SCML1_HUMAN - dbPTM
SCML1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCML1_HUMAN
UniProt AC Q9UN30
Protein Name Sex comb on midleg-like protein 1
Gene Name SCML1
Organism Homo sapiens (Human).
Sequence Length 329
Subcellular Localization Nucleus .
Protein Description Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity)..
Protein Sequence MMSNSSSEIDVIKTRIPTYDEDDNTILYAYETKPEFVNKEPNIVSDASCNTEEQLKTVDDVLIHCQVIYDALQNLDKKIDVIRRKVSKIQRFHARSLWTNHKRYGYKKHSYRLVKKLKLQKMKKNEVYETFSYPESYSPTLPVSRRENNSPSNLPRPSFCMEEYQRAELEEDPILSRTPSPVHPSDFSEHNCQPYYASDGATYGSSSGLCLGNPRADSIHNTYSTDHASAAPPSVTRSPVENDGYIEEGSITKHPSTWSVEAVVLFLKQTDPLALCPLVDLFRSHEIDGKALLLLTSDVLLKHLGVKLGTAVKLCYYIDRLKQGKCFEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationEIDVIKTRIPTYDED
CCEEEECCCCCCCCC		28.0818669648
17PhosphorylationDVIKTRIPTYDEDDN
EEEECCCCCCCCCCC		22.9318452278
18PhosphorylationVIKTRIPTYDEDDNT
EEECCCCCCCCCCCE		41.03-
19PhosphorylationIKTRIPTYDEDDNTI
EECCCCCCCCCCCEE		16.39-
55PhosphorylationSCNTEEQLKTVDDVL
CCCHHHHHCCHHHHH		5.9318452278
117PhosphorylationSYRLVKKLKLQKMKK
HHHHHHHHCHHHCCC		5.7718452278
128PhosphorylationKMKKNEVYETFSYPE
HCCCCCCEECCCCCC		11.7629978859
130PhosphorylationKKNEVYETFSYPESY
CCCCCEECCCCCCCC		10.5328348404
132PhosphorylationNEVYETFSYPESYSP
CCCEECCCCCCCCCC		47.3928348404
133PhosphorylationEVYETFSYPESYSPT
CCEECCCCCCCCCCC		13.5629978859
136PhosphorylationETFSYPESYSPTLPV
ECCCCCCCCCCCCCC		26.8028387310
137PhosphorylationTFSYPESYSPTLPVS
CCCCCCCCCCCCCCC		19.6024626860
138PhosphorylationFSYPESYSPTLPVSR
CCCCCCCCCCCCCCC		22.2321082442
140PhosphorylationYPESYSPTLPVSRRE
CCCCCCCCCCCCCCC		37.4422496350
144PhosphorylationYSPTLPVSRRENNSP
CCCCCCCCCCCCCCC		24.5522496350
150PhosphorylationVSRRENNSPSNLPRP
CCCCCCCCCCCCCCC		41.0923663014
152PhosphorylationRRENNSPSNLPRPSF
CCCCCCCCCCCCCCC		51.3123663014
176PhosphorylationLEEDPILSRTPSPVH
HHCCCCCCCCCCCCC		34.5229255136
218PhosphorylationLGNPRADSIHNTYST
CCCCCHHHCCCCCCC		25.4325002506
222PhosphorylationRADSIHNTYSTDHAS
CHHHCCCCCCCCCCC		12.5125002506
223PhosphorylationADSIHNTYSTDHASA
HHHCCCCCCCCCCCC		18.1925002506
224PhosphorylationDSIHNTYSTDHASAA
HHCCCCCCCCCCCCC		25.8925002506
225PhosphorylationSIHNTYSTDHASAAP
HCCCCCCCCCCCCCC		22.7625002506
229PhosphorylationTYSTDHASAAPPSVT
CCCCCCCCCCCCCCC		22.8825002506
234PhosphorylationHASAAPPSVTRSPVE
CCCCCCCCCCCCCCC		34.7522496350
236PhosphorylationSAAPPSVTRSPVEND
CCCCCCCCCCCCCCC		29.7519060867
238PhosphorylationAPPSVTRSPVENDGY
CCCCCCCCCCCCCCC		24.7521082442
245PhosphorylationSPVENDGYIEEGSIT
CCCCCCCCCCCCCCC		14.1825002506
250PhosphorylationDGYIEEGSITKHPST
CCCCCCCCCCCCCCC		30.2925002506
252PhosphorylationYIEEGSITKHPSTWS
CCCCCCCCCCCCCCE		25.6225002506
259PhosphorylationTKHPSTWSVEAVVLF
CCCCCCCEEEEEEEH		15.3524260401
284PhosphorylationPLVDLFRSHEIDGKA
HHHHHHHHCCCCCHH		20.3824260401
296PhosphorylationGKALLLLTSDVLLKH
CHHHHHHCHHHHHHH		23.8930301811
297PhosphorylationKALLLLTSDVLLKHL
HHHHHHCHHHHHHHH		26.2030301811
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCML1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCML1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCML1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDAC1_HUMANCDADC1physical
27173435
UH1BL_HUMANUHRF1BP1Lphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCML1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, AND MASSSPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.

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