dbPTM

AMOL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AMOL1_HUMAN
UniProt AC	Q8IY63
Protein Name	Angiomotin-like protein 1
Gene Name	AMOTL1
Organism	Homo sapiens (Human).
Sequence Length	956
Subcellular Localization	Cell junction, tight junction.
Protein Description	Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus..
Protein Sequence	MWRAKLRRGTCEPAVKGSPSACYSPSSPVQVLEDSTYFSPDFQLYSGRHETSALTVEATSSIREKVVEDPLCNFHSPNFLRISEVEMRGSEDAAAGTVLQRLIQEQLRYGTPTENMNLLAIQHQATGSAGPAHPTNNFSSTENLTQEDPQMVYQSARQEPQGQEHQVDNTVMEKQVRSTQPQQNNEELPTYEEAKAQSQFFRGQQQQQQQQGAVGHGYYMAGGTSQKSRTEGRPTVNRANSGQAHKDEALKELKQGHVRSLSERIMQLSLERNGAKQHLPGSGNGKGFKVGGGPSPAQPAGKVLDPRGPPPEYPFKTKQMMSPVSKTQEHGLFYGDQHPGMLHEMVKPYPAPQPVRTDVAVLRYQPPPEYGVTSRPCQLPFPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPPPAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRLHDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEADMTKWEQKYLEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTGSKDSSTQTDKSAELFWPSMASLPSRGRLSTTPAHSPVLKHPAAKGTAEKLENSPGHGKSPDHRGRVSSLLHKPEFPDGEMMEVLI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	GTCEPAVKGSPSACY CCCCCCCCCCCCCCC	56.64	-
51	Phosphorylation	LYSGRHETSALTVEA EECCCCCCCCEEEEE	17.11	72500125
52	Phosphorylation	YSGRHETSALTVEAT ECCCCCCCCEEEEEC	20.49	72500131
61	Phosphorylation	LTVEATSSIREKVVE EEEEECHHHHHHHCC	22.70	17924679
76	Phosphorylation	DPLCNFHSPNFLRIS CCCCCCCCCCEEEEE	19.87	29449344
135	Phosphorylation	SAGPAHPTNNFSSTE CCCCCCCCCCCCCCC	32.69	28348404
139	Phosphorylation	AHPTNNFSSTENLTQ CCCCCCCCCCCCCCC	38.17	28348404
140	Phosphorylation	HPTNNFSSTENLTQE CCCCCCCCCCCCCCC	35.29	28348404
141	Phosphorylation	PTNNFSSTENLTQED CCCCCCCCCCCCCCC	27.91	28348404
145	Phosphorylation	FSSTENLTQEDPQMV CCCCCCCCCCCHHHH	41.30	28348404
145 (in isoform 2)	Ubiquitination	-	41.30	21890473
174	Ubiquitination	VDNTVMEKQVRSTQP CCCHHHHHHHHHCCC	35.68	-
177 (in isoform 2)	Ubiquitination	-	31.34	21890473
190	Phosphorylation	QNNEELPTYEEAKAQ CCCCCCCCHHHHHHH	57.07	28796482
191	Phosphorylation	NNEELPTYEEAKAQS CCCCCCCHHHHHHHH	15.16	28796482
195	Ubiquitination	LPTYEEAKAQSQFFR CCCHHHHHHHHHHHH	50.68	21906983
195 (in isoform 1)	Ubiquitination	-	50.68	21890473
198	Phosphorylation	YEEAKAQSQFFRGQQ HHHHHHHHHHHHHHH	33.54	68724781
218	Phosphorylation	QGAVGHGYYMAGGTS CCCCCCCCCCCCCCC	5.61	28796482
219	Phosphorylation	GAVGHGYYMAGGTSQ CCCCCCCCCCCCCCC	5.77	28796482
224	Phosphorylation	GYYMAGGTSQKSRTE CCCCCCCCCCCCCCC	27.37	23401153
225	Phosphorylation	YYMAGGTSQKSRTEG CCCCCCCCCCCCCCC	38.60	28796482
227	Ubiquitination	MAGGTSQKSRTEGRP CCCCCCCCCCCCCCC	41.49	21906983
227 (in isoform 1)	Ubiquitination	-	41.49	21890473
239 (in isoform 2)	Ubiquitination	-	14.88	-
241	Phosphorylation	PTVNRANSGQAHKDE CCCCCCCCCCCCHHH	31.15	23927012
251	Ubiquitination	AHKDEALKELKQGHV CCHHHHHHHHHHHHH	68.96	-
252 (in isoform 2)	Ubiquitination	-	63.15	21890473
260	Phosphorylation	LKQGHVRSLSERIMQ HHHHHHHHHHHHHHH	34.85	23403867
262	Phosphorylation	QGHVRSLSERIMQLS HHHHHHHHHHHHHHH	26.52	23403867
269	Phosphorylation	SERIMQLSLERNGAK HHHHHHHHHHHCCCC	15.99	29255136
289	Ubiquitination	SGNGKGFKVGGGPSP CCCCCCCCCCCCCCC	48.95	-
295	Phosphorylation	FKVGGGPSPAQPAGK CCCCCCCCCCCCCCC	35.82	25159151
302	Acetylation	SPAQPAGKVLDPRGP CCCCCCCCCCCCCCC	41.55	26051181
302	Ubiquitination	SPAQPAGKVLDPRGP CCCCCCCCCCCCCCC	41.55	2189047
302 (in isoform 1)	Ubiquitination	-	41.55	21890473
302	Ubiquitination	SPAQPAGKVLDPRGP CCCCCCCCCCCCCCC	41.55	21890473
316	Methylation	PPPEYPFKTKQMMSP CCCCCCCCCCCCCCC	50.76	-
316	Ubiquitination	PPPEYPFKTKQMMSP CCCCCCCCCCCCCCC	50.76	-
318	Methylation	PEYPFKTKQMMSPVS CCCCCCCCCCCCCCC	36.47	-
318	Ubiquitination	PEYPFKTKQMMSPVS CCCCCCCCCCCCCCC	36.47	-
322	Phosphorylation	FKTKQMMSPVSKTQE CCCCCCCCCCCCHHH	19.46	54886879
325	Phosphorylation	KQMMSPVSKTQEHGL CCCCCCCCCHHHCCC	33.11	22199227
347	Ubiquitination	GMLHEMVKPYPAPQP CHHHHHCCCCCCCCC	37.21	-
373	Phosphorylation	PPPEYGVTSRPCQLP CCCCCCCCCCCCCCC	18.04	7899741
374	Phosphorylation	PPEYGVTSRPCQLPF CCCCCCCCCCCCCCC	31.64	11763373
425	Phosphorylation	PQPPPAASPSQQLGP CCCCCCCCHHHHCCC	27.47	26657352
471	Ubiquitination	DNADKLHKFEKELQR CCHHHHHHHHHHHHH	66.70	-
474	Ubiquitination	DKLHKFEKELQRISE HHHHHHHHHHHHHHH	67.85	-
480	Phosphorylation	EKELQRISEAYESLV HHHHHHHHHHHHHHH	20.54	29083192
483	Phosphorylation	LQRISEAYESLVKST HHHHHHHHHHHHHHH	11.29	29083192
485	Phosphorylation	RISEAYESLVKSTTK HHHHHHHHHHHHHHC	26.28	25850435
489	Phosphorylation	AYESLVKSTTKRESL HHHHHHHHHHCHHHH	33.55	29083192
490	Phosphorylation	YESLVKSTTKRESLD HHHHHHHHHCHHHHH	30.53	29083192
491	Phosphorylation	ESLVKSTTKRESLDK HHHHHHHHCHHHHHH	34.88	29083192
503	Ubiquitination	LDKAMRNKLEGEIRR HHHHHHHHHHHHHHH	37.23	-
534	Phosphorylation	RQLSSREYEGHEDKA HHHHHCHHCCCCCHH	26.54	28796482
540	Ubiquitination	EYEGHEDKAAEGHYA HHCCCCCHHHHCCHH	46.65	-
546	Phosphorylation	DKAAEGHYASQNKEF CHHHHCCHHHHCHHH	20.85	28796482
548	Phosphorylation	AAEGHYASQNKEFLK HHHCCHHHHCHHHHH	27.41	28796482
551	Ubiquitination	GHYASQNKEFLKEKE CCHHHHCHHHHHHHH	42.05	-
594	Ubiquitination	NAQARVIKLEEELRE HHHHHHHHHHHHHHH	47.17	-
611	Ubiquitination	AYVEKVEKLQQALTQ HHHHHHHHHHHHHHH	55.36	-
625	Ubiquitination	QLQSACEKREQMERR HHHHHHHHHHHHHHH	62.21	-
649	Ubiquitination	DALRTQQKHGNGQPA HHHHHHHHCCCCCCC	43.60	-
661	Phosphorylation	QPANMPEYNAPALLE CCCCCCCCCHHHHHH	15.68	30835315
686	Ubiquitination	ALEADMTKWEQKYLE HHHCCCHHHHHHHHH	41.94	-
690	Ubiquitination	DMTKWEQKYLEESTI CCHHHHHHHHHHHHH	40.04	-
691	Phosphorylation	MTKWEQKYLEESTIR CHHHHHHHHHHHHHH	21.02	27642862
707	Phosphorylation	FAMNAAATAAAERDT HHHHHHHHHHHHCCC	16.47	113326225
714	Phosphorylation	TAAAERDTTIINHSR HHHHHCCCEEEECCC	26.56	29255136
715	Phosphorylation	AAAERDTTIINHSRN HHHHCCCEEEECCCC	24.93	29255136
720	Phosphorylation	DTTIINHSRNGSYGE CCEEEECCCCCCCCC	23.97	29255136
724	Phosphorylation	INHSRNGSYGESSLE EECCCCCCCCCCHHH	33.25	22617229
725	Phosphorylation	NHSRNGSYGESSLEA ECCCCCCCCCCHHHH	26.72	23663014
728	Phosphorylation	RNGSYGESSLEAHIW CCCCCCCCHHHHEEC	35.54	23663014
729	Phosphorylation	NGSYGESSLEAHIWQ CCCCCCCHHHHEECH	26.40	23663014
756	Ubiquitination	QDMEYTIKNLHAKII HCHHHHHHHHHHHHH	45.73	-
761	Ubiquitination	TIKNLHAKIIEKDAM HHHHHHHHHHHHHHH	33.21	-
765	Ubiquitination	LHAKIIEKDAMIKVL HHHHHHHHHHHHHHH	40.14	-
782	Ubiquitination	RSRKDAGKTDSSSLR HHHHCCCCCCCCCCC	51.37	-
783	Phosphorylation	SRKDAGKTDSSSLRP HHHCCCCCCCCCCCC	39.95	23186163
785	Phosphorylation	KDAGKTDSSSLRPAR HCCCCCCCCCCCCCC	27.36	26074081
786	Phosphorylation	DAGKTDSSSLRPARS CCCCCCCCCCCCCCC	35.88	30576142
787	Phosphorylation	AGKTDSSSLRPARSV CCCCCCCCCCCCCCC	32.14	30576142
793	Phosphorylation	SSLRPARSVPSIAAA CCCCCCCCCCCHHHH	40.25	29255136
796	Phosphorylation	RPARSVPSIAAATGT CCCCCCCCHHHHCCC	23.78	29255136
801	Phosphorylation	VPSIAAATGTHSRQT CCCHHHHCCCCHHHC	37.58	23927012
803	Phosphorylation	SIAAATGTHSRQTSL CHHHHCCCCHHHCCC	16.60	23927012
805	Phosphorylation	AAATGTHSRQTSLTS HHHCCCCHHHCCCCH	26.39	19276368
808	Phosphorylation	TGTHSRQTSLTSSQL CCCCHHHCCCCHHHH	25.29	29255136
809	Phosphorylation	GTHSRQTSLTSSQLA CCCHHHCCCCHHHHH	22.70	29255136
811	Phosphorylation	HSRQTSLTSSQLAEE CHHHCCCCHHHHHHH	26.54	27794612
812	Phosphorylation	SRQTSLTSSQLAEEK HHHCCCCHHHHHHHH	22.75	19691289
813	Phosphorylation	RQTSLTSSQLAEEKK HHCCCCHHHHHHHHH	24.79	19691289
823	Ubiquitination	AEEKKEEKTWKGSIG HHHHHHHHCCHHHHH	61.86	-
824	Phosphorylation	EEKKEEKTWKGSIGL HHHHHHHCCHHHHHH	35.37	23186163
828	Phosphorylation	EEKTWKGSIGLLLGK HHHCCHHHHHHHHCC	15.12	22617229
842	Phosphorylation	KEHHEHASAPLLPPP CCCCCCCCCCCCCCC	32.12	22468782
851	Phosphorylation	PLLPPPPTSALSSIA CCCCCCCCCHHHHHH	32.19	22468782
852	Phosphorylation	LLPPPPTSALSSIAS CCCCCCCCHHHHHHH	32.74	22468782
860	Phosphorylation	ALSSIASTTAASSAH HHHHHHHHHHHHHHH	16.07	22468782
861	Phosphorylation	LSSIASTTAASSAHA HHHHHHHHHHHHHHH	20.10	22468782
872	Phosphorylation	SAHAKTGSKDSSTQT HHHHHCCCCCCCCCC	38.22	24719451
875	Phosphorylation	AKTGSKDSSTQTDKS HHCCCCCCCCCCHHH	38.73	28985074
876	Phosphorylation	KTGSKDSSTQTDKSA HCCCCCCCCCCHHHH	34.37	10394463
877	Phosphorylation	TGSKDSSTQTDKSAE CCCCCCCCCCHHHHH	39.17	10394473
879	Phosphorylation	SKDSSTQTDKSAELF CCCCCCCCHHHHHHH	45.54	22269353
882	Phosphorylation	SSTQTDKSAELFWPS CCCCCHHHHHHHCHH	29.77	23090842
889	Phosphorylation	SAELFWPSMASLPSR HHHHHCHHHCCCCCC	19.99	25850435
892	Phosphorylation	LFWPSMASLPSRGRL HHCHHHCCCCCCCCC	31.97	25850435
895	Phosphorylation	PSMASLPSRGRLSTT HHHCCCCCCCCCCCC	53.30	25850435
900	Phosphorylation	LPSRGRLSTTPAHSP CCCCCCCCCCCCCCC	28.95	29255136
901	Phosphorylation	PSRGRLSTTPAHSPV CCCCCCCCCCCCCCC	41.20	29255136
902	Phosphorylation	SRGRLSTTPAHSPVL CCCCCCCCCCCCCCC	18.33	23401153
906	Phosphorylation	LSTTPAHSPVLKHPA CCCCCCCCCCCCCCC	20.86	23401153
917	Phosphorylation	KHPAAKGTAEKLENS CCCCCCCCHHHHHCC	30.82	20068231
924	Phosphorylation	TAEKLENSPGHGKSP CHHHHHCCCCCCCCC	23.92	23898821
930	Phosphorylation	NSPGHGKSPDHRGRV CCCCCCCCCCCCCCH	39.90	21712546
938	Phosphorylation	PDHRGRVSSLLHKPE CCCCCCHHHHHCCCC	17.57	28122231
939	Phosphorylation	DHRGRVSSLLHKPEF CCCCCHHHHHCCCCC	31.90	21984501

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
793	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AMOL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AMOL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NED4L_HUMAN	NEDD4L	physical	22558212
CDAC1_HUMAN	CDADC1	physical	27173435
SCML1_HUMAN	SCML1	physical	27173435
DDHD1_HUMAN	DDHD1	physical	27173435
UH1BL_HUMAN	UHRF1BP1L	physical	27173435
HECW2_HUMAN	HECW2	physical	27498087
USP9X_HUMAN	USP9X	physical	28720576

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AMOL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-803 AND SER-805, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425; SER-720 ANDSER-809, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; SER-52 AND SER-61,AND MASS SPECTROMETRY.	17924679 [Abstract]