dbPTM

UH1BL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UH1BL_HUMAN
UniProt AC	A0JNW5
Protein Name	UHRF1-binding protein 1-like {ECO:0000312\|HGNC:HGNC:29102}
Gene Name	UHRF1BP1L {ECO:0000312\|HGNC:HGNC:29102}
Organism	Homo sapiens (Human).
Sequence Length	1464
Subcellular Localization	Cytoplasm, cytosol . Early endosome . Primarily cytosolic. Recruited to early endosomes following STX6 overexpression. Overexpression of both STX6 and UHRF1BP1L results in aberrant tubulation of endosomal membranes.
Protein Description
Protein Sequence	MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRSPNGPSPIATASGQSEYGFAEKVVEGISVSVNSIVIRIGAKAFNASFELSQLRIYSVNAHWEHGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMCAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAPEPTQSSTVVASAQQVKTTQTSNAPDVNDAIVKLFNDFDVKETSHHLVISHLDLHICDDIHAKEKESNRRITGGAMQLSFTQLTIDYYPYHKAGDSCNHWMYFSDATKTKNGWANELLHEFECNVEMLKQAVKDHNVGSPPKSPTHASPQHTQTEKDYPLKGTCRTPSVLSQQSKAKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMICCNKKSLYLPQEMSAVYIEFTEYYYPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFLLDLKQSLNQFMAVYKLNDNSKSDEHVDVRVDGLMLKFVIPSEVKSECHQDQPRAISIQSSEMIATNTRHCPNCRHSDLEALFQDFKDCDFFSKTYTSFPKSCDNFNLLHPIFQRHAHEQDTKMHEIYKGNITPQLNKNTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPISFVDSFPLSIWICQPTRYAESQKEPQTCNQVSLNTSQSESSDLAGRLKRKKLLKEYYSTESEPLTNGGQKPSSSDTFFRFSPSSSEADIHLLVHVHKHVSMQINHYQYLLLLFLHESLILLSENLRKDVEAVTGSPASQTSICIGILLRSAELALLLHPVDQANTLKSPVSESVSPVVPDYLPTENGDFLSSKRKQISRDINRIRSVTVNHMSDNRSMSVDLSHIPLKDPLLFKSASDTNLQKGISFMDYLSDKHLGKISEDESSGLVYKSGSGEIGSETSDKKDSFYTDSSSILNYREDSNILSFDSDGNQNILSSTLTSKGNETIESIFKAEDLLPEAASLSENLDISKEETPPVRTLKSQSSLSGKPKERCPPNLAPLCVSYKNMKRSSSQMSLDTISLDSMILEEQLLESDGSDSHMFLEKGNKKNSTTNYRGTAESVNAGANLQNYGETSPDAISTNSEGAQENHDDLMSVVVFKITGVNGEIDIRGEDTEICLQVNQVTPDQLGNISLRHYLCNRPVGSDQKAVIHSKSSPEISLRFESGPGAVIHSLLAEKNGFLQCHIENFSTEFLTSSLMNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRSSTVSLEPAPVTVHIDHLVVERSDDGSFHIRDSHMLNTGNDLKENVKSDSVLLTSGKYDLKKQRSVTQATQTSPGVPWPSQSANFPEFSFDFTREQLMEENESLKQELAKAKMALAEAHLEKDALLHHIKKMTVE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MAGIIKKQILKHL --CCCHHHHHHHHHH	36.38	30593243
14	Phosphorylation	KQILKHLSRFTKNLS HHHHHHHHHHHCCCC	25.68	22817900
21	Phosphorylation	SRFTKNLSPDKINLS HHHHCCCCCCCCCHH	40.21	20873877
24	Ubiquitination	TKNLSPDKINLSTLK HCCCCCCCCCHHHCC	36.56	-
67	Phosphorylation	KVFCNKASIRIPWTK HHHCCCCCEECCCHH	17.63	-
73	Phosphorylation	ASIRIPWTKLKTHPI CCEECCCHHCCCCCE	22.57	-
126	Phosphorylation	EKVVEGISVSVNSIV HHHCCCCEEEECEEE	21.13	-
131	Phosphorylation	GISVSVNSIVIRIGA CCEEEECEEEEEECH	18.97	-
256	Phosphorylation	QLKAMVQYAKSLSEA HHHHHHHHHHHHHHH	12.46	30576142
259	Phosphorylation	AMVQYAKSLSEAIEK HHHHHHHHHHHHHHH	29.02	-
261	Phosphorylation	VQYAKSLSEAIEKST HHHHHHHHHHHHHHH	31.88	-
266	Ubiquitination	SLSEAIEKSTEQRKS HHHHHHHHHHHHHHH	57.47	29967540
308	Ubiquitination	DVNDAIVKLFNDFDV CHHHHHHHHHCCCCC	41.05	29967540
362	Phosphorylation	FTQLTIDYYPYHKAG EEEEEEEECCCCCCC	11.50	-
363	Phosphorylation	TQLTIDYYPYHKAGD EEEEEEECCCCCCCC	8.12	-
365	Phosphorylation	LTIDYYPYHKAGDSC EEEEECCCCCCCCCC	10.38	-
414	Phosphorylation	VKDHNVGSPPKSPTH HHHCCCCCCCCCCCC	33.47	23401153
414 (in isoform 2)	Phosphorylation	-	33.47	-
418	Phosphorylation	NVGSPPKSPTHASPQ CCCCCCCCCCCCCCC	40.58	29255136
418 (in isoform 2)	Phosphorylation	-	40.58	-
420	Phosphorylation	GSPPKSPTHASPQHT CCCCCCCCCCCCCCC	36.85	25159151
423	Phosphorylation	PKSPTHASPQHTQTE CCCCCCCCCCCCCCC	19.93	25159151
427	Phosphorylation	THASPQHTQTEKDYP CCCCCCCCCCCCCCC	31.75	23927012
429	Phosphorylation	ASPQHTQTEKDYPLK CCCCCCCCCCCCCCC	46.27	23663014
433	Phosphorylation	HTQTEKDYPLKGTCR CCCCCCCCCCCCCCC	22.87	25002506
441	Phosphorylation	PLKGTCRTPSVLSQQ CCCCCCCCHHHHCHH	23.28	21815630
443	Phosphorylation	KGTCRTPSVLSQQSK CCCCCCHHHHCHHHH	34.77	28857561
446	Phosphorylation	CRTPSVLSQQSKAKL CCCHHHHCHHHHHHH	24.82	-
449	Phosphorylation	PSVLSQQSKAKLMSS HHHHCHHHHHHHCCC	27.26	-
450	Ubiquitination	SVLSQQSKAKLMSSS HHHCHHHHHHHCCCC	45.24	29967540
559	Phosphorylation	LNQFMAVYKLNDNSK HHHHHHEEECCCCCC	10.54	30387612
612	Phosphorylation	SEMIATNTRHCPNCR HHHHHCCCCCCCCCC	19.89	-
677	Phosphorylation	EIYKGNITPQLNKNT HHHCCCCCCCCCCCC	14.69	25159151
751	Phosphorylation	CNQVSLNTSQSESSD CCEEECCCCCCCCCC	33.17	21712546
752	Phosphorylation	NQVSLNTSQSESSDL CEEECCCCCCCCCCH	30.54	25159151
754	Phosphorylation	VSLNTSQSESSDLAG EECCCCCCCCCCHHH	38.93	28985074
772	Phosphorylation	RKKLLKEYYSTESEP HHHHHHHHHCCCCCC	10.92	23312004
773	Phosphorylation	KKLLKEYYSTESEPL HHHHHHHHCCCCCCC	15.37	23312004
774	Phosphorylation	KLLKEYYSTESEPLT HHHHHHHCCCCCCCC	25.46	23401153
775	Phosphorylation	LLKEYYSTESEPLTN HHHHHHCCCCCCCCC	27.66	26657352
777	Phosphorylation	KEYYSTESEPLTNGG HHHHCCCCCCCCCCC	44.60	23312004
781	Phosphorylation	STESEPLTNGGQKPS CCCCCCCCCCCCCCC	42.40	27080861
788	Phosphorylation	TNGGQKPSSSDTFFR CCCCCCCCCCCCCEE	49.89	27080861
789	Phosphorylation	NGGQKPSSSDTFFRF CCCCCCCCCCCCEEE	40.54	27080861
790	Phosphorylation	GGQKPSSSDTFFRFS CCCCCCCCCCCEEEC	45.03	27080861
792	Phosphorylation	QKPSSSDTFFRFSPS CCCCCCCCCEEECCC	26.99	27080861
881	Phosphorylation	HPVDQANTLKSPVSE CCCCCCCCCCCCCCC	38.28	27251275
884	Phosphorylation	DQANTLKSPVSESVS CCCCCCCCCCCCCCC	33.38	28450419
887	Phosphorylation	NTLKSPVSESVSPVV CCCCCCCCCCCCCCC	27.77	28450419
889	Phosphorylation	LKSPVSESVSPVVPD CCCCCCCCCCCCCCC	22.01	22115753
891	Phosphorylation	SPVSESVSPVVPDYL CCCCCCCCCCCCCCC	22.66	22115753
897	Phosphorylation	VSPVVPDYLPTENGD CCCCCCCCCCCCCCC	14.44	28450419
900	Phosphorylation	VVPDYLPTENGDFLS CCCCCCCCCCCCCCC	39.21	22199227
907	Phosphorylation	TENGDFLSSKRKQIS CCCCCCCCHHHHHHH	33.53	22199227
908	Phosphorylation	ENGDFLSSKRKQISR CCCCCCCHHHHHHHH	38.33	22199227
922	Phosphorylation	RDINRIRSVTVNHMS HHHHHHHEEEEEECC	21.55	29083192
924	Phosphorylation	INRIRSVTVNHMSDN HHHHHEEEEEECCCC	19.48	30576142
933	Phosphorylation	NHMSDNRSMSVDLSH EECCCCCCCCEECCC	22.97	22617229
935	Phosphorylation	MSDNRSMSVDLSHIP CCCCCCCCEECCCCC	17.46	22617229
939	Phosphorylation	RSMSVDLSHIPLKDP CCCCEECCCCCCCCC	18.20	22617229
950	Methylation	LKDPLLFKSASDTNL CCCCEEEECCCCCCC	45.11	115978955
951	Phosphorylation	KDPLLFKSASDTNLQ CCCEEEECCCCCCCH	26.18	29396449
953	Phosphorylation	PLLFKSASDTNLQKG CEEEECCCCCCCHHC	52.65	25159151
955	Phosphorylation	LFKSASDTNLQKGIS EEECCCCCCCHHCCC	35.02	28985074
962	Phosphorylation	TNLQKGISFMDYLSD CCCHHCCCHHHHHCH	24.16	22617229
966	Phosphorylation	KGISFMDYLSDKHLG HCCCHHHHHCHHCCC	9.05	27642862
968	Phosphorylation	ISFMDYLSDKHLGKI CCHHHHHCHHCCCCC	38.08	28348404
976	Phosphorylation	DKHLGKISEDESSGL HHCCCCCCCCCCCCE	42.34	21815630
980	Phosphorylation	GKISEDESSGLVYKS CCCCCCCCCCEEEEC	41.87	25849741
981	Phosphorylation	KISEDESSGLVYKSG CCCCCCCCCEEEECC	33.81	25849741
985	Phosphorylation	DESSGLVYKSGSGEI CCCCCEEEECCCCCC	12.41	29978859
986	Ubiquitination	ESSGLVYKSGSGEIG CCCCEEEECCCCCCC	40.64	29967540
987	Phosphorylation	SSGLVYKSGSGEIGS CCCEEEECCCCCCCC	22.09	29255136
989	Phosphorylation	GLVYKSGSGEIGSET CEEEECCCCCCCCCC	40.10	23401153
994	Phosphorylation	SGSGEIGSETSDKKD CCCCCCCCCCCCCCC	43.28	23403867
996	Phosphorylation	SGEIGSETSDKKDSF CCCCCCCCCCCCCCC	43.87	23403867
997	Phosphorylation	GEIGSETSDKKDSFY CCCCCCCCCCCCCCC	43.30	23403867
1002	Phosphorylation	ETSDKKDSFYTDSSS CCCCCCCCCCCCCCH	29.09	28122231
1004	Phosphorylation	SDKKDSFYTDSSSIL CCCCCCCCCCCCHHC	17.37	27732954
1005	Phosphorylation	DKKDSFYTDSSSILN CCCCCCCCCCCHHCC	27.65	27732954
1007	Phosphorylation	KDSFYTDSSSILNYR CCCCCCCCCHHCCCC	20.41	27732954
1008	Phosphorylation	DSFYTDSSSILNYRE CCCCCCCCHHCCCCC	24.98	27732954
1009	Phosphorylation	SFYTDSSSILNYRED CCCCCCCHHCCCCCC	34.74	27732954
1021	Phosphorylation	REDSNILSFDSDGNQ CCCCCEEEECCCCCC	24.18	27080861
1024	Phosphorylation	SNILSFDSDGNQNIL CCEEEECCCCCCEEE	45.46	27080861
1042	Phosphorylation	LTSKGNETIESIFKA EEECCCHHHHHHHCH	33.76	21815630
1045	Phosphorylation	KGNETIESIFKAEDL CCCHHHHHHHCHHHH	29.49	24719451
1058	Phosphorylation	DLLPEAASLSENLDI HHHHHHHHHHCCCCC	39.20	29759185
1060	Phosphorylation	LPEAASLSENLDISK HHHHHHHHCCCCCCC	23.19	29759185
1066	Phosphorylation	LSENLDISKEETPPV HHCCCCCCCCCCCCC	33.41	22199227
1070	Phosphorylation	LDISKEETPPVRTLK CCCCCCCCCCCEECC	33.70	21815630
1077	Methylation	TPPVRTLKSQSSLSG CCCCEECCCCCCCCC	45.92	-
1078	Phosphorylation	PPVRTLKSQSSLSGK CCCEECCCCCCCCCC	38.11	29396449
1080	Phosphorylation	VRTLKSQSSLSGKPK CEECCCCCCCCCCCH	40.10	26657352
1081	Phosphorylation	RTLKSQSSLSGKPKE EECCCCCCCCCCCHH	20.93	24972180
1083	Phosphorylation	LKSQSSLSGKPKERC CCCCCCCCCCCHHHC	46.87	29396449
1100	Phosphorylation	NLAPLCVSYKNMKRS CHHHHHHHHHCCCCC	29.41	28555341
1101	Phosphorylation	LAPLCVSYKNMKRSS HHHHHHHHHCCCCCC	5.98	24719451
1102	Acetylation	APLCVSYKNMKRSSS HHHHHHHHCCCCCCC	42.96	25953088
1107	Phosphorylation	SYKNMKRSSSQMSLD HHHCCCCCCCCCCCC	28.90	27251275
1108	Phosphorylation	YKNMKRSSSQMSLDT HHCCCCCCCCCCCCC	28.73	27251275
1109	Phosphorylation	KNMKRSSSQMSLDTI HCCCCCCCCCCCCCC	31.02	27251275
1112	Phosphorylation	KRSSSQMSLDTISLD CCCCCCCCCCCCCHH	18.56	28348404
1167	Phosphorylation	AGANLQNYGETSPDA CCCCCCCCCCCCCCH	11.90	27251275
1170	Phosphorylation	NLQNYGETSPDAIST CCCCCCCCCCCHHHC	40.99	27251275
1171	Phosphorylation	LQNYGETSPDAISTN CCCCCCCCCCHHHCC	19.24	27251275
1176	Phosphorylation	ETSPDAISTNSEGAQ CCCCCHHHCCCCCCH	24.21	27251275
1177	Phosphorylation	TSPDAISTNSEGAQE CCCCHHHCCCCCCHH	36.33	27251275
1179	Phosphorylation	PDAISTNSEGAQENH CCHHHCCCCCCHHCH	37.18	26471730
1191	Phosphorylation	ENHDDLMSVVVFKIT HCHHCCEEEEEEEEE	21.03	27251275
1241	Phosphorylation	LCNRPVGSDQKAVIH HHCCCCCCCCCEEEE	36.78	28674419
1244	Ubiquitination	RPVGSDQKAVIHSKS CCCCCCCCEEEECCC	50.00	29967540
1251	Phosphorylation	KAVIHSKSSPEISLR CEEEECCCCCCEEEE	54.89	27499020
1252	Phosphorylation	AVIHSKSSPEISLRF EEEECCCCCCEEEEE	30.23	22985185
1269	Phosphorylation	GPGAVIHSLLAEKNG CCHHHHHHHHHHHCC	17.60	-
1327	Phosphorylation	KINLKDDSPRSSTVS EEECCCCCCCCCCEE	32.14	28387310
1367	Phosphorylation	RDSHMLNTGNDLKEN CHHHCCCCCCCHHHH	33.14	27251275
1394	Phosphorylation	YDLKKQRSVTQATQT CCHHHCCCCCCCCCC	27.33	23663014
1396	Phosphorylation	LKKQRSVTQATQTSP HHHCCCCCCCCCCCC	17.46	23663014
1399	Phosphorylation	QRSVTQATQTSPGVP CCCCCCCCCCCCCCC	23.67	23663014
1401	Phosphorylation	SVTQATQTSPGVPWP CCCCCCCCCCCCCCC	32.31	23663014
1402	Phosphorylation	VTQATQTSPGVPWPS CCCCCCCCCCCCCCC	15.16	28176443
1409	Phosphorylation	SPGVPWPSQSANFPE CCCCCCCCCCCCCCC	32.66	23663014
1411	Phosphorylation	GVPWPSQSANFPEFS CCCCCCCCCCCCCCC	29.53	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UH1BL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UH1BL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UH1BL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of UH1BL_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UH1BL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414 AND SER-418, ANDMASS SPECTROMETRY.	17081983 [Abstract]