEPLPN CCCCCCCCCCCCCCC	30.71	30266825
880	Phosphorylation	KPKPNLRTEHQVPSS CCCCCCCCCCCCCCC	40.77	23927012
886	Phosphorylation	RTEHQVPSSVSSPDD CCCCCCCCCCCCCCC	44.51	30576142
887	Phosphorylation	TEHQVPSSVSSPDDA CCCCCCCCCCCCCCC	21.68	23927012
889	Phosphorylation	HQVPSSVSSPDDAMV CCCCCCCCCCCCCCC	37.79	25159151
890	Phosphorylation	QVPSSVSSPDDAMVS CCCCCCCCCCCCCCC	30.14	23927012
891	Phosphorylation	VPSSVSSPDDAMVSP CCCCCCCCCCCCCCC	35.67	27251275
893	Phosphorylation	SSVSSPDDAMVSPLK CCCCCCCCCCCCCCC	39.69	-
897	Phosphorylation	SPDDAMVSPLKPAPK CCCCCCCCCCCCCCC	16.07	25159151
909	Phosphorylation	APKMTRDTGTAPFAP CCCCCCCCCCCCCCC	32.89	-
911	Phosphorylation	KMTRDTGTAPFAPNL CCCCCCCCCCCCCCH	33.00	24275569
914	Phosphorylation	RDTGTAPFAPNLEEI CCCCCCCCCCCHHHH	19.16	24719451
915	Phosphorylation	DTGTAPFAPNLEEIN CCCCCCCCCCHHHHH	7.33	27251275
916	Phosphorylation	TGTAPFAPNLEEINN CCCCCCCCCHHHHHH	46.44	18669648
917	Phosphorylation	GTAPFAPNLEEINNI CCCCCCCCHHHHHHH	57.57	23186163
918	Phosphorylation	TAPFAPNLEEINNIL CCCCCCCHHHHHHHH	6.43	27251275
919	Phosphorylation	APFAPNLEEINNILE CCCCCCHHHHHHHHH	64.57	18669648
926	Phosphorylation	EEINNILESKFKSRA HHHHHHHHHHHHHHH	48.35	18669648
947	Phosphorylation	PSSFFLQMQKRVSGH CCHHHHHHHHHHCCC	5.73	-
949	Phosphorylation	SFFLQMQKRVSGHYV HHHHHHHHHHCCCCC	49.80	24719451
952	Phosphorylation	LQMQKRVSGHYVTSA HHHHHHHCCCCCCHH	24.72	23927012
955	Phosphorylation	QKRVSGHYVTSAAAK HHHHCCCCCCHHHHH	14.67	28152594
957	Phosphorylation	RVSGHYVTSAAAKSV HHCCCCCCHHHHHHH	12.89	28152594
958	Phosphorylation	VSGHYVTSAAAKSVH HCCCCCCHHHHHHHH	13.08	28152594
963	Phosphorylation	VTSAAAKSVHAAPNP CCHHHHHHHHCCCCC	17.89	28857561
976	Phosphorylation	NPAPKELTNKEAERD CCCCHHHCCHHHHHH	45.39	22210691
981	Phosphorylation	ELTNKEAERDMLPSP HHCCHHHHHHCCCCH	50.75	27251275
984	Phosphorylation	NKEAERDMLPSPEQT CHHHHHHCCCCHHHC	8.10	-
987	Phosphorylation	AERDMLPSPEQTLSP HHHHCCCCHHHCCCH	36.79	30266825
991	Phosphorylation	MLPSPEQTLSPLSKM CCCCHHHCCCHHHCC	27.78	30266825
993	Phosphorylation	PSPEQTLSPLSKMPH CCHHHCCCHHHCCCC	27.47	30266825
996	Phosphorylation	EQTLSPLSKMPHSVP HHCCCHHHCCCCCCC	30.23	30266825
1016	Phosphorylation	KTDDDVIGQAPAEAS CCCCCCCCCCCCCCC	19.90	20068231
1020	Phosphorylation	DVIGQAPAEASPPPI CCCCCCCCCCCCCCC	28.18	27251275
1021	Phosphorylation	VIGQAPAEASPPPIA CCCCCCCCCCCCCCC	48.93	24719451
1022	Phosphorylation	IGQAPAEASPPPIAP CCCCCCCCCCCCCCC	29.46	20068231
1023	Phosphorylation	GQAPAEASPPPIAPK CCCCCCCCCCCCCCC	29.46	19664994
1025	Phosphorylation	APAEASPPPIAPKPV CCCCCCCCCCCCCCC	30.36	18669648
1033	Phosphorylation	PIAPKPVTIPASQVS CCCCCCCEECHHHCC	29.75	26699800
1037	Phosphorylation	KPVTIPASQVSTQNL CCCEECHHHCCCCCC	26.26	26699800
1040	Phosphorylation	TIPASQVSTQNLKTL EECHHHCCCCCCCCC	19.35	26699800
1041	Phosphorylation	IPASQVSTQNLKTLK ECHHHCCCCCCCCCH	23.71	26699800
1045	Methylation	QVSTQNLKTLKTFGA HCCCCCCCCCHHHCC	60.40	-
1049	Phosphorylation	QNLKTLKTFGAPRPY CCCCCCHHHCCCCCC	30.34	21945579
1052	Phosphorylation	KTLKTFGAPRPYSSS CCCHHHCCCCCCCCC	7.85	19664994
1056	Phosphorylation	TFGAPRPYSSSGPSP HHCCCCCCCCCCCCC	23.59	21945579
1057	Phosphorylation	FGAPRPYSSSGPSPF HCCCCCCCCCCCCCE	22.25	21945579
1058	Phosphorylation	GAPRPYSSSGPSPFA CCCCCCCCCCCCCEE	33.21	21945579
1059	Phosphorylation	APRPYSSSGPSPFAL CCCCCCCCCCCCEEE	49.10	21945579
1062	Phosphorylation	PYSSSGPSPFALAVV CCCCCCCCCEEEEHH	35.85	25159151
1069	Phosphorylation	SPFALAVVKRSQSFS CCEEEEHHHHCCCCC	3.38	-
1070	Phosphorylation	PFALAVVKRSQSFSK CEEEEHHHHCCCCCC	39.47	-
1072	Phosphorylation	ALAVVKRSQSFSKER EEEHHHHCCCCCCCC	25.18	20068231
1074	Methylation	AVVKRSQSFSKERTE EHHHHCCCCCCCCCC	32.50	-
1074	Phosphorylation	AVVKRSQSFSKERTE EHHHHCCCCCCCCCC	32.50	23911959
1076	Phosphorylation	VKRSQSFSKERTESP HHHCCCCCCCCCCCC	38.56	20068231
1080	Phosphorylation	QSFSKERTESPSASA CCCCCCCCCCCCCCC	41.74	22199227
1082	Phosphorylation	FSKERTESPSASALV CCCCCCCCCCCCCCC	24.44	28674419
1084	Phosphorylation	KERTESPSASALVQP CCCCCCCCCCCCCCC	44.10	22199227
1086	Phosphorylation	RTESPSASALVQPPA CCCCCCCCCCCCCCC	26.86	22199227
1088	Phosphorylation	ESPSASALVQPPANT CCCCCCCCCCCCCCC	3.22	27251275
1091	Phosphorylation	SASALVQPPANTEEG CCCCCCCCCCCCCCC	23.61	-
1101	Phosphorylation	NTEEGKTHSVNKFVD CCCCCCCCCCCEECC	32.98	27251275
1103	Phosphorylation	EEGKTHSVNKFVDIP CCCCCCCCCEECCCC	7.58	20068231
1108	Phosphorylation	HSVNKFVDIPQLGVS CCCCEECCCCCCCCC	50.40	24719451
1121	Phosphorylation	VSDKENNSAHNEQNS CCCCCCCCCCCCCCC	42.35	20068231
1128	Phosphorylation	SAHNEQNSQIPTPTD CCCCCCCCCCCCCCC	29.22	27251275
1132	Phosphorylation	EQNSQIPTPTDGPSF CCCCCCCCCCCCCCE	40.21	26657352
1134	Phosphorylation	NSQIPTPTDGPSFTV CCCCCCCCCCCCEEE	56.94	25850435
1138	Phosphorylation	PTPTDGPSFTVMRQS CCCCCCCCEEEEEEE	38.79	25850435
1140	Phosphorylation	PTDGPSFTVMRQSSL CCCCCCEEEEEEEEE	20.10	25850435
1145	Phosphorylation	SFTVMRQSSLTFQSS CEEEEEEEEEEEECC	19.56	23401153
1146	Phosphorylation	FTVMRQSSLTFQSSD EEEEEEEEEEEECCC	24.08	23401153
1148	Phosphorylation	VMRQSSLTFQSSDPE EEEEEEEEEECCCHH	22.90	23927012
1151	Phosphorylation	QSSLTFQSSDPEQMR EEEEEEECCCHHHHH	32.30	23403867
1152	Phosphorylation	SSLTFQSSDPEQMRQ EEEEEECCCHHHHHH	46.53	23403867
1159	Phosphorylation	SDPEQMRQSLLTAIR CCHHHHHHHHHHHHH	32.84	24719451
1160	Phosphorylation	DPEQMRQSLLTAIRS CHHHHHHHHHHHHHH	18.25	-
1161	Phosphorylation	PEQMRQSLLTAIRSG HHHHHHHHHHHHHHC	3.59	27251275
1163	Phosphorylation	QMRQSLLTAIRSGEA HHHHHHHHHHHHCHH	25.90	-
1167	Phosphorylation	SLLTAIRSGEAAAKL HHHHHHHHCHHHHHC	34.57	28555341
1174	Phosphorylation	SGEAAAKLKRVTIPS HCHHHHHCCEEEECC	3.52	20166139
1175	Phosphorylation	GEAAAKLKRVTIPSN CHHHHHCCEEEECCC	44.08	20166139
1177	Phosphorylation	AAAKLKRVTIPSNTI HHHHCCEEEECCCEE	5.63	-
1181	Phosphorylation	LKRVTIPSNTISVNG CCEEEECCCEEEECC	42.63	-
1185	Phosphorylation	TIPSNTISVNGRSRL EECCCEEEECCCCCC	13.90	-
1190	Phosphorylation	TISVNGRSRLSHSMS EEEECCCCCCCCCCC	38.68	23927012
1193	Phosphorylation	VNGRSRLSHSMSPDA ECCCCCCCCCCCCCC	16.65	25394399
1195	Phosphorylation	GRSRLSHSMSPDAQD CCCCCCCCCCCCCCC	19.99	25159151
1197	Phosphorylation	SRLSHSMSPDAQDGH CCCCCCCCCCCCCCC	23.73	25159151
1219	Phosphorylation	---------------------- ----------------------		-
1222	Phosphorylation	------------------------- -------------------------		27251275
1224	Phosphorylation	--------------------------- ---------------------------		20068231
1226	Phosphorylation	----------------------------- -----------------------------		20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
876	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
952	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COBL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
947	Phosphorylation	947 (0)	N ⇒ D	rs7607980	Type 2 diabetes Fasting blood insulin Fasting blood insulin (BMI interaction)	28869590 22581228
952	Phosphorylation	947 (5)	N ⇒ D	rs7607980	Type 2 diabetes Fasting blood insulin Fasting blood insulin (BMI interaction)	28869590 22581228
955	Phosphorylation	947 (8)	N ⇒ D	rs7607980	Type 2 diabetes Fasting blood insulin Fasting blood insulin (BMI interaction)	28869590 22581228
996	Phosphorylation	1006 (10)	N ⇒ D	rs7607980	Type 2 diabetes Fasting blood insulin Fasting blood insulin (BMI interaction)	28869590 22581228
998	Phosphorylation	1006 (8)	N ⇒ D	rs7607980	Type 2 diabetes Fasting blood insulin Fasting blood insulin (BMI interaction)	28869590 22581228

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMBX1_HUMAN	HMBOX1	physical	27173435
AMOL1_HUMAN	AMOTL1	physical	27173435
CDAC1_HUMAN	CDADC1	physical	27173435
SCML1_HUMAN	SCML1	physical	27173435
UH1BL_HUMAN	UHRF1BP1L	physical	27173435
DDHD1_HUMAN	DDHD1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COBL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294; THR-298; SER-364;SER-518; SER-887; SER-897; SER-987 AND SER-993, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294 AND THR-298, ANDMASS SPECTROMETRY.	16964243 [Abstract]